Category: 5259-98-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloropentan-1-ol

A solution of 5-chloro-l-pentanol (10 g, 80 mmol) in DMF (100 mL) at 0 0C was treated with imidazole (19 g, 185 mmol) and TBDPS-Cl (26 g, 95 mmol), and the mixture was stirred and allowed to warm to room temperature over 2 hours before being quenched with the addition of water and extracted with EtOAc. The organic extract was washed with aqueous IN HCl, saturated aqueous NaHCOs, saturated aqueous NaCl, dried (Na2SO4), concentrated under reduced pressure, and subjected to flash chromatography to give 5 -(t-butyldimethylsilyloxy)-l -chloropentane as a colorless liquid (11 g, 38percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5259-98-3, 5-Chloropentan-1-ol.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.; WO2008/124575; (2008); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5259-98-3, name is 5-Chloropentan-1-ol, the common compound, a new synthetic route is introduced below. Safety of 5-Chloropentan-1-ol

5-chloro-l-pentanol (12,26 g, 0,1 mol) was dissolved in dry dichloromethane (400 mL). 3,4-Dihydro-2H-pyrane (12,62 g, 0,15 mol) and pyridine toluene-4-sulphonate (1,26 g, 5 mmol) was then added and the reaction mixture was stirred magneti- cally in a nitrogen atmosphere at room temperature over night. Sodium-hydrogen-carbonate, saturated solution (150 mL) was added and the phases were separated. The aqueous phase was then extracted with dichloromethane (4 x 25 mL). The com- bined dichloromethane phases were washed with water (2 x 20 mL) and then dried (MGS04). Dichloromethane was then dis- tilled out on a rotary evaporator and yielded 19,6 g (95 percent) of a pale yellow oil. NMR indicated a pure product.

The synthetic route of 5259-98-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AXIMED AS; WO2005/25314; (2005); A1;,
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Reference of 5259-98-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below.

To a solution of benzylamine (0.66?mL, 6.03?mmol) and 5-chloropentan-1-ol (0.42?mL, 4.02?mmol) in 5?mL of anhydrous acetonitrile, 555?mg of K2CO3 (4.02?mmol) were added. The mixture was stirred at 80?°C for 48?h and concentrated in vacuo. The residue was dissolved with CH2Cl2, and the organic layer was washed twice with a solution of 10percent NaOH, dried on Na2SO4 and evaporated to give the crude product that was purified by flash chromatography, using CH2Cl2/MeOH/NH4OH 95:5:0.5 as eluting system. 160?mg (20.6percent) of title compound as a yellow oil were obtained. 1H NMR (CDCl3) delta: 7.33-7.26 (m, 5H, CH arom.); 3.78 (s, 2H, NCH2Ph); 3.61 (t, J?=?6.4?Hz, 2H, CH2OH); 2.65 (t, J?=?6.8?Hz, 2H, NCH2); 1.88 (s, 1H, NH); 1.61-1.50 (m, 4H, CH2); 1.47-1.42 (m, 2H, CH2) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5259-98-3, its application will become more common.

Reference:
Article; Dei, Silvia; Romanelli, Maria Novella; Manetti, Dina; Chiaramonte, Niccolo; Coronnello, Marcella; Salerno, Milena; Teodori, Elisabetta; Bioorganic and Medicinal Chemistry; vol. 26; 1; (2018); p. 50 – 64;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5259-98-3, name is 5-Chloropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 5-Chloropentan-1-ol

General procedure: A solution of phthalimide (14.7 g, 0.1 mol) and 5-chloropentanol (11.25 g, 0.1 mol) or6-chloro-hexanol (12.45 g, 0.1 mol) in anhydrous DMF (100 mL) was heated at 150 °C with vigorousstirring in the presence of finely-powdered anhydrous K2CO3 (13.8 g, 0.1 mol) for 12 h. After cooling,the inorganic materials were filtered off and the solvent was evaporated in vacuo (2 mmHg, 100 °C).The residue was dissolved in 150 mL of ethyl acetate, and after standing overnight at 5 °C, the solutionwas filtered and concentrated in vacuo. The residue was taken up in 80 mL of CHCl3. After extractionwith 60 mL of 5percent aqueous solution of NaHCO3 and 3 60 mL of H2O, the solvent was dried overNa2SO4 and removed in vacuo, giving: 2-(5-Hydroxypentyl)-1H-isoindole-1,3(2H)-dione (5a). A sticky oil (on standing for a prolonged period theviscous oil crystallized giving a solid), yield 70percent (16.32 g); m.p. 41?43 °C; Rf = 0.39 (CHCl3/CH3OH20:1); 1H-NMR (300 MHz, CDCl3): delta= 1.40?1.43 (m, 4H, CH2C), 1.53?1.58 (m, CH2CH2OH), 1.66?1.71(m, 3H, CH2CH2N, OH), 3.61?3.63 (t, J = 6.6 Hz, 2H, CH2N), 3.66?3.68 (t, J = 7.2 Hz, 2H, CH2OH),7.68?7.71 (m, 2H, Harom); 7.81?7.84 (m, 2H, H) ppm.

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Reference:
Article; Guryn, Roman; Staszewski, Marek; Stasiak, Anna; Flores, Daniel McNaught; Fogel, Wies?awa Agnieszka; Leurs, Rob; Walczynski, Krzysztof; Molecules; vol. 23; 2; (2018);,
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Synthetic Route of 5259-98-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5259-98-3, name is 5-Chloropentan-1-ol, molecular formula is C5H11ClO, molecular weight is 122.59, as common compound, the synthetic route is as follows.

General procedure: The thiophenylmannoside 1 (440mg, 1.00mmol, 1.0equiv) and the corresponding alcohol (1.05equiv) in CH2Cl2 (5mL) were stirred at 25 °C in the presence of 4 A MS (500mg) for 30 min. After cooling to ?2°C with an ice/NaCl bath N-iodosuccinimide (270mg, 1.2mmol, 1.2equiv) and trifluoromethanesulfonic acid (30.0mg, 17.7mL, 200mmol, 0.2equiv) were slowly added and stirring continued at this temperature for 1h. The reaction mixture was allowed to warm to 25 °C and then acetic anhydride (0.2-0.3mL, 2.0-3.0equiv) added. Work-up was analogous to GP1 and column chromatography was performed with a gradient 3:1?1:1 petrol/EtOAc to yield the mono, di and trisaccharides as colourless materials.

The chemical industry reduces the impact on the environment during synthesis 5259-98-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Schuster, Heiko J.; Vijayakrishnan, Balakumar; Davis, Benjamin G.; Carbohydrate Research; vol. 403; (2015); p. 135 – 141;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H11ClO

General procedure: Compounds 2M-6M were prepared by a similar method. The synthesis of compound 6M is described below. 4,4?-Dihydroxydiphenyl (9.3 g, 0.05 mol) and 6-chloro-1-hexanol (15.1 g, 0.11 mol) were added to a solution of sodium hydroxide (4.4 g, 0.11 mol) in ethanol (200 mL, 95percent). The solution was heated to reflux for 20 h then was cooled and the solid salt was removed by filtration. The remaining solid was recrystallized from DMF/H2O to yield 15.6 g (81percent) of crystals.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5259-98-3, 5-Chloropentan-1-ol.

Reference:
Article; Chen, Cheng-Chih; Lin, Chih-Hung; Oriental Journal of Chemistry; vol. 34; 1; (2018); p. 125 – 133;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H11ClO

EXAMPLE 155 Preparation of 5-chloro-1-(2-furyl)-1-pentanol To a stirred suspension of 2-furyllithium [prepared from 0.53 moles of n-butyllithium and 39.5 g of furan by the procedure of J. Org. Chem., 27, 1216 (1962)] in 350 ml. of ether and with 200 ml. of hexane at -78° C is added a solution of 57.9 g of 5-chloropentanol [Chem. Abstr. 59, 7579F (1963)] in 80 ml. of ether during 25 minutes. The mixtures is warmed to 0° C. during 20 minutes, stirred at 0° C for 15 minutes, and treated with 140 ml. of saturated ammonium chloride. The ether phase is washed with water and brine, dried over magnesium sulfate and potassium carbonate mixture, and concentrated to give a liquid, pmr spectrum (CDCl3) delta 3.59 (triplet, CH2 Cl) and 4.70 (triplet, CH2 CHOH).

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Reference:
Patent; American Cyanamid Company; US4131737; (1978); A;,
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Application of 5259-98-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5259-98-3, name is 5-Chloropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Under a nitrogen atmosphere, 7.0 g of a compound represented by the formula (D-9-6)0.7 g of pyridinium p-toluenesulfonate,70 mL of dichloromethane was added.5.8 g of 3,4-dihydro-2H-pyran was added dropwise while cooling with ice, and the mixture was stirred at room temperature for 8 hours.After washing successively with a 5percent aqueous sodium hydrogencarbonate solution and brine,Purification by column chromatography (silica gel, dichloromethane) gave 10.6 g of a compound represented by the formula (D-9-7).

According to the analysis of related databases, 5259-98-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; HAYASHI, MASANAO; (134 pag.)JP2018/70546; (2018); A;,
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Related Products of 5259-98-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5259-98-3 as follows.

4-chlorobutan-1-ol (1.0 equiv, 46.05 mmol, 5.00 g) and sodium azide (2.0 equiv, 92.10mmol, 5.99g) were dissolved in Water (50 mL) and refluxed at 100°C overnight. Reaction progression was checked by TLC, which showed full conversion. The reaction was left to cool to room temperature and the product was extracted with diethylether (5x). The combined organic layers were washed with brine and dried with sodium sulfate. Concentration in vacuo yielded the desired product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5259-98-3, its application will become more common.

Reference:
Article; Saarbach, Jacques; Masi, Daniela; Zambaldo, Claudio; Winssinger, Nicolas; Bioorganic and Medicinal Chemistry; vol. 25; 19; (2017); p. 5171 – 5177;,
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Adding a certain compound to certain chemical reactions, such as: 5259-98-3, 5-Chloropentan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H11ClO, blongs to alcohols-buliding-blocks compound. COA of Formula: C5H11ClO

Intermediate 1; 4-(5-Chloro-pentyloxy)-benzoic acid methyl ester; 4-Hydroxy-benzoic acid methyl ester (1.52 g, 10 mmol), 5-chloro-l-pentanol (1.22 g, 10 mmol) and triphenylphosphine (2.62 g, 10 mmol) are dissolved in dry THF (30 rnL) and cooled to 0 0C. Diethylazodicarboxylate (DEAD) (1.74 g, 10 mmol) is dropped into this mixture at 0 ¡ãC and stirred at room temperature for 3 days. The reaction mixture is washed with brine, dried over Na2SO4, filtered and evaporated. The crude product is purified using silica-gel column chromatography (CH2CI2 only to CH2Cl2:2 M NH3 in MeOH=20:l) to give the desired product (1.14 g, 45percent). NMR (CDCI3): delta 7.98 (d, 2H , J = 8.8 Hz), 6.89 (d, 2H, / = 8.8Hz), 4.02 (t, 2H, J = 6.5 Hz), 3.88 (s, 3H), 3.57 (t, 2H, / = 6.7 Hz), 1.85 (m, 4H), 1.64 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5259-98-3, 5-Chloropentan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/101808; (2006); A1;,
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