Category: 52160-51-7

Schliebe, Christian; Noll, Julian; Scharf, Sebastian; Gemming, Thomas; Seifert, Andreas; Spange, Stefan; Lehmann, Daniel; Zahn, Dietrich R. T.; Fiedler, Benjamin; Friedrich, Joachim; Blaudeck, Thomas; Lang, Heinrich published the artcile< Nitrogen-containing porous carbon materials by twin polymerization>, HPLC of Formula: 52160-51-7, the main research area is nitrogen doping porous carbon hybrid material twin polymerization copolymerization.

The preparation of Si(OCH2cC4H3NR)4 (5, R = Me; 6, R = H) by the reaction of 2-HOCH2-cC4H3NR (3, R = Me; 4, R = H) with SiCl4 in the ratio of 4:1 in the presence of NEt3 is described. The thermal behavior of twin monomers 5 and 6 was investigated by thermogravimetry and differential scanning calorimetry. Compound 6 shows with 93 °C the lowest polymerization temperature for twin monomers reported so far. In addition to the thermal-induced twin polymerization of 5 and 6, the acidic initiation and copolymerization with 2,2′-spiro-bi[4H-1,3,2-benzodioxasiline] was investigated. The resulting hybrid materials were characterized by 1H, 13C{1H}, and 29Si{1H} solid-state NMR spectroscopy confirming the transformation of the SiOCH2 moieties into CH2 groups enabling the formation of the resp. polymers. These results are supported by HAADF-STEM studies, showing the typical microstructuring of a twin polymer. Furthermore, nitrogen-containing porous carbon materials with a surface area between 200 and 800 m2 g-1 and a nitrogen content of up to 9.1% were obtained. The chem. nature of the incorporated nitrogen was investigated by XPS spectroscopy, revealing that mostly pyrrolic nitrogen is observed, but also pyridinic species are present. [Figure not available: see fulltext.].

Colloid and Polymer Science published new progress about Copolymerization. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, HPLC of Formula: 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Jisung; Nabae, Yuta; Hayakawa, Teruaki; Kakimoto, Masa-aki published the artcile< Highly Selective Two-Electron Oxygen Reduction Catalyzed by Mesoporous Nitrogen-Doped Carbon>, Formula: C6H9NO, the main research area is highly selective two electron oxygen reduction catalyzed; mesoporous nitrogen doped carbon.

Electrochem. reduction of oxygen mols. can produce H2O2, which is an important chem. for a green and sustainable society; therefore, the development of catalysts for this reaction is necessary. We propose mesoporous nitrogen-doped carbon prepared from (1-methyl-1H-pyrrole-2-yl)methanol in the presence of a mesoporous SiO2 template (KIT-6). The nitrogen content of the resulting carbon can be controlled in the range of 0-10 at. % and all prepared samples have well-ordered mesopores with diameters of 3.4-4.0 nm. Electrochem. studies indicate the present materials have high catalytic activities with high selectivity toward H2O2 over 90%. Such high selectivity toward H2O2 is probably due to good mass transport in the catalyst layer, which is enhanced by the mesoporous structure.

ACS Catalysis published new progress about Doping. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Formula: C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yingze; Krause, Jeanette A.; Guan, Hairong published the artcile< Silane Activation with Cobalt on the POCOP Pincer Ligand Platform>, HPLC of Formula: 52160-51-7, the main research area is aldehyde hydrosilylation cobalt pincer complex catalyst silane siloxane; bisphosphinoxyphenyl cobalt pincer complex preparation crystal structure hydrosilylation catalyst; mol structure phosphinoxyphenyl cobalt pincer complex.

Co POCOP pincer complexes {κP,κC,κP-2,6-(iPr2PO)2C6H3}Co(PMe3)2 (1) and {κP,κC,κP-2,6-(iPr2PO)2-4-NMe2-C6H2}Co(PMe3)2 (2) were synthesized via C-H bond activation of the pincer ligands with HCo(PMe3)4. Silanes such as PhSiH3, Ph2SiH2, and (EtO)3SiH can undergo Si-H oxidative addition with these Co(I) complexes, though reversibly. One of the silane activation products, namely, {κP,κC,κP-2,6-(iPr2PO)2C6H3}Co(H)(SiH2Ph)(PMe3) (3), was isolated and shown to eliminate PhSiH3 upon evaporation to form {κP,κC,κP-2,6-(iPr2PO)2C6H3}Co(PMe3) (4). Under heating, redistribution of PhSiH3 in 3 can take place, resulting in {κP,κC,κP-2,6-(iPr2PO)2C6H3}Co(H)(SiH3)(PMe3) (5) and Ph2SiH2. Complexes 1-3 were established as catalysts for the hydrosilylation of aldehydes bearing various functional groups. According to the mechanistic studies, the silyl hydride species exists in the catalytic cycle, whereas the bis(trimethylphosphine) species sits outside the catalytic cycle. Dissociation of PMe3 is required prior to aldehyde insertion into the silyl hydride species, which is the turnover-limiting step of the catalytic cycle. Consequently, 3 outperforms 1 in catalyzing the hydrosilylation reaction due to the presence of only one PMe3 ligand. The structures of 1-4 were studied by x-ray crystallog.

Organometallics published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, HPLC of Formula: 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattocks, A. R. published the artcile< Liver cell enlargement in rats given hydroxymethylpyrroles analogous to pyrrolizidine alkaloid metabolites, followed later by the hepatotoxin dimethylnitrosamine>, Electric Literature of 52160-51-7, the main research area is hydroxymethylpyrrole DMN liver.

Male rats aged 4-5 wk were given single doses of pyrrolic alcs. having alkylating properties similar to those of pyrrolizidine alkaloid metabolites, followed several days later by 1 of the hepatotoxins, DMN [62-75-9], thioacetamide (TA) [62-55-5] or CCl4 [56-23-5]. After 24-32 days the livers of animals given the pyrroles 1-methyl-2,3-bis(hydroxymethyl)pyrrole (I) [53365-77-8] or 1-phenyl-5-methyl-2,3-bis(hydroxymethyl)pyrrole (II) [68384-87-2] and then DMN, contained enlarged parenchymal cells (megalocytes) similar to those seen in chronic pyrrolizidine alkaloid poisoning. At this time such abnormal cells were not found in rats given any of the other pyrroles followed by DMN, or compound I and then TA or CCl4.

Toxicology Letters published new progress about Liver. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Electric Literature of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattocks, A. R.; Driver, H. Elizabeth published the artcile< A comparison of the pneumotoxicity of some pyrrolic esters and similar compounds analogous to pyrrolizidine alkaloid metabolites, given intravenously to rats>, Computed Properties of 52160-51-7, the main research area is pyrrole ester toxicity lung; heart pyrrole ester toxicity; liver pyrrole ester toxicity.

Toxic effects of 14 esters with chem. properties similar to those of pyrrolic pyrrolizidine alkaloid metabolites, were investigated in rats. The compounds were either mono- or bifunctional alkylating agents. When single doses were injected into a tail vein, the lungs were the main organ affected. All but 1 of the compounds tested caused pulmonary edema and congestion, accompanied by pleural effusion, and animals often died between 1 and 2 days after the injection. Smaller amounts of some of the esters caused a characteristic chronic lung lesion, with proliferation of alveolar tissue, resembling that produced by the pyrrolizidine alkaloids fulvine and monocrotaline. All the compounds which caused death associated with chronic lung damage were bifunctional alkylating agents. Very large doses, especially when injected rapidly, sometimes caused death within a few minutes. Thus, the ability to damage the lungs, and sometimes the heart, is a property of certain esters capable of alkylating tissues with which they come into contact, and is dependent on the chem. reactivity rather than the mol. structure of the compound Nevertheless the latter may play a part, as shown by the exceptionally high pneumotoxicity of an indole ester having a lipophilic structure with high affinity for tissue. Necrosis of the liver in some rats might be due to metabolites formed in the liver from the injected compounds or their decomposition products, rather than the active esters themselves.

Toxicology published new progress about Animal organ. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Computed Properties of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cavallo, Marzia; Arnodo, Davide; Mannu, Alberto; Blangetti, Marco; Prandi, Cristina; Baratta, Walter; Baldino, Salvatore published the artcile< Deep eutectic solvents as H2-sources for Ru(II)-catalyzed transfer hydrogenation of carbonyl compounds under mild conditions>, Related Products of 52160-51-7, the main research area is aldehyde ketone transfer hydrogenation ruthenium catalyst deep eutectic solvent.

The employment of easily affordable ruthenium(II)-complexes as pre-catalysts in the transfer hydrogenation of carbonyl compounds in deep eutectic media is described for the first time. The eutectic mixture tetrabutylammonium bromide/formic acid = 1/1 (TBABr/HCOOH = 1/1) acts both as reaction medium and hydrogen source. The addition of a base is required for the process to occur. An extensive optimization of the reaction conditions has been carried out, in terms of catalyst loading, type of complexes, H2-donors, reaction temperature and time. The combination of the dimeric complex [RuCl(p-cymene)-μ-Cl]2 (0.01-0.05 equivalent) and the ligand dppf (1,1′-ferrocenediyl-bis(diphenylphosphine)ferrocene) in 1/1 molar ratio has proven to be a suitable catalytic system for the reduction of several and diverse aldehydes and ketones to their corresponding alcs. under mild conditions (40-60°) in air, showing from moderate to excellent tolerability towards different functional groups (halogen, cyano, nitro, phenol). The reduction of imine compounds to their corresponding amine derivatives was also studied. In addition, the comparison between the results obtained in TBABr/HCOOH and in organic solvents suggests a non-innocent effect of the DES medium during the process.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Related Products of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Plestina, R.; Stoner, H. B.; Jones, Glenys; Butler, W. H.; Mattocks, A. R. published the artcile< Vascular changes in the lungs of rats after the intravenous injection of pyrrole carbamates>, Application of C6H9NO, the main research area is lung pathol pyrrole carbamate; monocrotaline derivative lung toxicity; alkaloid pyrrolizidine derivative lung.

Acute pulmonary edema was produced in mice and rats, after injection into a systemic vein, of 1-methyl-2-(N-ethylcarbamoyloxymethyl)pyrrole (I) [62435-67-0] and 1-methyl-2,3-bis(N-ethylcarbamoyloxymethyl)pyrrole (II) [36504-91-3], 2 synthetic compounds related to monocrotaline pyrrole. 1-Methyl-2-hydroxymethylpyrrole (III) [52160-51-7] and Et N-ethylcarbamate [623-78-9] had no such effect and although 3-(N-ethylcarbamoyloxymethyl)furan (IV) [50884-33-8] did not cause pleural effusion in rats it did in mice. Like monocrotaline pyrrole, the pyrrole carbamates, when injected into other vessels, produced edema in the region of the 1st capillary bed encountered. S labeling occurred in both the postcapillary venules and the capillaries of the lungs when colloidal C was injected i.v. after the pyrrole carbamates. Venular labeling occurred before capillary labeling, which occurred optimally when C was injected >4 h after the pyrrole. No C labeling was observed after IV injection. The effects of the synthetic pyrrole esters were similar to those of monocrotaline pyrrole. The pyrrole carbamates were less active on a mol. basis, but they had a broader action on the pulmonary vasculature, causing both venular and capillary labeling. The compounds required the pyrrole ring structure and ≥1 ester side-chain to affect the lungs acutely.

Journal of Pathology published new progress about Lung. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application of C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Plestina, R.; Stoner, H. B.; Jones, Glenys; Butler, W. H.; Mattocks, A. R. published the artcile< Vascular changes in the lungs of rats after the intravenous injection of pyrrole carbamates>, Application of C6H9NO, the main research area is lung pathol pyrrole carbamate; monocrotaline derivative lung toxicity; alkaloid pyrrolizidine derivative lung.

Acute pulmonary edema was produced in mice and rats, after injection into a systemic vein, of 1-methyl-2-(N-ethylcarbamoyloxymethyl)pyrrole (I) [62435-67-0] and 1-methyl-2,3-bis(N-ethylcarbamoyloxymethyl)pyrrole (II) [36504-91-3], 2 synthetic compounds related to monocrotaline pyrrole. 1-Methyl-2-hydroxymethylpyrrole (III) [52160-51-7] and Et N-ethylcarbamate [623-78-9] had no such effect and although 3-(N-ethylcarbamoyloxymethyl)furan (IV) [50884-33-8] did not cause pleural effusion in rats it did in mice. Like monocrotaline pyrrole, the pyrrole carbamates, when injected into other vessels, produced edema in the region of the 1st capillary bed encountered. S labeling occurred in both the postcapillary venules and the capillaries of the lungs when colloidal C was injected i.v. after the pyrrole carbamates. Venular labeling occurred before capillary labeling, which occurred optimally when C was injected >4 h after the pyrrole. No C labeling was observed after IV injection. The effects of the synthetic pyrrole esters were similar to those of monocrotaline pyrrole. The pyrrole carbamates were less active on a mol. basis, but they had a broader action on the pulmonary vasculature, causing both venular and capillary labeling. The compounds required the pyrrole ring structure and ≥1 ester side-chain to affect the lungs acutely.

Journal of Pathology published new progress about Lung. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application of C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattocks, A. Robin published the artcile< Pyrrolizidine alkaloid analogs. Part 2. Further hydroxymethyl-1-methyl-3-pyrrolines (synthanecines), and the preparation and esterification of some hydroxymethylpyrroles>, Related Products of 52160-51-7, the main research area is synthanecine D E total synthesis; esterification hydroxymethylpyrrole hydroxymethylindole; pyrrolizidine alkaloid analog; pyrrole hydroxymethyl esterification; indole hydroxymethyl esterification; alkylation hydroxymethylpyrrole kinetics.

Synthanecine D and E [I; R = (CH2)2OH, Me] were each prepared in 5 steps from EtO2CCH:CHCH2CO2Et and MeNHCHMeCH2CO2Et, resp. Esters of I [R = (CH2)2OH, Me] behave as analogs of pyrrolizidine alkaloids which can be metabolically dehydrogenated in animals to pyrrole derivatives II [R = (CH2)2OH, Me, R1 = CH2OH, R2 = H] which are monofunctional alkylating agents. The successful esterification of (hydroxymethyl)pyrroles requires rigorous exclusion of moisture and the presence of a tertiary base to prevent polymerization The electrophilic reactivities of 19 (hydroxymethyl)pyrrole and -indole derivatives, including II [R = (CH2)2OH, Me, R1 = CH2OH, R1 = H], towards 4-p-nitrobenzylpyridine are compared. KOH-catalyzed cyclization of EtO2CCH2NMeCH(CH2CO2Et)2, an intermediate in the preparation of I [R = (CH2)2OH], gave 45% II (R = H, R1 = CO2Et, R2 = OH).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Alkylation kinetics. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Related Products of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tressl, Roland; Kersten, Evelyn; Wondrak, Georg; Rewicki, Dieter; Kruger, Ralph-Peter published the artcile< Fragmentation of sugar skeletons and formation of Maillard polymers>, Formula: C6H9NO, the main research area is fragmentation pathway sugar skeleton; Maillard polymer formation.

Labeling experiments involving the reaction of 13C-labeled hexoses, pentoses, and D-lactose with 4-aminobutyric acid (GABA) (isoleucine) are described. The distribution of the label was investigated by MS and gave an insight into the formation pathways leading to complementary labeled compounds from hexoses and pentoses with intact carbon skeletons and indicated distinct fragmentations of the sugar skeletons into C5- and C4-compounds (furans, N-alkylpyrrolemethanols, N-alkyl-2-formylpyrroles and N-alkylpyrroles). These compounds undergo polycondensations to melanoidin-like macromols. under mild reaction conditions. In a series of model experiments, different types of polymers were investigated, and individual oligomers (e.g. I) were characterized by 1H/13C-NMR spectroscopy and FAB-/MALDI-TOF-MS. The authors postulate that these polycondensation reactions represent the most important driving force in the Maillard reaction.

Special Publication – Royal Society of Chemistry published new progress about Fragmentation reaction. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Formula: C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts