Category: 473-81-4

On January 25, 2022, Heremans, Isaac P.; Caligiore, Francesco; Gerin, Isabelle; Bury, Marina; Lutz, Marilena; Graff, Julie; Stroobant, Vincent; Vertommen, Didier; Teleman, Aurelio A.; Van Schaftingen, Emile; Bommera, Guido T. published an article.Related Products of 473-81-4 The title of the article was Parkinson′s disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite. And the article contained the following:

Cells are continuously exposed to potentially dangerous compounds Progressive accumulation of damage is suspected to contribute to neurodegenerative diseases and aging, but the mol. identity of the damage remains largely unknown. Here we report that PARK7, an enzyme mutated in hereditary Parkinson′s disease, prevents damage of proteins and metabolites caused by a metabolite of glycolysis. We found that the glycolytic metabolite 1,3-bisphosphoglycerate (1,3-BPG) spontaneously forms a novel reactive intermediate that avidly reacts with amino groups. PARK7 acts by destroying this intermediate, thereby preventing the formation of proteins and metabolites with glycerate and phosphoglycerate modifications on amino groups. As a consequence, inactivation of PARK7 (or its orthologs) in human cell lines, mouse brain, and Drosophila melanogaster leads to the accumulation of these damaged compounds, most of which have not been described before. Our work demonstrates that PARK7 function represents a highly conserved strategy to prevent damage in cells that metabolize carbohydrates. This represents a fundamental link between metabolism and a type of cellular damage that might contribute to the development of Parkinson′s disease. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4

The Article related to park7 neuroprotectant metabolite protein cell damage glycolysis parkinson disease, parkinson’s disease, glycolysis, metabolite damage, posttranslational modification, protein damage and other aspects.Related Products of 473-81-4

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Masip, Jenifer; Rallon, Norma; Yeregui, Elena; Olona, Montserrat; Resino, Salvador; Benito, Jose M.; Vilades, Consuelo; Garcia-Pardo, Graciano; Alcami, Jose; Ruiz-Mateos, Ezequiel; Gomez-Bertomeu, Frederic; Vargas, Montserrat; Navarro, Marta; Oteo, Jose A.; Pineda, Juan A.; Marti, Anna; Alba, Veronica; Vidal, Francesc; Peraire, Joaquin; Rull, Anna; ECRIS Integrated In The Spanish AIDS Research Network published an article in 2022, the title of the article was Elevated α-ketoglutaric acid concentrations and a lipid-balanced signature are the key factors in long-term HIV control.Name: 2,3-Dihydroxypropanoic acid And the article contains the following content:

Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunol. HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunol. HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatog.-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF])in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunol. control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunol. control (less than 5 years; no-LTEC patients). Long-term viral and immunol. HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biol. processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid

The Article related to long term hiv control alpha ketoglutaric acid lipidomics metabolomics, hiv infection, kreb’s cycle, elite controllers (ecs), lipidomics, long-term, mass spectrometry, metabolomics, viral and other aspects.Name: 2,3-Dihydroxypropanoic acid

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On June 30, 2022, Toushik, Sazzad Hossen; Park, Jun-Ha; Kim, Kyeongjun; Ashrafudoulla, Md.; Senakpon Isaie Ulrich, Mevo; Mizan, Furkanur Rahman Md.; Roy, Pantu Kumar; Shim, Won-Bo; Kim, Young-Mog; Park, Si Hong; Ha, Sang-Do published an article.Category: alcohols-buliding-blocks The title of the article was Antibiofilm efficacy of Leuconostoc mesenteroides J.27-derived postbiotic and food-grade essential oils against Vibrio parahaemolyticus, Pseudomonas aeruginosa, and Escherichia coli alone and in combination, and their application as a green preservative in the seafood industry. And the article contained the following:

Foodborne pathogen-mediated biofilms in food processing environments are severe threats to human lives. In the interest of human and environmental safety, natural substances with antimicrobial properties and generally regarded as safe (GRAS) status are the futuristic disinfectants of the food industry. In this study, the efficacy of bioactive, soluble products (metabolic byproducts) from lactic acid bacteria (LAB) and plant-derived essential oils (EO) were investigated as biocidal agents. The postbiotic produced by kimchi-derived Leuconostoc mesenteroides J.27 isolate was analyzed for its metabolic components to reveal its antimicrobial potential against three pathogenic microorganisms (Vibrio parahaemolyticus, Pseudomonas aeruginosa, and Escherichia coli). Addnl., the efficacy of food-grade EO (eugenol and thymol, resp.) was also assessed in our study. Determination of the min. inhibitory concentration (MIC) of postbiotic and EO against three tested pathogens revealed that the sub-MIC (0.5 MIC) of postbiotic and EO could efficiently inhibit the biofilm formation on both seafood (squid) and seafood-processing surfaces (rubber and low-d. polyethylene plastic). Moreover, the polymerase chain reaction (PCR) anal. confirmed that the LAB J.27 isolate possesses bacteriocin- and enzyme-coding genes. The residual antibacterial activity of the produced postbiotic was maintained over a diverse pH range (pH 1-6) but was entirely abolished at neutral or higher pH values. However, the activity was unaffected by exposure to high temperatures (100 and 121 °C) and storage (30 days). Notably, the leakage of intracellular metabolites, damage to DNA, and the down-regulation of biofilm-associated gene expression in the pathogens increased significantly (p > 0.05) following the combination treatment of postbiotic with thymol compared to postbiotic with eugenol. Nonetheless, all in vitro results indicated the prospective use of combining Leu. mesenteroides J.27-derived postbiotic with both EO as a “green preservative” in the seafood industry to inhibit the formation of pathogenic microbial biofilms. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to leuconostoc thymol postbiotic antibiofilm preservative pseudomonas escherichia vibrio seafood, bacterial biofilm, bio-preservative, foodborne pathogen, lactic acid bacteria, seafood safety and other aspects.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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Li, Zhou; Cheng, Bizhen; Liu, Wei; Feng, Guangyan; Zhao, Junming; Zhang, Liquan; Peng, Yan published an article in 2022, the title of the article was Global Metabolites Reprogramming Induced by Spermine Contributing to Salt Tolerance in Creeping Bentgrass.Quality Control of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Soil salinization has become a serious challenge to modern agriculture worldwide. The purpose of the study was to reveal salt tolerance induced by spermine (Spm) associated with alterations in water and redox homeostasis, photosynthetic performance, and global metabolites reprogramming based on analyses of physiol. responses and metabolomics in creeping bentgrass (Agrostis stolonifera). Plants pretreated with or without 0.5 mM Spm were subjected to salt stress induced by NaCl for 25 days in controlled growth chambers. Results showed that a prolonged period of salt stress caused a great deal of sodium (Na) accumulation, water loss, photoinhibition, and oxidative damage to plants. However, exogenous application of Spm significantly improved endogenous spermidine (Spd) and Spm contents, followed by significant enhancement of osmotic adjustment (OA), photosynthesis, and antioxidant capacity in leaves under salt stress. The Spm inhibited salt-induced Na accumulation but did not affect potassium (K) content. The anal. of metabolomics demonstrated that the Spm increased intermediate metabolites of γ-aminobutyric acid (GABA) shunt (GABA, glutamic acid, and alanine) and tricarboxylic acid (TCA) cycle (aconitic acid) under salt stress. In addition, the Spm also up-regulated the accumulation of multiple amino acids (glutamine, valine, isoleucine, methionine, serine, lysine, tyrosine, phenylalanine, and tryptophan), sugars (mannose, fructose, sucrose-6-phosphate, tagatose, and cellobiose), organic acid (gallic acid), and other metabolites (glycerol) in response to salt stress. These metabolites played important roles in OA, energy metabolism, signal transduction, and antioxidant defense under salt stress. More importantly, the Spm enhanced GABA shunt and the TCA cycle for energy supply in leaves. Current findings provide new evidence about the regulatory roles of the Spm in alleviating salt damage to plants associated with global metabolites reprogramming and metabolic homeostasis. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Quality Control of 2,3-Dihydroxypropanoic acid

The Article related to creeping bentgrass spermine salt tolerance metabolism metabolite reprogramming, antioxidant capacity, energy metabolism, ions homeostasis, metabolic pathway, osmotic adjustment, polyamines and other aspects.Quality Control of 2,3-Dihydroxypropanoic acid

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On April 30, 2022, Li, Kun-Ping; Yuan, Min; Wu, Yong-Lin; Pineda, Miguel; Zhang, Chu-Mei; Chen, Yan-Fen; Chen, Zhi-quan; Rong, Xiang-Lu; Turnbull, Jeremy E.; Guo, Jiao published an article.Synthetic Route of 473-81-4 The title of the article was A High-Fat High-Fructose Diet Dysregulates the Homeostatic Crosstalk Between Gut Microbiome, Metabolome, and Immunity in an Experimental Model of Obesity. And the article contained the following:

Ample evidence supports the prominent role of gut-liver axis in perpetuating pathol. networks of high-fat high-fructose (HFF) diet induced metabolic disorders, however, the mol. mechanisms are still not fully understood. Herein, this study aims to present a holistic delineation and scientific explanation for the crosstalk between the gut and liver, including the potential mediators involved in orchestrating the metabolic and immune systems. An exptl. obesity-associated metaflammation rat model is induced with a HFF diet. An integrative multi-omics anal. is then performed. Following the clues illustrated by the multi-omics discoveries, putative pathways are subsequently validated by RT-qPCR and Western blotting. HFF diet leads to obese phenotypes in rats, as well as histopathol. changes. Integrated omics anal. shows that there exists a strong interdependence among gut microbiota composition, intestinal metabolites, and innate immunity regulation in the liver. Some carboxylic acids may contribute to gut-liver communication. Moreover, activation of the hepatic LPS-TLR4 pathway in obesity is confirmed. HFF-intake disturbs gut flora homeostasis. Crosstalk between gut microbiota and innate immune system mediates hepatic metaflammation in obese rats, associated with LPS-TLR4 signaling pathway activation. Moreover, α-hydroxyisobutyric acid and some other organic acids may play a role as messengers in the liver-gut axis. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4

The Article related to high fructose diet gut microbiome metabolome immunity obesity, lps-tlr4, chronic inflammation, gut microbiota, innate immune system, integrated multi-omics analysis, α-hydroxyisobutyric acid and other aspects.Synthetic Route of 473-81-4

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On June 15, 2022, Li, Zhiheng; Chen, Jiazheng; Chen, Jie; Jin, Jiaojun; Chen, Hanmei; Liu, Huijun published an article.Product Details of 473-81-4 The title of the article was Metabolomic analysis of Scenedesmus obliquus reveals new insights into the phytotoxicity of imidazolium nitrate ionic liquids. And the article contained the following:

Due to the persistence of ionic liquids (ILs) in aquatic environments, it is necessary to reveal their ecol. risk to aquatic organisms. Herein, the biotoxicity of two alkyl-methylimidazolium nitrate ILs ([C10mim]NO3 and [C12mim]NO3) against Scenedesmus obliquus were studied. The results showed that the growth inhibition of S. obliquus increased with increasing concentrations of ILs, maximum values of 94.61% at 4 mg/L of [C10mim]NO3 and 97.34% at 0.8 mg/L of [C12min]NO3 were observed The fluorescence parameters of photosystem II, such as light quantum yield and electron transfer rate, showed a neg. relationship with the exposure dose. [C12mim]NO3 had a more significant effect than [C10mim]NO3. Moreover, the redox homeostasis of algae was disrupted; the accumulation of reactive oxygen species, leading to obvious inhibition of superoxide dismutase and catalase activities was observed A metabolomic anal. indicated that the contents of most metabolites were reduced significantly, and fructose and galactose decreased significantly by 42.3% and 88.6%, resp., in the [C10mim]NO3 treatment compared to those in the control. The inhibition of amino acid biosynthesis and glyoxylate and dicarboxylate metabolism explained the more serious biotoxicity of [C12mim]NO3 than that of [C10mim]NO3. This study facilitates a better understanding of the environmental safety and ecol. risks of ILs. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Product Details of 473-81-4

The Article related to scenedesmus phytotoxicity imidazolium nitrate ionic liquid, 1-alkyl-3-methylimidazolium nitrate ionic liquid, metabolomic analysis, oxidative stress, photosynthetic system, scenedesmus obliquus and other aspects.Product Details of 473-81-4

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Alcohol – Wikipedia,
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On September 30, 2022, Chung, Hyuk-Jin; Lee, Hwanhui; Kim, Myeongsun; Lee, Ji Won; Saeed, Maham; Lee, Hayera; Jung, Seung-Hee; Shim, Jae-Jung; Lee, Jung-Lyoul; Heo, Keon; Choi, Hyung-Kyoon published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Development and metabolic profiling of a postbiotic complex exhibiting antibacterial activity against skin microorganisms and anti-inflammatory effect on human keratinocytes. And the article contained the following:

Beyond probiotics, the interest in the application of postbiotics to various fields has been growing. We aimed to develop a novel postbiotic complex (PC) with antibacterial and anti-inflammatory properties. Through antibacterial activity testing against Staphylococcus aureus or Cutibacterium acnes, a PC [a mixture of cell-free supernatants (postbiotics) from probiotic Lactobacillus helveticus (HY7801) and Lactococcus lactis (HY449)] was developed. Anti-inflammatory activity of the PC was investigated using HaCaT keratinocytes treated with S. aureus or C. acnes. PC significantly decreased IL-8 levels and increased hyaluronic acid levels in HaCaT cells cultured with S. aureus or C. acnes. GC-MS based metabolic profiling suggested 2-hydroxyisocaproic acid, hypoxanthine, succinic acid, ornithine, and γ-aminobutyric acid as potential contributing metabolites for the antibacterial and anti-inflammatory effects of PC. The PC developed in this study could be utilized in food, cosmetics, and pharmaceutical products as an alternative or complementary resources of probiotics. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to skin microorganism postbiotic antibacterial antiinflammatory human keratinocyte metabolic profiling, anti-inflammatory activity, antibacterial activity, metabolic profiling, postbiotics, probiotics and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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Lee, Ji-Youn; Seo, Sumin; Shin, Bohyun; Hong, Se Hee; Kwon, Eunjin; Park, Sunwha; Hur, Young Min; Lee, Dong-Kyu; Kim, Young Ju; Han, Sang Beom published an article in 2022, the title of the article was Development of a New Biomarker Model for Predicting Preterm Birth in Cervicovaginal Fluid.Name: 2,3-Dihydroxypropanoic acid And the article contains the following content:

Preterm birth (PTB) is a social problem that adversely affects not only the survival rate of the fetus, but also the premature babies and families, so there is an urgent need to find accurate biomarkers. We noted that among causes, eubiosis of the vaginal microbial community to dysbiosis leads to changes in metabolite composition In this study, short chain fatty acids (SCFAs) representing dysbiosis were derivatized using (N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide, MTBSTFA) and targeted anal. was conducted in extracted organic phases of cervicovaginal fluid (CVF). In residual aqueous CVF, polar metabolites produced biochem. process were derivatized using methoxyamine and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), and non-targeted anal. were conducted. Nine SCFAs were quantified, and 58 polar metabolites were detected in 90 clin. samples using gas chromatog./mass spectrometry (GC/MS). The criteria of statistical anal. and detection rate of clin. sample for development of PTB biomarkers were presented, and 19 biomarkers were selected based on it, consisting of 1 SCFA, 2 organic acids, 4 amine compounds, and 12 amino acids. In addition, the model was evaluated as a suitable indicator for predicting PTB without distinction between sample collection time. We hope that the developed biomarkers based on microbiota-derived metabolites could provide useful diagnostic biomarkers for actual patients and pre-pregnancy. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid

The Article related to cervicovaginal fluid preterm birth biomarker model development, biomarker model, cervicovaginal fluid (cvf), polar metabolite, preterm birth (ptb), short chain fatty acid (scfa), vaginal microbiome and other aspects.Name: 2,3-Dihydroxypropanoic acid

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On July 31, 2022, Kim, Sooah; Hwang, Jiwon; Kim, Jungyeon; Lee, Sun-Hee; Cheong, Yu Eun; Lee, Seulkee; Kim, Kyoung Heon; Cha, Hoon-Suk published an article.Name: 2,3-Dihydroxypropanoic acid The title of the article was Metabolic discrimination of synovial fluid between rheumatoid arthritis and osteoarthritis using gas chromatography/time-of-flight mass spectrometry. And the article contained the following:

Rheumatoid arthritis (RA) and osteoarthritis (OA) are clinicopathol. different. We aimed to assess the feasibility of metabolomics in differentiating the metabolite profiles of synovial fluid between RA and OA using gas chromatog./time-of-flight mass spectrometry. We first compared the global metabolomic changes in the synovial fluid of 19 patients with RA and OA. Partial least squares-discriminant, hierarchical clustering, and univariate analyses were performed to distinguish metabolites of RA and OA. These findings were then validated using synovial fluid samples from another set of 15 patients with RA and OA. We identified 121 metabolites in the synovial fluid of the first 19 samples. The score plot of PLS-DA showed a clear separation between RA and OA. Twenty-eight crucial metabolites, including hypoxanthine, xanthine, adenosine, citrulline, histidine, and tryptophan, were identified to be capable of distinguishing RA metabolism from that of OA; these were found to be associated with purine and amino acid metabolism Our results demonstrated that metabolite profiling of synovial fluid could clearly discriminate between RA and OA, suggesting that metabolomics may be a feasible tool to assist in the diagnosis and advance the comprehension of pathol. processes for diseases. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid

The Article related to metabolome synovial fluid gas chromatog tofms rheumatoid arthritis osteoarthritis, gas chromatography–mass spectrometry, metabolite profiling, osteoarthritis, rheumatoid arthritis, synovial fluid and other aspects.Name: 2,3-Dihydroxypropanoic acid

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On June 30, 2022, Wu, Fan-lin; Hu, Yong-hao; Ji, Peng; Li, Chen-chen; He, Jian published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Metabonomics study on the hepatoprotective effect mechanism of polysaccharides from different processed products of Angelica sinensis on layer chickens based on UPLC-Q/TOF-MS/MS, multivariate statistical analysis and conjoint analysis. And the article contained the following:

Chicken colibacillosis is one of the most severe diseases in the poultry industry. Ceftiofur sodium (CS) is often used to treat it in clin. practice and lipopolysaccharide (LPS) accumulates in the chicken ′s body. Previous exptl. studies found that CS combined with LPS could induce liver injury in layer chickens, and polysaccharides from charred Angelica sinensis(CASP) had a better hepatoprotective effect than polysaccharides from unprocessed Angelica sinensis(UASP). However, the intervention mechanism was unclear. Thus, UPLC-Q/TOF-MS/MS-based metabonomics and transcriptomics were used in this study to clarify the hepatoprotective effect mechanism of CASP and UASP in layer chickens. Transcriptomics and ELISA were used for biol. verification of some critical mutual metabolic pathways screened with metabonomics. The comprehensive anal. results showed that in a layer chicken liver injury model built with LPS and CS, 12 critical metabolic pathways were disturbed, involving 10 important differential metabolites. The hepatoprotective effect mechanism of CASP is related to the arachidonic acid metabolism and mTOR signaling pathways, involving nine important differential metabolites. In contrast, the hepatoprotective effect mechanism of UASP is related to the arachidonic acid metabolism pathway, involving six important differential metabolites. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to angelica sinensis polysaccharide hepatoprotective metabonomic multivariate statistical analysis, lps, layer chickens, liver injury, metabonomics, polysaccharides from charred angelica sinensis(casp), polysaccharides from unprocessed angelica sinensis(uasp) and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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