Category: 473-81-4

Zhao, Shuang; Fu, Haoshuang; Zhou, Tianhui; Cai, Minghao; Huang, Yan; Gan, Qinyi; Zhang, Chenxi; Qian, Cong; Wang, Jiexiao; Zhang, Zhenglan; Wang, Xiaolin; Xiang, Xiaogang; Xie, Qing published an article in 2022, the title of the article was Alteration of bile acids and omega-6 PUFAs are correlated with the progression and prognosis of drug-induced liver injury.Electric Literature of 473-81-4 And the article contains the following content:

Drug-induced liver injury (DILI) is one of the leading causes of liver failure with some of the patients progressed to chronic DILI. The mechanisms underlying the severity and chronicity of DILI are poorly elucidated and the biomarkers are limited. Metabolites and gut microbiota played a crucial role in the development of various liver diseases. Herein, a systematic anal. of serum metabolites and gut microbiota was performed in DILI patients, aiming to identify metabolites correlated with the progression and clin. prognosis of DILI. Various serum metabolites were quantitated using a metabolite array technol. in this prospective study. Gut microbiome compositions and the expression profiles of liver genes were determined in patients with DILI and healthy controls. Metabolomic anal. revealed that bile acids (BAs) and polyunsaturated fatty acids (PUFAs) were closely related to DILI severity and chronicity resp. The ratios of serum primary/secondary BAs and omega-6/omega-3 PUFAs were elevated in DILI patients. A model established by adrenic acid (AdA) and aspartic acid (Asp) exerts good performance for predicting the chronicity of DLIL. Hepatic transcriptome revealed enhanced expression of PUFA peroxidation and suppressed expression of BA synthesis related genes in DILI patients. In addition, Lactic acid bacteria and BA converting bacteria were increased in gut of DILI patients. Besides, elevated serum malondialdehyde (MDA) and fibroblast growth factor 19 (FGF19) was observed in DILI patients. BAs and PUFAs could be potent markers for the severity and chronicity of DILI resp. The panel of AdA and Asp could be ideal predictive model for the risk of chronicity at the acute stage of DILI. Gut microbiota might act as a neg. feedback mechanism to maintain the homeostasis of BAs and PUFAs via FGF19 signalling and PUFA saturation, resp. Our study revealed novel biomarkers for severe and chronic DILI and provided new therapeutic targets for DILI. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Electric Literature of 473-81-4

The Article related to bile acid pufa drug induced liver injury progression prognosis, bas, dili, pufas, chronicity, gut microbiota, Placeholder for records without volume info and other aspects.Electric Literature of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, de Falco, Bruna; Grauso, Laura; Fiore, Alberto; Bonanomi, Giuliano; Lanzotti, Virginia published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Metabolomics and chemometrics of seven aromatic plants: Carob, eucalyptus, laurel, mint, myrtle, rosemary and strawberry tree. And the article contained the following:

Arbutus unedo L. (strawberry tree), Ceratonia siliqua L. (carob), Eucalyptus camaldulensis Dehnh. (eucalyptus), Laurus nobilis L. (laurel), Mentha aquatica L. (water mint), Myrtus communis L. (common myrtle), and Rosmarinus officinalis L. (rosemary) are aromatic plants from the Mediterranean region whose parts and preparations are used for their nutritional properties and health benefits. To evaluate and compare the metabolites profile, total phenol content (TPC), and antioxidant activity of plant leaves for their future use. Gas chromatog.-mass spectrometry (GC-MS) was used for metabolomics. Data comparison was performed by chemometrics. Polar and apolar extracts were analyzed using untargeted GC-MS metabolomics followed by chemometrics (principal component anal., heatmap correlation and dendrogram) to identify, quantify and compare the major organic compounds in the plants. Addnl., NMR (NMR) spectroscopy was used for the laurel polar extract to identify D-gluco-L-glycero-3-octulose whose presence was unclear from the GC-MS data. TPC and antioxidant assays were performed using classical methods (Folin-Ciocalteu, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH)) and correlated to the phytochem. profiles. Forty-three metabolites were identified including amino acids, organic acids, carbohydrates, phenols, polyols, fatty acids, and alkanes. Eight metabolites (D-fructose, D-glucose, D-mannose, gallic acid, quinic acid, myo-inositol, palmitic and stearic acids) were in common between all species. D-Gluco-L-glycero-3-octulose (37.29 ± 1.19%), D-pinitol (31.33 ± 5.12%), and arbutin (1.30 ± 0.44%,) were characteristic compounds of laurel, carob, and strawberry tree, resp. Carob showed the highest values of TPC and antioxidant activity. GC-MS metabolomics and chemometrics analyses are fast and useful methods to determine and compare the metabolomics profiling of aromatic plants of food and industrial interest. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to arbutus ceratonia eucalyptus laurus mentha chemometrics metabolomics, gc-ms, nmr, pca, dendrogram, heatmap, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bu, Ting; Zhang, Ming; Lee, Sun-Hee; Cheong, Yu Eun; Park, Yukyung; Kim, Kyoung Heon; Kim, Dongwon; Kim, Sooah published an article in 2022, the title of the article was GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types.Reference of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Skin has heterogenous identities on different body sites despite similar cellular compositions There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these different skin types remain unclear. To investigate these, we profiled the cellular metabolites of volar and non-volar skin in mice using gas chromatog.-time-of-flight/mass spectrometry (GC-TOF/MS), and further assessed the metabolic differences between them. In total, 96 metabolites from both volar and non-volar skin of mice were identified using the BinBase database system. Metabolomics anal. revealed important differences associated with amino acid metabolism (phenylalanine, tyrosine, and tryptophan biosynthesis; aspartate and glutamate metabolism), sugar metabolism (pentose phosphate pathway), and nucleotide metabolism (pyrimidine metabolism) in volar skin. Fifty metabolites were identified as potential biomarkers differentiating the physiol. characteristics of these skin types. Of these, nine were highly increased whereas 41 were significantly decreased in volar skin compared with those in non-volar skin. Overall, these results provide valuable information for understanding the metabolic differences between volar and non-volar skin. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to volar nonvolar skin metabolomics gctof ms, gc-tof/ms, metabolomic analysis, non-volar skin, volar skin, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shukla, Ila; Azmi, Lubna; Rao, Ch. V.; Jawaid, Talha; Kamal, Mehnaz; Alkhamees, Osama A.; Alaseem, Ali M.; Alsanad, Saud M. published an article in 2022, the title of the article was Inclusive roles of protocetraric acid, a secondary metabolite from the common green shield lichen Flavoparmelia caperata in alcohol-induced hepatic injury.Safety of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Flavoparmelia caperata belongs to the family Parmeliaceae which is a huge family of lichens and comprises of species that draw much attention about pharmacol. activities. Several medicinally important compounds have been reported in this lichen. Protocetraric acid is among the major metabolites possessed by this lichen. Hence, the present study is designed to look into the more inclusive role of protocetraric acid in case of alc.-induced hepatotoxicity in rats. Thirty rats were randomly divided into six groups: Group 1 served as the control group, Group 2 received ethanol, Group 3 received F. caperata ethanolic extract (FCE) 50 mg/kg, Group 4 received FCE 100 mg/kg, Group 5 received FCE 200 mg/kg and Group 6 received Liv.52 (Standard drug). At the end of the experiment, biochem. parameters, oxidative stress markers, inflammatory mediators, caspase-3 and 8 activities were studied. The liver tissues were further examined histopathol. for localization of areas of severe hepatotoxicity. Cell viability was determined by using the MTT assay in MCF-7 and HepG2 cells. Moreover, FCE increased cell viability. Protocetraric acid, erythritol, and myo-inositol were detected in GC-MS anal. The outcomes of this study reveal that FCE may prove to be supportive in the treatment of alc.-induced hepatotoxicity and oxidative stress. Results of different markers have revealed that among all, FCE (100 mg/kg) has demonstrated the best hepatoprotective activity. It also ameliorated the morphol. changes induced by alc. These observations speak about the significance of the components of the lichen extract The corrective action of FCE in alc.-induced liver damage may be due to its antioxidant, anti-inflammatory, and anti-apoptotic activities. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Safety of 2,3-Dihydroxypropanoic acid

The Article related to flavoparmelia caperata alc protocetraric acid secondary metabolite hepatic injury, Placeholder for records without volume info and other aspects.Safety of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 13, 2022, Cechanaviciute, Ieva A.; Bobrowski, Tim; Jambrec, Daliborka; Krysiak, Olga A.; Brix, Ann Cathrin; Braun, Michael; Quast, Thomas; Wilde, Patrick; Morales, Dulce M.; Andronescu, Corina; Schuhmann, Wolfgang published an article.Category: alcohols-buliding-blocks The title of the article was Aerosol-Based Synthesis of Multi-metal Electrocatalysts for Oxygen Evolution and Glycerol Oxidation. And the article contained the following:

Discovery of new catalysts is crucial for future growth and development of environmentally friendly energy conversion processes e. g. the production of hydrogen by water electrolysis. We developed an aerosol-based synthesis technique as a comparatively fast and facile method to prepare multi-metal catalysts. 22 different quinary metal compositions were synthesized and investigated with respect to their activity for the oxygen evolution (OER) and the glycerol oxidation (GOR) reactions. The impact of the element composition and the homogeneous distribution of the elements in the particles on catalytic performance were evaluated. The highest activity for OER was found for Co20Cu20Ni20Fe20Zn20. For GOR, Ag-containing catalysts were the most active, however, in most cases Ag was locally enriched and not homogeneously mixed with the other metals in the particles. Ag-based catalysts outperformed similar compositions containing one or more noble metals. The GOR selectivity of selected catalysts during long-term electrolysis was also investigated and it was shown that varying the catalyst composition via aerosol-based synthesis is a potential way to modulate the GOR selectivity. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to aerosol multi metal electrocatalyst oxygen evolution glycerol oxidation reaction, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 13, 2022, Cechanaviciute, Ieva A.; Bobrowski, Tim; Jambrec, Daliborka; Krysiak, Olga A.; Brix, Ann Cathrin; Braun, Michael; Quast, Thomas; Wilde, Patrick; Morales, Dulce M.; Andronescu, Corina; Schuhmann, Wolfgang published an article.Category: alcohols-buliding-blocks The title of the article was Aerosol-Based Synthesis of Multi-metal Electrocatalysts for Oxygen Evolution and Glycerol Oxidation. And the article contained the following:

Discovery of new catalysts is crucial for future growth and development of environmentally friendly energy conversion processes e. g. the production of hydrogen by water electrolysis. We developed an aerosol-based synthesis technique as a comparatively fast and facile method to prepare multi-metal catalysts. 22 different quinary metal compositions were synthesized and investigated with respect to their activity for the oxygen evolution (OER) and the glycerol oxidation (GOR) reactions. The impact of the element composition and the homogeneous distribution of the elements in the particles on catalytic performance were evaluated. The highest activity for OER was found for Co20Cu20Ni20Fe20Zn20. For GOR, Ag-containing catalysts were the most active, however, in most cases Ag was locally enriched and not homogeneously mixed with the other metals in the particles. Ag-based catalysts outperformed similar compositions containing one or more noble metals. The GOR selectivity of selected catalysts during long-term electrolysis was also investigated and it was shown that varying the catalyst composition via aerosol-based synthesis is a potential way to modulate the GOR selectivity. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to aerosol multi metal electrocatalyst oxygen evolution glycerol oxidation reaction, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shukla, Ila; Azmi, Lubna; Rao, Ch. V.; Jawaid, Talha; Kamal, Mehnaz; Alkhamees, Osama A.; Alaseem, Ali M.; Alsanad, Saud M. published an article in 2022, the title of the article was Inclusive roles of protocetraric acid, a secondary metabolite from the common green shield lichen Flavoparmelia caperata in alcohol-induced hepatic injury.Safety of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Flavoparmelia caperata belongs to the family Parmeliaceae which is a huge family of lichens and comprises of species that draw much attention about pharmacol. activities. Several medicinally important compounds have been reported in this lichen. Protocetraric acid is among the major metabolites possessed by this lichen. Hence, the present study is designed to look into the more inclusive role of protocetraric acid in case of alc.-induced hepatotoxicity in rats. Thirty rats were randomly divided into six groups: Group 1 served as the control group, Group 2 received ethanol, Group 3 received F. caperata ethanolic extract (FCE) 50 mg/kg, Group 4 received FCE 100 mg/kg, Group 5 received FCE 200 mg/kg and Group 6 received Liv.52 (Standard drug). At the end of the experiment, biochem. parameters, oxidative stress markers, inflammatory mediators, caspase-3 and 8 activities were studied. The liver tissues were further examined histopathol. for localization of areas of severe hepatotoxicity. Cell viability was determined by using the MTT assay in MCF-7 and HepG2 cells. Moreover, FCE increased cell viability. Protocetraric acid, erythritol, and myo-inositol were detected in GC-MS anal. The outcomes of this study reveal that FCE may prove to be supportive in the treatment of alc.-induced hepatotoxicity and oxidative stress. Results of different markers have revealed that among all, FCE (100 mg/kg) has demonstrated the best hepatoprotective activity. It also ameliorated the morphol. changes induced by alc. These observations speak about the significance of the components of the lichen extract The corrective action of FCE in alc.-induced liver damage may be due to its antioxidant, anti-inflammatory, and anti-apoptotic activities. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Safety of 2,3-Dihydroxypropanoic acid

The Article related to flavoparmelia caperata alc protocetraric acid secondary metabolite hepatic injury, Placeholder for records without volume info and other aspects.Safety of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhanjiang; Shen, Guang; Yang, Yihua; Li, Cui; Chen, Xiaoying; Yang, Xiaonan; Guo, Xiaoyun; Miao, Jianhua; Li, Li; Lei, Ming published an article in 2022, the title of the article was Metabolic and Transcriptomic Analyses Reveal the Effects of Ethephon on Taraxacum kok-saghyz Rodin.Category: alcohols-buliding-blocks And the article contains the following content:

The roots of Taraxacum kok-saghyz Rodin (TKS) are well-known and valued for their rubber-producing ability. Therefore, research on the anal. and detection of metabolites from the roots of TKS have been reported in previous studies. However, all of these studies have the shortcoming of focusing on only the rubber of TKS, without profiling the other metabolites in a systematic and comprehensive way. Here, the primary and secondary metabolites from the leaves of TKS were investigated using UPLC-ESI-MS/MS, and a total of 229 metabolites were characterized. Carboxylic acid derivatives, fatty acyls, phenols, and organooxygen compounds were found to be the major metabolites of TKS. The transcriptome data indicated that ribosomal, glycolysis/gluconeogenesis, phenylpropanoid biosynthesis, and linoleic acid metabolism genes were significantly differentially expressed. This study is the first to report the differences in the metabolic and transcriptome profiles of TKS leaves under exogenous ethephon spray, which improves our understanding of the main metabolites and their mol. mechanisms in TKS leaves. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to taraxacum ethephon transcriptomic analyses, taraxacum kok-saghyz rodin, metabolomics, transcriptomics, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bu, Ting; Zhang, Ming; Lee, Sun-Hee; Cheong, Yu Eun; Park, Yukyung; Kim, Kyoung Heon; Kim, Dongwon; Kim, Sooah published an article in 2022, the title of the article was GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types.Reference of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Skin has heterogenous identities on different body sites despite similar cellular compositions There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these different skin types remain unclear. To investigate these, we profiled the cellular metabolites of volar and non-volar skin in mice using gas chromatog.-time-of-flight/mass spectrometry (GC-TOF/MS), and further assessed the metabolic differences between them. In total, 96 metabolites from both volar and non-volar skin of mice were identified using the BinBase database system. Metabolomics anal. revealed important differences associated with amino acid metabolism (phenylalanine, tyrosine, and tryptophan biosynthesis; aspartate and glutamate metabolism), sugar metabolism (pentose phosphate pathway), and nucleotide metabolism (pyrimidine metabolism) in volar skin. Fifty metabolites were identified as potential biomarkers differentiating the physiol. characteristics of these skin types. Of these, nine were highly increased whereas 41 were significantly decreased in volar skin compared with those in non-volar skin. Overall, these results provide valuable information for understanding the metabolic differences between volar and non-volar skin. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to volar nonvolar skin metabolomics gctof ms, gc-tof/ms, metabolomic analysis, non-volar skin, volar skin, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, de Falco, Bruna; Grauso, Laura; Fiore, Alberto; Bonanomi, Giuliano; Lanzotti, Virginia published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Metabolomics and chemometrics of seven aromatic plants: Carob, eucalyptus, laurel, mint, myrtle, rosemary and strawberry tree. And the article contained the following:

Arbutus unedo L. (strawberry tree), Ceratonia siliqua L. (carob), Eucalyptus camaldulensis Dehnh. (eucalyptus), Laurus nobilis L. (laurel), Mentha aquatica L. (water mint), Myrtus communis L. (common myrtle), and Rosmarinus officinalis L. (rosemary) are aromatic plants from the Mediterranean region whose parts and preparations are used for their nutritional properties and health benefits. To evaluate and compare the metabolites profile, total phenol content (TPC), and antioxidant activity of plant leaves for their future use. Gas chromatog.-mass spectrometry (GC-MS) was used for metabolomics. Data comparison was performed by chemometrics. Polar and apolar extracts were analyzed using untargeted GC-MS metabolomics followed by chemometrics (principal component anal., heatmap correlation and dendrogram) to identify, quantify and compare the major organic compounds in the plants. Addnl., NMR (NMR) spectroscopy was used for the laurel polar extract to identify D-gluco-L-glycero-3-octulose whose presence was unclear from the GC-MS data. TPC and antioxidant assays were performed using classical methods (Folin-Ciocalteu, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH)) and correlated to the phytochem. profiles. Forty-three metabolites were identified including amino acids, organic acids, carbohydrates, phenols, polyols, fatty acids, and alkanes. Eight metabolites (D-fructose, D-glucose, D-mannose, gallic acid, quinic acid, myo-inositol, palmitic and stearic acids) were in common between all species. D-Gluco-L-glycero-3-octulose (37.29 ± 1.19%), D-pinitol (31.33 ± 5.12%), and arbutin (1.30 ± 0.44%,) were characteristic compounds of laurel, carob, and strawberry tree, resp. Carob showed the highest values of TPC and antioxidant activity. GC-MS metabolomics and chemometrics analyses are fast and useful methods to determine and compare the metabolomics profiling of aromatic plants of food and industrial interest. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to arbutus ceratonia eucalyptus laurus mentha chemometrics metabolomics, gc-ms, nmr, pca, dendrogram, heatmap, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts