Category: 5299-60-5

Application of 5299-60-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5299-60-5 as follows.

Ethyl 6-methylsulfonyloxyhexanoate (2). A solution of monodispersed ethyl 6-hydroxyhexanoate (50.76 ml, 50.41 g, 227 mmol) in dry dichloromethane (75 ml) was chilled in an ice bath and placed under a nitrogen atmosphere. Triethylamine (34.43 ml, 24.99 g, 247 mmol) was added. A solution of methanesulfonyl chloride (19.15 ml, 28.3 g, 247 mmol) in dry dichloromethane (75 ml) was added dropwise from an addition funnel. The mixture was stirred for three and one half hours, slowly being allowed to come to room temperature as the ice bath melted. The mixture was filtered through silica gel, and the filtrate was washed successively with water, saturated NaHCO3, water and brine. The organics were dried over Na2SO4, filtered and concentrated in vacuo to a pale yellow oil. Final purification of the crude product was achieved by flash chromatography (silica gel, 1/1 hexanes/ethyl acetate) to give the monodispersed compound 2 (46.13 g, 85%) as a clear, colorless oil. FAB MS: m/e 239 (M+H), 193 (M-C2H5O).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5299-60-5, its application will become more common.

Reference:
Patent; Soltero, Richard; Ekwuribe, Nnochiri N.; Opawale, Foyeke; Rehlander, Bruce; Hickey, Anthony; Li Li, Bovet; US2003/69170; (2003); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. A new synthetic method of this compound is introduced below., Safety of Ethyl 6-hydroxyhexanoate

KBr (0.1 1 1 g, 0.936 mmol) in water (30 ml) was treated with sodium bicarbonate (4.72 g, 56.2 mmol). The solution was cooled (ice-bath) and treated with a solution of (2,2,6,6- tetramethyl piperidin-1 -yl)oxidanyl (0.029 g, 0.187 mmol) in DCM (30 ml) followed by sodium hypochlorite (1.387 ml, 22.47 mmol) and ethyl 6-hydroxyhexaonate (3 g, 18.73 mmol). The reaction mixture was partitioned between EtOAc and water and the organic portion was separated, dried (MgS04) and concentrated under reduced pressure to afford the titled compound

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5299-60-5, Ethyl 6-hydroxyhexanoate.

Reference:
Patent; NOVARTIS AG; CHARLTON, Steven John; LEBLANC, Catherine; MCKEOWN, Stephen Carl; WO2013/105065; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 5299-60-5, Ethyl 6-hydroxyhexanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5299-60-5, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H16O3

KBr (0.1 11 g, 0.936 mmol) in water (30 ml) was treated with sodium bicarbonate (4.72 g, 56.2 mmol). The solution was cooled (ice-bath) and treated with a solution of (2,2,6,6-tetramethyl piperidin-1-yl)oxidanyl (0.029 g, 0.187 mmol) in DCM (30 ml) followed by sodium hypochlorite (1.387 ml, 22.47 mmol) and ethyl 6-hydroxyhexaonate (3 g, 18.73 mmol). The reaction mixture was partitioned between EtOAc and water and the organic portion was separated, dried (MgS04) and concentrated under reduced pressure to afford the titled compound

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5299-60-5, its application will become more common.

Reference:
Patent; NOVARTIS AG; CHARLTON, Steven John; LEBLANC, Catherine; MCKEOWN, Stephen Carl; WO2013/105063; (2013); A1;,
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Electric Literature of 5299-60-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. A new synthetic method of this compound is introduced below.

General procedure: According to a modified literature procedure,[2] a flame-dried Schlenk flask is charged withpoly(4-vinylpyridine) (2.1 equiv) in CH2Cl2. At 0 C, Tf2O (1.1 equiv) is added dropwisefollowed by the addition of the corresponding primary alcohol in CH2Cl2. The reaction mixtureis then allowed to warm to room temperature. After completion of reaction (TLC monitoring),the reaction mixture is filtered under gravity, and the residue is washed with CH2Cl2.Evaporation of the solvents at room temperature (due to decomposition of the triflates athigher temperatures) affords the crude title compounds. Purification by vacuum filtration oversilica gel using a sintered funnel (grade 4) with the indicated eluent affords the analyticallypure alkyltriflates.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5299-60-5, its application will become more common.

Reference:
Article; Scharfbier, Jonas; Oestreich, Martin; Synlett; vol. 27; 8; (2016); p. 1274 – 1276;,
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Adding a certain compound to certain chemical reactions, such as: 5299-60-5, Ethyl 6-hydroxyhexanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Ethyl 6-hydroxyhexanoate, blongs to alcohols-buliding-blocks compound. Recommanded Product: Ethyl 6-hydroxyhexanoate

Example 1 : Preparation of tetranor-PGDMPreparation of Ester (2A) from 6-hydroxyhexanoate (1A EtO.OTBDMSO2A(2, wherein R is ethylR2 is methyl, andR3 is ieri-butyl)- 50.0 g (312.1 mmol) of ethyl 6-hydroxyhexanoate (1A)- 61.15 g (405.72 mmol) of TBDMSC1;- 42.5 g (624.2) of imidazole;- 500 ml of DMF.[0048] A solution of ethyl 6-hydroxyhexanoate (1 A) in dry DMF was cooled with an ice bath and treated with TBDMSC1 and imidazole portion wise for 10 minutes. The cooling bath was removed and the reaction mixture was stin-ed overnight (controlled by TLC, hexane – ethyl acetate 90: 10). The next day the reaction mixture was treated with ice (200 g), stirred for 5 minutes, and extracted with H-EA (10: 1 , 800 ml, 2×200 ml). The combined organic phases were washed with water-brine (1 : 1 , 2 x 100 ml), brine (100 ml), dried over Na2SC>4, and evaporated. The residue was purified by flash chromatography: Silica gel (300 g), hexane (H) – ethyl acetate (EA) 100: 1 – 70: 1. The mass of the collected product (Ester (2 A)) was 81.5 g (95%), TLC Rf = 0.8 (solvent system: hexane – ethyl acetate 90: 10).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5299-60-5, Ethyl 6-hydroxyhexanoate, and friends who are interested can also refer to it.

Reference:
Patent; CAYMAN CHEMICAL COMPANY, INCORPORATED; ENDRES, Gregory, W.; KORNILOV, Andriy, M.; UZIEBLO, Adam; WO2011/159740; (2011); A2;,
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Reference of 5299-60-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5299-60-5, name is Ethyl 6-hydroxyhexanoate, molecular formula is C8H16O3, molecular weight is 160.21, as common compound, the synthetic route is as follows.

The PCC (16.20g, 75 . 50mmol) dissolved in dichloromethane (140 ml) in, lowering the temperature to 0 C, dropping 6 – hydroxy hexanoic acid ester (10.30g, 64 . 30mmol) of dichloromethane (20 ml) solution. Heating the reaction to room temperature, stirring the reaction 2 hours, adding ethyl acetate (100 ml), filtered, the filtrate is concentrated. The residue by silica gel column chromatography (petroleum ether/ethyl acetate (v/v)=10/1) to obtain the title compound as white solid (9.28g, 45.0%).

Statistics shows that 5299-60-5 is playing an increasingly important role. we look forward to future research findings about Ethyl 6-hydroxyhexanoate.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Gao Jinheng; Zhang Yingjun; (37 pag.)CN106279153; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 5299-60-5, Ethyl 6-hydroxyhexanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5299-60-5, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H16O3

PREPARATION 280 To a solution of pyridinium chlorochromate (2.0 g) in dichloromethane (15 ml) was added a solution of 6-hydroxyhexanoic acid ethyl ester (1.0 g) in dichloromethane (1.5 ml) in one portion and stirred for 1.5 hours at ambient temperature. Ether (15 ml) was added to the reaction mixture, and the insoluble material removed by filtration and discarded. The filtrate was purified by silica gel chromatography (diethyl ether) to give 6-oxohexanoic acid ethyl ester (884.6 mg), as a pale green oil. IR (KBr): 2981.4, 2940.9, 2871.5, 2827.1, 2723.0, 1731.8, 1184.1 cm-1. NMR (CDCl3, delta): 1.26 (3H, t, J=7.1 Hz), 1.5-1.8 (4H, m), 2.2-2.6 (4H, m), 4.13 (2H, q, J=7.1 Hz), 9.77 (1H, t, J=1.6 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5299-60-5, its application will become more common.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6884868; (2005); B1;,
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Related Products of 5299-60-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5299-60-5, name is Ethyl 6-hydroxyhexanoate, molecular formula is C8H16O3, molecular weight is 160.21, as common compound, the synthetic route is as follows.

To an oven-dried 3-necked 10 mL round-bottom flask under nitrogen was added l-cyclopentyl-3-(2-(4-hydroxyphenyl)-l,l-bis(3- (trifluoromethoxy)phenyl)ethyl)urea, prepared as described in Procedure 11, 6, 2 and 59, (50 mg, 0.1 mmol ), triphenylphosphine (34 mg, 0.1 mmol), ethyl 6- hydroxyhexanoate (17 mg, 0.1 mmol ) and dry THF (0.5 mL ). The reaction mixture was cooled in an ice-methanol bath and diethylazodicarboxylate ( 23 mg, 0.13 mmol ) was added via syringe. The reaction was allowed to warm to rt and stirred overnight. The reaction mixture was concentrated in vacuo and purified by ISCO silica gel chromatography using a gradient of 5-25% EtOAc / hexanes as eluent to yield ethyl 6-(4-(2-(3-cyclopentylureido)-2,2-bis(3-(trifluoromethoxy)phenyl)ethyl)phenoxy)hexanoate (Example 313) was isolated as a white solid (43 mg, 61% yield). HPLC: RT = 4.69 minutes ( Phenomenex Luna C18 5mu column 4.6 x 50 mm eluting with 10-90% aqueous methanol containing 0.1% phosphoric acid over a 4 minute gradient monitoring at 220 nni). LC/MS [M+H] 711.3 ( Phenomenex Luna C18 5mu column 4.6 x 30 mm eluting with 10-90% aqueous methanol containing 0.1% TFA over a 4 minute gradient monitoring at 220 nm). 1H NMR (400MHz , CDCl3) delta ppm 7.33 (t, J= 7.9 Hz, 2 H), 7.20 (d, J= 7.9 Hz, 2 H), 7.12 (d, J= 7.9 Hz, 2 H), 7.07 (s, 2 H), 6.62 (d, J= 8.8 Hz, 2 H), 6.56 (d, J= 8.8 Hz, 2 H), 4.10 (q, J= 7.1 Hz, 2 H), 3.86 t, J = 6.1Hz, 2 H), 3.68 (s, 1 H), 3.62 (t, J= 6.6Hz, 1 H), 2.30-2.27 (m, 2 H), 1.82-1.14 (m, 17 H), 1.23 (t, J= 7.1Hz, 3 H).

The chemical industry reduces the impact on the environment during synthesis 5299-60-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2007/62308; (2007); A2;,
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Related Products of 5299-60-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5299-60-5, name is Ethyl 6-hydroxyhexanoate, molecular formula is C8H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of donor (1 mmol) in dry CH2Cl2 (5-10 ml) was added under argon ethyl 6-hydroxy-hexanoate (1.5 mmol) and 4 A molecular sieves (mass = donor + acceptor weight) then the mixture was stirred for 15 min. N-Iodosuccinimide (3 mmol) and trifluoromethanesulfonic acid (0.3 mmol) were successively added and after stirring 30 min at room temperature, the mixture was diluted with CH2Cl2, filtered on a celite pad and washed with satd aq NaHCO3 and satd aq Na2S2O3. The aqueous layer was extracted with CH2Cl2 then the combined organic layers were dried (MgSO4), filtered and concentrated. The residue was purified by flash chromatography.

According to the analysis of related databases, 5299-60-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Despras, Guillaume; Robert, Raymond; Sendid, Boualem; MacHez, Emeline; Poulain, Daniel; Mallet, Jean-Maurice; Bioorganic and Medicinal Chemistry; vol. 20; 5; (2012); p. 1817 – 1831;,
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Application of 5299-60-5 ,Some common heterocyclic compound, 5299-60-5, molecular formula is C8H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a stirred solution of esters 2a-2j (70 mmol) in MeOH (30 mL) cooled in an ice-water bath was added dropwise 80% aqueous hydrazine hydrate (6.26 g, 100 mmol). The resulting solution was stirred at room temperature (2a-2b or 2d-2j), or reflux (2c), until the completion of reaction as indicated by TLC analysis (typically within 5 h). The reaction mixture was evaporated on a rotary evaporator to give a residue, which was purified by column chromatography through a short silica gel column to yield 3a-3k after trituration with n-hexane if possible.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5299-60-5, Ethyl 6-hydroxyhexanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tian, He; Liu, Wei; Zhou, Zhixing; Shang, Qian; Liu, Yuqiang; Xie, Yafei; Liu, Changying; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Molecules; vol. 21; 11; (2016);,
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