Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5272-36-6, name is 3-(Trimethylsilyl)propargyl alcohol. A new synthetic method of this compound is introduced below., name: 3-(Trimethylsilyl)propargyl alcohol
According to Ladmiral V. and co-workers (16) 3-(trimethylsilyl)prop-2- yn-1-ol (2.31 ml, 15.6 mmol) and triethylamine (2.83 ml, 20.27 mmol) were dissolved in Et20 (20 ml) and cooled to -20C. A solution of methacryloyl chloride (1.81 ml, 18.56 mmol) in Et20 (10 ml) was added drop wise over 1 hour. The mixture was stirred at -20C for 30 minutes and then overnight at room temperature. Ammonium salts were removed by filtration and the volatiles were removed under reduced pressure. The yellow oil residue was purified by flash chromatography (EtP:Et2O=50:1, Rf= 0.39) (2.48 g, 12.64 mmol, Yield 81%). 1H-NMR (400 MHz, CDCI3): delta = 0.18 (s, 9H, Si(CH3)3); 1.97 (m, 3H, CH3C=CH2); 4.76 (s, 2H, OCH2); 5.62 (m, 1 H, C=CHH); 6.17 (m, 1 H, C=CHH).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5272-36-6, 3-(Trimethylsilyl)propargyl alcohol.
Reference:
Patent; CHIARI, Marcella; (54 pag.)WO2016/92372; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts