Category: 501-36-0

Jeandet, Philippe; Sobarzo-Sanchez, Eduardo; Silva, Ana Sanches; Clement, Christophe; Nabavi, Seyed Fazel; Battino, Maurizio; Rasekhian, Mahsa; Belwal, Tarun; Habtemariam, Solomon; Koffas, Mattheos; Nabavi, Seyed Mohammad published the artcile< Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives>, Application of C14H12O3, the main research area is Biocatalysis; Enzymatic transformation; Green chemistry; Laccases; Peroxidases; Resveratrol; Resveratrol glucosides; Resveratrol oligomers; Stilbenes; Whole cell biocatalysis.

Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with diverse pharmacol. effects. The versatile functions of these compounds in plant defense mechanisms as phytoalexins on one hand, and in human health as potential pharmaceutical agents on the other, have attracted lots of interest in recent years to understand their biosynthetic pathways and their biol. properties. Because of difficulties in obtaining resveratrol and its glucosylated derivatives as well as oligomeric forms in sufficient amounts for evaluation of their activity by plant sourcing or total synthesis, biotechnol. may provide a competitive approach for the large-scale and low cost production of biol. active stilbenes. Addnl., one major limitation in the use of resveratrol and related aglycon derivatives as therapeutic agents is associated with their inherent poor aqueous solubility and low bioavailability. This article examines approaches for the synthesis of potential pharmacol. resveratrol derivatives in vivo by exploiting whole microorganisms, enzymic and biocatalytic approaches allowing their full utilization for medicine, food and cosmetic applications. These methods also have the advantage of enabling the one-step production of stilbene compounds, compared to the time-consuming and environmentally unfriendly procedures used for their total synthesis or their extraction from plants. Increasing the desired products yield and biol. activity through glucosylation (β-D-glucosides vs. α-D-glucosides) and oligomerization methodologies of resveratrol including green chem. methods in organic solvent-free media are discussed as well.

Biotechnology Advances published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fogacci, Federica; Tocci, Giuliano; Presta, Vivianne; Fratter, Andrea; Borghi, Claudio; Cicero, Arrigo F. G. published the artcile< Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials>, Reference of 501-36-0 , the main research area is Resveratrol; blood pressure; meta-analysis; metaregression; type 2 diabetes.

Results of previous clin. trials evaluating the effect of resveratrol supplementation on blood pressure (BP) are controversial. We aimed to assess the impact of resveratrol on BP through systematic review of literature and meta-anal. of available randomized, controlled clin. trials (RCTs). Literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 17th Oct. 2017 to identify RCTs investigating the impact of resveratrol on BP. Two review authors independently extracted data on study characteristics, methods and outcomes. Overall, the impact of resveratrol on BP was reported in 17 trials. Administration of resveratrol did not significantly affect neither systolic BP [weighted mean difference (WMD): -2.5 95% CI:(-5.5, 0.6) mmHg; p=0.116; I2=62.1%], nor diastolic BP [WMD: -0.5 95% CI:(-2.2, 1.3) mmHg; p=0.613; I2=50.8], nor mean BP [MAP; WMD: -1.3 95% CI:(-2.8, 0.1) mmHg; p=0.070; I2=39.5%] nor pulse pressure [PP; WMD: -0.9 95% CI:(-3.1, 1.4) mmHg; p=0.449; I2=19.2%]. However, significant WMDs were detected in subsets of studies categorized according to high resveratrol daily dosage (≥300 mg/day) and presence of diabetes. Meta-regression anal. revealed a pos. association between systolic BP-lowering resveratrol activity (slope: 1.99; 95% CI: 0.05, 3.93; two-tailed p= 0.04) and Body Mass Index (BMI) at baseline, while no association was detected neither between baseline BMI and MAP-lowering resveratrol activity (slope: 1.35; 95% CI: -0.22, 2.91; two-tailed p= 0.09) nor between baseline BMI and PP-lowering resveratrol activity (slope: 1.03; 95% CI: -1.33, 3.39; two-tailed p= 0.39). Resveratrol was fairly well-tolerated and no serious adverse events occurred among most of the eligible trials. The favorable effect of resveratrol emerging from the current meta-anal. suggests the possible use of this nutraceutical as active compound in order to promote cardiovascular health, mostly when used in high daily dose (≥300 mg/day) and in diabetic patients.

Critical Reviews in Food Science and Nutrition published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Siliang; Luo, Huaiyong; Chen, Haiwen; Guo, Jianbin; Yu, Bolun; Zhang, Huan; Li, Weitao; Chen, Weigang; Zhou, Xiaojin; Huang, Li; Liu, Nian; Lei, Yong; Liao, Boshou; Jiang, Huifang published the artcile< Optimization of extraction of total trans-resveratrol from peanut seeds and its determination by HPLC>, HPLC of Formula: 501-36-0 , the main research area is tran resveratrol peanut extraction optimization; high performance liquid chromatography; peanut seed; response surface methodology; trans-resveratrol.

Resveratrol, a stilbene phytoalexin in plants, is believed to benefit human health. In this study, an optimized enzyme-assisted method was developed to extract the total content of trans-resveratrol (free or combined with glucose) in peanut seeds, followed by detection using high-performance liquid chromatog. The extraction process was optimized by Box-Behnken design and response surface methodol. The optimized enzyme concentration, digestion time, pH, and temperature were 3.02 g/L, 57.06 min, 5.88, and 51.05°C, resp. Validation tests indicated that the exptl. yield of trans-resveratrol was 0.183 ± 0.007μg/g with a relative standard deviation of 3.87% (n = 5) under the optimal condition, which was closely agreed with the predicted value (0.182μg/g). The recoveries obtained from the spiked samples were varied from 89.4 to 103.9%. Therefore, this study will provide a useful method for quantification of total trans-resveratrol in peanut seeds.

Journal of Separation Science published new progress about Arachis hypogaea. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohd, Azirah; Zainal, Nurhafiza; Tan, Kim-Kee; AbuBakar, Sazaly published the artcile< Resveratrol affects Zika virus replication in vitro>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol phytoalexin antiviral agent zika virus infection.

Here, a plant-secreted phytoalexin, resveratrol (RES), was investigated for its ability to inhibit ZIKV replication in vitro. Several RES treatment regimens were used. The ZIKV titers of mock- and RES-treated infected cell cultures were determined using the focus-forming assay and the Zika mRNA copy number as determined using qRT-PCR. Our results suggested that RES treatment reduced ZIKV titers in a dose-dependent manner. A reduction of >90% of virus titer and ZIKV mRNA copy number was achieved when infected cells were treated with 80μM of RES post-infection. Pre-incubation of the virus with 80μM RES showed >30% reduction in ZIKV titers and ZIKV mRNA copy number, implying potential direct virucidal effects of RES against the virus. The RES treatment reduced >70% virus titer in the anti-adsorption assay, suggesting the possibility that RES also interferes with ZIKV binding. However, there was no significant decrease in ZIKV titer when a short-period of RES treatment was applied to cells before ZIKV infection (pre-infection) and after the virus bound to the cells (virus internalization inhibition), implying that RES acts through its continuous presence in the cell cultures after virus infection. Overall, our results suggested that RES exhibited direct virucidal activity against ZIKV and possessed anti-ZIKV replication properties, highlighting the need for further exploration of RES as a potential antiviral mol. against ZIKV infection.

Scientific Reports published new progress about Antiviral agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Honari, Mohadese; Shafabakhsh, Rana; Reiter, Russel J.; Mirzaei, Hamed; Asemi, Zatollah published the artcile< Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms>, Related Products of 501-36-0, the main research area is resveratrol colorectal cancer prevention review; Anti-inflammatory; Anti-oncotic; Colorectal cancer; Resveratrol.

A review. Colorectal cancer (CRC) is the third most common cancer and one of the main causes of cancer death entire the world. Environmental, dietary, and lifestyle factors including red meat consumption, cigarette smoking, alc. intake and family history are the most important risk factors of CRC. Multiple pathways including inflammation, oxidative stress, and apoptosis are involved in its incidence and progression. Resveratrol, a polyphenolic compound, has different pharmacol. functions including anti-inflammation, cancer prevention, lipid-lowering effect, and hypoglycemic effect. Many studies have proved that resveratrol might also represent a chemo preventive effect on CRC. Thus, the aim of the current review is to depict the role of resveratrol in treatment of CRC in a mol. manner.

Cancer Cell International published new progress about Apoptosis. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Related Products of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Oh Yoen; Chung, Ji Yeon; Song, Juhyun published the artcile< Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol adipokine myokine fat browning obesity human review; Adipokine; Fat browning; Myokine; Obesity; Resveratrol.

A review. Obesity is a globally widespread metabolic disorder, characterized by immoderate fat accumulation in the body. There are different types of body fats such as white adipose tissue (WAT), which stores surplus energy in the body, and brown adipose tissue (BAT) which utilize energy to produce heat during metabolism BAT acts many beneficial functions in metabolic disorders including type 2 diabetes and obesity. Recent studies have investigated methods for promoting the fat browning process of WAT in obesity because of various reasons such as the improvement of insulin resistance, and weight loss. Among natural polyphenolic compounds, resveratrol has been highlighted due to its anti-oxidant and anti-obesity as well as anti-inflammation and anti-cancer properties. Recent studies have paid a lot of attention to that resveratrol may act as a fat browning activator, involved in the secretion of many myokines and adipokines. Here, we reviewed the role of resveratrol in fat browning and also the association between resveratrol and adipokines/myokines in the fat browning process. Our review may provide novel insight into the role of resveratrol in fat browning, leading to the maintenance of a healthy weight against obesity.

Pharmacological Research published new progress about Adipokines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Akbari, Maryam; Tamtaji, Omid Reza; Lankarani, Kamran B.; Tabrizi, Reza; Dadgostar, Ehsan; Kolahdooz, Fariba; Jamilian, Mehri; Mirzaei, Hamed; Asemi, Zatollah published the artcile< The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials>, Computed Properties of 501-36-0 , the main research area is resveratrol RCT endothelial function blood pressure MetS human; Blood pressures; Endothelial function; Meta-analysis; Metabolic syndrome; Resveratrol.

There are current trials investigating the effect of resveratrol supplementation on endothelial function and blood pressures among patients with metabolic syndrome (MetS); however, the findings are controversial. This systematic review and meta-anal. of randomized controlled trials (RCTs) were carried out to summarize the effects of resveratrol supplementation on endothelial activation and blood pressures among patients with MetS and related disorders. This study searched systematically online databases including: PubMed-Medline, Embase, ISI Web of Science and Cochrane Central Register of Controlled Trials until Oct., 2018. Two independent authors extracted data and assessed the quality of included articles. Data were pooled using the fixed- or random-effects model and considered as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Out of 831 electronic citations, 28 RCTs (with 33 findings reported) were included in the meta-analyses. The findings showed that resveratrol intervention significantly increased flow-mediated dilatation (FMD) levels (SMD 1.77; 95% CI 0.25, 3.29; P = 0.02; I2: 96.5). However, resveratrol supplements did not affect systolic blood pressure (SBP) (SMD – 0.27; 95% CI – 0.57, 0.03; P = 0.07; I2: 88.9) and diastolic blood pressure (DBP) (SMD – 0.21; 95% CI – 0.52, 0.11; P = 0.19; I2: 89.8). Resveratrol supplementation significantly increased FMD among patients with MetS and related disorders, but did not affect SBP and DBP. Addnl. prospective studies are needed to investigate the effect of resveratrol supplementation on endothelial function and blood pressures, using higher-dose of resveratrol with longer durations.

High Blood Pressure & Cardiovascular Prevention published new progress about Diastolic blood pressure. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fogacci, Federica; Tocci, Giuliano; Presta, Vivianne; Fratter, Andrea; Borghi, Claudio; Cicero, Arrigo F. G. published the artcile< Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials>, Reference of 501-36-0, the main research area is Resveratrol; blood pressure; meta-analysis; metaregression; type 2 diabetes.

Results of previous clin. trials evaluating the effect of resveratrol supplementation on blood pressure (BP) are controversial. We aimed to assess the impact of resveratrol on BP through systematic review of literature and meta-anal. of available randomized, controlled clin. trials (RCTs). Literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 17th Oct. 2017 to identify RCTs investigating the impact of resveratrol on BP. Two review authors independently extracted data on study characteristics, methods and outcomes. Overall, the impact of resveratrol on BP was reported in 17 trials. Administration of resveratrol did not significantly affect neither systolic BP [weighted mean difference (WMD): -2.5 95% CI:(-5.5, 0.6) mmHg; p=0.116; I2=62.1%], nor diastolic BP [WMD: -0.5 95% CI:(-2.2, 1.3) mmHg; p=0.613; I2=50.8], nor mean BP [MAP; WMD: -1.3 95% CI:(-2.8, 0.1) mmHg; p=0.070; I2=39.5%] nor pulse pressure [PP; WMD: -0.9 95% CI:(-3.1, 1.4) mmHg; p=0.449; I2=19.2%]. However, significant WMDs were detected in subsets of studies categorized according to high resveratrol daily dosage (≥300 mg/day) and presence of diabetes. Meta-regression anal. revealed a pos. association between systolic BP-lowering resveratrol activity (slope: 1.99; 95% CI: 0.05, 3.93; two-tailed p= 0.04) and Body Mass Index (BMI) at baseline, while no association was detected neither between baseline BMI and MAP-lowering resveratrol activity (slope: 1.35; 95% CI: -0.22, 2.91; two-tailed p= 0.09) nor between baseline BMI and PP-lowering resveratrol activity (slope: 1.03; 95% CI: -1.33, 3.39; two-tailed p= 0.39). Resveratrol was fairly well-tolerated and no serious adverse events occurred among most of the eligible trials. The favorable effect of resveratrol emerging from the current meta-anal. suggests the possible use of this nutraceutical as active compound in order to promote cardiovascular health, mostly when used in high daily dose (≥300 mg/day) and in diabetic patients.

Critical Reviews in Food Science and Nutrition published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dull, Ana-Maria; Moga, Marius Alexandru; Dimienescu, Oana Gabriela; Sechel, Gabriela; Burtea, Victoria; Anastasiu, Costin Vlad published the artcile< Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-angiogenic pathways>, Electric Literature of 501-36-0 , the main research area is review endometriosis resveratrol anti inflammation angiogenic therapeutics; anti-inflammatory; cytokines; endometriosis; inflammatory disease; resveratrol.

A review. Endometriosis represents a severe gynecol. pathol., defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathol. affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Despite long periods of studies and investigations, the etiol. and pathogenesis of this disease still remain not fully understood. Initially, endometriosis was related to retrograde menstruation, but new theories have been launched, suggesting that chronic inflammation can influence the development of endometriosis because inflammatory mediators have been identified elevated in patients with endometriosis, specifically in the peritoneal fluid. The importance of dietary phytochems. and their effect on different inflammatory diseases have been highlighted, and nowadays more and more studies are focused on the anal. of nutraceuticals. Resveratrol is a phytoestrogen, a natural polyphenolic compound with antiproliferative and anti-inflammatory actions, found in many dietary sources such as grapes, wine, peanuts, soy, berries, and stilbenes. Resveratrol possesses a significant anti-inflammatory effect via inhibition of prostaglandin synthesis and it has been proved that resveratrol can exhibit apoptosis-inducing activities. From the studies reviewed in this paper, it is clear that the anti-inflammatory effect of this natural compound can contribute to the prevention of endometriosis, this phenolic compound now being considered a new innovative drug in the prevention and treatment of this disease.

Molecules published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Grinan-Ferre, Christian; Bellver-Sanchis, Aina; Izquierdo, Vanessa; Corpas, Ruben; Roig-Soriano, Joan; Chillon, Miguel; Andres-Lacueva, Cristina; Somogyvari, Milan; Soti, Csaba; Sanfeliu, Coral; Pallas, Merce published the artcile< The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer′s disease pathology: From antioxidant to epigenetic therapy>, Reference of 501-36-0 , the main research area is review cognitive decline alzheimer disease neuroprotective antioxidant epigenetic resveratrol; Antioxidants; Epigenetic; Gut microbiota; Klotho; Neurodegeneration; Resveratrol; Senescence.

A review. While the elderly segment of the population continues growing in importance, neurodegenerative diseases in crease exponentially. Lifestyle factors such as nutrition, exercise, and education, among others, influence ageing progression, throughout life. Notably, the Central Nervous System (CNS) can benefit from nutritional strategies and dietary interventions that prevent signs of senescence, such as cognitive decline or neurodegenerative dis eases such as Alzheimer′s disease and Parkinson′s Disease. The dietary polyphenol Resveratrol (RV) possesses antioxidant and cytoprotective effects, producing neuroprotection in several organisms. The (OS) occurs because of (ROS) accumulation that has been proposed to explain the cause of the ageing. One of the most harmful effects of ROS in the cell is DNA damage. Nevertheless, there is also evidence demonstrating that OS can produce other mol. changes such as mitochondrial dysfunction, inflammation, apoptosis, and epigenetic modifications, among others. Interestingly, the dietary polyphenol RV is a potent antioxidant and possesses pleiotropic actions, exerting its activity through various mol. pathways. In this review, we give a comprehensive overview of the main mechanisms of action of RV in different exptl. models, including clin. trials and discuss how the interconnection of these mol. events could explain the neuroprotective effects induced by RV.

Ageing Research Reviews published new progress about Accelerated aging disorder. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts