Category: 5259-98-3

Application of 5259-98-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5259-98-3, name is 5-Chloropentan-1-ol, molecular formula is C5H11ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under a nitrogen atmosphere, 5.0 g of the compound represented by the formula (I-8-12), 0.2 g of pyridinium p-toluenesulfonate and 30 mL of dichloromethane were added to the reaction vessel. 3.8 g of 3,4-dihydro-2H-pyran was added with ice cooling and the mixture was stirred. After washing with a saturated aqueous solution of sodium bicarbonate and brine, purification was carried out by column chromatography (alumina, dichloromethane) to obtain 7.6 g of the compound represented by the formula (I-8-13).

According to the analysis of related databases, 5259-98-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; AOKI, YOSHIO; HAYASHI, TAKUO; TSURUTA, TORU; (69 pag.)JP2017/218391; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5259-98-3 , The common heterocyclic compound, 5259-98-3, name is 5-Chloropentan-1-ol, molecular formula is C5H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of Compound 13 To a solution of 5-chloro-l-pentanol (3.0 g, 24.47 mmol) Compound 11 in DMF (20 mL) was added sodium azide (1.909 g, 29.4 mmol) Compound 12. After being stirred at 60 ¡ãC for overnight, the reaction mixture was concentrated in vacu. The residue was purified by silica gel chromatography (EtOAc/Hexane 1 :3), to give product Compound 13 as clear liquid. 1H NMR (500 MHz, CDC13) delta 3.62 (m, 2H), 3.25 (t, J= 6.9 Hz, 2H), 1.63-1.53 (m, 4H), 1.45-1.40 (m, 2H).

The synthetic route of 5259-98-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TELLERS, David; COLLETTI, Steven, L.; DUDKIN, Vadim; AARONSON, Jeffrey; MOMOSE, Aaron; TUCKER, Thomas, Joseph; YUAN, Yu; CALATI, Kathleen, B.; TIAN, Lu; PARMAR, Rubina, G.; SHAW, Anthony, W.; WANG, Weimin; STORR, Rachel, Anne; BUSUEK, Marina; KOWTONIUK, Robert, A.; WO2013/166155; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts