With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.478163-35-8, name is (2-Fluoro-6-methylphenyl)methanol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.Recommanded Product: (2-Fluoro-6-methylphenyl)methanol
After dissolving (2-fluoro-6-methylphenyl)methanol (CAS 478163-35-8) (2.35 g) in toluene (20 ml), thionyl chloride (3.68 ml) was added dropwise while stirring on ice. A catalytic amount of N,N-dimethylformamide was added, and the mixture was stirred at room temperature for 25 hours and 30 minutes. The reaction mixture was concentrated under reduced pressure, a saturated aqueous solution of sodium hydrogencarbonate was added to the residue, and extraction was performed with n-heptane. The organic layer was washed with water and brine in that order and then dried over anhydrous magnesium sulfate. After filtration with NH silica gel, the filtrate was concentrated under reduced pressure. The title compound (2.04 g) was thus obtained.1H-NMR (400 MHz, CDCl3); delta 2.45 (s, 3H), 4.68 (d, J=1.6 Hz, 2H), 6.89-7.01 (m, 2H), 7.17-7.24 (m, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,478163-35-8, (2-Fluoro-6-methylphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Eisai R&D Management Co., Ltd.; US2009/270369; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts