Category: 534-03-2

Adding a certain compound to certain chemical reactions, such as: 534-03-2, 2-Aminopropane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C3H9NO2, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C3H9NO2

Compound 2. Methylated lithocholic acid (1) (1.5 g, 3.8 mmol), serinol (0.41 g, 4.6 mmol), 1-hydroxybenzotriazole monohydrate (HOBt) (0.61 g, 4.6 mmol) was dissolved in anhydrous DMF (30 mL). 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl) (0.87 g, 4.55 mmol) was added in small portions at 0 C. and the resulting solution left stirring at room temperature for 20 h. The solution was taken up with EtOAc (100 mL) and was washed successively with a 1 M aqueous NaHCO3 solution (100 mL), a 0.1 M aqueous HCl solution (100 mL) and brine (2×100 mL). Then the organic layer was dried with anhydrous Na2SO4 and the solvent was removed by rotary evaporation. The reaction mixture was precipitated with ether (100 mL) and the resulting solid was collected and dried in vacuo to afford amide-containing diol (2) as a white solid (1.60 g, 91%). This product was used for next reaction without further purification. 1H NMR (300 MHz, CDCl3): delta 6.86 (d, J=7.9 Hz, 1H), 3.88-3.80 (m, 4H), 3.76-3.64 (m, 2H), 3.64-3.52 (m, 2H), 3.36 (s, 3H), 3.26-3.12 (m, 1H), 2.34-2.21 (m, 1H), 2.17-2.05 (m, 1H), 1.98-1.50 (m, 9H), 1.48-0.94 (m, 16H), 0.94-0.84 (m, 6H), 0.65 (s, 3H); 13C NMR (75 MHz, CDCl3): delta 175.4, 80.7, 61.4, 56.5, 56.0, 55.4, 52.5, 49.3, 49.0, 48.7, 48.4, 42.8, 42.1, 40.4, 40.2, 35.9, 35.6, 35.2, 34.9, 32.7, 31.8, 28.2, 27.3, 26.7, 26.4, 24.2, 23.4, 20.8, 18.3, 12.0; MS (MALDI-TOF): calcd. for C28H49NO4 [M+Na]+ 486.3554, found 486.3570.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; Gellman, Samuel Helmer; Chae, Pil Seok; Kobilka, Brian; Rasmussen, Soren; US2013/266656; (2013); A1;,
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Related Products of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

735 ml of methylenechloride is put in a flask after a stir bar is put in the flask and cooled down to 0 C. under a nitrogen stream, 85 g (147 mmol) of sulforhodamine B acid chloride is added thereto, and the mixture is agitated. Subsequently, 16.1 g (177 mmol) of serinol, 0.899 g (7.37 mmol) of N,N-dimethylamino pyridine, and 38.3 g (53 ml, 295 mmol) of triethyl amine are further added thereto, and the mixture is agitated at room temperature for 15 hours. Then, the mixture is concentrated under a reduced pressure by using a rotary evaporator to obtain a red solid, and the red solid is rinsed with ethylacetate, obtaining 70.1.5 g of a solid compound represented by the following Chemical Formula 6-4 (a yield of 69%).

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Cheil Industries Co., Ltd.; Kim, Won Jung; Kang, Kyung Hee; Park, Chae Won; Sin, Myung Yeop; Jeon, Hwan Sung; Jung, Uii Soo; Hwang, Ki Wook; (43 pag.)KR2016/91878; (2016); A;,
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Electric Literature of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

Intermediate 131: 2-(l,3-Dihvdroxypropan-2-yl)isoindoline-l,3-dione (0848) To a stirring solution of 2-aminopropane-l,3-diol (327.2 mg, 3.59 mmol, commercially available from, for example, Sigma-Aldrich) in DMF (15 ml.) was added phthalic anhydride (533.6 mg, 3.60 mmol) portionwise. The resulting colourless solution was stirred at 90 C under nitrogen for 5 h, after which the reaction mixture was cooled to rt and the volatiles evaporated in vacuo. This was partitioned between ethyl acetate (25 ml.) and water (25 ml.) and the layers separated. The aqueous phase was extracted with further ethyl acetate (4 x 25 ml.) and the organic layers combined and filtered through a cartridge fitted with a hydrophobic frit. The filtrate was evaporated in vacuo. This was redissolved in ethyl acetate (approx. 4 ml.) and 3: 1 ethyl acetate :ethanol (approx. 4 ml.) and directly applied to the top of a 25 g SNAP cartridge and purified by flash column chromatography. The column was eluted with a gradient of 0% – 40% (3: 1 ethyl acetate:ethanol) in cyclohexane. The appropriate fractions were combined and evaporated in vacuo to give 2-(l,3-dihydroxypropan-2- yl)isoindoline-l,3-dione (380.0 mg, 1.72 mmol, 48 % yield) as a white solid. (0849) LCMS (2 min High pH): Rt = 0.55 min, [MH]+ = 222.3.

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LEVERNIER, Etienne; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (225 pag.)WO2017/174621; (2017); A1;,
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Synthetic Route of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.

Add 735ml of ethyl acetate in the flask cooled to 0C under a stream of nitrogen, Sulforhodamine B acid chloride 85g (147mmol) added to the agitation. And serinol 16.1g (177mmol), N, N-dimethylaminopyridine 0.899g (7.37mmol), triethylamine and 38.3g (53ml, 295mmol) was further added the mixture was stirred at room temperature for 15 hours.Then the solid was obtained 70.1.5g compound (yield 69%) of the title mixture of the red solid obtained by concentration under reduced pressure by a rotary evaporator by the formula 6-4 to by washing with ethyl acetate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,534-03-2, its application will become more common.

Reference:
Patent; Cheil Industries Co.Ltd; Kim, Won Jung; Kang, Gyung Hee; Park, Chae Won; Sin, Myung Yeop; Jeon, Hwan Sung; Jung, Uii Soo; Hwang, Gi Wook; (40 pag.)KR2015/89702; (2015); A;,
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Related Products of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

Fmoc-beta-alanine (84.5 g, 271 mmol) and N-hydroxysuccinimide (31.2 g, 271 mmol) are dissolved in dichloromethane (850 mL) and DMF (43 mL) with magnetic stirring. N,N-dicyclohexylcarbodiimide (56.0 g, 271 mmol) dissolved in dichloromethane (100 mL) is added in one portion. After stirring 1.5 hours at room temperature, the reaction mixture was filtered, and transferred to a mixture of serinol (24.7 g, 271 mmol) in pyridine (380 mL) and allowed to react 16 hours overnight. The mixture is evaporated to a semi-solid residue, and co-evaporated 3*400 mL toluene to remove the remaining pyridine. The solid residue is refluxed in dichloromethane (3.0 L) and stored at -20 C. for 2 hours. The product was collect by filtration in a sintered glass funnel, and washed 2*1000 mL dichloromethane, and 1*1000 mL diethyl ether. Drying overnight under high vacuum yielded 92.8 g (89%) of 1.

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nelson Biotechnologies, Inc.; Glen Research Corporation; US2011/77389; (2011); A1;,
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Synthetic Route of 534-03-2 ,Some common heterocyclic compound, 534-03-2, molecular formula is C3H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8Hz), 7.41 (2H, t, J=8Hz), 7.22 (2H, t, J=7Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sankyo Company Limited; EP1069110; (2001); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 534-03-2, name is 2-Aminopropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C3H9NO2

General procedure: To a stirred mixture of serinol 8 (1 equivalent) and K2CO3 (3 equivalents) in DMSO at 70-80 oC wasadded the appropriate fluoroaromatic 7d-f in portions over 5 minutes. The resulting colouredmixture was stirred (typically 3 hours), allowed to cool to room temperature, and then poured intoice-water with stirring. The resulting diol 9c-f was collected, washed with water and allowed to dry inair.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 534-03-2, 2-Aminopropane-1,3-diol.

Reference:
Article; Chappel, Lucy; Leong, Chee-Onn; Mai, Chun-Wai; Meikle, Ian T.; Stanforth, Stephen P.; Truong, Thang V.; Wong, Lai Chun; Bioorganic and medicinal chemistry letters; (2019);,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 534-03-2, name is 2-Aminopropane-1,3-diol, the common compound, a new synthetic route is introduced below. Quality Control of 2-Aminopropane-1,3-diol

0.91 g of 2-amino-l , 3-propandiol and 1.13 g of triethylamine are solubilised in 15 ml of tetrahydrofuran at 0C. The solution is stirred and placed under nitrogen atmosphere. A solution of 2.74 g of palmitoyl chloride is added dropwise slowly within 30 min. After another 30 min of stirring at ambient temperature, the mixture is dry evaporated. The residue is solubilised using 15 ml of ethyl acetate and extracted using 10 ml of water which is disposed. The organic phase is anhydrified using Na2S04 and dry evaporated under vacuum. The raw amide thus obtained is used without further purification. The residue is suspended at 0C and under nitrogen gas atmosphere in 20 ml of S0C12. The mixture is stirred at 0C for 30 minutes, then at ambient temperature for 6 hours. The solution thus obtained is dry evaporated at a low pressure. The residue is purified by crystallization from 15 ml of tert-butyl methyl ether, isolated and dried under vacuum. The crystallized product is suspended in 20 ml of anhydrous toluene and 1.3 g of potassium tert- butoxide are added. The mixture is heated at 40C for 2 hours, then it is cooled at 4C. The solution is extracted 3 times using 6 ml of water and the extracts are disposed. The organic phase is dry evaporated at’ a low pressure and the residue purified through flash chromatography in a column of silica gel using – as eluent – a mixture of hexane and ethyl acetate 1:3. The fractions containing the pure product are recombined and dry evaporated under vacuum. (About 90% yield) The 2-pentadecyl-4-hydroxymethyl-2-oxazoline product has the following characteristics: Molecular formula C19H37N02; C=73.26%, H=11.97%, N=4.50%, 0=10.27%; Solubility: poorly soluble in water, >10 mg/ml in ethanol; Mr 311.5; ESI-MS: 312 (MH+) .

The synthetic route of 534-03-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EPITECH GROUP S.r.L.; DELLA VALLE, Francesco; DELLA VALLE maria Federica; DI MARZO, Vincenzo; CUZZOCREA, Salvatore; WO2013/121449; (2013); A1;,
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Reference of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.

45.6 g of 2-amino-1,3-dihydroxypropane was mixed with 113 mL of formic acid solution,Then add 90 mL of 37% formaldehyde solution.The mixture was stirred at room temperature for 2h,The reaction was then warmed to 80 C,And kept at this temperature overnight.When the temperature reaches 80 , there will be a lot of gas discharge. After the reaction was completed, it was cooled to room temperature. 60 mL of 37% strength hydrochloric acid was added and stirred for 1 h.Solid sodium hydroxide was added to adjust the pH of the solution to 12, the mixture was distilled under reduced pressure,Add a lot of methanol.At this point the white precipitate generated in the system filter, the filtrate was distilled off under reduced pressure,The concentrated initial product was dissolved in trichloromethane and dried over anhydrous magnesium sulfate.In the conditions of 100 -102 / 100Kpa by distillation,40.9 g was obtained2-N, N-dimethyl-1,3-dihydroxypropane,The yield was 68.65%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; University of Science and Technology Beijing; Gong Aijun; Yang Jing; Qiu Lina; Xie Yanping; Zhao Yunbo; (9 pag.)CN105198773; (2017); B;,
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Electric Literature of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

To a solution of 2-amino-1,3-propanediol (S2, 299 mg, 3.28 mmol, 1.0 equiv) in MeCN (10 mL), K2CO3 (2.27 g, 16.4 mmol, 5.0 equiv) and benzyl bromide (0.98 mL, 1.4 g, 8.3 mmol, 2.5 equiv) were added at room temperature. The reaction mixture was stirred at this temperature for 18 h and then diluted with water (10 mL). The aqueous layer was extracted with EtOAc (3 × 10 mL) and the combined organics were dried over Na2SO4. The solvent was removed under reduced pressure and the resultant residue was purified by column chromatography (SiO2, petroleum ether/EtOAc 1:1) to yield 716 mg (2.64 mmol, 80%) of S3 as a white solid. TLC Rf 0.20 (petroleum ether/EtOAc 1:1); mp 113 C; 1H NMR (300 MHz, C6D6): 2.30 (bs, 2H, OH), 2.93 (tt, 1H, J = 7.5, 5.9 Hz, 2-H), 3.37 (dd, 2H, J = 10.8, 5.9 Hz, 1-Ha, 3-Ha), 3.48 (dd, 2H, J = 10.8, 7.5 Hz, 1-Hb, 3-Hb), 3.53-3.66 (m, 4H, CH2Ph), 7.01-7.32 (m, 10H, Ph-H); 13C NMR (76 MHz, C6D6): 54.4, 60.2, 60.3, 127.4, 128.7, 129.2, 140.1; IR (ATR) nu 3245, 1493, 1451, 1049, 1025, 999, 741, 730, 695; UV (MeCN) lambdamax (log epsilon) 206 (4.28), 259 (2.77); MS (ESI+) m/z 272.2 (M+H+), 294.2 (M+Na+); HRMS (ESI+) m/z calcd for C17H21NNaO2 294.1465 (M+Na+), found 294.1466.

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ries, Oliver; Bueschleb, Martin; Granitzka, Markus; Stalke, Dietmar; Ducho, Christian; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 1135 – 1142;,
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