Category: 501-36-0

de Ligt, Marlies; Bergman, Maaike; Fuentes, Rodrigo Mancilla; Essers, Hans; Moonen-Kornips, Esther; Havekes, Bas; Schrauwen-Hinderling, Vera B; Schrauwen, Patrick published the artcile< No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial.>, Application of C14H12O3, the main research area is glycemic control; insulin resistance; intrahepatic lipid content; obesity; resveratrol.

BACKGROUND: Effects of resveratrol on metabolic health have been studied in several short-term human clinical trials, with conflicting results. Next to dose, the duration of the clinical trials may explain the lack of effect in some studies, but long-term studies are still limited. OBJECTIVES: The objective of this study was to investigate the effects of 6-mo resveratrol supplementation on metabolic health outcome parameters. METHODS: Forty-one overweight men and women (BMI: 27-35 kg/m2; aged 40-70 y) completed the study. In this parallel-group, double-blind clinical trial, participants were randomized to receive either 150 mg/d of resveratrol (n = 20) or placebo (n = 21) for 6 mo. The primary outcome of the study was insulin sensitivity, using the Matsuda index. Secondary outcome measures were intrahepatic lipid (IHL) content, body composition, resting energy metabolism, blood pressure, plasma markers, physical performance, quality of life, and quality of sleep. Postintervention differences between the resveratrol and placebo arms were evaluated by ANCOVA adjusting for corresponding preintervention variables. RESULTS: Preintervention, no differences were observed between the 2 treatment arms. Insulin sensitivity was not affected after 6 mo of resveratrol treatment (adjusted mean Matsuda index: 5.18 ± 0.35 in the resveratrol arm compared with 5.50 ± 0.34 in the placebo arm), although there was a significant difference in postintervention glycated hemoglobin (HbA1c) between the arms (P = 0.007). The adjusted means showed that postintervention HbA1c was lower on resveratrol (35.8 ± 0.43 mmol/mol) compared with placebo (37.6 ± 0.44 mmol/mol). No postintervention differences were found in IHL, body composition, blood pressure, energy metabolism, physical performance, or quality of life and sleep between treatment arms. CONCLUSIONS: After 6 mo of resveratrol supplementation, insulin sensitivity was unaffected in the resveratrol arm compared with the placebo arm. Nonetheless, HbA1c was lower in overweight men and women in the resveratrol arm. This trial was registered at Clinicaltrials.gov as NCT02565979.

The American journal of clinical nutrition published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Qinyang; Cheng, Xiaofang; Cui, Yueyue; Xia, Qin; Yan, Xueyu; Zhang, Mingyuan; Lan, Ganqiu; Liu, Jiaqi; Shan, Tizhong; Huang, Yanna published the artcile< Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway>, Formula: C14H12O3, the main research area is resveratrol skeletal muscle fiber AdipoR1 AMPK PGC1 alpha.

This study was conducted to investigate the effect and underlying mechanism of Resveratrol (RES) in regulating skeletal muscle fiber-type switching. We found that RES had no effect on the body weight and food intake of Kunming mice (KM mice) that were orally administered with 400 mg kg-1 d-1 RES for 12 wk. Notably, the RES administration significantly increased the expression of myosin heavy chain (MyHC) 1, MyHC2a, and MyHC2x in the extensor digitorum longus (EDL) and soleus (SOL) muscles. Furthermore, the muscle immunostaining of the results showed that the RES treatment led to the myofiber type transition from glycolytic to oxidative in muscles. The mRNA and protein levels of the adiponectin receptor (AdipoR), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in EDL and SOL were drastically increased after RES treatment. Moreover, the plasma Adiponectin (AdipoQ) protein levels were higher in the RES-treated mice compared to the control mice. Moreover, the in vitro results further demonstrated that the 20μM RES treatment increased the expression of AdipoR1, AdipoR2, AMPK, PGC-1α and MyHC1, but decreased the expression of MyHC2b in C2C12 myoblasts. Furthermore, mechanistic studies revealed that silencing the AdiopR1, not the AdiopR2, abolished the effect of RES on the expression of AMPK and PGC-1α in the C2C12 cells. These results indicated that RES could regulate skeletal fiber switching through the AdiopR1-AMPK-PGC-1α pathway. This work may provide a new strategy for enhancing endurance and relieving muscle diseases caused by oxidative muscle fiber deficiency.

Food & Function published new progress about Adiponectin receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tian, Bingren; Liu, Jiayue published the artcile< Resveratrol: a review of plant sources, synthesis, stability, modification and food application>, Quality Control of 501-36-0 , the main research area is botanical origin; common reaction; resveratrol; stability; synthesis.

Resveratrol, a stilbene mol. belonging to the polyphenol family, is usually extracted from a great many natural plants. The technologies of preparation and extraction methods are developing rapidly. As resveratrol has many beneficial properties, it has been widely utilized in food and medicine industry. In terms of its structure, it is susceptible to degradation and can undergo chem. changes during food processing. Different studies have therefore given more attention to various aspects of resveratrol, including anti-aging, anti-oxidant, and anti-cancer activity. This review classifies the study of resveratrol, considers plant sources, synthesis, stability, common reactions, and food applications, and provides references to boost its food and medical utilization. © 2019 Society of Chem. Industry

Journal of the Science of Food and Agriculture published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Quality Control of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Ligt, Marlies; Bergman, Maaike; Fuentes, Rodrigo Mancilla; Essers, Hans; Moonen-Kornips, Esther; Havekes, Bas; Schrauwen-Hinderling, Vera B; Schrauwen, Patrick published the artcile< No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial.>, Application of C14H12O3, the main research area is glycemic control; insulin resistance; intrahepatic lipid content; obesity; resveratrol.

BACKGROUND: Effects of resveratrol on metabolic health have been studied in several short-term human clinical trials, with conflicting results. Next to dose, the duration of the clinical trials may explain the lack of effect in some studies, but long-term studies are still limited. OBJECTIVES: The objective of this study was to investigate the effects of 6-mo resveratrol supplementation on metabolic health outcome parameters. METHODS: Forty-one overweight men and women (BMI: 27-35 kg/m2; aged 40-70 y) completed the study. In this parallel-group, double-blind clinical trial, participants were randomized to receive either 150 mg/d of resveratrol (n = 20) or placebo (n = 21) for 6 mo. The primary outcome of the study was insulin sensitivity, using the Matsuda index. Secondary outcome measures were intrahepatic lipid (IHL) content, body composition, resting energy metabolism, blood pressure, plasma markers, physical performance, quality of life, and quality of sleep. Postintervention differences between the resveratrol and placebo arms were evaluated by ANCOVA adjusting for corresponding preintervention variables. RESULTS: Preintervention, no differences were observed between the 2 treatment arms. Insulin sensitivity was not affected after 6 mo of resveratrol treatment (adjusted mean Matsuda index: 5.18 ± 0.35 in the resveratrol arm compared with 5.50 ± 0.34 in the placebo arm), although there was a significant difference in postintervention glycated hemoglobin (HbA1c) between the arms (P = 0.007). The adjusted means showed that postintervention HbA1c was lower on resveratrol (35.8 ± 0.43 mmol/mol) compared with placebo (37.6 ± 0.44 mmol/mol). No postintervention differences were found in IHL, body composition, blood pressure, energy metabolism, physical performance, or quality of life and sleep between treatment arms. CONCLUSIONS: After 6 mo of resveratrol supplementation, insulin sensitivity was unaffected in the resveratrol arm compared with the placebo arm. Nonetheless, HbA1c was lower in overweight men and women in the resveratrol arm. This trial was registered at Clinicaltrials.gov as NCT02565979.

The American journal of clinical nutrition published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Qinyang; Cheng, Xiaofang; Cui, Yueyue; Xia, Qin; Yan, Xueyu; Zhang, Mingyuan; Lan, Ganqiu; Liu, Jiaqi; Shan, Tizhong; Huang, Yanna published the artcile< Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway>, Formula: C14H12O3, the main research area is resveratrol skeletal muscle fiber AdipoR1 AMPK PGC1 alpha.

This study was conducted to investigate the effect and underlying mechanism of Resveratrol (RES) in regulating skeletal muscle fiber-type switching. We found that RES had no effect on the body weight and food intake of Kunming mice (KM mice) that were orally administered with 400 mg kg-1 d-1 RES for 12 wk. Notably, the RES administration significantly increased the expression of myosin heavy chain (MyHC) 1, MyHC2a, and MyHC2x in the extensor digitorum longus (EDL) and soleus (SOL) muscles. Furthermore, the muscle immunostaining of the results showed that the RES treatment led to the myofiber type transition from glycolytic to oxidative in muscles. The mRNA and protein levels of the adiponectin receptor (AdipoR), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in EDL and SOL were drastically increased after RES treatment. Moreover, the plasma Adiponectin (AdipoQ) protein levels were higher in the RES-treated mice compared to the control mice. Moreover, the in vitro results further demonstrated that the 20μM RES treatment increased the expression of AdipoR1, AdipoR2, AMPK, PGC-1α and MyHC1, but decreased the expression of MyHC2b in C2C12 myoblasts. Furthermore, mechanistic studies revealed that silencing the AdiopR1, not the AdiopR2, abolished the effect of RES on the expression of AMPK and PGC-1α in the C2C12 cells. These results indicated that RES could regulate skeletal fiber switching through the AdiopR1-AMPK-PGC-1α pathway. This work may provide a new strategy for enhancing endurance and relieving muscle diseases caused by oxidative muscle fiber deficiency.

Food & Function published new progress about Adiponectin receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tian, Bingren; Liu, Jiayue published the artcile< Resveratrol: a review of plant sources, synthesis, stability, modification and food application>, Quality Control of 501-36-0 , the main research area is botanical origin; common reaction; resveratrol; stability; synthesis.

Resveratrol, a stilbene mol. belonging to the polyphenol family, is usually extracted from a great many natural plants. The technologies of preparation and extraction methods are developing rapidly. As resveratrol has many beneficial properties, it has been widely utilized in food and medicine industry. In terms of its structure, it is susceptible to degradation and can undergo chem. changes during food processing. Different studies have therefore given more attention to various aspects of resveratrol, including anti-aging, anti-oxidant, and anti-cancer activity. This review classifies the study of resveratrol, considers plant sources, synthesis, stability, common reactions, and food applications, and provides references to boost its food and medical utilization. © 2019 Society of Chem. Industry

Journal of the Science of Food and Agriculture published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Quality Control of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdelgawad, Ibrahim Y.; Grant, Marianne K. O.; Zordoky, Beshay N. published the artcile< Leveraging the cardio-protective and anticancer properties of resveratrol in cardio-oncology>, SDS of cas: 501-36-0 , the main research area is review cardioncol cardiprotection resveratrol anticancer; anthracycline; cancer; cardio-oncology; cardiotoxicity; cardiovascular; resveratrol.

A review. Cardio-oncol. is a clin./scientific discipline which aims to prevent and/or treat cardiovascular diseases in cancer patients. Although a large number of cancer treatments are known to cause cardiovascular toxicity, they are still widely used because they are highly effective. Unfortunately, therapeutic interventions to prevent and/or treat cancer treatment-induced cardiovascular toxicity have not been established yet. A major challenge for such interventions is to protect the cardiovascular system without compromising the therapeutic benefit of anticancer medications. Intriguingly, the polyphenolic natural compound resveratrol and its analogs have been shown in preclin. studies to protect against cancer treatment-induced cardiovascular toxicity. They have also been shown to possess significant anticancer properties on their own, and to enhance the anticancer effect of other cancer treatments. Thus, they hold significant promise to protect the cardiovascular system and fight the cancer at the same time. In this review, we will discuss the current knowledge regarding the cardio-protective and the anticancer properties of resveratrol and its analogs. Thereafter, we will discuss the challenges that face the clin. application of these agents. To conclude, we will highlight important gaps of knowledge and future research directions to accelerate the translation of these exciting preclin. findings to cancer patient care.

Nutrients published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Dan-Dan; Shi, Guangjiang; Jiang, Yaping; Yao, Chao; Zhu, Chuanlin published the artcile< A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications>, Electric Literature of 501-36-0, the main research area is review resveratrol antidiabetic agent diabetes mellitus; Anti-diabetes; Anti-inflammatory; Anti-oxidant; Diabetic complications; Hypoglycemic effect; Resveratrol.

A review. Diabetes mellitus (DM) is a major world health problem and one of the most studied diseases, which are highly prevalent in the whole world, it is frequently associated with severe clin. complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy etc. Scientific research is continuously casting about for new monomer mols. from Chinese herbal medicine that could be invoked as candidate drugs for fighting against diabetes and its complications. Resveratrol (RES), a polyphenol phytoalexin, possesses diverse biochem. and physiol. actions, including antiplatelet, estrogenic, and anti-inflammatory properties. It is recently gaining scientific interest for RES in controlling blood sugar and fighting against diabetes and its complications properties in various types of diabetic models. These beneficial effects seem to be due to the multiple actions of RES on cellular functions, which make RES become a promising mol. for the treatment of diabetes and diabetic complications. Here, we review the mechanism of action and potential therapeutic use of RES in prevention and mitigation of these diseases in recent ten years to provide a reference for further research and development of RES.

Biomedicine & Pharmacotherapy published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mortezaee, Keywan; Najafi, Masoud; Farhood, Bagher; Ahmadi, Amirhossein; Shabeeb, Dheyauldeen; Musa, Ahmed E. published the artcile< Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol anticancer agent cancer; Resveratrol; chemotherapy; molecular targeted therapy; neoplasm; radiation; radiotherapy; tumor microenvironment..

A review. Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clin. studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clin. studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clin. translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.

Current Cancer Drug Targets published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Xiang-tao; Li, Xi; Xie, Ming-ling; Huang, Zhen; Huang, Yong-xiu; Wu, Gui-xian; Peng, Zhi-rong; Sun, Yan-ni; Ming, Qian-liang; Liu, Yan-xia; Chen, Jie-ping; Xu, Shuang-nian published the artcile< Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics>, Reference of 501-36-0 , the main research area is review resveratrol antileukemia agent pharmacokinetics leukemia; Anti-Leukemia; Drug candidate; Resveratrol.

A review. Resveratrol, found in variety of plants, is a natural stilbene structure polyphenol. It has various pharmacol. effects, such as antioxidation, anti-aging, anti-inflammation, anti-cancer, antiobesity, anti-diabetes, cardioprotection, neuroprotection. Recently, anti-leukemia activities of resveratrol has been studied extensively via its effects on a variety of biol. processes involving cell proliferation, apoptosis, autophagy. Current treatments of leukemia mainly rely on intensive chemotherapy or hematopoietic stem cell transplantation, however, these treatments are still with poor survival and high treatment-related mortality. Therefore, it is extremely needed to find relatively non-toxic medicines with minimal side effects but sufficient therapeutic efficacy. Resveratrol is one such potential candidate owing to its reported anti-leukemia effect. In this review, we summarized resveratrol’s discovery, sources and isolation methods, administration methods, effects in different types of leukemia, pharmacokinetics and toxicities, aiming to exploit resveratrol as a potential drug candidate for anti-leukemia.

Chemico-Biological Interactions published new progress about Anti-aging agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts