Category: 473-81-4

On July 31, 2022, Li, Yangfan; Yao, Weijie; Gao, Yanbin published an article.COA of Formula: C3H6O4 The title of the article was Effects of Tang Luo Ning on diabetic peripheral neuropathy in rats revealed by LC-MS metabolomics approach. And the article contained the following:

Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes with limited therapies. Tang Luo Ning (TLN), a traditional Chinese medicine compound, has been proved to be effective in the treatment of DPN in clin. and exptl. studies. However, the potential metabolic mechanism of TLN for the treatment of DPN is still unclear. Here the therapeutic effect of TLN on DPN was studied, and HPLC-IT-TOF/MS was used to explore the metabolic changes related to DPN and to explore the mechanism of TLN on DPN induced by high glucose. Furthermore, metabolic pathway anal. was used to explore the metabolic changes induced by DPN and TLN. As a result, TLN could improve the peripheral nerve function of DPN rats, and TLN could reduce the demyelination of the sciatic nerve in DPN rats. Metabolomics anal. showed that 14 potential biomarkers (citrate, creatine, fumarate, glyceric acid, glycine, succinate, etc.) of both DPN and TLN treatment were identified. Pathway anal. showed that the changes in these metabolites were mainly related to the citrate cycle (TCA cycle); glycine, serine, and threonine metabolism; and glyoxylate and dicarboxylate metabolism The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).COA of Formula: C3H6O4

The Article related to tang luo ning antidiabetic agent metabolome diabetic peripheral neuropathy, tang luo ning, diabetic peripheral neuropathy, metabolomics, pathway analysis, Placeholder for records without volume info and other aspects.COA of Formula: C3H6O4

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On May 31, 2022, van Drooge, Barend L.; Garatachea, Roger; Reche, Cristina; Titos, Gloria; Alastuey, Andres; Lyamani, Hassan; Alados-Arboledas, Lucas; Querol, Xavier; Grimalt, Joan O. published an article.HPLC of Formula: 473-81-4 The title of the article was Primary and secondary organic winter aerosols in Mediterranean cities under different mixing layer conditions (Barcelona and Granada). And the article contained the following:

PM10 was collected during an EMEP winter campaign of 2017-2018 in two urban background sites in Barcelona (BCN) and Granada (GRA), two Mediterranean cities in the coast and inland, resp. The concentrations of PM10, organic carbon (OC), elemental carbon (EC), and organic mol. tracer compounds such as hopanes, anhydro-saccharides, polycyclic aromatic hydrocarbon, and several biogenic and anthropogenic markers of secondary organic aerosols (SOA) were two times higher in GRA compared to BCN and related to the atm. mixing heights in the areas. Multivariate curve resolution (MCR-ALS) source apportionment anal. identified primary emissions sources (traffic + biomass burning) that were responsible for the 50% and 20% of the organic aerosol contributions in Granada and Barcelona, resp. The contribution of biomass burning was higher in the holidays than in the working days in GRA while all primary combustion emissions decreased in holidays in BCN. The MCR-ALS identified that oxidative species and SOA formation processes contributed to 40% and 80% in Granada and Barcelona, resp. Aged SOA was dominant in Granada and Barcelona under stagnant atm. conditions and in presence of air pollution. On the other hand, fresh SOA contributions from α-pinene oxidation (cis-pinonic acid) were three times higher in Barcelona than Granada and could be related to new particle formation, essentially due to overall cleaner air conditions and elevated air temperatures The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).HPLC of Formula: 473-81-4

The Article related to polycyclic aromatic hydrocarbon primary secondary organic aerosol barcelona granada, organic aerosol, pah, pm, soa, source apportionment, urban air quality, Placeholder for records without volume info and other aspects.HPLC of Formula: 473-81-4

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On September 30, 2022, Xue, Guiren; Su, Shanshan; Yan, Pengfei; Shang, Jiawei; Wang, Jianxin; Yan, Chengye; Li, Jiaxi; Wang, Qiao; Xiong, Xue; Xu, Huijun published an article.Related Products of 473-81-4 The title of the article was Integrative analyses of widely targeted metabolomic profiling and derivatization-based LC-MS/MS reveals metabolic changes of Zingiberis Rhizoma and its processed products. And the article contained the following:

Zingiberis Rhizoma (ZR) has nutritional value and application potentiality, while Zingiberis Rhizoma Praeparatum (ZRP) and Carbonised Ginger (CG) are two main processed products of ZR based on different methods. Here, we performed a widely targeted metabolomics method with Sequential Windowed Acquisition of all Theor. fragment ions (SWATH) mode to analyze differential metabolites in ZR, ZRP and CG. Addnl., the chem. derivatization was applied to characterize different submetabolomes and improve the separation effect and MS response of metabolites. In total, 369 metabolites were identified and divided into 14 categories, 104 of which were differential metabolites. Our results suggest that carbohydrates, nucleotides, organic acids, vitamins, lipids, indoles, alkaloids, and terpenes contributed to a downward trend after processing, but the maximum content of flavanones, phenylpropanes and polyphenols appeared in ZRP, and that of alcs. appeared in CG. These findings serve as promising perspectives for developing functional food in ZR, ZRP and CG. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4

The Article related to metabolomic profiling zingiberis rhizoma, chemical derivatization, differentiate, processed products, widely targeted metabolomic analysis, zingiberis rhizoma, Placeholder for records without volume info and other aspects.Related Products of 473-81-4

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Li, Ji; Pan, Weiwei; Qian, Jianqin; Ni, Yan; Fu, Junfen; Ni, Shaoqing published an article in 2022, the title of the article was Metabolomic differential compounds reflecting the clinical efficacy of polyethylene glycol recombinant human growth hormone in the treatment of childhood growth hormone deficiency.Category: alcohols-buliding-blocks And the article contains the following content:

Understanding metabolite profiles may aid in providing a reference for individualized treatment using PEG-rhGH. Therefore, this study aimed to evaluate the clin. efficacy of PEG-rhGH in treating GHD patients by using a metabolomic approach. Fifty-seven pediatric participants treated with PEG-rhGH were enrolled (28 GHD patients with high clin. efficacy and 29 GHD patients with lower clin. efficacy). Serum samples from all patients were first collected at baseline for biochem. detection; then metabolite levels were measured using gas chromatog. time-of-flight mass spectrometry. The candidates included heptadecanoic acid, stearic acid, 2-hydroxybutyric acid, myristic acid, palmitoleic acid, D-galactose, dodecanoic acid, and oleic acid. The related metabolic pathways involved fatty acid metabolism and energy metabolism This study suggested that growth gains of PEG-rhGH treatment might be differentiated by altered serum levels of fatty acid. Collectively, the metabolomic study provides unique insights into the use of PEG-rhGH as a therapeutic strategy for individualized treatment. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to polyethylene glycol human growth hormone deficiency energy metabolism metabolomic, peg-rhgh, biomarkers, clinical efficacy, growth hormone deficiency, metabolomics, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

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Hagenbeek, Fiona A.; van Dongen, Jenny; Pool, Rene; Harms, Amy C.; Roetman, Peter J.; Fanos, Vassilios; van Keulen, Britt J.; Walker, Brian R.; Karu, Naama; Hulshoff Pol, Hilleke E.; Rotteveel, Joost; Finken, Martijn J. J.; Vermeiren, Robert R. J. M.; Kluft, Cornelis; Bartels, Meike; Hankemeier, Thomas; Boomsma, Dorret I. published an article in 2022, the title of the article was Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children.Synthetic Route of 473-81-4 And the article contains the following content:

Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7-12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the urinary metabolites indicated a role for non-additive genetic factors for 50 amines, 13 organic acids, and 6 steroids. The average broad-sense heritability for these amines, organic acids, and steroids was 0.49 (range: 0.25-0.64), 0.50 (range: 0.33-0.62), and 0.64 (range: 0.43-0.81), resp. For 6 amines, 7 organic acids, and 4 steroids the twin correlations indicated a role for shared environmental factors and the average narrow-sense heritability was 0.50 (range: 0.37-0.68), 0.50 (range; 0.23-0.61), and 0.47 (range: 0.32-0.70) for these amines, organic acids, and steroids. We conclude that urinary metabolites in children have substantial heritability, with similar estimates for amines and organic acids, and higher estimates for steroid hormones. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4

The Article related to steroid hormone organic acids urinary amines metabolomics, amines, children, classical twin design, heritability, metabolites, organic acids, steroid hormones, urine, Placeholder for records without volume info and other aspects.Synthetic Route of 473-81-4

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On August 31, 2022, Sun, Min-Fei; Xu, Youfu; Yuan, Jun-Jie; Fang, Wei-Jie published an article.COA of Formula: C3H6O4 The title of the article was Identification and characterization of chemical and physical stability of insulin formulations utilizing degraded glycerol after repeated use and storage. And the article contained the following:

Insulin treatment is currently considered to be the main strategy for controlling diabetes. Although the recombinant insulin formulation is relatively mature, we found that a batch of insulin formulation exhibited an unusual degradation rate in the stability experiment The main purposes of this article are to identify the root cause for this phenomenon and characterize of chem. and phys. degradation products. We compared the chem. and phys. stability of two batches of insulin formulations prepared sep. with simulated repeated use and freshly opened glycerol. The chem. stability of insulin was identified by liquid chromatog. coupled with tandem mass spectrometry (LC- MS/MS). Micro-flow imaging (MFI), far-UV CD (Far-UV CD) and Thioflavin T (ThT) fluorescent assays were used to reveal protein aggregation and fibrosis. The chem. and phys. stability of the insulin formulation with newly opened glycerol was much better than that with degraded glycerol, and both groups of formulations were extremely sensitive to light. The results indicated that the original batch insulin formulation with abnormal stability was indeed caused by the excipient glycerol after long-term storage and repeated usage. More attention should be paid to the quality changes of excipients during repeated usage and storage of excipients for the practical purpose. Moreover, we have discovered a novel degradation pathway for insulin and peptides in general. In addition, LC-MS/MS results suggested that the N-terminus of insulin B-chain was prone to chem. degradation which enlightens that it could be potentially modified to improve the stability of insulin formulations. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).COA of Formula: C3H6O4

The Article related to chem phys stability insulin formulation glycerol, formulation, glycerol, insulin, lc-ms/ms, stability, stress test, sub-visible particle, Pharmaceuticals: Formulation and Compounding and other aspects.COA of Formula: C3H6O4

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On March 22, 2022, Murthy, Palle Ramana; Selvam, Parasuraman published an article.Quality Control of 2,3-Dihydroxypropanoic acid The title of the article was Ordered Mesoporous Carbon-supported Morphologically-controlled Nano-Gold: Role of Support as well as the Shape and Size of Gold Nanoparticles on the Selective Oxidation of Glycerol. And the article contained the following:

Glyceric acid is one of the important intermediates of glycerol oxidation However, it is extremely difficult to achieve high glyceric acid selectively as the reaction follows a complex pathway with the formation of a variety of undesired products. In this context, periodic mesoporous carbon-supported gold catalysts show promise for selective formation of the targeted product. Therefore, in this investigation, an effort has made to study the effect of particle size and shape of a series of carbon supported with varied sized/shaped gold catalysts on the liquid-phase oxidation of glycerol. Further, the role played by the surface of gold-nanoparticles has prompted us to investigate in detail the isotropic (nanocube/nanosphere) and anisotropic (nanoslabs/nanorods) gold supported onto both activated/amorphous carbon (Au/AC) and ordered mesoporous carbon (Au/CMK-3) towards glycerol oxidation It was observed that the CMK-3 supported gold nanocube exhibited the highest yield towards glyceric acid with an excellent stability in terms of recyclability/reusability. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Quality Control of 2,3-Dihydroxypropanoic acid

The Article related to gold nanoparticle carbon glycerol selective oxidation morphol, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Quality Control of 2,3-Dihydroxypropanoic acid

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On March 31, 2022, Ji, Jiacheng; Zhang, Shuo; Tang, Li; Zhang, Min; Yuan, Minyan; Wang, Pengjiao; Gao, Xiuli published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Integrative analysis of fecal metabolome and gut microbiota in high-fat diet-induced hyperlipidemic rats treated with Rosa Roxburghii Tratt juice. And the article contained the following:

The fruit of Rosa Roxburghii Tratt (RRT) is edible and has been considered as a medicinal fruit with a lipid-lowering effect, but the mechanism is still unclear. In this study, we integrated the results of 16S rRNA gene sequence and fecal metabolome to explore the potential mechanisms of RRTJ treatment in hyperlipidemia. The result suggests the useful effects of RRT juice (RRTJ) in hyperlipidemic rats. The 12 wk of RRT juice (RRTJ) treatment decreased serum lipids, fat accumulation, body weight and liver weight RRTJ treatment reversed the HFD-induced gut dysbiosis by lowering Dorea, Coprobacillus abundance and enriching Bifidobacterium, Roseburia abundance. Also, we conducted a targeted metabolic profile anal. of 160 metabolites in feces and 19 feces metabolites have significant changes. Correlation analyzes suggest that the reductions in serum lipids by RRTJ are associated with the gut microbial community (Dorea, Coprobacillus and Roseburia, Bifidobacterium) and their associated metabolites (palmitoleic acid, succinic acid, propionic acid, Glyceric acid). In conclusion, the 12 wk of treatment with RRT juice (RRTJ) can regulate dyslipidemia by improving intestinal microbiota disorders and related metabolites disorders. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to fecal metabolome gut microbiota high fat diet hyperlipidemic rat, rosa roxburghii tratt juice, Animal Nutrition: Carbohydrates, Fiber, and Energy and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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On November 1, 2022, Apriyanto, Ardha; Compart, Julia; Zimmermann, Vincent; Alseekh, Saleh; Fernie, Alisdair R.; Fettke, Joerg published an article.Computed Properties of 473-81-4 The title of the article was Indication that starch and sucrose are biomarkers for oil yield in oil palm (Elaeis guineensis Jacq.). And the article contained the following:

Oil palm (Elaeis guineensis Jacq.) is the most productive oil-producing crop per ha of land. The oil that accumulates in the mesocarp tissue of the fruit is the highest observed among fruit-producing plants. A comparative anal. between high-, medium-, and low-yielding oil palms, particularly during fruit development, revealed unique characteristics. Metabolomics anal. was able to distinguish accumulation patterns defining of the various developmental stages and oil yield. Interestingly, high- and medium-yielding oil palms exhibited substantially increased sucrose levels compared to low-yielding palms. In addition, parameters such as starch granule morphol., granule size, total starch content, and starch chain length distribution (CLD) differed significantly among the oil yield categories with a clear correlation between oil yield and various starch parameters. These results provide new insights into carbohydrate and starch metabolism for biosynthesis of oil palm fruits, indicating that starch and sucrose can be used as novel, easy-to-analyze, and reliable biomarker for oil yield. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to starch sucrose biomarker oil palm elaeis metabolism, carbohydrate, mesocarp, metabolites, oil palm, oil yield, starch, sucrose, Food and Feed Chemistry: Fats, Oils, and Margarine and other aspects.Computed Properties of 473-81-4

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On October 15, 2022, Michailidis, Michail; Titeli, Vaia Styliani; Karagiannis, Evangelos; Feidaki, Kyriaki; Ganopoulos, Ioannis; Tanou, Georgia; Argiriou, Anagnostis; Molassiotis, Athanassios published an article.Name: 2,3-Dihydroxypropanoic acid The title of the article was Tissue-specific transcriptional analysis outlines calcium-induced core metabolic changes in sweet cherry fruit. And the article contained the following:

The role of calcium in fruit ripening has been established, however knowledge regarding the mol. anal. at fruit tissue-level is still lacking. To address this, we examined the impact of foliar-applied calcium (0.5% CaCl2) in the ripening metabolism in skin and flesh tissues of the sweet cherry ‘Tragana Edessis’ fruit at the harvest stage. Exogenously applied calcium increased endogenous calcium level in flesh tissue and reduced fruit respiration rate and cracking traits. Fruit metabolomic along with transcriptomic anal. unraveled common and tissue-specific metabolic pathways associated with calcium feeding. Treatment with calcium diminished several alcs. (arabitol, sorbitol), sugars (fructose, maltose), acids (glyceric acid, threonic acid) and increased ribose and proline in both fruit tissues. Moreover, numerous primary metabolites, such as proline and galacturonic acid, were differentially accumulated in calcium-exposed tissues. Calcium-affected genes that involved in ubiquitin/ubl conjugation and cell wall biogenesis/degradation were differentially expressed between skin and flesh samples. Notably, skin and flesh tissues shared common calcium-responsive genes and exhibited substantial similarity in their expression patterns. In both tissues, calcium activated gene expression, most strongly those involved in plant-pathogen interaction, plant hormone signaling and MAPK signaling pathway, thus affecting related metabolic processes. By contrast, calcium depressed the expression of genes related to TCA cycle, oxidative phosphorylation, and starch/sucrose metabolism in both tissues. This work established both calcium-driven common and specialized metabolic suites in skin and flesh cherry tissues, demonstrating the utility of this approach to characterize fundamental aspects of calcium in fruit physiol. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid

The Article related to sweet cherry fruit calcium metabolic change tissue transcriptional analysis, calcium, flesh and skin tissues, metabolomic, sweet cherry fruit, transcriptomic, Plant Biochemistry: Classical Genetics and Phylogeny and other aspects.Name: 2,3-Dihydroxypropanoic acid

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