Category: 53066-19-6

Application of 53066-19-6, Adding some certain compound to certain chemical reactions, such as: 53066-19-6, name is 1-(2,6-Dichlorophenyl)ethanol,molecular formula is C8H8Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53066-19-6.

A solution of 1- (2,6-dichlorophenyl) ethanol (9.0 g, 47.11 mmol)Of tetrahydrofuran (200 mL)The solution was cooled to 0 C,Sodium hydride (60% dispersion in mineral oil, 2.45 g, 61.24 mmol) was added thereto in portions.When no bubbles are generated,A solution of 3-fluoro-2-nitropyridine (6.69 g, 47.11 mmol)In tetrahydrofuran (50 mL).The reaction was stirred at room temperature overnight, cooled to 0 C,Water (10 mL) was quenched and concentrated under reduced pressure. The residue was diluted with water (200 mL) and extracted with ethyl acetate(150 mL x 3). The combined organic phases were washed successively with saturated sodium bicarbonate solution (200 mL), brine (200 mL), anhydrous sulfurSodium sulfate, filtered, and concentrated under reduced pressure,The title compound was

According to the analysis of related databases, 53066-19-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Ruyong; Wang Liang; (112 pag.)CN104016979; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

53066-19-6 , The common heterocyclic compound, 53066-19-6, name is 1-(2,6-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 1 -(2,6-dichlorophenyl)ethanol (9.0 g, 47.11 mmol) in THF (200 niL) at 0 C was added NaH (60% dispersion in mineral oil, 2.45 g, 61.24 mmol) inportions. When the evolution of gas bubble stopped, a solution of 3-fluoro-2-nitropyridine (6.69 g, 47.11 mmol) in THF (50 mL) was added to the system. The reaction was stirred at room temperature overnight, then quenched with H20 (10 mL) at 0 C, and concentrated in vacuo. The residue was diluted with H 0 (200 mL), and extracted with EtOAc (150 mL x 3). The combined organic phases were washed with saturated aqueous aHC03 (200 mL) followed by brine (200 mL), dried over anhydrous a2S04, filtered and concentrated in vacuo to give the title compound as a brown solid (14.34g,97.2%).

According to the analysis of related databases, 53066-19-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; WANG, Ruyong; WANG, Liang; WO2014/89324; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts