Category: 52059-53-7

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-(3-Fluorophenyl)ethanol

(ii) To a stirred suspension of pyridinium chlorochromate (75.5 g, 0.35 mol) in dry dichloromethane (300 ml) under a nitrogen atmosphere was added 2-(3-fluorophenyl)ethanol (43 g, 0.31 mol) dropwise. After the addition the mixture was stirred for 1 hour, allowed to stand overnight then poured down a florisil column. The column was washed with ether and the combined filtrate and washings were evaporated to leave the crude 3-fluorophenyl acetaldehyde as an unstable liquid which was not purified further (34 g), NMR delta 9.75 (1H, t), 7.3 (1H, m), 7.05-6.9 (3H, m), 3.7 (2H, d).

With the rapid development of chemical substances, we look forward to future research findings about 52059-53-7.

Reference:
Patent; Larkin; John P.; Weston; John B.; Smith; Ian H.; Palmer; Christopher J.; Casida; John E.; US5204333; (1993); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C8H9FO

General procedure: To a neat mixture of 3-(3-((6-fluoropyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (Intermediate IV, 50 mg, 0.19 mmol) and (3-fluorophenyl)methanol (187 mg, 1.48 mmol) was added potassium tert-butoxide (1M in THF, 1.85 mL, 1.85 mmol) and the mixture was stirred for 30 min. The mixture was transferred to a silica gel samplet and purified by column chromatography (SiO2, hexane/ethyl acetate). Combined fractions containing the product were concentrated under reduced pressure. Residue was dissolved in acetonitrile (5 mL) and water (10 mL), frozen and lyophilized to yield 3-(3-((6-((3-fluorobenzyl)oxy)pyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (45 mg, 0.12 mmol, 65%) as a white solid.

The synthetic route of 52059-53-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Trzoss, Michael; Covel, Jonathan A.; Kapoor, Mili; Moloney, Molly K.; Soltow, Quinlyn A.; Webb, Peter J.; Shaw, Karen Joy; Bioorganic and Medicinal Chemistry Letters; vol. 29; 23; (2019);,
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Related Products of 52059-53-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52059-53-7, name is 2-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.

To a solution of (S)-isopropyl 2-(2-amino-4-(4,4-dimethylpiperidin- 1 -yl)-5 ?,6?-difluoro-6-methyl- [3,3 ?-bipyridinj -5 -yl)-2-(tert-butoxy)acetate (0.042 g, 0.059 mmol, 1 equiv) and 2-(3-fluorophenyl)ethanol (0.042 g, 0.297 mmol, 5 equiv) in THF (1.5 mL)was added 60% NaH (0.012 g, 0.297 mmol, 5 equiv). The reaction was heated at 60 C for 1 h. EtOH (0.9 mL) and 10 N NaOH (0.1 mL) were added and the temperature was raised to 80 C for 4 h. After cooling to ambient temperature, the reaction was filtered. The cmde mixture was purified by preparative LC/MS to provide the product (9 mg, 26%). ?H NMR (500 MHz, DMSO-d6) 7.89 – 7.44 (m, 2H), 7.38 – 7.32 (m, 1H), 7.17 -7.10 (m, 2H), 7.07 -7.00 (m, 1H), 5.70 (s, 1H), 5.09 (br s, 1H), 4.75 -4.53 (m, 2H), 3.18- 3.02 (m, 2H), 2.91 – 2.64 (m, 1H), 2.32 (s, 3H), 1.60 – 1.43 (m, 1H), 1.26 (s, 2H), 1.16 (s, 9H), 1.09 – 0.98 (m, 1H), 0.86 (br s, 3H), 0.62 (br s, 3H) [note: appears to be a 60:40 mixture ofrotamers around pyridine pyridine biaryl bond, piperidine protons are broad and not all visiblej. LCMS (M+1) = 583.3.

Statistics shows that 52059-53-7 is playing an increasingly important role. we look forward to future research findings about 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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Electric Literature of 52059-53-7, Adding some certain compound to certain chemical reactions, such as: 52059-53-7, name is 2-(3-Fluorophenyl)ethanol,molecular formula is C8H9FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52059-53-7.

Dess-Martin periodinane (16.781 mmol, 1 .2 eq) is added to a solution of 3-fluorophenethyl alcohol (13.984 mmol, 1 eq) in DCM (32 mL). The resulting reaction mixture is stirred at RT for 4 h. The solvent is then partially evaporated, and the residue filtered through a short pad of Celite. The filtrate is concentrated under reduced pressure and the residue purified by FC (EtOAc/heptane, 5:95). Crude 2-(3-fluorophenyl)acetaldehyde is obtained as a colorless oil (2.58 g). The compound is used in the next step without further purification. 1H NMR (CDCI3): £9.77 (t, J = 3.0 Hz, 1 H), 7.33 (m, 1 H), 6.98 (m, 3 H), 3.69 (d, J = 3.0 Hz, 2 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52059-53-7, 2-(3-Fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi T.; WO2012/85857; (2012); A1;,
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Application of 52059-53-7 ,Some common heterocyclic compound, 52059-53-7, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 119: 1 -Methanesulfonyloxy-2-(3 -fluorophenyl)ethane Methanesulfonyl chloride (0.92mL) was added to a stirred, cooled solution of 2-(3-fluorophenyl)ethanol (1.28g) and triethylamine (2mL) in DCM (l5mL) at 0C under an atmosphere of nitrogen. On completion of the addition, the mixture was stirred at 0C for 30 minutes then at room temperature for 1.5 hours. The mixture was partitioned between DCM and 1M hydrochloric acid and the aqueous layer was extracted with DCM. The combined organic layers were dried (Na2SO4) and filtered. The filtrate was evaporated to dryness and theresidue was purified by chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane, with a gradient of 0-100% to give 1-methanesulfonyloxy-2-(3- fluorophenyl)ethane (1.92g) as a colourless oil.1007021 ?H NMR (CDC13) : 7.33-7.26 (1H, m), 7.05-6.92 (3H, m), 4.42 (2H, t), 3.06 (2H, t), 2.89 (3H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52059-53-7, its application will become more common.

Reference:
Patent; ZAFGEN, INC.; PALLIN, Thomas, David; CRAMP, Susan, Mary; DYKE, Hazel, Joan; ZAHLER, Robert; WO2014/71369; (2014); A1;,
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Synthetic Route of 52059-53-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52059-53-7, name is 2-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.

General procedure: To a solution of 2-(4-fluorophenyl)ethan-1-ol (1.12g, 7.99mmol) in DCM (45mL) at 0C was added imidazole (0.60g, 8.8mmol), triphenylphosphine (2.31g, 8.80mmol), and iodine (2.03g, 8.00mmol) in rapid succession. The mixture was allowed to stir at 0C for 10min before being gradually warmed to room temperature and let stir an additional 3h. Once TLC confirmed complete conversion the reaction was quenched with saturated aqueous Na2S2O3 (90mL) and the resulting solution extracted with DCM (3×30mL). The resulting organics were dried over MgSO4 and concentrated in vacuo. The resulting white solid was resuspended in 100mL hexanes and filtered to remove the byproduct triphenylphosphine oxide as a white precipitate. Following filtration the crude material was purified using Teledyne ISCO Combi Flash system (40g column, solid loading on silica, 100% hexanes, 20min run) to afford 1-fluoro-4-(2-iodoethyl)benzene (1.43g, 72%) as a clear oil.

The chemical industry reduces the impact on the environment during synthesis 52059-53-7, I believe this compound will play a more active role in future production and life.

Reference:
Article; Jeffries, Daniel E.; Witt, Jonathan O.; McCollum, Andrea L.; Temple, Kayla J.; Hurtado, Miguel A.; Harp, Joel M.; Blobaum, Anna L.; Lindsley, Craig W.; Hopkins, Corey R.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5757 – 5764;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(3-Fluorophenyl)ethanol

Dess-Martin periodinane (16.781 mmol, 1 .2 eq) is added to a solution of 3-fluorophenethyl alcohol (13.984 mmol, 1 eq) in DCM (32 mL). The resulting reaction mixture is stirred at RT for 4 h. The solvent is then partially evaporated, and the residue filtered through a short pad of Celite. The filtrate is concentrated under reduced pressure and the residue purified by FC (EtOAc/heptane, 5:95). Crude 2-(3-fluorophenyl)acetaldehyde is obtained as a colorless oil (2.58 g). The compound is used in the next step without further purification. 1H NMR (CDCI3): ?9.77 (t, J = 3.0 Hz, 1 H), 7.33 (m, 1 H), 6.98 (m, 3 H), 3.69 (d, J = 3.0 Hz, 2 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52059-53-7, 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi T.; WO2012/85852; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(3-Fluorophenyl)ethanol

A mixture of 2-(3-fluorophenyl)ethanol (0.052 mL, 0.419 mmol), NaH (0.017 g, 0.419 mmol), and (S)-isopropyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin- 1 -yl)-5 ?,6?- difluoro-6-methyl-[3,3?-bipyridinj-5-yl)acetate (0.041 g, 0.084 mmol) in THF was stirred at ambient temperature for 1 h. Then, 5 M NaOH (0.167 mL, 0.837 mmol) was added andthe mixture was heated at 80 C for 2 h. After cooling to ambient temperature, the reaction was filtered. The cmde mixture was purified by preparative LC/MS to provide the product (23.4 mg, 49%). ?H NMR (500 MHz, DMSO-d6) 8.14 – 8.03 (m, 1H), 7.93 (d,J= 1.8Hz, 1H),7.70(dd,J 11.0, 1.8Hz, 1H),7.42-7.24(m, 1H),7.21 -6.97(m, 3H), 5.83 (s, 1H), 4.67 (t, J= 6.6 Hz, 2H), 3.18 -3.00 (m, 1H), 1.32 (br s, 3H), 1.14 (s, 1OH), 0.89 – 0.76 (m, 6H) [note: piper/dine protons not all visiblej. LCMS (M+1) =568.3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52059-53-7, 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Example 149E (20 mg, 0.06 mmol) and 2-(3-fiuorophenyl)ethanol (9.3 mg, 0.066 mmol) were dissolved in 1 mL tetrahydrofuran. To this, PS-triphenylphosphine (58 mg, 0.18 mmol, 3.1 mmol/g) was added followed by di-tert-buty azodicarboxylate (20.9 mg, 0.09 mmol). The mixture was stirred at room temperature overnight. The resulting mixture was filtered, concentrated and purified by flash chromatography (0-50% ethyl acetate in hexane). To the material thus obtained was added 0.5 mL 4 MEtaC1 in dioxane. The reaction was stirred at 50 0C until completion. The mixture was concentrated to give the title compound as the hydrochloride salt. 1H NMR (500 MHz, DMSO-J6) delta ppm 9.44 (br, IH), 9.07 (br, 2H), 7.36 (dd, J = 14.4, 7.9 Hz, IH), 7.18 (t, J = 8.0 Hz, 2H), 7.05 (td, J = 8.8, 2.4 Hz, IH), 6.87 (d, J = 8.6 Hz, IH), 6.70 – 6.54 (m, 2H), 4.26 – 4.08 (m, 2H), 3.59 – 3.47 (m, IH), 3.30 (m, 4H), 3.11 – 2.85 (m, 4H), 2.60 (dd, J = 13.4, 7.0 Hz, IH), 1.97 (d, J = 13.5 Hz, IH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52059-53-7, 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT GMBH &; CO. KG; WANG, Ying; BREWER, Jason, T.; AKRITOPOULOU-ZANZE, Irini; DJURIC, Stevan, W.; POHLKI, Frauke; BRAJE, Wilfried; RELO, Ana-Lucia; WO2010/124042; (2010); A2;,
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Electric Literature of 52059-53-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

A mixture of 2-(3-fluorophenyl)ethan-1-ol (0.031 g, 0.223 mmol, 5 equiv), 60%NaH (8.90 mg, 0.223 mmol, 5 equiv), and isopropyl (S)-2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin- 1 -yl)-6?-fluoro-6-methyl- [3,3 ?-bipyridinj -5-yl)acetate (0.021 g, 0.045 mmol, 1 equiv) in THF (1.5 mL) was stirred at ambient temperature for 1 h. Upon complete addition, 5 M NaOH (0.089 mL, 0.445 mmol, 10 equiv) was added and the mixture was heated at 80 C for 2 h. The reaction was allowed to cool to ambienttemperature, filtered, and purified by preparative reverse phase HPLC to provide the product (10 mg, 40%). ?H NMR (500 MHz, DMSO-d6) 8.18 – 7.97 (m, 2H), 7.73 – 7.60 (m, 1H), 7.40 – 7.29 (m, 1H), 7.21 – 6.94 (m, 3H), 6.93 – 6.83 (m, 1H), 5.86 – 5.75 (m, 1H), 4.62 -4.50 (m, 2H), 3.14 -3.02 (m, 1H), 1.38 – 1.24 (m, 3H), 1.18 – 1.02 (m, 1OH),0.91 – 0.70 (m, 6H). LCMS (M+1): 550.3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52059-53-7, 2-(3-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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