Reference of 52085-92-4 , The common heterocyclic compound, 52085-92-4, name is 5-Fluoro-2,3-dihydro-1H-inden-1-ol, molecular formula is C9H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 5-fluoroindan-l-ol (2.03 g, 13.32 mmol) and thionyl chloride (1.5 mL, 19.98 mmol) in 20 mL of toluene was stirred for 30 min at room temperature, followed by 17 h at 55 0C. After cooling to room temperature, the solvents were evaporated to give a brown oil. The oil was taken up in ethyl acetate (25 mL) and washed with water (20 mL) and saturated NaHCO3 (20 mL). The ethyl acetate layer was dried (Na2SO4), filtered, and evaporated in vacuo to give the title compound as a brown oil (1.9 g, 84 %). 1H NMR (400 MHz, CDCl3) delta 7.37 (IH, m), 6.92 (2H, m), 5.40 (IH, m), 3.20 (IH, m), 2.90 (IH, m), 2.62 (IH, m), 2.41 (IH, m).
The synthetic route of 52085-92-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; NEUROGEN CORPORATION; WO2006/122200; (2006); A1;,
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