Category: 473-81-4

Zhao, Shuang; Fu, Haoshuang; Zhou, Tianhui; Cai, Minghao; Huang, Yan; Gan, Qinyi; Zhang, Chenxi; Qian, Cong; Wang, Jiexiao; Zhang, Zhenglan; Wang, Xiaolin; Xiang, Xiaogang; Xie, Qing published an article in 2022, the title of the article was Alteration of bile acids and omega-6 PUFAs are correlated with the progression and prognosis of drug-induced liver injury.Electric Literature of 473-81-4 And the article contains the following content:

Drug-induced liver injury (DILI) is one of the leading causes of liver failure with some of the patients progressed to chronic DILI. The mechanisms underlying the severity and chronicity of DILI are poorly elucidated and the biomarkers are limited. Metabolites and gut microbiota played a crucial role in the development of various liver diseases. Herein, a systematic anal. of serum metabolites and gut microbiota was performed in DILI patients, aiming to identify metabolites correlated with the progression and clin. prognosis of DILI. Various serum metabolites were quantitated using a metabolite array technol. in this prospective study. Gut microbiome compositions and the expression profiles of liver genes were determined in patients with DILI and healthy controls. Metabolomic anal. revealed that bile acids (BAs) and polyunsaturated fatty acids (PUFAs) were closely related to DILI severity and chronicity resp. The ratios of serum primary/secondary BAs and omega-6/omega-3 PUFAs were elevated in DILI patients. A model established by adrenic acid (AdA) and aspartic acid (Asp) exerts good performance for predicting the chronicity of DLIL. Hepatic transcriptome revealed enhanced expression of PUFA peroxidation and suppressed expression of BA synthesis related genes in DILI patients. In addition, Lactic acid bacteria and BA converting bacteria were increased in gut of DILI patients. Besides, elevated serum malondialdehyde (MDA) and fibroblast growth factor 19 (FGF19) was observed in DILI patients. BAs and PUFAs could be potent markers for the severity and chronicity of DILI resp. The panel of AdA and Asp could be ideal predictive model for the risk of chronicity at the acute stage of DILI. Gut microbiota might act as a neg. feedback mechanism to maintain the homeostasis of BAs and PUFAs via FGF19 signalling and PUFA saturation, resp. Our study revealed novel biomarkers for severe and chronic DILI and provided new therapeutic targets for DILI. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Electric Literature of 473-81-4

The Article related to bile acid pufa drug induced liver injury progression prognosis, bas, dili, pufas, chronicity, gut microbiota, Placeholder for records without volume info and other aspects.Electric Literature of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 1, 2022, Yadav, Renu; Saini, Rashmi; Adhikary, Arindam; Kumar, Sanjeev published an article.Related Products of 473-81-4 The title of the article was Unravelling cross priming induced heat stress, combinatorial heat and drought stress response in contrasting chickpea varieties. And the article contained the following:

Drought and high temperature stress affect chickpea growth and productivity. Often these stresses occur simultaneously in the field and lead to a wide range of mol. and metabolic adaptations. Two chickpea varieties; GPF2 (heat sensitive) and PDG4 variety (heat tolerant) were exposed to 35 °C for 24 h individually and along with drought stress. Five heat responsive signalling genes and 11 structural genes were analyzed using qPCR along with untargeted metabolites anal. using GC MS. Expression of antioxidant genes (CaSOD and CaGPX, CaAPX and CaCAT), transcription factors (CaHSFB2, CaHSFB2A, CaHSFB2B, CaHSP17.5 and CaHSP22.7) and signalling genes (CaCAM, CaGAD, and CaMAPK) were upregulated in GPF2 as compared to PDG4 variety. Principal component anal. (PCA), partial least-square discriminant anal. (PLS-DA), and heat map anal. were applied to the metabolomics data to identify the differential response of metabolites in two chickpea varieties. GC-MS anal. identified 107 and 83 metabolites in PDG4 and GPF2 varieties resp. PDG4 variety accumulated more sugars, amino acids, sugar alcs., TCA cycle intermediates which provided heat resistance. Addnl., the differential metabolic pathways involved in heat tolerance were alanine, aspartate, and glutamate metabolism, pantothenate CoA biosynthesis, fructose and mannose metabolism and pentose phosphate pathway in PDG4 variety. There was less accumulation of metabolites in the primed plants of both varieties as compared to the non-primed plants indicating less damage due to heat stress. The present study gives an overview of the mol. changes occurring in response to heat stress in sensitive and tolerant chickpea. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4

The Article related to cicer drought leaf mannonic amino fatty acid, chickpea, gc-ms, gene expression, heat stress, metabolites, real time pcr, tolerance, Placeholder for records without volume info and other aspects.Related Products of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Buszewska-Forajta, Magdalena; Raczak-Gutknecht, Joanna; Struck-Lewicka, Wiktoria; Niziol, Magdalena; Artymowicz, Malgorzata; Markuszewski, Marcin; Kordalewska, Marta; Matuszewski, Marcin; Markuszewsk, Michal J. published an article in 2022, the title of the article was Untargeted metabolomics study of three matrices: seminal fluid, urine, and serum to search the potential indicators of prostate cancer.Recommanded Product: 2,3-Dihydroxypropanoic acid And the article contains the following content:

The simultaneous determination of metabolites from biol. fluids may provide more accurate information about the current body condition. So far, the metabolomics approach has been successfully applied to study the mechanism of several disorders and to search for novel biomarkers. Urine and plasma are widely accepted matrixes for the evaluation of several pathologies, while prostate cancer (CaP) development is still unknown. For this reason, an alternative matrix, the seminal fluid, was proposed to expand the knowledge about the CaP pathomechanism. The main aim of this study was to develop and optimize the sample preparation protocol to ensure the highest coverage of the metabolome of ejaculate samples. Parameters like the type and composition of the solvent mixture, time of extraction, and applied volume of the solvent were tested. The optimized method was applied for the untargeted metabolomics profiling of seminal fluid samples obtained from CaP patients. Moreover, urine and serum samples were also prepared for untargeted metabolomics anal. Analyses were carried out with the use of two complementary anal. techniques: GC-EI-QqQ/MS and LC-ESI-TOF/MS. Finally, the metabolic signature of seminal fluid (n = 7), urine (n = 7), and plasma (n = 7) samples was compared. Furthermore, the hypothesis of the increased level of metabolites in ejaculate samples related to the CaP development was evaluated. The results indicated that the developed and optimized sample preparation protocol for seminal fluid may be successfully applied for metabolomics study. Untargeted anal. of ejaculate enabled to determine the following classes of compounds: fatty acids, sphingolipids, phospholipids, sugars, and their derivatives, as well as amino acids. Finally, a comparison of the three tested matrixes was carried out. To our best knowledge, it is the first time when the metabolic profile of the three matrixes, namely, urine, plasma, and seminal fluid, was compared. Based on the results, it can be pointed out that ejaculate comprises the metabolic signature of both matrixes (polar compounds characteristic for urine, and nonpolar ones present in plasma samples). Compared to plasma, semen samples revealed to have a similar profile; however, determined levels of metabolites were lower in case of ejaculate. In case of urine samples, compared to semen metabolic profiles, the levels of detected metabolites were decreased in the latter ones. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to seminal fluid urine serum prostate cancer metabolomic analysis, hplc, metabolites, metabolomics, plasma, prostate cancer, seminal fluid, urine, Placeholder for records without volume info and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Farag, Mohamed A.; Kabbash, Eman M.; Mediani, Ahmed; Doll, Stefanie; Esatbeyoglu, Tuba; Afifi, Sherif M. published an article in 2022, the title of the article was Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC-MS and GC-MS and Chemometric Tools.Safety of 2,3-Dihydroxypropanoic acid And the article contains the following content:

The present study aimed to assess metabolites heterogeneity among four major Cinnamomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cassia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocyanidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum vs. procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS anal. encompassing different classes, viz. sugars, fatty acids, and sugar alcs., with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Safety of 2,3-Dihydroxypropanoic acid

The Article related to cinnamomum phenolic acid tannin flavonoid lignan glycerol erythritol, cinnamomum, chemometrics, erythritol, metabolomics, proanthocyanidin, Placeholder for records without volume info and other aspects.Safety of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 30, 2022, Ijaz, Muawuz; Zhang, Dequan; Hou, Chengli; Mahmood, Mubarik; Hussain, Zubair; Zheng, Xiaochun; Li, Xin published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Changes in postmortem metabolites profile of atypical and typical DFD beef. And the article contained the following:

This study explored the changes in postmortem metabolites of atypical and typical DFD beef using UHPLC-Q-TOF/MS. The longissimus thoracis muscles were categorized into normal, atypical DFD and typical DFD groups. The L*, a*, b*, glycogen and lactic acid contents were lower (P < 0.05) in typical DFD than normal beef. A total of 240 compounds were significantly different among groups. Levels of glycerol-3-phosphate, D-ribose-5-phosphate, D-glucose-6-phosphate, D-fructose-6-phosphate, alpha-D-glucose-1-phosphate and dihydroxyacetone phosphate were higher in atypical DFD than those in the normal and typical DFD beef and the contents of 9 amino acids were elevated in typical DFD. KEGG anal. showed that metabolomic changes were primarily related with ATP-binding cassette transporters, metabolism of purine, central carbon, glycine, serine and threonine, biosynthesis of aminoacyl-tRNA, digestion and absorption of proteins, metabolism of amino sugar and nucleotide sugar, pyrimidine, bile secretion and galactose. In conclusion, development of atypical and typical DFD meat results in differences at level of postmortem metabolite concentrations of different metabolic pathways. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to beef atypical typical dark firm dry postmortem metabolite profile, beef, biochemical basis, dfd, non-targeted metabolomics, uhplc q-tof/ms, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, Lee, Hyun-Jong; Kim, Mi-Ja published an article.Synthetic Route of 473-81-4 The title of the article was Metabolites of oregano (Origanum vulgare) seed and their anti-obesity effects on 3T3-L1 adipocytes through down-regulated adipogenesis. And the article contained the following:

Metabolites of the 80% ethanol extract (OSE) and Et acetate fraction (OSEA) of oregano seed were analyzed by GC-MS, and anti-obesity effects of OSE and OSEA were evaluated in 3T3-L1 adipocyte. OSE possessed high content of glucose, fructofuranose, and sucrose while OSEA had high content of phenolic chems. OSEA contained higher levels of gallic acid, syringic acid, protocatechuic acid, and catechin than OSE. OSEA inhibited lipid droplet accumulation with concentration dependent manner in 3T3-L1 preadipocytes during differentiation. OSEA showed more inhibition ability than OSE by 13.7-fold at the level of 125 μg/mL. Addnl., relative mRNA and protein expression levels of pparγ, c/ebpα, fas, and srebp-1c which are related to adipogenesis were significantly lower in OSEA treatment group than in OSE treatment group (p < 0.05). Therefore, OSEA could be used as anti-obesity functional ingredient. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4

The Article related to origanum vulgare seed metabolite adipocyte adipogenesis antiobesity effect, anti-obesity, antioxidant, metabolite, oregano seed, spice, Placeholder for records without volume info and other aspects.Synthetic Route of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 30, 2022, Balic, Ivan; Olmedo, Patricio; Zepeda, Baltasar; Rojas, Barbara; Ejsmentewicz, Troy; Barros, Miriam; Aguayo, Daniel; Moreno, Adrian A.; Pedreschi, Romina; Meneses, Claudio; Campos-Vargas, Reinaldo published an article.Product Details of 473-81-4 The title of the article was Metabolomic and biochemical analysis of mesocarp tissues from table grape berries with contrasting firmness reveals cell wall modifications associated to harvest and cold storage. And the article contained the following:

Tissue texture influences the grape berry consumers acceptance. We studied the biol. differences between the inner and outer mesocarp tissues in hard and soft berries of table grapes cv NN107. Texture anal. revealed lower levels of firmness in the inner mesocarp as compared with the outer tissue. HPAEC-PAD anal. showed an increased abundance of cell wall monosaccharides in the inner mesocarp of harder berries at harvest. Immunohistochem. anal. displayed differences in homogalacturonan methylesterification and cell wall calcium between soft and hard berries. This last finding correlated with a differential abundance of calcium measured in the alc.-insoluble residues (AIR) of the inner tissue of the hard berries. Anal. of abundance of polar metabolites suggested changes in cell wall carbon supply precursors, providing new clues in the identification of the biochem. factors that define the texture of the mesocarp of grape berries. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Product Details of 473-81-4

The Article related to table grape mesocarp cell wall metabolomic harvest cold storage, calcium, pectin, polar metabolites, texture, vitis vinifera, Placeholder for records without volume info and other aspects.Product Details of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 1, 2022, Oberschelp, Gustavo Pedro Javier; Morales, Luisina Lourdes; Montecchiarini, Marina Lucia; Harrand, Leonel; Podesta, Florencio Esteban; Margarit, Ezequiel published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Harder, better, faster, stronger: Frost tolerance of Eucalyptus benthamii under cold acclimation. And the article contained the following:

Eucalypts are the most planted hardwood trees worldwide because of their very rapid growth, exceptional wood quality and adaptability. However, most com. species and derived hybrids are sensitive to frost, which remains as the largest obstacle to their introduction in warm/temperate climates. As evergreen species, Eucalypts have developed the ability to tolerate frost events based on physiol. and mol. responses triggered by previous exposure to cold temperatures, globally named cold acclimation. To characterize the acclimation process in two species with different tolerance to frost, E. grandis (Eg) and E. benthamii (Eb), seedlings were exposed for different times to low temperatures Frost tolerance was estimated in leaves by an electrolyte leakage assay, and metabolome and morpho-physiol. changes studied and correlated to the observed acclimation responses. Eb showed higher basal frost tolerance and an earlier and stronger acclimation response to cold temperatures than in the frost sensitive Eg. Eb was able to modify several morpho-physiol. parameters, with a restriction in plant height, leaf area and leaf fresh weight during acclimation. Metabolome characterization allowed us to differentiate species and strengthen our understanding of their acclimation response dynamics. Interestingly, Eb displayed an early phase of sugar accumulation followed by a rise of different metabolites with possible roles as osmolytes and antioxidants, that correlated to frost tolerance and may explain Eb higher capacity to acclimate. This novel approach has helped us to point to the main metabolic processes underlying the cold tolerance acquisition process in two relevant Eucalyptus species. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to eucalyptus benthamii frost tolerance cold acclimation, acclimation, cold, eucalyptus, freezing, metabolomics, tolerance, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, Lee, Jang-Eun; Yun, Jeong-Hyun; Lee, Eunjung; Hong, Sang Pil published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Untargeted Metabolomics reveals Doenjang metabolites affected by manufacturing process and microorganisms. And the article contained the following:

Doenjang is a traditional Korean fermented soybean-based food that is now produced industrially as traditional Doenjang and modernized Doenjang, depending on the conditions of the manufacturing process. In this study, the effect of the production process on Doenjang metabolites was analyzed using untargeted capillary electrophoresis time-of-flight mass spectrometry (CE-TOF/MS). Of the 247 metabolites detected in 19 traditional and three modernized Doenjang samples, the level of 55 metabolites were significantly different between the two production groups. The S-plot of the orthogonal projection to latent structures-discriminant anal. (OPLS-DA) revealed that nine compounds (tryptamine, 2-phenylethylamine, citrulline, gamma-aminobutyric acid, putrescine, tyramine, 2-aminoisobutyric acid, stachydrine, and N5-ethylglutamine) were highly distributed in the traditional group, and six compounds (arginine, citric acid, choline, cytidine, hypoxanthine, and glucaric acid) were considered distinguishable metabolites of the modernized group. Microbial community anal. indicated that the levels of these metabolites were significantly altered by the presence of Bacillus spp., Enterococcus faecium, Tetragenococcus halophilus, Aspergillus oryzae, Penicillium spp., and Saccharomyces cerevisiae. These findings will give better understanding of the influence of the manufacturing process on Doenjang production in terms of both microbial activity and metabolite profiles. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to doenjang metabolite manufacturing process microorganism metabolomics, ce-tof/ms, doenjang, metabolite, microbial community, untargeted metabolomics, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Manting; Cai, Bolin; Kong, Shaofen; Zhou, Zhen; Zhang, Jing; Zhang, Xiquan; Nie, Qinghua published an article in 2022, the title of the article was PPARGC1A Is a Moderator of Skeletal Muscle Development Regulated by miR-193b-3p.Application In Synthesis of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Meat production performance is one of the most important factors in determining the economic value of poultry. Myofiber is the basic unit of skeletal muscle, and its phys. and chem. properties determine the meat quality of livestock and poultry to a certain extent. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) as a transcriptional coactivator has been found to be widely involved in a series of biol. processes. However, PPARGC1A is still poorly understood in chickens. In this manuscript, we reported that PPARGC1A was highly expressed in slow-twitch myofibers. PPARGC1A facilitated mitochondrial biogenesis and regulated skeletal muscle metabolism by mediating the flux of glycolysis and the TCA cycle. Gain- and loss-of-function analyses revealed that PPARGC1A promoted i.m. fatty acid oxidation, drove the transformation of fast-twitch to slow-twitch myofibers, and increased chicken skeletal muscle mass. Mechanistically, the expression level of PPARGC1A is regulated by miR-193b-3p. Our findings help to understand the genetic regulation of skeletal muscle development and provide a mol. basis for further research on the antagonism of skeletal muscle development and fat deposition in chickens. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to skeletal muscle development microrna genetic regulation, ppargc1a, mir-193b-3p, mitochondrial biogenesis, muscle metabolism, skeletal muscle development, Placeholder for records without volume info and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts