Category: 526-98-7

Dang, Ya-Li published the artcilePreparation of porous carbon spheres under different activation conditions from 2-keto-L-gulonic acid mother liquor for electric double-layer capacitor, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Waste and Biomass Valorization (2020), 11(8), 4429-4440, database is CAplus.

2-Keto-L-gulonic acid mother liquor (GAML) as an organic waste solution contained highly polluting contents would pollute the environment if discharged directly. As reported in our previous paper, GAML was used as the precursor to prepare porous carbon sphere (PCS) as carbon-based electrode materials of elec. double-layer capacitor (EDLC) to create its high value-added utilization, and in the carbonization process, Fe(NO₃)₃·9H₂O acted as an oxidizing agent. Since the carbon sphere was a carbon material with a special morphol., the effect of activation conditions (activation ratio, activation temperature and activation time) on the pore structure and the electrochem. performance of PCS were explored in this paper. PCS was derived via hydrothermal carbonization, carbonization and KOH activation successively, and the as-prepared samples had excellent porosity and high SSA of 2747 m² g^-1. Besides, the specific capacitance of PCS-7-700-1 could reach as high as 303.7 F g^-1 (206.5 F cm^-3) in 6 M KOH electrolyte at 40 mA g^-1.

Waste and Biomass Valorization published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Li-na published the artcileEffect of metallic ions on the esterifying conversion of vitamin C, SDS of cas: 526-98-7, the publication is Liaoning Huagong (2014), 43(6), 713-714, database is CAplus.

The machines and pipes in chem. production industry are mainly made of metal. The corrosion can normally cause metallic ions to be separated from the equipments to diffuse into the product, which will lead to the deviation of the quality and productivity. In this paper, effect of iron ions coming from vitamin C production equipments on the esterifying conversion of vitamin C was investigated.

Liaoning Huagong published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C12H17NS2, SDS of cas: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jirasek, Fabian published the artcileSolid-liquid equilibrium in the system 2-keto-L-gulonic acid + sodium-2-keto-L-gulonate + water, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Fluid Phase Equilibria (2018), 318-322, database is CAplus.

The solid-liquid equilibrium (SLE) in the ternary system 2-keto-L-gulonic acid (HKGA) + sodium-2-keto-L-gulonate (NaKGA) + water was studied exptl. at temperatures between 275 and 313 K and ambient pressure. At these conditions, HKGA and NaKGA precipitate as monohydrates: HKGA·H₂O and NaKGA·H₂O, resp. Phase diagrams with one eutonic point are found for all temperatures A thermodn. model of the SLE that is based on an extended version of the Debye-Huckel theory was developed and the dissociation constant of HKGA as well as the solubility products of HKGA·H₂O and NaKGA·H₂O were determined The agreement between the exptl. data and the results from the model is excellent.

Fluid Phase Equilibria published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jia, Yong published the artcileAn aldo-keto reductase with 2-keto-L-gulonate reductase activity functions in L-tartaric acid biosynthesis from vitamin C in Vitis vinifera, Formula: C6H10O7, the publication is Journal of Biological Chemistry (2019), 294(44), 15932-15946, database is CAplus and MEDLINE.

Tartaric acid has high economic value as an antioxidant and flavorant in food and wine industries. L-Tartaric acid biosynthesis in wine grape (Vitis vinifera) uses ascorbic acid (vitamin C) as precursor, representing an unusual metabolic fate for ascorbic acid degradation Reduction of the ascorbate breakdown product 2-keto-L-gulonic acid to L-idonic acid constitutes a critical step in this L-tartaric acid biosynthetic pathway. However, the underlying enzymic mechanisms remain obscure. Here, we identified a V. vinifera aldo-keto reductase, Vv2KGR, with 2-keto-L-gulonic acid reductase activity. Vv2KGR belongs to the D-isomer-specific 2-hydroxyacid dehydrogenase superfamily and displayed the highest similarity to the hydroxyl pyruvate reductase isoform 2 in Arabidopsis thaliana. Enzymic analyses revealed that Vv2KGR efficiently reduces 2-keto-L-gulonic acid to L-idonic acid and uses NADPH as preferred coenzyme. Moreover, Vv2KGR exhibited broad substrate specificity toward glyoxylate, pyruvate, and hydroxypyruvate, having the highest catalytic efficiency for glyoxylate. We further determined the X-ray crystal structure of Vv2KGR at 1.58 Å resolution Comparison of the Vv2KGR structure with those of D-isomer-specific 2-hydroxyacid dehydrogenases from animals and microorganisms revealed several unique structural features of this plant hydroxyl pyruvate reductase. Substrate structural anal. indicated that Vv2KGR uses two modes (A and B) to bind different substrates. 2-Keto-L-gulonic acid displayed the lowest predicted free-energy binding to Vv2KGR among all docked substrates. Hence, we propose that Vv2KGR functions in L-tartaric acid biosynthesis. To the best of our knowledge, this is the first report of a D-isomer-specific 2-hydroxyacid dehydrogenase that reduces 2-keto-L-gulonic acid to L-idonic acid in plants.

Journal of Biological Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abohalaka, Reshed published the artcileThe effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs, HPLC of Formula: 526-98-7, the publication is Biomedical Chromatography (2022), 36(1), e5231, database is CAplus and MEDLINE.

The contribution of the endocannabinoid system to both physiol. and pathol. processes in the respiratory system makes it a promising target for inflammatory airway diseases. Previously, we have shown that increasing the tissue endocannabinoid levels by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitors can prevent airway inflammation and hyperreactivity. In this study, the changes in the levels of major metabolites of endocannabinoids by systemic and local FAAH or MAGL inhibitor treatments were evaluated. Mice were treated with either the FAAH inhibitor URB597 or the MAGL inhibitor JZL184 by local (intranasal) or systemic (i.p.) application. Bronchoalveolar lavage (BAL) fluids and lungs were isolated afterward in order to perform histopathol. and metabolomic analyses. There were no significant histopathol. changes in the lungs and neutrophil, and macrophage and lymphocyte numbers in BAL fluid were not altered after local and systemic treatments. However, GC-MS-based metabolomics profile allowed us to identify 102 metabolites in lung samples, among which levels of 75 metabolites were significantly different from the control. The metabolites whose levels were changed by treatments were mostly related to the endocannabinoid system and energy metabolism Therefore, these changes may contribute to the anti-inflammatory effects of URB597 and JZL184 treatments in mice.

Biomedical Chromatography published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Qian published the artcileIntegrated proteomic and metabolomic analysis of a reconstructed three-species microbial consortium for one-step fermentation of 2-keto-L-gulonic acid, the precursor of vitamin C, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Industrial Microbiology & Biotechnology (2019), 46(1), 21-31, database is CAplus and MEDLINE.

Microbial consortia, with the merits of strong stability, robustness, and multi-function, played critical roles in human health, bioenergy, and food manufacture, etc. On the basis of ‘build a consortium to understand it’, a novel microbial consortium consisted of Gluconobacter oxydans, Ketogulonicigenium vulgare and Bacillus endophyticus was reconstructed to produce 2-keto-L-gulonic acid (2-KGA), the precursor of vitamin C. With this synthetic consortium, 73.7 g/L 2-KGA was obtained within 30 h, which is comparable to the conventional industrial method. A combined time-series proteomic and metabolomic anal. of the fermentation process was conducted to further investigate the cell-cell interaction. The results suggested that the existence of B. endophyticus and G. oxydans together promoted the growth of K. vulgare by supplying addnl. nutrients, and promoted the 2-KGA production by supplying more substrate. Meanwhile, the growth of B. endophyticus and G. oxydans was compromised from the competition of the nutrients by K. vulgare, enabling the efficient production of 2-KGA. This study provides valuable guidance for further study of synthetic microbial consortia.

Journal of Industrial Microbiology & Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Karpe, Avinash V. published the artcileUntargeted Metabolic Profiling of Winery-Derived Biomass Waste Degradation by Penicillium chrysogenum, Formula: C6H10O7, the publication is Journal of Agricultural and Food Chemistry (2015), 63(49), 10696-10704, database is CAplus and MEDLINE.

Winery-derived biomass waste was degraded by Penicillium chrysogenum under solid state fermentation over 8 days in a ²H₂O-supplemented medium. Multivariate statistical anal. of the gas chromatog.-mass spectrometry (GC-MS) data resulted in the identification of 94 significant metabolites, within 28 different metabolic pathways. The majority of biomass sugars were utilized by day 4 to yield products such as sugars, fatty acids, isoprenoids, and amino acids. The fungus was observed to metabolize xylose to xylitol, an intermediate of ethanol production However, enzyme inhibition and autolysis were observed from day 6, indicating 5 days as the optimal time for fermentation P. chrysogenum displayed metabolism of pentoses (to alcs.) and degraded tannins and lignins, properties that are lacking in other biomass-degrading ascomycetes. Rapid fermentation (3-5 days) may not only increase the pentose metabolizing efficiency but also increase the yield of medicinally important metabolites, such as syringate.

Journal of Agricultural and Food Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Du, Jin published the artcileCombinational expression of sorbose/sorbosone dehydrogenases and cofactor pyrroloquinoline quinone increases 2-keto-L-gulonic acid production in Ketogulonigenium vulgare-Bacillus cereus consortium, HPLC of Formula: 526-98-7, the publication is Metabolic Engineering (2013), 50-56, database is CAplus and MEDLINE.

The expression levels of sorbose/sorbosone dehydrogenase genes (sdh and sndh) and the synthesis genes (pqqABCDEN) of the adjoint cofactor pyrroloquinoline quinone (PQQ) were genetically manipulated in Ketogulonigenium vulgare to increase the production of 2-keto-L-gulonic acid (2-KLG), the precursor of vitamin C, in the consortium of K. vulgare and Bacillus cereus. We found that overexpression of sdh-sndh alone in K. vulgare could not significantly enhance the production of 2-KLG, revealing the cofactor PQQ was required for the biosynthesis of 2-KLG. Various expression levels of PQQ were achieved by differential expression of pqqA, pqqABCDE and pqqABCDEN, resp. The combinatorial expression of sdh/sndh and pqqABCDEN in K. vulgare enabled a 20% increase in the production of 2-KLG (79.1±0.6 g l^-1) than that of the parental K. vulgare (65.9±0.4 g l^-1) in shaking flasks. Our results demonstrated the balanced co-expression of both the key enzymes and the related cofactors was an efficient strategy to increase chems.’ biosynthesis.

Metabolic Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vu, Thu Ha Thi published the artcileEsterification of 2-keto-L-gulonic acid catalyzed by a solid heteropoly acid, HPLC of Formula: 526-98-7, the publication is Catalysis Science & Technology (2013), 3(3), 699-705, database is CAplus.

The efficacy of a potassium 12-phosphotungstate (KPW) catalyst in the synthesis of Me 2-keto-L-gulonate from 2-keto-L-gulonic acid (2-KLGA) and methanol is investigated. The KPW catalyst gives high yields in short reaction times. The present procedure represents a clean, efficient, practical, simple, mild, time-saving and eco-friendly method for the synthesis of Me 2-keto-L-gulonate. The KPW catalyst is found to be a truly heterogeneous catalyst, highly efficient and reusable in the synthesis of Me 2-keto-L-gulonate.

Catalysis Science & Technology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C2H4ClNO, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts