Category: 534-03-2

Kim, Joseph Byung-Kyu’s team published research in International Journal of Radiation Biology in 2021 | CAS: 534-03-2

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Product Details of 534-03-2

Kim, Joseph Byung-Kyu; Mackeyev, Yuri; Raghuram, Subhiksha; Cho, Sang Hyun; Krishnan, Sunil published an article in 2021. The article was titled 《Synthesis and characterization of gadolinium-decorated [60]fullerene for tumor imaging and radiation sensitization》, and you may find the article in International Journal of Radiation Biology.Product Details of 534-03-2 The information in the text is summarized as follows:

The excellent contrast of high at. number (Z) elements compared to soft tissues has advanced their use as contrast agents for computed tomog. imaging and as potential radiation sensitizers. We evaluated whether gadolinium (Gd) could serve as such a theranostic agent for high-resolution magnetic resonance imaging (MRI) due to its paramagnetic properties and radiosensitization due to its high Z. To improve the relaxivity of Gd, we coupled it to [60]fullerene, an elemental carbon allotropic nanoparticle that seamlessly traverses physiol. barriers . By adding serinol, an aliphatic alc. derived from amino acid serine, we turned [60]fullerene, which is otherwise insoluble in water, into a highly water-soluble derivative and decorated it externally with a payload of chelated gadolinium ions. When [60]fullerene was functionalized in this manner with two gadolinium ions (Gd2C60), it displayed considerably higher T1 relaxivity at 4.7 T than the com. used MRI contrast agent, Magnevist, (18.2 mM-1s-1 vs. 4.7 mM-1s-1). Attempts to increase this even further via decoration of [60]fullerene with 12 gadolinium ions was unsuccessful due to a poor water solubility However, the current formulation of Gd2C60 did not result in any appreciable radiosensitization. Our results show a successful generation of a novel contrast agent via decoration of fullerene with two chelated Gd ions. Though this formulation was not successful in generating radiosensitization, other chem. modifications can be further explored to increase radiosensitization potential. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Product Details of 534-03-2

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Ogo, A. O.’s team published research in International Journal of Current Pharmaceutical Research in 2020 | CAS: 534-03-2

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 2-Aminopropane-1,3-diol

《Phoenix dactylifera fruit extract ameliorates altered biochemical parameters in streptozotocin-induced diabetes mellitus albino rats》 was written by Ogo, A. O.; Abah, S. F.; Inalegwu, B.; Eru, U. E.. Safety of 2-Aminopropane-1,3-diol And the article was included in International Journal of Current Pharmaceutical Research in 2020. The article conveys some information:

Objective: Consistent projections have indicated a steady increase in the global burden of diabetes mellitus. Given the increased cost in conventional management of the condition in addition to reported side effects and cost of orthodox management, attention is shifting to the use of alternative methods such as plants materials with dual benefits as food and medicine. Thus, this study was designed to investigate the effect of date palm fruit on some biochem. parameters in streptozotocin-induced wistar rats. Methods: Animals were divided into 5 groups of 6 rats each (I as normal control, II as diabetic control and 3-5 as extract-treated groups) maintained for 14 d. At the end of the treatment, the animals were fasted overnight, then sacrificed and blood samples collected for anal. of biochem. parameters (including blood glucose, blood lipids and enzymes). Results: The results show that treatment of diabetic animals with extract of date palm fruit show a significant (P<0.05) reduction in glucose levels in groups II-V compared to group I. Similar pos. effects were observed in the levels of lipids and enzymes in treated groups compared to diabetic control group II. A GC-MS anal. of the fraction of the fruit extract revealed some bioactive compounds that may be responsible for the effects exhibited in the study. Conclusion: These findings which demonstrate the ameliorative effect on hyperglycemia and hyperlipidemia, further support the use of date palm fruit as a nutraceutical agent. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 2-Aminopropane-1,3-diol

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Sifaki, Kleanthi’s team published research in Acta Crystallographica, Section C: Structural Chemistry in 2021 | CAS: 534-03-2

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H9NO2

《Synthesis and characterization of the Anderson-Evans tungstoantimonate [Na5(H2O)18{(HOCH2)2-CHNH3}2][SbW6O24]》 was written by Sifaki, Kleanthi; Gumerova, Nadiia I.; Giester, Gerald; Rompel, Annette. COA of Formula: C3H9NO2This research focused ontungstoantimonate polyoxometalate Anderson Evan; POM; POT; crystal structure; organic-inorganic hybrid; polyoxometalate; polyoxotungstate; serinol. The article conveys some information:

A novel tungstoantimonate, [Na5(H2O)18{(HOCH2)2-CHNH3}2][SbVWVI6O24] (SbW6), was synthesized from an aqueous solution and structurally characterized by single-crystal X-ray diffraction, which revealed C2/c symmetry. The structure contains two serinol [(HOCH2)2CHNH3]+ and five Na+ cations, which are octahedrally surrounded by 18 water mols., and one [SbVWVI6O24]7- anion. The serinol mols. also play a critical role in the synthesis by acting as a mild buffering agent. Each of the WVI and SbV ions is six-coordinated and displays a distorted octahedral motif. A three-dimensional supramol. framework is formed via hydrogen-bonding interactions between the tungstoantimonates and cations. Powder X-ray diffraction, elemental anal., thermogravimetric anal. and IR spectroscopy were performed on SbW6 to prove the purity, to identify the water content and to characterize the vibrational modes of the crystallized phase. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2COA of Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H9NO2

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Murayama, Keiji’s team published research in Methods in Molecular Biology (New York, NY, United States) in 2019 | CAS: 534-03-2

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 534-03-2

Recommanded Product: 534-03-2In 2019 ,《The use of serinol nucleic acids as ultrasensitive molecular beacons》 was published in Methods in Molecular Biology (New York, NY, United States). The article was written by Murayama, Keiji; Kashida, Hiromu; Asanuma, Hiroyuki. The article contains the following contents:

Mol. beacons composed of the artificial serinol nucleic acid (SNA) have demonstrated utility as novel fluorescence probes for visualization of RNA in fixed cells using both conventional fluorescence in situ hybridization (FISH) and wash-free FISH protocols. The SNA mol. beacons have higher affinity for target RNA and greater sensitivity than mol. beacons composed of DNA. Here we describe facile synthesis of the SNA using a conventional DNA synthesizer and protocols for purification by PAGE and HPLC as well as methods for use of the SNA mol. beacon in FISH. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 534-03-2

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Ding, Ruihua’s team published research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2019 | CAS: 534-03-2

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 534-03-2

The author of 《Design and Synthesis of Galactose-Biotin Lipid Materials for Liposomes to Promote the Hepatoma Cell-Targeting Effect》 were Ding, Ruihua; Li, Zhenjie; Wang, Jianyi; Zhu, Xueyan; Zhao, Zhuang; Wang, Mian. And the article was published in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2019. SDS of cas: 534-03-2 The author mentioned the following in the article:

A series of novel low-toxic hepatoma cell-targeting lipid materials were designed and synthesized, in which monogalactose, digalactose, and galactose-biotin were used as targeting moieties and hydrophilic heads while stearate was used as hydrophobic tail (Mono-Gal-ST, Di-Gal-ST, and Gal-Biotin-ST). The corresponding galactose-biotin-modified liposomes (Mono-Gal-LPs, Di-Gal-LPs, and Gal-Biotin-LPs) and conventional liposomes (LPs) were prepared These galactose-biotin-modified liposomes can distinguish hepatoma cells from other tissue cells owing to the recognition of asialoglycoprotein receptor by galactose group. Moreover, the ability of liposomes to distinguish hepatoma cells from normal hepatocytes follows a trend of LPs < Mono-Gal-LPs < Di-Gal-LPs < Gal-Biotin-LPs, which is attributed to the cluster glycoside effect and the synergistic effect of galactose and biotin. In addition, the endocytosis of these galactose-biotin-modified liposomes were competitively inhibited by galactose, further confirming these liposomes entered hepatoma cells via asialoglycoprotein receptor-mediated pathway. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

9/28 News Brief introduction of 534-03-2

According to the analysis of related databases, 534-03-2, the application of this compound in the production field has become more and more popular.

Electric Literature of 534-03-2, Adding some certain compound to certain chemical reactions, such as: 534-03-2, name is 2-Aminopropane-1,3-diol,molecular formula is C3H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 534-03-2.

General procedure: A stirred solution of 2-amino-1,3-propanediol (serinol) 4 (1 eq) and triethylamine (TEA) inMeOH (10 mL) was cooled at -20 C (carbon dioxide snow) and added dropwise a solutionof the corresponding acyl chloride (1.1 eq) in THF (5 mL). The reaction mixture was allowed towarm to room temperature and stirred overnight. Then it was poured into brine and extractedwith dichloromethane (3 10 mL). The combined organic phases were washed with brine, driedover MgSO4 and concentrated under reduced pressure. The residue was purified by flash columnchromatography on silica gel using as eluent EtOAc/MeOH (20:1 to 7:1) to provide the correspondingN-acyl serinol derivatives. 4.1.4. N-octanoyl Serinol (5)According to the general procedure serinol 4 (150 mg, 1.64 mmol) was treated with octyl chloride(1.81 mmol, 0.3 mL) and TEA (0.4 mL) to give 267 mg (75%) of 5 as an amorphous white solid. 1H NMR(400 MHz, DMSO-d6) 7.40 (d, J = 8.1 Hz, 1H, NHCO), 4.55 (t, J = 5.5 Hz, 2H, OH), 3.69 (m, 1H, CHNH),3.37 (t, J = 5.6 Hz, 4H, CH2OH), 2.06 (t, J = 7.4 Hz, 2H, CH2CO), 1.46 (m, 2H, CH2), 1.22 (m, 8H, CH2),0.86 (t, J = 6.8 Hz, 3H, CH3).

According to the analysis of related databases, 534-03-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jimenez, Aranza; Garcia, Pablo; De La Puente, Sofia; Madrona, Andres; Camarasa, Maria Jose; Perez-Perez, Maria-Jesus; Quintela, Jose-Carlos; Garcia-del Portillo, Francisco; San-Felix, Ana; Molecules; vol. 23; 7; (2018);,
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Application of 2-Aminopropane-1,3-diol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.

Synthetic Route of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.

Preparation of the compound of formula (III) starting from the isolated compound (II), in the presence of calcium hydroxide. Calcium hydroxide (12.8 g, 0.173 mol) was slowly added, under stirring and keeping the temperature below 25C, to a solution of compound (II) (120 g, 0.169 mol) in 305 g of DMA.Further on, to the reaction mixture a solution of 2-amino-l,3-propandiol in DMA (133 g, 28% w/w, 0.406 mol) was added dropwise in a period of time of about 45 minutes. The mixture was kept at about 300C for 10 hours, up to the completion of the reaction. The crude reaction material containing the derivative of formula (III) may be purified and hydro lyzed according to the procedure of the Example 3 below. HPLC profile of the mixture after treatment of the sample with NaOH: Iopamidol (IV): 97.9%; F-impurity: 0.2%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; BRACCO IMAGING SpA; CERAGIOLI, Silvia; CIARCIELLO, Giovanni; INCANDELA, Salvatore; MINOTTI, Pietro; WO2010/57765; (2010); A1;,
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Share a compound : 534-03-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,534-03-2, its application will become more common.

Application of 534-03-2 ,Some common heterocyclic compound, 534-03-2, molecular formula is C3H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To serinol (10.40g, 114mmol) and sodium carbonate (42.30g, 399mmol) was added water (200mL), was added triphosgene (20.00g, 70mmol). Stirred for 12 hours at room temperature. After completion of the reaction, water (200 mL), dichloromethane (120mL × 3) extracted together The organic phase was washed with saturated brine (150 mL) and washed. Filtered and thesolvent evaporated under reduced pressure and the crude product purified by column chromatography (ethyl acetate / methanol(v / v) = 10/1) to give a colorless oil (5.2g, 39%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,534-03-2, its application will become more common.

Reference:
Patent; GUANGDONG HEC PHARMACEUTICAL CO., LTD; ZUO, YINGLIN; LAO, JINHUA; ZHENG, JINFU; WEN, LIANG; ZHANG, JIN; WU, SHOUTAO; YUAN, XIAOFENG; WANG, XIAOJUN; ZHANG, YINGJUN; (32 pag.)CN104497008; (2016); B;,
Alcohol – Wikipedia,
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Application of 2-Aminopropane-1,3-diol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.

Synthetic Route of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.

Preparation of the compound of formula (III) starting from the isolated compound (II), in the presence of calcium hydroxide. Calcium hydroxide (12.8 g, 0.173 mol) was slowly added, under stirring and keeping the temperature below 25C, to a solution of compound (II) (120 g, 0.169 mol) in 305 g of DMA.Further on, to the reaction mixture a solution of 2-amino-l,3-propandiol in DMA (133 g, 28% w/w, 0.406 mol) was added dropwise in a period of time of about 45 minutes. The mixture was kept at about 300C for 10 hours, up to the completion of the reaction. The crude reaction material containing the derivative of formula (III) may be purified and hydro lyzed according to the procedure of the Example 3 below. HPLC profile of the mixture after treatment of the sample with NaOH: Iopamidol (IV): 97.9%; F-impurity: 0.2%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; BRACCO IMAGING SpA; CERAGIOLI, Silvia; CIARCIELLO, Giovanni; INCANDELA, Salvatore; MINOTTI, Pietro; WO2010/57765; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The origin of a common compound about 2-Aminopropane-1,3-diol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Application of 534-03-2, Adding some certain compound to certain chemical reactions, such as: 534-03-2, name is 2-Aminopropane-1,3-diol,molecular formula is C3H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 534-03-2.

General procedure: A stirred solution of 2-amino-1,3-propanediol (serinol) 1 (1 eq) andtriethylamine in MeOH (10 ml) was cooled at 220C and treateddropwise with a solution of the corresponding acyl chloride (1.1 eq) intetrahydrofurane (THF) (5 ml). The reaction mixture was allowed towarm to room temperature and stirred overnight. Then it was pouredinto brine and extracted with dichloromethane (3 10 ml). Thecombined organic phases were washed with brine, dried over MgSO4,and concentrated under reduced pressure. The residue was purified byflash column chromatography on silica gel using as eluent EtOAc/MeOH (10:1 to 7:1) to provide the corresponding N-acyl serinolderivatives.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Gomez de Cedron, Marta; Vargas, Teodoro; Madrona, Andres; Jimenez, Aranza; Perez-Perez, Maria-Jesus; Quintela, Jose-Carlos; Reglero, Guillermo; San-Felix, Ana; Ramirez de Molina, Ana; Journal of Pharmacology and Experimental Therapeutics; vol. 366; 2; (2018); p. 377 – 389;,
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