Category: 492-62-6

Cerulli, Antonietta; Masullo, Milena; Piacente, Sonia published the artcile< Metabolite Profiling of Helichrysum italicum Derived Food Supplements by 1H-NMR-Based Metabolomics>, COA of Formula: C6H12O6, the main research area is Helichrysum italicum food supplement metabolomics multivariate data analysis; Helichrysum italicum derived food supplements; NMR metabolomics; green extractions; multivariate data analysis.

Helichrysum italicum is a medicinal plant from the Mediterranean area, widely used in traditional medicine for its anti-inflammatory, antibacterial and antioxidant properties and for its preventive effects on microcirculation diseases. Due to these properties, it finds large applications in cosmetic, food and pharmaceutical fields. Addnl., hydroalcoholic extracts and mother tinctures based on H. italicum represent products with a high com. value, widely distributed not only in drug stores but also on online markets. The different extraction procedures used can greatly affect the fingerprints of the extracts, resulting in a different qual. or quant. profile of the chem. constituents responsible for biol. activity. The aim of the present study was to characterize the composition of bioactive compounds present in water-ethanol and glycerol extracts of H. italicum derived food supplements. Metabolite profiles of the extracts were obtained by 1H NMR experiments and data were processed by multivariate statistical anal. to highlight differences in the extracts and to evidence the extracts with the highest concentrations of bioactive metabolites. In detail, this work highlights how derived food supplements of H. italicum obtained using ethanol-water mixtures ranging from 45% to 20% of ethanol represent the products with the highest amount of both primary (amino acids) and secondary metabolites including 3,4-dicaffeoylquinic acid (9), chlorogenic acid (10), 3,5-dicaffeoylquinic acid (11), and kaempferol 3-O-glucopyranoside (12). Moreover, it is evident that the use of an ethanol-water mixture 20:80 is the most suitable method to afford the highest number of phenolic compounds, while food-derived supplements obtained by glycerol extraction are characterized by a high amount of β-glucose and α-glucose and a low content of phenolic compounds

Molecules published new progress about Bioactive agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Furusawa, Yuka; Nakamura, Hitoshi; Ashitani, Tatsuya published the artcile< Differences in the ""egumi"" taste of moso-bamboo shoots: research using chemical analysis and two types of taste sensors>, COA of Formula: C6H12O6, the main research area is Phyllostachys shoot oxalic acid fructose egumi taste.

We conducted our research with the aim of determining whether the “”egumi”” taste of moso-bamboo shoots differs depending on the production area and how the “”egumi”” taste of bamboo shoots from Yamagata Prefecture, which is near the northern limit of cultivation, differs. The investigation was conducted using conventional chem. anal. methods to quant. evaluate the presence and content of homogentisic acid and oxalic acid in bamboo shoots from different regions. In addition, qual. evaluation, for which chem. anal. alone is insufficient, was conducted using taste sensors, which have rarely been used. As a result, chem. anal. showed that homogentisic acid was not identified among the two substances considered to be major components of egumi taste, while oxalic acid was identified in all samples. Therefore, it is highly likely that oxalic acid is responsible for the “”egumi”” taste in this study. In addition, qual. anal. using taste sensors revealed that there is a difference in “”egumi”” taste depending on the origin of the bamboo shoot. It was suggested that bamboo shoots from Yamagata Prefecture, near the northern limit of cultivation, had a stronger “”egumi”” taste than those from Kyoto and Fukuoka Prefectures.

Journal of Wood Science published new progress about Astringency. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mumcu, Akin published the artcile< A simple and feasible method for the quantification of metabolites in the human follicular fluid using 1H HR-MAS NMR spectroscopy>, Category: alcohols-buliding-blocks, the main research area is metabolite follicular fluid magic angle spinning spectroscopy.

This study presents a reliable method for the quantification of metabolite concentrations in follicular fluid with the high-resolution magic angle spinning NMR (HRMAS NMR) spectroscopy and the ERETIC2 (Electronic Reference To access In vivo Concentrations) based on PULCON (pulse length based concentration determination) principle. The pos. effect of the HR-MAS probe technol. on spectral quality and its ability to perform analyses with very low sample amounts were the most important factors of proposing this method. In evaluating the performance of the proposed method, standard creatine solutions in different concentrations containing DSS (2,2-dimethyl-2-silapentane-5-sulfonate sodium salt) as an internal reference standard were analyzed using different pulse programs (cpmgpr1d and zg30). The results obtained with the ERETIC2 were compared with the classical internal standard NMR quantification method (DSS method). The relative standard deviation (RSD) values for ERETIC2 were in the range of 0.3% – 5.7% and recovery values were calculated as min. 90.3%, while RSD values for DSS method were in the range of 0.1% – 3.1% and recovery values were min. 97.0%. Besides, it was observed that the metabolite concentration values calculated using the ERETIC2 procedure of follicular fluid samples obtained from the women with endometriosis and healthy controls were compatible with the values those obtained using different methodologies. The obtained results showed that the proposed quantification method based on the HR-MAS spectroscopy can easily be used in biol. fluids and therefore it can be utilized as a good alternative to the internal standard method considering its accuracy and precision.

Journal of the Turkish Chemical Society, Section A: Chemistry published new progress about Endometriosis. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tian, Sinuo; Yan, Sen; Meng, Zhiyuan; Huang, Shiran; Sun, Wei; Jia, Ming; Teng, Miaomiao; Zhou, Zhiqiang; Zhu, Wentao published the artcile< New insights into bisphenols induced obesity in zebrafish (Danio rerio): Activation of cannabinoid receptor CB1>, Application In Synthesis of 492-62-6, the main research area is metabolome bisphenol tetrabromobisphenol cannabinoid CB1 receptor obesity Danio; Bisphenols; Metabolomic modulations; Molecular structure; PCR array; Zebrafish.

Bisphenols (BPs), as widely used plastic additives, penetrate into our daily lives. BPs are considered endocrine disruptors and could potentially induce obesity. In this study, the effects of bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) on food intake and lipid metabolism in zebrafish were determined Moreover, the impact of BPA and TBBPA on the endocannabinoid system (ECS) of zebrafish was further explored by metabolomics, transcriptomics, and mol. docking anal. Here we show that exposure to BPA and TBBPA at concentrations commonly found in the environment (20, 100, and 500μg/L) led to hyperphagia and obesity in adult male zebrafish. Metabolomics and histopathol. anal. revealed significant lipid accumulation in the liver of zebrafish exposed to BPA and TBBPA. The expression of ECS-related genes, in conjunction with RNA-Seq results, further indicated that BPA and TBBPA increased appetite and induced obesity by activating cannabinoid receptor type 1(CB1). Furthermore, mol. docking revealed that six representative BPs including BPA and TBBPA could bind to the CB1 receptor. Collectively, these findings indicate that CB1 may be a potential target for BPs to induce obesity.

Journal of Hazardous Materials published new progress about Adult, nonmammalian. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sundar, Smrithi; Sandilya, Avilasha A.; Priya, M. Hamsa published the artcile< Unraveling the Influence of Osmolytes on Water Hydrogen-Bond Network: From Local Structure to Graph Theory Analysis>, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is osmolyte water hydrogen bond network MD simulations graph theory; protein conformation water osmolyte MD simulation graph theory.

Water structure in aqueous osmolyte solutions, deduced from the slight alteration in the water-water radial distribution function, the decrease in water-water hydrogen bonding, and tetrahedral ordering based only on the orientation of nearest water mols. derived from the mol. dynamics simulations, appears to have been perturbed. A careful anal., however, reveals that the hydrogen bonding and the tetrahedral ordering around a water mol. in binary solutions remain intact as in neat water when the contribution of osmolyte-water interactions is appropriately incorporated. Furthermore, the distribution of the water binding energies and the water excess chem. potential of solvation in solutions are also pretty much the same as in neat water. Osmolytes are, therefore, well integrated into the hydrogen-bond network of water. Indeed, osmolytes tend to preferentially hydrogen bond with water mols. and their interaction energies are strongly correlated to their hydrogen-bonding capability. The graph network anal., further, illustrates that osmolytes act as hubs in the percolated hydrogen-bond network of solutions The degree of hydrogen bonding of osmolytes predominantly determines all of the network properties. Osmolytes like ethanol that form fewer hydrogen bonds than a water mol. disrupt the water hydrogen-bond network, while other osmolytes that form more hydrogen bonds effectively increase the connectivity among water mols. Our observation of minimal variation in the local structure and the vitality of osmolyte-water hydrogen bonds on the solution network properties clearly imply that the direct interaction between protein and osmolytes is solely responsible for the protein stability. Further, the relevance of hydrogen bonds on solution properties suggests that the hydrogen-bonding interaction among protein, water, and osmolyte could be the key determinant of the protein conformation in solutions

Journal of Chemical Information and Modeling published new progress about Binding energy (of water mols.). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carlomagno, C.; Banfi, P. I.; Gualerzi, A.; Picciolini, S.; Volpato, E.; Meloni, M.; Lax, A.; Colombo, E.; Ticozzi, N.; Verde, F.; Silani, V.; Bedoni, M. published the artcile< Human salivary Raman fingerprint as biomarker for the diagnosis of Amyotrophic Lateral Sclerosis>, Application of C6H12O6, the main research area is human amyotrophic lateral sclerosis saliva Raman fingerprint biomarker diagnosis.

Abstract: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease leading to progressive and irreversible muscle atrophy. The diagnosis of ALS is time-consuming and complex, with the clin. and neurophysiol. evaluation accompanied by monitoring of progression and a long procedure for the discrimination of similar neurodegenerative diseases. The delayed diagnosis strongly slows the potential development of adequate therapies and the time frame for a prompt intervention. The discovery of new biomarkers could improve the disease diagnosis, as well as the therapeutic and rehabilitative effectiveness and monitoring of the pathol. progression. In this work saliva collected from 19 patients with ALS, 10 affected by Parkinson’s disease, 10 affected by Alzheimer’s disease and 10 healthy subjects, was analyzed using Raman spectroscopy, optimizing the parameters for detailed and reproducible spectra. The statistical multivariate anal. of the data revealed a significant difference between the groups, allowing the discrimination of the disease onset. Correlation of Raman data revealed a direct relationship with paraclin. scores, identifying multifactorial biochem. modifications related to the pathol. The proposed approach showed a promising accuracy in ALS onset discrimination, using a fast and sensitive procedure that can make more efficient the diagnostic procedure and the monitoring of therapeutic and rehabilitative processes in ALS.

Scientific Reports published new progress about Alzheimer disease. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aburas, Hani; Ispirli, Humeyra; Taylan, Osman; Yilmaz, Mustafa Tahsin; Dertli, Enes published the artcile< Structural and physicochemical characterisation and antioxidant activity of an α-D-glucan produced by sourdough isolate Weissella cibaria MED17>, Product Details of C6H12O6, the main research area is Weissella sourdough alpha D glucan antioxidant activity; Antioxidant polysaccharides; Exopolysaccharides; Functional roles.

An exopolysaccharide (EPS) producer slimy-mucoid type colony was isolated from sourdough and identified as Weissella cibaria MED17. The 1H and 13C NMR spectra of EPS MED17 demonstrated that this EPS was a dextran type glucan ((1 → 6)-linked α-D-glucose core structure) containing (1 → 3)-linked α-D-glucose branches and proportion of (1 → 6)-linked α-D-glucose units to (1 → 3)-linked α-D-glucose units was 94.3:5.7%. The FTIR anal. also confirmed the (1 → 6)-linked α-D-glucose linkage. A high level of thermal stability was observed for glucan MED17 as no degradation up to 300 °C was observed by TGA and DSC anal. The XRD anal. of glucan MED17 showed its semi- crystalline nature and its compact sheet-like morphol. was observed by SEM anal. Finally, antioxidant characteristics of glucan MED17 were determined by ABTS and DPPH radical scavenging activity tests that revealed a moderate antioxidant activity of glucan MED17. These findings show potential techno-functional characteristics of glucan MED17.

International Journal of Biological Macromolecules published new progress about Exopolysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Yuqin; Jia, Jia; Miao, Hengfeng; Ruan, Wenquan; Wang, Xinhua published the artcile< Performance improvement and biofouling mitigation in osmotic microbial fuel cells via in situ formation of silver nanoparticles on forward osmosis membrane>, Reference of 492-62-6, the main research area is silver nanoparticle biofouling mitigation forward osmosis membrane; forward osmosis; membrane fouling; osmotic microbial fuel cell; silver nanoparticle.

An osmotic microbial fuel cell (OsMFC) using a forward osmosis (FO) membrane to replace the proton exchange membrane in a typical MFC achieves superior electricity production and better effluent water quality during municipal wastewater treatment. However, inevitable FO membrane fouling, especially biofouling, has a significantly adverse impact on water flux and thus hinders the stable operation of the OsMFC. Here, we proposed a method for biofouling mitigation of the FO membrane and further improvement in current generation of the OsMFC by applying a silver nanoparticle (AgNP) modified FO membrane. The characteristic tests revealed that the AgNP modified thin film composite (TFC) polyamide FO membrane showed advanced hydrophilicity, more neg. zeta potential and better antibacterial property. The biofouling of the FO membrane in OsMFC was effectively alleviated by using the AgNP modified membrane. This phenomenon could be attributed to the changes of TFC-FO membrane properties and the antibacterial property of AgNPs on the membrane surface. An increased hydrophilicity and a more neg. zeta potential of the modified membrane enhanced the repulsion between foulants and membrane surface. In addition, AgNPs directly disturbed the functions of microorganisms deposited on the membrane surface. Owing to the biofouling mitigation of the AgNP modified membrane, the water flux and electricity generation of OsMFC were correspondingly improved.

Membranes (Basel, Switzerland) published new progress about Bacteria (colonies). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yu-Ting; Wei, Wei; Wang, Chen; Ni, Bing-Jie published the artcile< Microbial and physicochemical responses of anaerobic hydrogen-producing granular sludge to polyethylene micro(nano)plastics>, COA of Formula: C6H12O6, the main research area is polyethylene microplastic anaerobic hydrogen producing granular sludge physicochem response; Anaerobic granular sludge; Extracellular polymeric substances; Hydrogen production; Nanoplastics; Polyethylene microplastics; Toxicity mechanism.

Micro(nano)plastics is an emerging contaminant in wastewater that has showed significant impacts on various biol. wastewater processes. Nevertheless, the underlying effects of micro(nano)plastics with different concentrations and sizes on the anaerobic hydrogen-producing granular sludge (HPG) were still unclear. This work firstly attempted to illustrate the microbial and physicochem. responses of HPG to a shock load of polyethylene microplastics (PE-MPs) with varied concentrations and sizes. The results revealed that the PE-MPs inhibitory effect on hydrogen production by HPG was both concentration- and size-dependent. Specifically, the increase of PE-MPs concentration and the decline of PE-MPs size to nano-sized plastics (NPs) significantly decreased the hydrogen yield, downgraded to 79.9 ± 2.6% and 63.0 ± 3.9% (p = 0.001, and 0.0002) of control, resp., at higher MPs concentration and the smaller MPs size (i.e., NPs). The higher PE-MPs concentration and PE-NPs also suppressed extracellular polymeric substances (EPS) generation more severely. The critical bio-processes involved in hydrogen production were disturbed by PE-MPs, with the extent of neg. impacts depending on the dosage and size of PE-MPs. These adverse impacts further manifested as granule disintegration and loss of cellular activity. Mechanism anal. highlighted the roles of oxidative stress, leachate released from PE-MPs, interaction between PE-NPs and granules inducing phys. crushing of HPG that led to possible direct contact between cells and toxic substances.

Water Research published new progress about Anaerobic fermentation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dong, Yue; Sui, Mingrui; Wang, Xin; Zhang, Peng; Jiang, Yiying; Wu, Jianyu published the artcile< Responses of electroactive biofilms to chronic chlorine exposure: Insights from the composition and spatial structure of extracellular polymeric substances>, Product Details of C6H12O6, the main research area is chlorine extracellular polymeric substance disinfection electroactive biofilm; Chronic chlorine exposure; Electroactive biofilms (EABs); Electron exchange capacities; Extracellular polymeric substances (EPS); Pollutant degradation.

Extensive amounts of chlorine disinfectants have been applied to wastewater system since the outbreak of coronavirus disease 2019 (COVID-19), which inevitably affects the pollutant degradation via interfering with electron transfer mediated by electroactive bacteria. Herein, the response of electroactive biofilm (EAB) to chronic chlorine exposure was investigated. Results showed the EAB formed without exposure (EAB-0) exhibited a 53% and 123% higher current output than that formed with 0.1 mg L-1 (EAB-0.1) and 0.5 mg L-1 (EAB-0.5) chlorine, resp. The chronic chlorine exposure of EAB boosted the contents of extracellular polymeric substances (EPS) in EAB-0.1 and EAB-0.5 by over secretion of extracellular polysaccharides. The EAB-0.1 and EAB-0.5 also presented lower electron exchange capacities (EECs) of EPS, coincided with reduced relative abundance of Geobacter from 61% in EAB-0 to 52% in EAB-0.5. This study provided new insights into the application of engineered EAB for wastewater treatment in a disinfection environment.

Bioelectrochemistry published new progress about Acinetobacter. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts