Category: 501-36-0

Santos, Ana Claudia; Pereira, Irina; Pereira-Silva, Miguel; Ferreira, Laura; Caldas, Mariana; Collado-Gonzalez, Mar; Magalhaes, Mariana; Figueiras, Ana; Ribeiro, Antonio J.; Veiga, Francisco published the artcile< Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity>, Computed Properties of 501-36-0 , the main research area is review resveratrol nanoformulation bioavailability nanocarrier; Bioactivity; Bioavailability; In vivo; Nanocarriers; Nanoencapsulation; Nanoformulations; Nanoparticles; Nanotechnology; Resveratrol.

A review. Resveratrol (RES), also known as 3,5,4′-trihydroxystilbene, is a polyphenolic phytoalexin that has been widely researched in the past decade due to its recognized numerous biol. activities. Despite the potential benefits of RES, its effective use is limited due to its poor solubility, photosensitivity and rapid metabolism, which strongly undermine RES bioavailability and bioactivity. Thereby, recently, nanotechnol. appeared as a potential strategy to circumvent RES physicochem. and pharmacokinetics constrains. However, only few studies have addressed the crucial in vivo suitability of the developed delivery systems to improve RES efficacy. Facing this scenario, in the present review, it is intended to present and discuss the in vivo resveratrol bioavailability and bioactivity, following its encapsulation or conjugation in nanotechnol.-based carriers, contemplating their pharmacokinetics effectiveness.

Colloids and Surfaces, B: Biointerfaces published new progress about Drug bioavailability. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Li; Zhou, Mengmeng; Huang, Dawei; Wasan, Harpreet S; Zhang, Kai; Sun, Leitao; Huang, Hong; Ma, Shenglin; Shen, Minhe; Ruan, Shanming published the artcile< Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑ mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway.>, Quality Control of 501-36-0, the main research area is .

The identification of safe and effective drugs that inhibit tumor invasion and metastasis is required to improve the clinical outcome of patients with colon cancer. The present study aimed to investigate the inhibitory effects and possible mechanisms of action of resveratrol against the invasion and metastasis of colon cancer. AKT1‑knockdown SW480 and SW620 colon cancer cells were used to detect the effects of resveratrol on cell invasion and metastasis, as well as changes in the expression of epithelial‑mesenchymal transition (EMT) markers and serine/threonine kinase (AKT)/glycogen synthase kinase (GSK)‑3β/Snail signaling pathway‑related molecules in vitro. Furthermore, nude mice were inoculated with SW480 cells in the tail vein to establish an in vivo lung metastasis model of colon cancer, to investigate the effects of resveratrol on lung metastasis in colon cancer. The results revealed that resveratrol treatment and AKT1 knockdown significantly inhibited cell migration and invasion in colon cancer, and markedly increased E‑cadherin expression and decreased that of N‑cadherin, phospho (p)‑AKT1, p‑GSK‑3β, and Snail in colon cancer both in vitro and in vivo. Furthermore, the effects of resveratrol were significantly weaker in the AKT1‑knockdown cells. In conclusion, resveratrol may suppress the invasion and metastasis of colon cancer through reversal of EMT via the AKT/GSK‑3β/Snail signaling pathway. AKT1 may therefore be a key regulator of EMT in colon cancer cells and a potential therapeutic target for this disease.

Molecular medicine reports published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Quality Control of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dyck, Garrison J. B.; Raj, Pema; Zieroth, Shelley; Dyck, Jason R. B.; Ezekowitz, Justin A. published the artcile< The effects of resveratrol in patients with cardiovascular disease and heart failure: a narrative review>, Application In Synthesis of 501-36-0 , the main research area is review resveratrol cardioprotectant cardiovascular disease heart failure; CVD; heart failure; resveratrol.

A review. Cardiovascular disease (CVD) is the main cause of death globally and responsible for the second highest number of deaths in Canada. Medical advancements in the treatment of CVD have led to patients living longer with CVD but often progressing to another condition called heart failure (HF). As a result, HF has emerged in the last decade as a major medical concern. Fortunately, various “”traditional”” pharmacotherapies for HF exist and have shown success in reducing HF-associated mortality. However, to augment the treatment of patients with CVD and/or HF, alternative pharmacotherapies using nutraceuticals have also shown promise in the prevention and treatment of these two conditions. One of these natural compounds considered to potentially help treat HF and CVD and prevent their development is resveratrol. Herein, we review the clin. findings of resveratrol’s ability to be used as an effective treatment to potentially help treat HF and CVD. This will allow us to gain a more fulsome appreciation for the effects of resveratrol in the health outcomes of specific patient populations who have various disorders that constitute CVD.

International Journal of Molecular Sciences published new progress about Cardioprotective agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bahramrezaie, Mojdeh; Amidi, Fardin; Aleyasin, Ashraf; Saremi, AboTaleb; Aghahoseini, Marzieh; Brenjian, Samaneh; Khodarahmian, Mahshad; Pooladi, Arash published the artcile< Effects of resveratrol on VEGF & HIF1 genes expression in granulosa cells in the angiogenesis pathway and laboratory parameters of polycystic ovary syndrome: a triple-blind randomized clinical trial.>, Category: alcohols-buliding-blocks, the main research area is HIF1 gene; Hormones; Intracytoplasmic sperm injection; Polycystic ovary syndrome; Resveratrol; VEGF gene.

OBJECTIVES: Management options for PCOS, as the most prevalent endocrine disorder in women of reproductive age, using natural supplements have a high priority for physicians, especially based on the etiological pathways. Therefore, this study was conducted to describe the effect of resveratrol on the angiogenesis pathway, for management of PCOS through assessing VEGF, HIF1 gene expression, and laboratory parameters. METHODS: In this triple-blind RCT, PCOS was confirmed in ICSI candidates based on the Rotterdam criteria. Sixty-two patients that met the inclusion criteria were randomly assigned to two groups. All patients took resveratrol 800 mg/day or placebo for 40 days orally from the beginning of their previous menstruation cycle until the oocyte retrieval day. The serum levels of different hormones were measured, and the expression of HIF1 & VEGF genes was quantified by real-time PCR. RESULTS: As for the laboratory hormone assay in 61 PCOS patients, a significant mean difference was seen in the FSH, LH, TSH, and testosterone between the two groups (P < 0.05). The results showed a reduction in the expression of VEGF & HIF1 genes under the effect of resveratrol in the granulosa cells (P = 0.0001). The number of mature oocytes, cleavage rate, fertilization rate, and fertility rate were not significantly different between the two groups (P > 0.05), but the high-quality oocyte rate and high-quality embryo rate were higher in the resveratrol group (P < 0.05). CONCLUSIONS: Based on the results, resveratrol may improve some outcomes of PCOS patients, probably through changing the serum levels of some sex hormones and expression of VEGF & HIF1 genes in the angiogenesis pathway of granulosa cells. Journal of assisted reproduction and genetics published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gianchecchi, Elena; Fierabracci, Alessandra published the artcile< Insights on the effects of resveratrol and some of its derivatives in cancer and autoimmunity: a molecule with a dual activity>, COA of Formula: C14H12O3, the main research area is review cancer autoimmunity type 1 diabetes resveratrol; autoimmunity; cancer; resveratrol.

A review. In recent years, the interest in natural compounds exerting immunoregulatory effects has enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods and beverages, including red grapes and red wine, has been demonstrated to exert both in vitro and in vivo biol. activities. More specifically, it has antiaging, cardioprotective, antioxidant, immunomodulatory, anti-inflammatory and chemopreventive activities. Due to its anti-proliferative, pro-apoptotic and immunoregulatory effects, resveratrol has gained substantial attention for the treatment of cancer or autoimmunity, which represent frequently diagnosed diseases with important consequences for the health of the patients affected. The aim of the present review is to focus on the role of resveratrol in the modulation of cancer as well as of several organ-specific or systemic autoimmune diseases, including autoimmune hepatitis, type 1 diabetes mellitus, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis.

Antioxidants published new progress about Anti-aging agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Tiantian; Xiao, Dingfu; Muhammed, Arowolo; Deng, Juying; Chen, Liang; He, Jianhua published the artcile< Anti-inflammatory action and mechanisms of resveratrol>, COA of Formula: C14H12O3, the main research area is review anti inflammation resveratrol mechanism; absorption and metabolism; anti-inflammation; antioxidant; mechanism; resveratrol.

A review. Resveratrol (3,4′,5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits antioxidant, anti-inflammatory, and anti-carcinogenic properties. This phytoalexin is well-absorbed and rapidly and extensively metabolized in the body. Inflammation is an adaptive response, which could be triggered by various danger signals, such as invasion by microorganisms or tissue injury. In this review, the anti-inflammatory activity and the mechanism of resveratrol modulates the inflammatory response are examined Multiple exptl. studies that illustrate regulatory mechanisms and the immunomodulatory function of resveratrol both in vivo and in vitro. The data acquired from those studies are discussed.

Molecules published new progress about Absorption. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ashrafizadeh, Milad; Ahmadi, Zahra; Farkhondeh, Tahereh; Samarghandian, Saeed published the artcile< Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities>, Product Details of C14H12O3, the main research area is Wnt signaling pathway; cancer therapy; medicinal plants; resveratrol.

Wingless-type MMTV integration site (Wnt) signaling pathway is considered as an important pathway regulating a variety of biol. processes such as tissue formation and homeostasis, cell proliferation, cell migration, cell differentiation, and embryogenesis. Impairment in the Wnt signaling pathway is associated with pathol. conditions, particularly cancer. So, modulation of this pathway can be considered as a promising strategy and several drugs have been developed in line with this strategy. Resveratrol (Res) is a naturally occurring nutraceutical compound exclusively found in different fruits and nuts such as grape, peanut, and pistachio. This compound has favorable biol. and therapeutic activities such as antioxidant, anti-inflammatory, antitumor, hepatoprotective, cardioprotective, and antidiabetic. At the present review, we demonstrate how Res modulates Wnt signaling pathway to exert its pharmacol. effects.

Journal of Cellular Physiology published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rahman, Habibur Md.; Akter, Rokeya; Bhattacharya, Tanima; Abdel-Daim, Mohamed M.; Alkahtani, Saad; Arafah, Mohammed W.; Al-Johani, Norah S.; Alhoshani, Norah M.; Alkeraishan, Nora; Alhenaky, Alhanof; Abd-Elkader, Omar H.; El-Seedi, Hesham R.; Kaushik, Deepak; Mittal, Vineet published the artcile< Resveratrol and neuroprotection: impact and its therapeutic potential in Alzheimer's disease>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol neuroprotection Alzheimer disease; Alzheimer’s disease; bioavailability; neuroprotective; oxidative stress; resveratrol; therapeutic agent.

A review. Alzheimer’s disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. The AD pathogen is a very complex process, including aggregation of Aβ (β-amyloid peptides), phosphorylation of tau-proteins, and chronic inflammation. Exactly, resveratrol, a polyphenol present in red wine, and many plants are indicated to show the neuroprotective effect on mechanisms mostly above. Resveratrol plays an important role in promotion of non-amyloidogenic cleavage of the amyloid precursor protein. It also enhances the clearance of amyloid beta-peptides and reduces the damage of neurons. Most exptl. research on AD and resveratrol has been performed in many species, both in vitro and in vivo, during the last few years. Nevertheless, resveratrol’s effects are restricted by its bioavailability in the reservoir. Therefore, scientists have tried to improve its efficiency by using different methods. This review focuses on recent work done on the cell and animal cultures and also focuses on the neuroprotective mol. mechanisms of resveratrol. It also discusses about the therapeutic potential onto the treatment of AD.

Frontiers in Pharmacology published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Badaoui, Antoine published the artcile< Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol Scutellaria root extract cosmetic product allergic contact dermatitis; Scutellaria baicalensis; CAS no 94279-99-9; CAS number 501-36-0; allergic contact dermatitis; case report; cosmetics; eczema; patch test; resveratrol.

Authors report the second case of allergic contact dermatitis caused by resveratrol (CAS number 501-36-0), and Scutellaria baicalensis root extract (CAS no 94279-99-9), both antioxidants, contained in the same cosmetic. A 37-yr-old woman with no past medical history, reported a papular and vesicular eruption of the face and neck, with itchy sensations, 48 h after the application of a new facial cream: Resveratrol BE cream (Skinceuticals). Patch tests were performed with the European baseline and cosmetic series (Chemotechnique Diagnostics), and with the Resveratrol BE cream ‘as is’. Patch test chambers used were IQ ultra (Chemotechnique Diagnostics), fixed with Hypafix (BSN Medical) for 48 h. Patch tests with resveratrol 1% aqueous and S. baicalensis root extract 0.5% aqueous were subsequently performed in four control healthy volunteers and were neg. until D7. Both resveratrol 1% aqueous and S. baicalensis 0.5% aqueous have been tested in healthy patients and showed no pos. reaction, confirming the absence of irritation when tested at these concentrations This case highlights this importance of patch testing all the cosmetics in question brought by the patient, and in case of a pos. reaction, to perform an addnl. patch test with the resp. ingredients, in order to identify new emerging allergens.

Contact Dermatitis published new progress about Allergic contact dermatitis. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Zhuying; Xie, Qigui; Chen, Zhanlei; Ni, Haibin; Xia, Liang; Zhao, Qiufeng; Chen, Zhiyun; Chen, Peifeng published the artcile< Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1-mediated epithelial-to-mesenchymal transition>, Application of C14H12O3, the main research area is MALAT EM resveratrol invasion migration human gastric cancer cell; epithelial-to-mesenchymal transition; gastric cancer; invasion; metastasis-associated lung adenocarcinoma transcript 1; migration; resveratrol.

Resveratrol, a natural polyphenolic phytoalexin, was reported to exert multiple anticancer effects as a traditional Chinese medicine. However, research regarding the anticancer mechanism of resveratrol for the treatment and prevention of gastric cancer has reported conflicting results. In the present study, it was determined that resveratrol inhibited cell viability in a dose-dependent manner in the human gastric cancer cell line BGC823. Cell migration and invasion were suppressed significantly following treatment with 200μM resveratrol. Addnl., resveratrol inhibited metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression, which was overexpressed in gastric cancer cells. Further experiments revealed that MALAT1 knockdown suppressed cell viability, migration, invasion and epithelial-to-mesenchymal transition in BGC823 cells. The present study indicated that resveratrol inhibited migration and invasion in human gastric cancer cells via suppressing MALAT1-mediated epithelial-to-mesenchymal transition, providing novel evidence for understanding the anticancer mechanism of resveratrol.

Experimental and Therapeutic Medicine published new progress about Cell invasion. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts