Category: 495-76-1

Reference of 495-76-1, Adding some certain compound to certain chemical reactions, such as: 495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol,molecular formula is C8H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 495-76-1.

Dissolve 5.8 ml (0.06 mol) of phosphorus tribromide in 20 ml of ether and slowly instill 7.1 g (0.05 mol)In a solution of 3,4-dioxymethylenebenzaldehyde in ether, the reaction was stirred at 0C for 3 hours. After stopping the reaction,Saturated sodium carbonate solution was quenched, and the mixture was partitioned and washed with saturated saline water and dried over anhydrous sodium sulfate for 8 hours.The desiccant was filtered off and the solvent was evaporated under reduced pressure to give 8.9 g of a pale yellow liquid of Vb in a yield of 83.7%.

According to the analysis of related databases, 495-76-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Zhong Bohua; Zhang Ping; He Xinhua; Shi Weiguo; Fan Shiyong; Yao Yishan; Jia Hongxin; (20 pag.)CN103804341; (2018); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

(2S,3R)-3-(2-(benzo[d] [l,3]dioxol-5-yl)ethyl)-4-oxo-l- (phenylcarbamoyl)azetidine-2-carboxylic acid (35): Compound 35 was synthesized by general method A (step 1) using 5-(2-bromoethyl)benzo[d][l,3] dioxole as the electrophile instead of 4-bromomethyl-2-bis-Boc-aminopyridine. The starting 5- (bromomethyl)benzo[Patent; DAIAMED, INC.; WO2006/108039; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.1473, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: To a solution of Cu(OAc)2 (0.025 mmol, 0.0046 g) and potassium tert-butoxide (0.175 g, 2.5 mmol) in anhydrous dioxane (3 mL), the corresponding amine 1 (2.5 mmol) or the triphenylphosphoranylidenaniline 18 (2.5 mmol) and the correspondent alcohol 2 or 4 (3.75 mmol) were added successively under inert argon atmosphere. After 2 or 5 days of reaction at 130 C (see Table 2 and Scheme 2), the resulting mixture was hydrolyzed with a saturated solution of ammonium chloride (10 mL). The mixture was extracted with AcOEt (3×10 mL) and washed with brine (10 mL), after drying with anhydrous MgSO4, was filtered on Celite and the solvents were removed under low pressure(15-18 Torr). The resulting mixture was purified by column chromatography (if needed).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Martinez-Asencio, Ana; Ramon, Diego J.; Yus, Miguel; Tetrahedron; vol. 67; 17; (2011); p. 3140 – 3149;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 495-76-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.1473, as common compound, the synthetic route is as follows.

To a solution of the piperonyl alcohol (8) (2.0 g, 13.15 mmol) in anhydrous CH2Cl2 (30 mL), cooled to 0 C and stirred, under an argon atmosphere, freshly distilled PBr3 (3.7 mL, 39.45 mmol), was added dropwise. The resulting solution was kept under stirring at 0 C for a further 20 minutes. After, the ice bath was removed, maintaining the stirring for a further 2 h. The system was cooled again to 0 C and a saturated solution of NaHCO3 (75 mL) was slowly added. Extraction was carried out with ethyl ether (3x 70 mL). The combined organic phases were washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford crude bromide (9). This bromide (used immediately after its preparation) was solubilized with anhydrous acetonitrile (30 mL), treated with triphenylphosphine (3.45 g, 13.15 mmol) and stirred overnight, under reflux. Acetonitrile was removed under reduced pressure and the residue was recrystallized from ethanol to provide (5.21 g) Wittig salt (10) in 83% overall yield. Rf 0.53 (CH2Cl2/MeOH 9:1). mp: 237.2-238.5 C. IR (neat) numax/cm-1: 3018, 1492, 1438, 1246, 1109, 750, 687. 1H NMR (400 MHz, CDCl3) delta 7.80-7.62 (m, 15H), 6.62-6.59 (m, 1H), 6.53 (d, 2H, J=5.5 Hz), 5.87 (s, 2H), 5.28 (d, 2H, J=13.9 Hz). 13C NMR (100 MHz, CDCl3) delta 147.6, 134.9 (d, J=11.5 Hz), 134.2 (d, J=38.6 Hz), 130.0 (d, J=49.7 Hz), 125.3, 119.9 (d, J=36 Hz), 118.0, 117.2, 111.2 (d, J=18.4 Hz), 108.4 (d, J=13.5 Hz), 101.1, 30.4 (d, J=187.4 Hz). HRMS (ESI+) calcd for C26H22BrO2P [M-HBr]+ 397.1352, found 397.1358.

Statistics shows that 495-76-1 is playing an increasingly important role. we look forward to future research findings about Benzo[d][1,3]dioxol-5-ylmethanol.

Reference:
Article; Diaz-Munoz, Gaspar; Isidorio, Raquel Geralda; Miranda, Izabel Luzia; de Souza Dias, Gabriel Nunes; Diaz, Marisa Alves Nogueira; Tetrahedron Letters; vol. 58; 33; (2017); p. 3311 – 3315;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 495-76-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol. A new synthetic method of this compound is introduced below.

To a round-bottomed flask were added piperonyl alcohol (4) (2 mmol, 304 mg) and dichloromethane (20 mL). The mixture was cooled to 0 oC under stirring and anhydrous conditions. Then, a solution of phosphorus tribromide (10 mmol, 2.71 g, 0.9 mL) in dichloromethane (9.1 mL) was added dropwise using syringe and needle. The reaction was maintained under stirring and anhydrous conditions at room temperature for 3 h. Afterwards, distilled water (50 mL) was added to the mixture, which was extracted with CH2Cl2 (3 x 50 mL). The organic phase was dried over MgSO4. After filtration, the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel using hexane/ethyl acetate (10:1) as eluent to afford the desired product 3. Yield: 371 mg (86%); off-white solid; m.p. 40-41 oC (m.p. lit.11 39 oC); Rf = 0.44 (eluent: hexane/ethyl acetate (10:1)); 1H NMR (300 MHz, CDCl3): delta 6.85 (d, J = 8.7 Hz, 2H), 6.74 (d, J = 7.9 Hz, 2H), 5.96 (s, 2H), 4.45 (s, 2H); 13C NMR (75 MHz, CDCl3): delta 147.9, 147.8, 131.5, 122.7, 109.4, 108.3, 101.3, 34.2; IR (KBr, cm-1) 3448.7, 2900.9, 1500.6, 1485.2, 1251.8; GC/MS (m/z, %): 214 (10.0), 215 (9.9), 135 (100.0), 77 (23.8), 51 (16.3), 105 (7.0).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Correa, Bianca K.; Silva, Tamiris R.C.; Raminelli, Cristiano; Tetrahedron Letters; vol. 59; 39; (2018); p. 3583 – 3585;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 495-76-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 495-76-1 as follows.

5-(Bromomethyl)-1,3-benzodioxole was prepared using reportedmethod [30]. Take a 250 ml round bottom flask A charged with 1,3-benzodioxole-5-methanol (5 g; 32.86 mmol) in dry diethyl ether(50 ml). Take another 100 ml round bottom flask B loaded with 3.1 ml(32.86 mmol; 1 equiv.) of phosphorous tribromide dissolved in 40 mlof diethyl ether. A dropwise addition was carried out from flask B toflask A maintaining the temperature at 0 C for and stirred for 15 min.After the completion of the reaction, the reaction mixture was workedupwithwater (3× 100ml) using a separating funnel followed bywashingwith brine (1:1). After drying over sodium sulphate and filtration,the solvent was evaporated on a vacuum rotary evaporator. The crudewas recrystallized in petroleum ether to get the desired white solidproduct.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,495-76-1, its application will become more common.

Reference:
Article; Sehrawat, Hitesh; Kumar, Neeraj; Tomar, Ravi; Kumar, Loveneesh; Tomar, Vartika; Madan, Jitender; Dass, Sujata K.; Chandra, Ramesh; Journal of Molecular Liquids; vol. 302; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.1473, as common compound, the synthetic route is as follows.Computed Properties of C8H8O3

General procedure: In a typical reaction, the catalyst was weighed into a screw-capped glass pressure vessel containing a stir bar. The required amounts of alcohol (0.5 mmol) and amine (0.6 mmol), pre-dissolved in solvent (2 mL), were added and the vessel was filled with oxygen, sealed, and heated to the desired temperature in an oil bath with stirring. The products of the reaction were analyzed by gas chromatography (GC, Agilent 7890A) and GC-mass spectrometry (MS, Agilent 7890A/5975C).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Zhixin; Wang, Yehong; Wang, Min; Lue, Jianmin; Li, Lihua; Zhang, Zhe; Li, Mingrun; Jiang, Jingyang; Wang, Feng; Chinese Journal of Catalysis; vol. 36; 9; (2015); p. 1623 – 1630;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Benzo[d][1,3]dioxol-5-ylmethanol, blongs to alcohols-buliding-blocks compound. Quality Control of Benzo[d][1,3]dioxol-5-ylmethanol

General procedure: General procedure for preparation of benzyl bromides from benzaldehydes: To a stirring solution of aldehyde (1.0 equiv) in methanol (0.2 M) was added sodium borohydride (2.0 equiv.). The resulting solution was stirred at RT for 30-60 mins, until no precipitate was evident in solution and flask was cool to the touch. Solvent was removed in vacuo and dichloromethane introduced. Organic layer was washed using water, dried over sodium sulfate, filtered and solvent removed in vacuo to yield crudebenzyl alcohol, which was used without further purification. To a stirring solution of benzyl alcohol (1.0 equiv.) in dry dichloromethane (0.1 M) at 0 C was added phosphorus tribromide (1.1 equiv.). The reaction solution was stirred at 0 00 for 30 mins, quenched with water, transferred to a separating funnel and the organic layer washed with water. Combined organic layers were dried over sodium sulfate, filteredand solvent removed in vacuo to yield crude benzyl bromide, which was used without purification in catalytic Wittig reactions. o Br 5-(Bromomethyl)-1,3-benzodioxole was prepared inaccordance with the general procedure. 1,3-Benzodioxol-5-o – ylmethanol was prepared in 88% yield (2.68 g, 17.6 mmol) fromthe reaction of piperonal (3.00 g, 20 mmol, 1 .0 equiv.) and sodium borohydride (1 .51 g,40 mmol, 2.0 equiv.). Upon reaction with phosphorus tribromide (1.82 mL, 19.4 mmol,1.1 equiv.), 5-(bromometh/l)-1,3-benzodioxole was obtained as a white solid in 85%yield (3.54 g, 16.5 mmol). H NMR (400 MHz, CDCI3) 6: 3.84 (s, 3H), 3.87 (s, 6H), 4.47(s, 2H), 6.62 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; DUBLIN CITY UNIVERSITY; O’BRIEN, Christopher; WO2014/140353; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Benzo[d][1,3]dioxol-5-ylmethanol

General procedure: Oxidative coupling of alcohols and amines was performed in aWP-TEC-1020HC parallel reactor provided by WATTCASTM (WATTECSLAB EQUIPMENT CO., LTD.). In a typical protocol, 0.5 mmolbenzyl alcohol, 0.75 mmol aniline, 5 mL toluene and 40 mg catalystwere added successively. And then the reaction mixture was stirred (900 rpm) at 60 C under air (1 atm) for 8 h. The tube wasimmediately cooled in ice water and the reaction mixture wasanalysed using a Thermo Scientific TRACE 1310 gas chromatograph(GC) equipped with a flame ionization detector (FID) and a TR-5column (30 m 0.32 mm 0.25 lm). The quantification was carriedout using the external standard method. A series of toluenesolutions in different concentrations of benzyl alcohol, benzaldehydeor benzylideneaniline were used as external standard, respectively.Each reaction was at least repeated twice to guarantee areproducible result. The conversion of benzyl alcohol, the selectivityto alkylamines and the yield of imine were calculated, on thebasis of a carbon balance. For the reusability test, the catalystwas separated by centrifugation (8000 rpm for 10 min), washedthree times in turn with ethanol (100 mL) and water (100 mL),dried at 50 C for 24 h under vacuum, and was used for the nextrun.

With the rapid development of chemical substances, we look forward to future research findings about 495-76-1.

Reference:
Article; Wu, Shipeng; Sun, Weixiao; Chen, Junjie; Zhao, Jinghan; Cao, Qiue; Fang, Wenhao; Zhao; Journal of Catalysis; vol. 377; (2019); p. 110 – 121;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts