Category: 499-75-2

Ex vivo, in vitro, and in silico approaches to unveil the mechanisms underlying vasorelaxation effect of Mentha Longifolia (L.) in porcine coronary artery was written by Alamgeer;Asif, Hira;Chohan, Tahir Ali;Irfan, Hafiz Muhammad;Asim, Mulazim Hussain;Bukhari, Syed Nasir Abbas;Younis, Waqas;Althobaiti, Yusuf S.;Ullah, Aman;Khan, Abdul Qayyum;Hakami, Alqassem Y.. And the article was included in Biomedicine & Pharmacotherapy in 2022.Quality Control of 5-Isopropyl-2-methylphenol This article mentions the following:

Mentha (M.) longifolia (L.) is traditionally used for various ailments. The current study was intended to explore the underlying vasorelaxation mechanisms of M. longifolia. Aqueous-methanol extract from the aerial parts of M. longifolia was prepared and subjected to activity-guided fractionation. The vasorelaxant activity was performed using porcine coronary arteries with intact and denuded endothelium. In-vitro PDE inhibitory activity of the active fraction was carried out using the radio-enzymic assay. The active fraction was also subjected to GCMS. Docking and mol. dynamic simulation studies were also performedWe had observed that aqueous-methanolic extract induced relaxation in the coronary artery in a dose-dependent manner when the endothelium was intact and denuded. n-butanol fraction (MLB) has produced a maximum effect, and it was selected for mechanistic studies. MLB has significantly enhanced the relaxation produced by cAMP and cGMP, elevating atrial natriuretic peptide, sodium nitroprusside, isoproterenol, and forskolin. The pre-treatment with MLB inhibited the contractile response produced by KCl, U46619, and CaCl2 in without endothelium rings. MLB has non-selectively inhibited the PDE isoforms. GCMS anal. of MLB has revealed the presence of menthol, thymol, and carvacrol in the active fraction. Docking and mol. dynamic simulation studies have indicated that thymol can be a competitive inhibitor for PDE1. It is postulated that an n-butanol fraction of Mentha longifolia produced endothelium-independent relaxation due to increased levels of cAMP and cGMP caused by the inhibition of various PDEs. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Quality Control of 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A New Combination Inhibitor Based on Tomato Pomace Extract and Organosilane for Enhanced Anticorrosion Performance of Steel was written by Vorobyova, Viktoria;Skiba, Margarita;Julia, Zaporozhets. And the article was included in Chemistry Africa in 2022.Formula: C10H14O This article mentions the following:

The study aims to assess the effect of extract based inhibiting mixture, i.e., tomato pomace and organosilanes (Vinyltrimethoxysilane (VS)) against corrosion of steel in atm. environment. Such compositions can be used as polymer-type corrosion inhibitors for steel. The developed blend VCI based on tomato pomace extract (TPE) and organosilane provide a long-term protection from corrosion processes under the model conditions of carbon steel. The results show that the protection efficiency of the film reaches 96.97%. The tomato pomace extract chem. composition was analyzed by Head Space-Solid Phase Micro Extraction-Gas Chromatog.-Mass Spectrometry (HS-SPME-GC-MS). The major volatile compounds ot the TPE include alcs., esters, aldehydes, ketones and terpene compounds as described by panelists of HS-SPME-GC-MS. Electrochem. studies reveal decreased corrosion current densities from 4.29 x 10-4 to 0.65 x 10-4 A cm^-2 and increased polarization resistance under the conditions of periodic moisture condensation. FT-IR absorption peak obtained at 954, 1142, 1230 cm^-1 revealed the formation of Fe-O-Si, Si-O-Si and Si-O-C bonds. The protective film consesed of silane and extract offered the highest corrosion resistance since the corrosion protective barrier minimized the oxygen access and prevented corrosion of mild steel to a greater extent where the EDX anal. showed a high intense signal of Si and C. The mixture of phytochem. extract and organosilane were incorporated in a paint coating. The addition of additive increases the inhibitory properties of the final coating while keeping the barrier properties of the coating. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of composts and potassium sulphate on root rot incidence, morphological growth, yield components, oil content and constitutes of marjoram plants (Majorana hortensis L.) was written by Eisa, El-Sayed E. A.;Meligy, Manal M.;Ziedan, El- Sayed H. E.. And the article was included in Biocatalysis and Agricultural Biotechnology in 2022.Name: 5-Isopropyl-2-methylphenol This article mentions the following:

Isolation of root rot tissue of diseased marjoram plants, yielded isolates fungal genera of Fusarium spp. and Rhizoctonia solani. Isolates of F. monoliforme and F. oxysporum, causing the highest root rot percentage and disease severity of marjoram plants in pot experiment In the field, soil amendement with either composts of sugarcane bagasse, soybean straw and rice straw and in combination with potassium sulfate at (50 or 75 kg/feddan.). Obtained indicated that, application of rice straw compost in combination with potassium sulfate (K2O) at 75 kg was the best treatment reduced root rot incidence of marjoram plants and highly significantly increased, plant height, fresh and dry weigh, yield components, content and percentage of essential oil as well in volatile oil high percentage of terpinene -4-ol (42.9%). Meanwhile, the high percentage of linalyl acetate (34.6%) in the application of (K2O) at 75 kg/feddan combined with soybean compost and carvacrol (32.3%) in the application of (K2O) at 75 kg/feddan. So, integration application of composts with (K2O) could be used as alternative strategies to fungicides for controlling root rot disease in marjoram, enhanching plant growth, yield components and constitutes of essential oil. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Name: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synergistic antibacterial activity and mechanism of action of nisin/carvacrol combination against Staphylococcus aureus and their application in the infecting pasteurized milk was written by Li, Qingxiang;Yu, Shuna;Han, Jinzhi;Wu, Jiulin;You, Lijun;Shi, Xiaodan;Wang, Shaoyun. And the article was included in Food Chemistry in 2022.Application of 499-75-2 This article mentions the following:

Synergistic antibacterial effect is a promising way to overcome the challenge of microbial contamination in food. In this study, we detected the synergistic interactions of nisin and carvacrol. The MIC of nisin and carvacrol against S. aureus were 60 and 125μg/mL, resp. The FICI and FBCI were 0.28125 and 0.09375, which suggested that the nisin/carvacrol combination presented synergistic antibacterial effect against S. aureus. The antibacterial activity of nisin/carvacrol combination was much higher than their individuals and the dose of antibacterials was obviously reduced. The combination could completely kill S. aureus within 8 h, accelerate the destruction of cell membrane, and inhibit formation of biofilm. Under the intervention of nisin, more CAR could enter cell to hunt intracellular targets, leading to an increase in intracellular antibacterial level. Besides, in the storage of pasteurized milk, the combinational treatment successfully inhibited microbial reproduction at 25°C and 4°C. Thus, the combination of nisin and carvacrol was a potential synergistic strategy for food preservation. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Application of 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 499-75-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts