Category: 5020-41-7

Electric Literature of 5020-41-7 ,Some common heterocyclic compound, 5020-41-7, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Alcohol S1 (2.0 mmol, 1.0 equiv) and H2SO4 (0.2 equiv) were added successively to a solution of aldehyde S2 (1.2 equiv) intoluene (5.0 mL). The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was quenched withwater (2.0 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated brine and dried withanhydrous MgSO4. After filtration and concentration, the residue was purified by flash chromatography to give substrate 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5020-41-7, 2-(3-Methoxyphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Zehua; Mao, Ying; Guan, Honghao; Cao, Min; Hua, Jing; Feng, Lei; Liu, Lei; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1241 – 1243;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 5020-41-7, Adding some certain compound to certain chemical reactions, such as: 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol,molecular formula is C9H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5020-41-7.

Step 2: Synthesis of l-(2-bromoethyl)-3-methoxybenzene: [0982] To a stirred solution of 2-(3-methoxyphenyl)ethan-l-ol (0.6 g, 3.94 mmol) in DCM, PPh3 (1.6 g, 5.92 mmol) was added and the solution was stirred at rt for 10 min. Then CBr4 (2.6 g, 7.88 mmol) was added at 0 C. The resulting reaction mixture was stirred at rt for 2 h. The progress of the reaction was monitored by TLC. Upon completion the reaction mass was diluted with water and extracted with DCM. The combined organic layers were dried over Na2S04 and concentrated under reduced pressure. The crude compound was purified by column chromatography to afford the title compound (0.725 g, 85%).

According to the analysis of related databases, 5020-41-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EPIZYME, INC.; CAMPBELL, John Emmerson; WO2015/10049; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 5020-41-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol, molecular formula is C9H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(i) 2-(2-Bromo-5-methoxyphenyl)ethanol To a stirred mixture of 3-methoxyphenethyl alcohol (1.18 g, 7.8 mmol) and pyridine (0.75 ml, 9.3 mmol) in dry dichloromethane (10 ml) was added bromine (0.47 ml, 18.0 mmol) dropwise under nitrogen at 0 C. The orange solution was stirred at room temperature for 4 hours (hr). The reaction mixture was quenched by the addition of 10% sodium bisulfite aqueous solution., and extracted with dichloromethane. The organic extracts were washed with brine, dried over magnesium sulfate, and concentrated to give crude products, which were purified by silica-gel column chromatography eluted with gradient of hexane and ethyl acetate (10:1, 8:1, 5:1) to give the title compound as a colorless oil (1.5 g, 83.2%). 1H-NMR (CDCl3): 7.43 (d, J=8.8 Hz, 1H), 6.83 (d, J=3.3 Hz, 1H), 6.67 (dd, J=8,8, 3.3 Hz, 1H), 3.91-3.81 (m, 2H), 3.78 (s, 3H), 2.99 (t, J=6.6 Hz, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5020-41-7, 2-(3-Methoxyphenyl)ethanol.

Reference:
Patent; Pfizer INC; US6239147; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 5020-41-7, Adding some certain compound to certain chemical reactions, such as: 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol,molecular formula is C9H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5020-41-7.

Preparation B 2-(3-Methoxyphenyl)ethylbromide 114.1 g (750 mmol) of 2-(3-methoxyphenyl)ethanol was dissolved in 500 mL of benzene and cooled to 0 C. 35.5 mL (375 mmol) of PBr3 was slowly added to the stirring reaction and the reactin then heated to reflux under a nitrogen atmosphere for three hours. The reaction was quenched by the addition of water and the organic layer separated. The aqueous layer was washed twice with benzene and all the benzene extracts were combined. The benzene extract was washed twice with brine, dried with Na2 SO4, and evaporated to an oil. The oil was distilled and the fraction at 115-124 C. a 4 mm Hg was taken. This yielded 131.7 g of the title compound as a clear oil. PMR: Consistent with the proposed structure. MS: m/e=214, 216 (M) FD EA: Calc: C, 50.26; H, 5.16 Fd: C, 50.22; H, 5.02 C9 H11 BrO

According to the analysis of related databases, 5020-41-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eli Lilly and Company; US5952350; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 5020-41-7, 2-(3-Methoxyphenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5020-41-7, blongs to alcohols-buliding-blocks compound. Recommanded Product: 5020-41-7

General procedure: All reactions were conducted in a 10-mL V-type vessel equipped with a triangular magnetic stirrer. In a typical reaction, 2-(3,4-dimethoxyphenyl)ethanol (91.1 mg, 0.5 mmol), benzaldehyde (64.8 mg, 0.6 mmol), and 1b (10 mg, 1 mol%) were mixed in 1,2-dichloroethane (1.0 mL) and stirred for 5 h at 80 C. After the reaction, the mixture was cooled to room temperature and then centrifuged, and the liquid phase was subjected to isolation with PTLC (eluting solvent: ethyl acetate/petroleum ether = 1/8). The desired product, 7a, was obtained in a yield of 96%. Tests of the substrate scope were conducted in the same manner. The recycling of 1b was realized after doubling the dose. After washing the solid phase with PE (3.0 mL × 3) and drying under vacuum, the recovered 1b was used in the next run with a similar procedure.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5020-41-7, its application will become more common.

Reference:
Article; Zeng, Kexing; Huang, Zhipeng; Yang, Jie; Gu, Yanlong; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 36; 9; (2015); p. 1606 – 1613;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol, the common compound, a new synthetic route is introduced below. COA of Formula: C9H12O2

General procedure: Alcohol S1 (2.0 mmol, 1.0 equiv) and H2SO4 (0.2 equiv) were added successively to a solution of aldehyde S2 (1.2 equiv) intoluene (5.0 mL). The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was quenched withwater (2.0 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated brine and dried withanhydrous MgSO4. After filtration and concentration, the residue was purified by flash chromatography to give substrate 1.

The synthetic route of 5020-41-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Zehua; Mao, Ying; Guan, Honghao; Cao, Min; Hua, Jing; Feng, Lei; Liu, Lei; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1241 – 1243;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5020-41-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5020-41-7, name is 2-(3-Methoxyphenyl)ethanol, molecular formula is C9H12O2, molecular weight is 152.1904, as common compound, the synthetic route is as follows.

28.90 g (0.217 mol) of aluminum chloride was slurried in 400 mL of methylene chloride under a N2 atmosphere and cooled to 0 C. 15.0 g (0.0985 mol) of 2-(3-Methoxy-phenyl)-ethanol and 17.02 g (0.217 mol) of acetyl chloride were combined in methylene chloride and following the exotherm, this solution was added dropwise to the aluminum chloride slurry at 0 C. The reaction mixture was allowed to stir at 0 C. for 1 h and at ambient temperature for 45 min. The reaction was carefully poured into 1M HCl (300 ml) and the aqueous layer was extracted with dichloromethane (3×100 ml) and the combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford crude product which was loaded onto a silica gel column. Using 20% ethyl acetate in hexane yielded 17.94 g (77%) of Acetic acid 2-(2-acetyl-5-methoxy-phenyl)-ethyl ester 38. 1H NMR (CDCl3): 2.00 (s-3H), 2.54 (s-3H), 3.24 (t-2H), 3.84 (s-3H), 4.28 (t-2H), 6.75-6.81 (m-2H), 7.77 (d-1H; J=8.52 Hz).

Statistics shows that 5020-41-7 is playing an increasingly important role. we look forward to future research findings about 2-(3-Methoxyphenyl)ethanol.

Reference:
Patent; Pfizer Inc., Pfizer Inc.; US2004/77853; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5020-41-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5020-41-7, name is 2-(3-Methoxyphenyl)ethanol, molecular formula is C9H12O2, molecular weight is 152.1904, as common compound, the synthetic route is as follows.

To a stirred mixture of 3-methoxyphenethylalcohol (1.18 g, 7.8 mmol) and pyridine (0.75 ml, 9.3 mmol) in dry dichloromethane (10 ml) was added bromine (0.47 ml, 18.0 mmol) dropwise under nitrogen at 0 C. The orange solution was stirred at room temperature for 4 hr. The reaction mixture was quenched by the addition of 10% sodium bisulfite aqueous solution., and extracted with dichloromethane. The organic extracts were washed with brine, dried over magnesium sulfate, and concentrated to give crude products, which were purified by silica-gel column chromatography eluted with gradient of hexane and ethyl acetate (10:1, 8:1, 5:1) to give the title compound as a colorless oil (1.5 g, 83.2%). [0141] 1H-NMR (CDCl3): 7.43 (d, J=8.8 Hz, 1H), 6.83 (d, J=3.3 Hz, 1H), 6.67 (dd, J=8.8, 3.3 Hz, 1H), 3.91-3.81 (m, 2H), 3.78 (s, 3H), 2.99 (t, J=6.6 Hz, 2H)

Statistics shows that 5020-41-7 is playing an increasingly important role. we look forward to future research findings about 2-(3-Methoxyphenyl)ethanol.

Reference:
Patent; Pfizer Inc.; US2003/208079; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 5020-41-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: Alcohol S1 (2.0 mmol, 1.0 equiv) and H2SO4 (0.2 equiv) were added successively to a solution of aldehyde S2 (1.2 equiv) intoluene (5.0 mL). The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was quenched withwater (2.0 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated brine and dried withanhydrous MgSO4. After filtration and concentration, the residue was purified by flash chromatography to give substrate 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5020-41-7, 2-(3-Methoxyphenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Wang, Zehua; Mao, Ying; Guan, Honghao; Cao, Min; Hua, Jing; Feng, Lei; Liu, Lei; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1241 – 1243;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts