Category: 526-98-7

Bi, Jianlu published the artcilePlasma metabonomic analysis of healthy qi-deficiency constitution after the intervention by Buzhongyiqi pills, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Chongqing Yike Daxue Xuebao (2014), 39(8), 1124-1127, database is CAplus.

Objective: To compare the endogenous metabolites in the plasma of people with qi-deficiency constitution after the intervention by Buzhongyiqi pills using NMR (NMR)-based metabonomics and to find the possible specific metabolites. Methods: healthy people with qi-deficiency constitution were recruited and divided into control group and intervention group. Buzhongyiqi pills were used to do the intervention and the plasma was tested by NMR-based metabonomics before and after the intervention. Multivariate statistical anal. was done to find the serum-derived metabolic differences after the intervention by Buzhongyiqi pills. Results: The plasma before and after the intervention was analyzed by Simca-P and 45 changed chem. shift values (VIP > 1, P < 0.05) were selected. Thirty specific metabolites were found through human metabolite database. Conclusion: These differences in metabolites are related to the tricarboxylic acid cycle. Buzhongyiqi pills can improve the disorder of energy metabolism, memory deterioration and fatigue of qi-deficiency population, which may associated with its regulation of GABA, phosphatidylcholine, blood ammonia concentration

Chongqing Yike Daxue Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Lei published the artcileOnline application-oriented optimal scheduling for 2-keto-l-gulonic acid production, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Canadian Journal of Chemical Engineering (2015), 93(7), 1160-1167, database is CAplus.

An optimal scheduling approach for the 2-keto-L-gulonic acid (2-KGA) fermentation process is proposed to improve allocation of L-sorbose resources with the aim of profit maximization in a multi-bioreactor workshop. The empirical operation in 2-KGA cultivation under study is to assign the same quantity of L-sorbose to each batch without taking batch-to-batch variations into account, while the optimal scheduling approach presented in this paper will determine L-sorbose feeding according to the evaluation of the profit-making ability of the individual batch. Each 2-KGA batch is classified online according to the prediction of the profit function, so that each batch is assigned into different profit-making categories. Pseudo-online scheduling is implemented with the data of industrial 2-KGA cultivations. A total profit increase of 6-7 % is found to be achievable for the workshop in comparison with the empirical operation.

Canadian Journal of Chemical Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hou, Wei published the artcileCloning, expression and activity analysis of sndh-sdh gene cluster of Gluconobacter oxydans, Category: alcohols-buliding-blocks, the publication is Shengwu Jishu Tongxun (2012), 23(3), 389-392, database is CAplus.

Objective: To clone the sndh-sdh gene cluster from Gluconobacter oxydans H763 and investigate the expression and biol. activity of sorbosone dehydrogenase-sorbose dehydrogenase (SNDH-SDH) in Escherichia coli DH5α and G. oxydans 621H. Methods & Results: The sndh-sdh gene cluster, including promoter, structural gene and terminator sequence, was directly amplified using PCR method from G. oxydans H763 genome DNA. Then the 3533 bp amplification product was retrieved and ligated into the vector pMD18T and transformed into E. coli DH5α. Its expression and biol. activity were examined by DCIP assay when sorbose or xylose was used as substrate. After the cell lysis was added to the DCIP detection solution, its color changed from bluish green to yellow, which suggested that the expression product had dehydrogenase activity. The vector pBBR1MCS2-sndh-sdh was constructed and conjugated into G. oxydans 621H. After the recombinant strain was cultivated in the medium containing sorbitol or sorbose as substrate, the metabolic products in the supernatant were assayed by thin-layer chromatog., and chromatoplate showed the 2-keto-L-gulonic acid (2-KLG) spots. Conclusion: The above results indicated that the SNDH-SDH was expressed in E. coli DH5α and G. oxydans 621H.

Shengwu Jishu Tongxun published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Ying published the artcileStructured modeling and validation for 2-KGA mixed cultivation, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Shanghai Jiaotong Daxue Xuebao (2012), 46(11), 1723-1728, database is CAplus.

The mechanism of interaction between Ketogulonicigenium vulgare and Bacillus megaterium was investigated for 2-keto-L-gulonic acid (2-KGA) mixed culture. Based on the metabolic pathway anal. in K. vulgare, a macrokinetic model was constructed, where, a first-order closed-loop regulator model was introduced to describe the induction of the enzyme pool responsible for the growth of K. vulgare at the beginning of the cultivation. The model describes the balance of intracellular substance and energy flow rates. The key reaction rates such as the specific substrate consumption rate, the specific growth rate, the specific acetyl-CoA formation rate as well as the specific oxygen uptake rate are obtained with this model. The specific substrate consumption rate and the specific growth rate are then coupled into a bioreactor model such that the relationship between substrate feeding rate and state variables is set up. The exptl. validation results were presented.

Shanghai Jiaotong Daxue Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C65H82N2O18S2, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Lei published the artcileData-driven prediction of the product formation in industrial 2-keto-L-gulonic acid fermentation, Related Products of alcohols-buliding-blocks, the publication is Computers & Chemical Engineering (2012), 386-391, database is CAplus.

Mixed culture fermentation of Bacillus megaterium and Gluconobacter oxydans is widely used to produce 2-keto-L-gulonic acid (2-KGA), a key precursor for L-ascorbic acid synthesis. For such mixed cultivation, kinetic modeling is difficult because the interactions between the two strains are not well known yet. In this paper, data-driven prediction of the product formation is presented for the purpose of better process monitoring. A rolling learning-prediction approach based on neural networks is practiced to predict 2-KGA formation. Techniques associated with the approach, such as the data pretreatment and the rolling learning-prediction mechanism, are given in more detail. The validation results by using the data from com. scale 2-KGA cultivation indicate that the prediction error is less than 5% in the later phase of fermentation and the reliable prediction time span is 8 h. The robustness of the prediction approach is further tested by adding extra noises to the process variables.

Computers & Chemical Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Lei published the artcilePhase identification using modified principal component analysis for industrial 2-keto-L-gulonic acid fermentation, Formula: C6H10O7, the publication is Jisuanji Yu Yingyong Huaxue (2017), 34(9), 693-696, database is CAplus.

In this paper, based on the dynamic characteristics of industrial 2-keto-L-gulonic acid fermentation, the principal component anal. (PCA) with time delay window is proposed to identify the different stages of fermentation process. Only the online measurement data of the current batch, which related to the state of the fermentation process, are needed in the method. In order to obtain the dynamic relationship of the fermentation process, the time delay window is introduced, and the dynamic state of the t moment is represented by the process variables during the period from t-D to t, not just the moment t. The PC Scores of the PCA is used to obtain the curve of Hotelling′s T² statistical variable. The singular points of the curve contain more information of dynamic behavior, and could be used to detect different fermentation stages. Furthermore, it has significance to improve the level of process control, for example, it could offer real-time guidance for off-line sampling and anal. time.

Jisuanji Yu Yingyong Huaxue published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Jiazhi published the artcileMetabolite profiling of tea (Camellia sinensis L.) leaves in winter., COA of Formula: C6H10O7, the publication is Scientia Horticulturae (Amsterdam, Netherlands) (2015), 1-9, database is CAplus.

Tea (Camellia sinensis L.) is a thermophilic evergreen woody perennial. It is poor in cold tolerance during winter. Changes occurred at metabolite level in low temperatures were poorly understood in tea plants. In this study, Metabolite profiling of tea leaves was performed to investigate the responses of tea plants to different cold conditions by using gas chromatog.-mass spectrometry (GC-MS) and multivariate anal. A total of 105 metabolites were identified. Principal component anal. (PCA) revealed that the tea leaves in plastic greenhouse (DP) and natural condition (OA) were clearly separated by their sampling times and growth conditions. The levels of changed metabolites could be organized in four clusters by hierarchical clustering anal. (HCA). According to the pathway, raffinose, maltose, glucose and fructose derived from the hydrolysis of sucrose were all more abundant in leaves of OA than those of DP. Despite temperature fluctuation, leucine, valine, threonine, alanine were all in higher level in leaves of DP than those of OA except Nov. 16. Citric acid, fumaric acid and malic acid were in higher level under the higher temperature in DP. Shikimic acid and quinic acid presented an absolutely distinct metabolism pattern. Shikimic acid was neg. correlated with quinic acid in both treatments except Mar. 16. They were at high level on Nov. 16, and then decreased sharply in the following periods in both treatments during the experiment The results indicated that the different low temperatures had significantly different effects on tea plants and could change their metabolic pathways in different ways. These might be helpful to understand the mechanism of cold resistance of tea plants at the metabolite level and to facilitate the future research on gene and protein expression in tea plants of DP and OA in winter.

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C15H14BNO4S, COA of Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zeng, Weizhu published the artcileProduction of 2-keto-L-gulonic acid by metabolically engineered Escherichia coli, Product Details of C6H10O7, the publication is Bioresource Technology (2020), 124069, database is CAplus and MEDLINE.

The 2-keto-L-gulonic acid (2-KLG) is the direct precursor for industrial vitamin C production The main biosynthetic method for 2-KLG production is the classical two-step fermentation route. However, disadvantages of this method are emerging, including high consumption of energy, difficulties in strain screening, complex operation, and poor stability. In this study, five recombinant Escherichia coli strains overexpressing different sorbose/sorbosone dehydrogenases were constructed and used for 2-KLG production By optimizing catalytic conditions and further expressing pyrroloquinoline quinone in the recombinant strain, the titer of 2-KLG reached 72.4 g/L, with a conversion ratio from L-sorbose of 71.2% in a 5-L bioreactor. To achieve direct biosynthesis of 2-KLG from D-sorbitol, a co-culture system consisting of Gluconobacter oxydans and recombinant E. coli was designed. With this co-culture system, 16.8 g/L of 2-KLG was harvested, with a conversion ratio from D-sorbitol of 33.6%. The approaches developed here provide alternative routes for the efficient biosynthesis of 2-KLG.

Bioresource Technology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C3H5BN2O2, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Zhaochen published the artcileMetabolic mechanism of plant defense against rice blast induced by probenazole, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Metabolites (2021), 11(4), 246, database is CAplus and MEDLINE.

The probenazole fungicide is used for controlling rice blast (Magnaporthe grisea) primarily by inducing disease resistance of the plant. To investigate the mechanism of induced plant defense, rice seedlings were treated with probenazole at 15 days post emergence, and non-treated plants were used for the control. The plants were infected with M. grisea 5 days after chem. treatment and incubated in a greenhouse. After 7 days, rice seedlings were sampled. The metabolome of rice seedlings was chem. extracted and analyzed using gas chromatog. and mass spectrum (GC-MS). The GC-MS data were processed using anal. of variance (ANOVA), principal component anal. (PCA) and metabolic pathway elucidation. Results showed that probenazole application significantly affected the metabolic profile of rice seedlings, and the effect was proportionally leveraged with the increase of probenazole concentration Probenazole resulted in a change of 54 metabolites. Salicylic acid, γ-aminobutyrate, shikimate and several other primary metabolites related to plant resistance were significantly up-regulated and some metabolites such as phenylalanine, valine and proline were down-regulated in probenazole-treated seedlings. These results revealed a metabolic pathway of rice seedlings induced by probenazole treatment regarding the resistance to M. grisea infection.

Metabolites published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C4H3Cl2N3, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Feng-xia published the artcileLiquor recovery process for vitamin C, COA of Formula: C6H10O7, the publication is Xiandai Huagong (2014), 34(3), 67-70, 72, database is CAplus.

A liquor recovery process for crystallization mother liquor of vitamin C is developed with the recovery of 2-keto-L-Gu salt as a process parameter. According to the characteristics of the mother liquor of vitamin C, vitamin C and 2-keto-L-Gu salt can be generated by adding a base to the mother liquor. Then, 2-keto-L-Gu salts and a sodium salt solution of vitamin C can be obtained by filtrating off 2-keto-L-Gu salt based on the different solubility The influences of proportion of a concentrated salt solution, the precipitation temperature and time on the recovery of 2-keto-L-Gu salt are investigated. The recovery of 2-keto-L-Gu salt can reach above 89.5% and the total yield of vitamin C is above 3% under the following conditions: 50% of optimal proportion of concentrate, 15°C of precipitation temperature and 6.5 h of precipitation time. The product quality can meet the standards, which indicates that the liquor recovery process can bring high economic efficiency and is worth promoting the industrial production

Xiandai Huagong published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, COA of Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts