Category: 530-91-6

Electric Literature of 530-91-6 , The common heterocyclic compound, 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, molecular formula is C10H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stuffed solution of 1,2,3,4-tetrahydronaphthalen-2-ol (250 mg, 1.68 mmol) in DCM (5 mL) was added triethylamine (1.17 mL, 8.50 mmol) at 0 C followed by addition of mesyl chloride (0.26 mL, 3.35 mmol). The reaction mixture was then stirred at 0 C for 2 h. The reaction was monitored by ?H NMR. After completion of reaction, the mixture was quenched with ice, and extracted with DCM (2×50 mL). The combined organic layer was dried over sodium sulfate and concentrated to afford 340 mg of 1 ,2,3,4-tetrahydronaphthalen- 2-yl methanesulfonate as a brown liquid which was taken to the next step without further purification.

The synthetic route of 530-91-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; GREEN, Michael, John; PHAM, Son, Minh; PUJALA, Brahmam; AGARWAL, Anil, Kumar; NAYAK, Ajan, Kumar; KHARE, Sweta; GUGULOTH, Rambabu; RANDIVE, Nitin, Atmaram; WO2015/58084; (2015); A1;,
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Electric Literature of 530-91-6 , The common heterocyclic compound, 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, molecular formula is C10H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stuffed solution of 1,2,3,4-tetrahydronaphthalen-2-ol (250 mg, 1.68 mmol) in DCM (5 mL) was added triethylamine (1.17 mL, 8.50 mmol) at 0 C followed by addition of mesyl chloride (0.26 mL, 3.35 mmol). The reaction mixture was then stirred at 0 C for 2 h. The reaction was monitored by ?H NMR. After completion of reaction, the mixture was quenched with ice, and extracted with DCM (2×50 mL). The combined organic layer was dried over sodium sulfate and concentrated to afford 340 mg of 1 ,2,3,4-tetrahydronaphthalen- 2-yl methanesulfonate as a brown liquid which was taken to the next step without further purification.

The synthetic route of 530-91-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; GREEN, Michael, John; PHAM, Son, Minh; PUJALA, Brahmam; AGARWAL, Anil, Kumar; NAYAK, Ajan, Kumar; KHARE, Sweta; GUGULOTH, Rambabu; RANDIVE, Nitin, Atmaram; WO2015/58084; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 530-91-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, molecular formula is C10H12O, molecular weight is 148.2017, as common compound, the synthetic route is as follows.

EXAMPLE 81 To a mixture of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropanol (318 mg), 2-hydroxytetralin (296 mg), tributylphosphine (405 mg) and tetrahydrofuran (10 ml) was added 1,1′-(azodicarbonyl)dipiperidine (400 mg) at room temperature, and the resulting mixture was stirred for 1 hour. After the reaction mixture was concentrated, the residue was subjected to silica gel column chromatography, and 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(5,6,7,8-tetrahydro-2-naphthoxy)propyl]oxazole was obtained as an oil from an ethyl acetate-hexane (1:1, v/v)-eluted fraction. (358 mg, 80%).

Statistics shows that 530-91-6 is playing an increasingly important role. we look forward to future research findings about 1,2,3,4-Tetrahydronaphthalen-2-ol.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6605629; (2003); B1;,
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Reference of 530-91-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol. A new synthetic method of this compound is introduced below.

Example 292 1,2,3,4-Tetrahydro-2-naphthalenyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline (50 mg) was added to toluene (5 ml), and triethylamine (0.5 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (68 mg) in methylene chloride was then added thereto, and the mixture was heated under reflux for 10 min. Next, 1,2,3,4-tetrahydro-2-naphthalenol (34 mg) was added thereto, and the mixture was further stirred with heating under reflux for 3 hr. A saturated aqueous sodium bicarbonate solution was added to stop the reaction, and the reaction solution was then extracted with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution, water, and saturated brine in that order. The extract was dried over sodium sulfate and was then concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (80 mg, yield 100%). 1H-NMR (CDCl3-d1, 400 MHz): delta 2.08 – 2.13 (m, 2H), 2.12 (s, 3H), 2.27 (s, 3H), 2.80 – 3.24 (m, 4H), 4.11 (s, 3H), 4.17 (s, 3H), 5.30 (brs, 1H), 6.43 (s, 1H), 6.57 (d, J = 6.6 Hz, 1H), 6.94 (s, 1H), 7.11 – 7.18 (m, 4H), 7.64 (s, 1H), 7.94 (brs, 1H), 8.15 (d, J = 3.9 Hz, 1H), 8.48 (brs, 1H) Mass spectrometry value (ESI-MS, m/z): 500 (M++1)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,530-91-6, 1,2,3,4-Tetrahydronaphthalen-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, the common compound, a new synthetic route is introduced below. SDS of cas: 530-91-6

A solution of alcohol 13 (262 mg, 1.77 mmol, 1 eq.), nosyl chloride (781.5 mg, 3.53 mmol,2.0 eq.), DMAP (73.2 mg, 0.60 mmol, 0.34 eq.) and Et3N (0.74 mL,540.2 mg, 5.34 mmol, 3.0 eq.) in CH2Cl2 (6 mL) wasstirred vigorously for 16 h at rt. 2M NaOH (6 mL) was added and the reactionmixture was extracted with CH2Cl2 (3 x 5 mL). The organiclayer was washed with 2M NaOH (7 mL), dried (Na2SO4),filtered and concentrated in vacuo. The crude product was purified by fc (d = 3cm, l = 13 cm, v = 25 mL, cyclohexane:EtOAc 8:2, Rf = 0.55) to obtain a colorlessoil, yield 380.0 mg (64 %). C16H15NO5S (333.4g/mol). 1H NMR (400 MHz, CDCl3): delta (ppm) = 2.03 – 2.15(m, 2H, 3-CH2), 2.77 – 2.85 (m, 1H, 1-CH2), 2.92 – 3.02(m, 2H, 4-CH2), 3.08 (dd, J = 16.8/4.9 Hz, 1H, 1-CH2),5.10 – 5.15 (m, 1H, 2-CH), 6.95 (dd, J = 7.3/1.5 Hz, 1H,tetraline), 7.05 – 7.16 (m, 3H, tetraline), 8.08 – 8.14 (m, 2H, nos), 8.35 -8.40 (m, 2H, nos).

The synthetic route of 530-91-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bechthold, Elena; Gawaskar, Sandeep; Robaa, Dina; Schepmann, Dirk; Schreiber, Julian A.; Seebohm, Guiscard; Sippl, Wolfgang; Temme, Louisa; Wuensch, Bernhard; European Journal of Medicinal Chemistry; vol. 190; (2020);,
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