Category: 501-36-0

Hartogh, Danja J. Den; Tsiani, Evangelia published the artcile< Health benefits of resveratrol in kidney disease: evidence from in vitro and in vivo studies>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol kidney disease health benefit review; fibroblasts; glomerulosclerosis; kidney disease; mesangial cells; renal cancer; renal epithelial cells; resveratrol.

A review. Different diseases and disorders that affect the kidneys include, but are not limited to, glomerulonephritis, diabetic nephropathy, polycystic kidney disease, kidney stones, renal fibrosis, sepsis, and renal cell carcinoma. Kidney disease tends to develop over many years, making it difficult to identify until much later when kidney function is severely impaired and undergoing kidney failure. Although conservative care, symptom management, medication, dialysis, transplantation, and aggressive renal cancer therapy are some of the current strategies/approaches to kidney disease treatment, new preventative targeted therapies are needed. Epidemiol. studies have suggested that a diet rich in fruits and vegetables is associated with health benefits including protection against kidney disease and renal cancer. Resveratrol, a polyphenol found in grapes and berries, has been reported to have antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, neuroprotective, and anti-cancer properties. The current review summarizes the existing in vitro and in vivo animal and human studies examining the nephroprotective effects of resveratrol.

Nutrients published new progress about Kidney disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kiskova, Terezia; Kubatka, Peter; Busselberg, Dietrich; Kassayova, Monika published the artcile< The plant-derived compound resveratrol in brain cancer: a review>, Related Products of 501-36-0 , the main research area is review brain cancer resveratrol; brain cancer; drug resistance; glioblastoma; resveratrol.

A review. Despite intensive research, malignant brain tumors are among the most difficult to treat due to high resistance to conventional therapeutic approaches. High-grade malignant gliomas, including glioblastoma and anaplastic astrocytoma, are among the most devastating and rapidly growing cancers. Despite the ability of standard treatment agents to achieve therapeutic concentrations in the brain, malignant gliomas are often resistant to alkylating agents. Resveratrol is a plant polyphenol occurring in nuts, berries, grapes, and red wine. Resveratrol crosses the blood-brain barrier and may influence the central nervous system. Moreover, it influences the enzyme isocitrate dehydrogenase and, more importantly, the resistance to standard treatment via various mechanisms, such as O6-methylguanine methyltransferase. This review summarizes the anticancer effects of resveratrol in various types of brain cancer. Several in vitro and in vivo studies have presented promising results; however, further clin. research is necessary to prove the therapeutic efficacy of resveratrol in brain cancer treatment.

Biomolecules published new progress about Astrocytoma. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Related Products of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jin, Xiaoxia; Wei, Yingze; Liu, Yushan; Lu, Xiaoyun; Ding, Fei; Wang, Jiatai; Yang, Shuyun published the artcile< Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/β-catenin signaling pathway in breast cancer>, SDS of cas: 501-36-0 , the main research area is breast cancer epithelial mesenchymal transition SIRT1 signaling; Doxorubicin; Drug resistance; EMT; SIRT1; breast cancer; resveratrol; β-catenin.

Breast cancer is one of the leading fatal diseases for women worldwide who cannot have surgery typically have to rely on systemic chemotherapy to extend their survival. Doxorubicin (DOX) is one of the most commonly used chemotherapeutic agents against breast cancer, but acquired resistance to DOX can seriously impede the efficacy of chemotherapy, leading to poor prognosis and recurrences of cancer. Resveratrol (RES) is a phytoalexin with pharmacol. antitumor properties, but its underlying mechanisms are not clearly understood in the treatment of DOX-resistant breast cancer. We used cell viability assays, cell scratch tests, and transwell assays combined with Western blotting and immunofluorescent staining to evaluate the effects of RES on chemoresistance and the epithelial-mesenchymal transitions (EMTs) in adriamycin-resistant MCF7/ADR breast cancer cells, and to investigate its underlying mechanisms. The results showed that a treatment of RES combining with DOX effectively inhibited cell growth, suppressed cell migration, and promoted cell apoptosis. RES reversed EMT properties of MCF7/ADR cells by modulating the connection between SIRT1 and β-catenin, which provides a hopeful therapeutic avenue to conquer DOX-resistance and thereby prolong survival rates in breast cancer patients.

Cancer Medicine published new progress about Apoptosis. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vervandier-Fasseur, Dominique; Latruffe, Norbert published the artcile< The potential use of resveratrol for cancer prevention>, Application of C14H12O3, the main research area is review resveratrol anticancer agent cancer; approach strategies; cancer; innovative formulations; mechanisms; prevention; resveratrol.

A review. In addition to the traditional treatments of cancer and cancer prevention, the use of natural compounds, especially those found in food, should be considered. To clarify if resveratrol has the potential for cancer prevention and the possibility of use in therapy, the following must be taken into account: data from epidemiol., clin. protocol (case and control), preclin. studies (lab animals), use of established cell lines as models of cancer cells, test tube assays (enzymes activities), and requirements of nanotechnologies in order to discover new drugs to fight cancer. From this perspective and future expected advances, more information is needed such as improved efficacy, methods of application, and the synergistic sensitization of resveratrol as an adjuvant. In addition, resveratrol nanoformulation is considered to overcome its weak bioavailability.

Molecules published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ahmadi, Reza; Ebrahimzadeh, Mohammad Ali published the artcile< Resveratrol - A comprehensive review of recent advances in anticancer drug design and development>, Computed Properties of 501-36-0, the main research area is review resveratrol derivative cancer drug design development; Anticancer; Antitumor; Chemotherapy; Phytoalexin; Polyphenol; Resveratrol; Stilbenoid.

A review. Resveratrol is a natural polyphenolic stilbene isolated from various plants, foods and beverages with a broad spectrum of biol. and pharmacol. properties through modulating diverse targets and signaling pathways. Particularly, it has attracted a great deal of attention as a promising and multitarget anticancer agent due to its potential use in chemoprevention and chemotherapy of various tumors. However, unfavorable pharmacokinetics/pharmacodynamics profile such as poor bioavailability restricted its applications. Therefore, medicinal chemists have synthesized a lot of novel derivatives and analogs of resveratrol using different modification strategies to overcome these limitations and improve anticancer efficacy. Herein, we reviewed the design, synthesis, structure-activity relationship and mechanism of the most potent and privileged resveratrol-based compounds that showed promising anticancer activities in the last five years. We classified these compounds into the ten different categories based on their chem. structure similarities.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tabrizi, Reza; Tamtaji, Omid Reza; Lankarani, Kamran B.; Akbari, Maryam; Dadgostar, Ehsan; Dabbaghmanesh, Mohammad Hossein; Kolahdooz, Fariba; Shamshirian, Amir; Momen-Heravi, Mansooreh; Asemi, Zatollah published the artcile< The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials>, Formula: C14H12O3, the main research area is meta analysis resveratrol antiobesity agent obesity; Resveratrol; meta-analysis; overweight; weight loss.

This systematic review and meta-anal. of randomized controlled trials (RCTs) was conducted to summarize the effect of resveratrol intake on weight loss. We searched the following databases until July 2018: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Out of 831 reports, 36 RCTs were eligible for including to our meta-anal. The pooled results, using random-effects model showed that resveratrol supplementation significantly decreased body weight (SMD = -0.17; 95% CI, -0.33, -0.01; P=0.03; I2: 62.6), body mass index (BMI) (SMD = -0.20; 95% CI, -0.35, -0.05; P=0.01; I2: 60.6), fat mass (SMD = -0.32; 95% CI, -0.62, -0.03; P=0.03; I2: 77.9) and waist circumference (WC) (SMD = -0.42; 95% CI, -0.68, -0.16; P=0.001; I2: 75.2), and significantly increased lean mass (SMD=1.21; 95% CI, 0.75, 1.67; P<0.001; I2: 87.6). We found no significant effect of resveratrol administration on leptin (SMD = -0.20; 95% CI, -0.68, 0.27; P=0.40; I2: 85.3) and adiponectin levels (SMD=0.08; 95% CI, -0.39, 0.55; P=0.74; I2: 91.0). Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-anal. demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels. Critical Reviews in Food Science and Nutrition published new progress about Adiponectins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dyck, Garrison J. B.; Raj, Pema; Zieroth, Shelley; Dyck, Jason R. B.; Ezekowitz, Justin A. published the artcile< The effects of resveratrol in patients with cardiovascular disease and heart failure: a narrative review>, Reference of 501-36-0, the main research area is review resveratrol cardioprotectant cardiovascular disease heart failure; CVD; heart failure; resveratrol.

A review. Cardiovascular disease (CVD) is the main cause of death globally and responsible for the second highest number of deaths in Canada. Medical advancements in the treatment of CVD have led to patients living longer with CVD but often progressing to another condition called heart failure (HF). As a result, HF has emerged in the last decade as a major medical concern. Fortunately, various “”traditional”” pharmacotherapies for HF exist and have shown success in reducing HF-associated mortality. However, to augment the treatment of patients with CVD and/or HF, alternative pharmacotherapies using nutraceuticals have also shown promise in the prevention and treatment of these two conditions. One of these natural compounds considered to potentially help treat HF and CVD and prevent their development is resveratrol. Herein, we review the clin. findings of resveratrol’s ability to be used as an effective treatment to potentially help treat HF and CVD. This will allow us to gain a more fulsome appreciation for the effects of resveratrol in the health outcomes of specific patient populations who have various disorders that constitute CVD.

International Journal of Molecular Sciences published new progress about Cardioprotective agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Akhand Pratap; Singh, Rachna; Verma, Sumit Singh; Rai, Vipin; Kaschula, Catherine H.; Maiti, Pralay; Gupta, Subash Chandra published the artcile< Health benefits of resveratrol: Evidence from clinical studies>, SDS of cas: 501-36-0 , the main research area is review resveratrol dietary supplement; chronic diseases; clinical trial; nutraceutical; pharmacokinetics; resveratrol.

A review. Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in over 244 clin. trials, with an addnl. 27 clin. trials currently ongoing. Resveretrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer’s disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The polyphenol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy. The mol. basis for the pleiotropic activities of resveratrol are based on its ability to modulate multiple cell signaling mols. such as cytokines, caspases, matrix metalloproteinases, Wnt, nuclear factor-κB, Notch, 5′-AMP-activated protein kinase, intercellular adhesion mol., vascular cell adhesion mol., sirtuin type 1, peroxisome proliferator-activated receptor-γ coactivator 1α, insulin-like growth factor 1, insulin-like growth factor-binding protein 3, Ras association domain family 1α, pAkt, vascular endothelial growth factor, cyclooxygenase 2, nuclear factor erythroid 2 like 2, and Kelch-like ECH-associated protein 1. Although the clin. utility of resveratrol is well documented, the rapid metabolism and poor bioavailability have limited its therapeutic use. In this regard, the recently produced micronized resveratrol formulation called SRT501, shows promise. This review discusses the currently available clin. data on resveratrol in the prevention, management, and treatment of various diseases and disorders. Based on the current evidence, the potential utility of this mol. in the clinic is discussed.

Medicinal Research Reviews published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Verdura, Sara; Cuyas, Elisabet; Cortada, Eric; Brunet, Joan; Lopez-Bonet, Eugeni; Martin-Castillo, Begona; Bosch-Barrera, Joaquim; Encinar, Jose Antonio; Menendez, Javier A. published the artcile< Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity>, HPLC of Formula: 501-36-0 , the main research area is PD-L1; T cells; glycosylation; immunotherapy; resveratrol.

New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1) are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs, exposure to the dietary polyphenol resveratrol (RSV) revealed its differential capacity to generate a distinct PD-L1 electrophoretic migration pattern. Using biochem. assays, computer-aided docking/mol. dynamics simulations, and fluorescence microscopy, we found that RSV can operate as a direct inhibitor of glyco-PD-L1-processing enzymes (α-glucosidase/α-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the endoplasmic reticulum retention of a mannose-rich, abnormally glycosylated form of PD-L1. RSV was also predicted to interact with the inner surface of PD-L1 involved in the interaction with PD-1, almost perfectly occupying the target space of the small compound BMS-202 that binds to and induces dimerization of PD-L1. The ability of RSV to directly target PD-L1 interferes with its stability and trafficking, ultimately impeding its targeting to the cancer cell plasma membrane. Impedance-based real-time cell anal. (xCELLigence) showed that cytotoxic T-lymphocyte activity was notably exacerbated when cancer cells were previously exposed to RSV. This unforeseen immunomodulating mechanism of RSV might illuminate new approaches to restore T-cell function by targeting the PD-1/PD-L1 immunol. checkpoint with natural polyphenols.

Aging published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ahmadi, Reza; Ebrahimzadeh, Mohammad Ali published the artcile< Resveratrol - A comprehensive review of recent advances in anticancer drug design and development>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol derivative cancer drug design development; Anticancer; Antitumor; Chemotherapy; Phytoalexin; Polyphenol; Resveratrol; Stilbenoid.

A review. Resveratrol is a natural polyphenolic stilbene isolated from various plants, foods and beverages with a broad spectrum of biol. and pharmacol. properties through modulating diverse targets and signaling pathways. Particularly, it has attracted a great deal of attention as a promising and multitarget anticancer agent due to its potential use in chemoprevention and chemotherapy of various tumors. However, unfavorable pharmacokinetics/pharmacodynamics profile such as poor bioavailability restricted its applications. Therefore, medicinal chemists have synthesized a lot of novel derivatives and analogs of resveratrol using different modification strategies to overcome these limitations and improve anticancer efficacy. Herein, we reviewed the design, synthesis, structure-activity relationship and mechanism of the most potent and privileged resveratrol-based compounds that showed promising anticancer activities in the last five years. We classified these compounds into the ten different categories based on their chem. structure similarities.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts