Category: 50411-26-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.50411-26-2, name is 1-Amino-3-phenylpropan-2-ol, molecular formula is C9H13NO, molecular weight is 151.2056, as common compound, the synthetic route is as follows.Formula: C9H13NO

EXAMPLE 7 5-{4-[2-(3-Phenyl-2-hydroxypropylamino)propoxy]benzyl}thiazolidine-2,4-dione (Compound No. 1-2) 550 mg of 3-phenyl-2-hydroxypropylamine (prepared as described in Preparation 17) and 1.0 g of 5-[4-(2-oxopropoxy)benzyl]thiazolidine-2,4-dione were suspended in 30 ml of anhydrous benzene, and the resulting suspension was heated under reflux for 30 minutes while removing water. Subsequently, the solvent was removed by evaporation under reduced pressure. The resulting oily product was dissolved in 20 ml of anhydrous methanol, 670 mg of sodium cyanoborohydride was added to the solution, whilst ice-cooling, and the mixture was stirred for 2 hours in a stream of nitrogen gas. After this, the reaction mixture was left to stand overnight, and then the solvent was removed by evaporation under reduced pressure. Water was added to the resulting residue, which was then extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was removed from the extract by evaporation under reduced pressure, and the resulting residue was applied to a silica gel chromatography column, which was eluted with a 5:1 by volume mixture of ethyl acetate and ethanol, and crystallized from ethyl acetate, to give 590 mg of the title compound, melting at 145 C. to 152 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,50411-26-2, 1-Amino-3-phenylpropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Sankyo Company, Limited; US5578620; (1996); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.50411-26-2, name is 1-Amino-3-phenylpropan-2-ol, molecular formula is C9H13NO, molecular weight is 151.2056, as common compound, the synthetic route is as follows.HPLC of Formula: C9H13NO

To a solution of E-2-03-2 (the above crude product) in DCM (200 mL) was added (Boc) 20 (18.1 g, 83.3 mmol) dropwise at 0 C. The solution was warmed to r.t. and continued to stir overnight. The solvent was removed under the reduce pressure and the residue was purified by column chromatography on silica gel (ethyl acetate/petroleum ether = 1/100 ~ 1/5) to give E-2-04-2 (3.0 g, 14 % two step) as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,50411-26-2, 1-Amino-3-phenylpropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; BUSCHMANN, Helmut; SZOLAR, Oliver; HANDLER, Norbert; ROCH, Franz-Ferdinand; CUSACK, Stephen; WEIKERT, Robert; NEIDHART, Werner; SCHULZ-GASCH, Tanja; WOLKERSTORFER, Andrea; (62 pag.)WO2017/46362; (2017); A1;,
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Reference of 50411-26-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 50411-26-2, name is 1-Amino-3-phenylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 26 1-[2-(Isochroman-1-yl)-1-methylethylamino]-3-phenyl-2-propanol (Compound 26) Compound 26 was obtained as an oily in the same manner as in Example 1, using (isochroman-1-yl)acetone and 1-amino-3-phenyl-2-propanol [J. Org. Chem., 46, 4051 (1981)]. FAB-MS (m/e): 326(M+ +1) IR (neat) cm-1: 3310 NMR (CDCl3) delta: 0.94 and 1.00(3H, d, J=6.0 Hz), 1.69-2.09(2H, m), 2.39-3.15(9H, m), 3.58-4.40(3H, m), 4.59-5.17(1H, m), 6.99(4H, s), 7.12(5H, s)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50411-26-2, 1-Amino-3-phenylpropan-2-ol.

Reference:
Patent; Kyowa Hakko Kogyo Co., Ltd.; US5128369; (1992); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.50411-26-2, name is 1-Amino-3-phenylpropan-2-ol, molecular formula is C9H13NO, molecular weight is 151.2056, as common compound, the synthetic route is as follows.Safety of 1-Amino-3-phenylpropan-2-ol

b) 1 ,1-dimethylethyl (2-hydroxy-3-phenylpropyl)carbamateTo a solution of 1-amino-3-phenyl-2-propanol ( 7.6 g, 50 mmole) in THF (50 mL) at RT was added (Boc)2O (12.0 g, 55 mmole). After stirring at RT for 2 h, the reaction solution was concentrated under vacuum and the residue purified on silica gel (5% MeOH in DCM (0.5% NH4OH)) affording the title compound (13.1 g, 91%) as a clear yellow oil: LCMS (ES) m/z 252 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,50411-26-2, 1-Amino-3-phenylpropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/121786; (2008); A1;,
Alcohol – Wikipedia,
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Application of 50411-26-2 ,Some common heterocyclic compound, 50411-26-2, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The object product (160 mg, 73%) was obtained in the same manner as in Example 36(3) and using 6-(1’H-spiro[indene-1,4′-piperidin]-1′-yl)pyridazine-3-carboxylic acid (150 mg) obtained in Example 36(2), 1-amino-3-phenylpropan-2-ol (91 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (150 mg) and hydroxybenzotriazole hydrate (120 mg).1H NMR (300 MHz, DMSO-d6) delta ppm 1.33 (d, J=13.37 Hz, 2H) 2.01-2.20 (m, 2H) 2.59-2.81 (m, 2H) 3.17-3.29 (m, 1H) 3.37-3.54 (m, 3H) 3.79-3.96 (m, 1H) 4.60 (d, J=13.56 Hz, 2H) 5.05 (d, J=5.65 Hz, 1H) 6.87 (d, J=5.65 Hz, 1H) 7.11-7.48 (m, 11H) 7.87 (d, J=9.42 Hz, 1H) 8.67 (t, J=5.75 Hz, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,50411-26-2, its application will become more common.

Reference:
Patent; Taniguchi, Takahiko; Miyata, Kenichi; Kubo, Osamu; US2010/69351; (2010); A1;,
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Reference of 50411-26-2, Adding some certain compound to certain chemical reactions, such as: 50411-26-2, name is 1-Amino-3-phenylpropan-2-ol,molecular formula is C9H13NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50411-26-2.

To a stirring solution of 1-amino-3-phenyl-propan-2-ol (0.51 g, 3.3 mmol) and triethylamine (0.45 mL, 3.3 mmol) in 20 mL dichloromethane was added (0.92 g, 2.6 mmol) 2-chloro-3-methyl-5-naphthalen-2-yl-6-pyridin-4-yl-3H-pyrimidin-4-one. The solution was stirred for 18 h at room temperature. The solution was diluted with ethyl acetate and washed with 5% sodium bicarbonate. The organic layer was dried over magnesium sulfate and purified on 10 g silica eluting product with 0 to 5% methanol/dichloromethane to give a pale yellow solid. M+1=463.2.

According to the analysis of related databases, 50411-26-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Amgen Inc.; US2005/43301; (2005); A1;,
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Alcohols – Chemistry LibreTexts