Category: 473-81-4

On December 31, 2022, An, Zhe; Zhang, Zilong; Huang, Zeyu; Han, Hongbo; Song, Binbin; Zhang, Jian; Ping, Qi; Zhu, Yanru; Song, Hongyan; Wang, Bin; Zheng, Lirong; He, Jing published an article.Related Products of 473-81-4 The title of the article was Pt1 enhanced C-H activation synergistic with Ptn catalysis for glycerol cascade oxidation to glyceric acid. And the article contained the following:

Abstract: The selective oxidation of glycerol to glyceric acid, an important value-added reaction from polyols, is a typical cascade catalytic process. It is still of great challenge to simultaneously achieve high glycerol activity and glyceric acid selectivity, suffering from either deep oxidation and C-C cleavage or poor oxidation efficiency from glyceraldehyde to glyceric acid. Herein, this work, inspired by nature, proposes a cascade synergistic catalysis strategy by at. and low-coordinated cluster Pt on well-defined Cu-CuZrOx, which involves enhanced C-H activation on at. Pt1 and O-H activation on cluster Ptn in the oxidation of glycerol to glyceraldehyde, and cluster Ptn for C=O activation followed by O-H insertion and at. Pt1 for C-H activation in the tandem oxidation of glyceraldehyde to glyceric acid. The enhanced C-H activation in the cascade process by at. Pt1 is revealed to be essential for the high glycerol activity (90.0卤0.1%) and the glyceric acid selectivity (80.2卤0.2%). The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4

2,3-Dihydroxypropanoic acid(cas:473-81-4) belongs to alcohols. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Related Products of 473-81-4

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On July 31, 2022, Chen, Zhou; Fei, Kangqing; Hu, Yangfan; Xu, Xiangyang; Gao, Xiao-Dong; Li, Zijie published an article.Application In Synthesis of 2,3-Dihydroxypropanoic acid The title of the article was Identification of a Novel Alditol Oxidase from Thermopolyspora flexuosa with Potential Application in D-Glyceric Acid Production. And the article contained the following:

Abstract: Glycerol is a potential sustainable feedstock, and biorefining processes to convert glycerol into value-added chems. have been developed over the past decade. Alditol oxidase (AldO) is capable of selectively oxidizing the primary hydroxyl groups of alditols such as glycerol. In this study, a new FAD-binding protein from Thermopolyspora flexuosa was expressed and identified as a novel alditol oxidase (AldOT.聽fle). AldOT.聽fle displayed the optimal activity at pH 8.0 and 25 掳C. AldOT.聽fle was not metal-dependent, but the activity was completely inhibited by Fe3+. AldOT.聽fle had a wide substrate specificity and high catalytic efficiency for glycerol. Furthermore, the recombinant AldOT.聽fle could produce D-glyceric acid from glycerol with a conversion rate ranging from 86.6% (5 mM glycerol) to 20.5% (500 mM glycerol). The recombinant E. coli with AldOT.聽fle could also produce 23.8 mM D-glyceric acid from 100 mM glycerol. The recombinant AldOT.聽fle had the potential to produce other aldehyde products by selectively oxidizing the hydroxyl groups of alditols and many other commodity chems. by redesigning glycerol metabolism The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to alditol oxidase, d-glyceric acid, glycerol, actinobacteria, escherichia coli: genetics, escherichia coli: metabolism, glyceric acids, glycerol: metabolism, oxidoreductases: genetics, sugar alcohols and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

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Merlani, M.; Barbakadze, V.; Amiranashvili, L.; Gogilashvili, L.; Petrou, A.; Geronikaki, A.; Ciric, A.; Glamoclija, J.; Sokovic, M. published an article in 2022, the title of the article was Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies.Category: alcohols-buliding-blocks And the article contains the following content:

Herein we report the evaluation of the antimicrobial activity of some previously synthesized 3-(3,4-dihydroxyphenyl)glyceric acid in benzylated and in free 3,4 hydroxy groups in catechol moiety along with some caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid amides using the microdilution method. The evaluation revealed that compounds showed in general moderate to low activity with MIC in range of 0.36-4.5 mg/mL. Compounds were also studied against three resistant bacteria strains MRSA (Methicillin-resistant Staphylococcus aureus), E. coli and P. aeruginosa. Seven out of ten compounds were more potent than reference drugs ampicillin and streptomycin against MRSA, while against another two resistant strains seven compounds showed low activity and the rest were inactive. Antifungal activity of the tested compounds was much better than antibacterial, with MIC in the range of 0.019-3.0 mg/mL. Compounds #7 and 15 showed good activity against all fungi tested, being more potent than ketoconazole and in some case even better than bifonazole used as reference drugs. Docking studies revealed that the most active compound #7 binds to the haem group of the enzyme in the same way as ketoconazole. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to anti-bacterial agents: pharmacology, anti-infective agents, escherichia coli, glyceric acids, ketoconazole, methicillin-resistant staphylococcus aureus, microbial sensitivity tests, molecular docking simulation, quantitative structure-activity relationship, structure-activity relationship and other aspects.Category: alcohols-buliding-blocks

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Fu, Yousi; Wang, Yali; Wang, Xingguo; Sun, Yidan; Ren, Jianlin; Fang, Baishan published an article in 2022, the title of the article was Responses of human gut microbiota abundance and amino acid metabolism in vitro to berberine.Computed Properties of 473-81-4 And the article contains the following content:

The intestine is a potential location for berberine (BBR) to exert its therapeutic effects, but the understanding of the influences of BBR on the gut microbiota is limited. Through in vitro fermentation of human intestinal microbiota, author investigated the effects of BBR on microbiota composition and metabolism The result indicated that BBR reduced the production of acetic acid and propionic acid and had no effect on the content of butyric acid. Anal. of the 16S rRNA gene-based community revealed that BBR increased the abundance of Faecalibacterium and decreased the abundance of Bifidobacterium, Streptococcus and Enterococcus. Through metabolomics anal., BBR treatment regulated various amino acid metabolism pathways of intestinal microbiota, especially tyrosine, serine and L-glutamate. Author study presented direct impacts of BBR on the intestinal microbiota, which provided the probable targets of the therapies by BBR and supported further exploration of the underlying mechanisms. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to berberine amino acid metabolism gut microbiota, Animal Nutrition: Other and other aspects.Computed Properties of 473-81-4

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On December 31, 2022, Xie, Fei; Jiang, Xue; Yi, Yang; Liu, Zi-Jia; Ma, Chen; He, Jin; Xun, Zhi-ming; Wang, Meng; Liu, Meng-yu; Yao, Mawulikplimi Adzavon; Zhao, Peng-xiang; Ma, Xue-mei published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status. And the article contained the following:

The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochem. parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen consumption, the plasma metabolome and gut microbiota were investigated in this study. Compared with the control group, 14 and 10 differential metabolites (DMs) were identified in hydrogen-rich water (HRW) and hydrogen inhalation (HI) group, resp. Pathway enrichment anal. showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. 16S rRNA gene sequencing showed that HRW intake induced significant changes in the structure of gut microbiota, while no marked bacterial community differences was observed in HI group. HRW intake mainly induced significant increase in the abundance of Lactobacillus, Ruminococcus, Clostridium XI, and decrease in Bacteroides. HI mainly induced decreased abundances of Blautia and Paraprevotella. The metabolic function was determined by metabolic cage anal. and showed that HI decreased the voluntary intake and excretions of rats, while HRW intake did not. The results of this study provide basic data for further research on hydrogen medicine. Determination of the effects of hydrogen intervention on microbiota profiles could also shed light on identification of mechanism underlying the biol. effects of mol. hydrogen. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to lactobacillus ruminococcus clostridium hydrogen rich water intake gas inhalation, Animal Nutrition: Other and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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Piccini, Ilaria; Sousa, Marta; Altendorf, Sabrina; Jimenez, Francisco; Rossi, Alfredo; Funk, Wolfgang; Biro, Tamas; Paus, Ralf; Seibel, Jens; Jakobs, Mira; Yesilkaya, Tanju; Edelkamp, Janin; Bertolini, Marta published an article in 2022, the title of the article was Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype.Formula: C3H6O4 And the article contains the following content:

Female pattern hair loss (FPHL) is a non-scarring alopecia resulting from the progressive conversion of the terminal (t) scalp hair follicles (HFs) into intermediate/miniaturized (i/m) HFs. Although data supporting nutrient deficiency in FPHL HFs are lacking, therapeutic strategies are often associated with nutritional supplementation. Here, we show by metabolic anal. that selected nutrients important for hair growth such as essential amino acids and vitamins are indeed decreased in affected iHFs compared to tHFs in FPHL scalp skin, confirming nutrient insufficiency. IHFs also displayed a more quiescent metabolic phenotype, as indicated by altered metabolite abundance in freshly collected HFs and release/consumption during organ culture of products/substrates of TCA cycle, aerobic glycolysis, and glutaminolysis. Yet, as assessed by exogenous nutrient supplementation ex vivo, nutrient uptake mechanisms are not impaired in affected FPHL iHFs. Moreover, blood vessel d. is not diminished in iHFs vs. tHFs, despite differences in tHFs from different FPHL scalp locations or vs. healthy scalp or changes in the expression of angiogenesis-associated growth factors. Thus, our data reveal that affected iHFs in FPHL display a relative nutrient insufficiency and dormant metabolism, but are still capable of absorbing nutrients, supporting the potential of nutritional supplementation as an adjunct therapy for FPHL. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Formula: C3H6O4

The Article related to hair follicle human nutrient insufficiency dormant metabolism, female pattern hair loss, hair follicle, metabolism, nutrient supplementation, Animal Nutrition: Other and other aspects.Formula: C3H6O4

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Alcohol – Wikipedia,
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Xu, Bingbing; Wang, Zhiying; Wang, Ruijun; Song, Guoxin; Zhang, Yanjun; Su, Rui; Liu, Yongbin; Li, Jinquan; Zhang, Jiaxin published an article in 2022, the title of the article was Metabolomics analysis of buck semen cryopreserved with trehalose.Computed Properties of 473-81-4 And the article contains the following content:

Trehalose is commonly used as an impermeable cryoprotectant for cryopreservation of cells, but its cryoprotective mechanism has now not but been determined This study investigated the cryopreservation impact of trehalose on buck semen cryopreservation and finished metabolic profiling of freeze-thawed media by way of the GC-MS-based metabolomics for the first time. Metabolic pattern recognition and metabolite identification by means of principal component anal. (PCA), partial least squares discriminant anal. (PLS-DA) and metabolic pathway topol. anal. revealed the results of trehalose on buck sperm metabolism at some point of cryopreservation. The results confirmed that trehalose drastically progressed sperm motility parameters and structural integrity after thawing. PCA and PLS-DA anal. discovered that the metabolic patterns of the freezing-thawing media of buck semen cryopreserved with trehalose (T group) or without trehalose (G group, Control) were certainly separated Using screening conditions of VIP >1.5 and p vaule <0.05, a total of 48 differential metabolites have been recognized, whithin l-isoleucine, L-leucine, L-threonine, and dihydroxyacetone were notably enriched in valine, leucine and isoleucine biosynthesis, glycerolipid metabolism, and aminoacyl-tRNA biosynthesis pathways. In brief, trehalose can efficiently improve membrane structural integrity and motion parameters in buck sperm after thawing, and it exerts a cryoprotective impact with the aid of changing sperm amino acid synthesis and the glycerol metabolism pathway. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to trehalose buck semen cryopreservation metabolomic analysis, buck, cryopreservation, metabolomics, spermatozoa, trehalose, Biochemical Methods: Biological and other aspects.Computed Properties of 473-81-4

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On January 1, 2022, Podolean, Iunia; Coman, Simona M.; Bucur, Cristina; Teodorescu, Cristian; Kikionis, Stefanos; Ioannou, Efstathia; Roussis, Vassilios; Primo, Ana; Garcia, Hermenegildo; Parvulescu, Vasile I. published an article.Application of 473-81-4 The title of the article was Catalytic transformation of the marine polysaccharide ulvan into rare sugars, tartaric and succinic acids. And the article contained the following:

The green macroalga Ulva rigida represents a promising feedstock for biorefinary due to its fast growth and cosmopolitan distribution. The main component of the cell walls of U. rigida is a sulfated glucuronorhamnan polysaccharide known as ulvan. Herein it was found that due to the high (hydrogen)sulfate group content of ulvan, hydrothermal autohydrolysis at 130°C renders a high percentage of rhamnose (78-79% recovery from the initial content in the raw material), a rare sugar of high added value. In addition, acid catalysis by a triflate-based graphene oxide under oxygen-free conditions at 180°C affords moderate amounts of tartaric acid (24-26%). The same triflate-based graphene oxide catalyst under oxygen pressure yields remarkably high percentages of succinic acid (65%). The catalyst preserves its activity for at least five consecutive reuses. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application of 473-81-4

The Article related to catalytic transformation marine polysaccharide ulvan rare sugar, Industrial Carbohydrates: General and other aspects.Application of 473-81-4

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On June 30, 2022, Zhang, Yuandi; Xu, Jingguo; Ding, Fang; Deng, Wanyu; Wang, Xi; Xue, Yansong; Chen, Xiaoxue; Han, Bei-Zhong published an article.Related Products of 473-81-4 The title of the article was Multidimensional profiling indicates the shifts and functionality of wheat-origin microbiota during high-temperature Daqu incubation. And the article contained the following:

Wheat-origin microbiota is a critical factor in the assembly of the microbial community during high-temperature Daqu incubation. However, the succession and functional mechanisms of these microbial communities in Daqu are still unclear. This study investigated the shifts in microbiota diversity from the wheat to the end of incubation by the third generation Pacific Biosciences (PacBio) single-mol., real-time (SMRT) sequencing technol. Results indicated that Staphylococcus, Pantoea, Alternaria, and Mycosphaerella were the dominant genera of wheat-origin microbiota while Bacillus and Thermoascus were the most predominant bacterial and fungal genera of Daqu microbiota, resp. Metabolite detection revealed that volatile organic compounds (VOCs) changed obviously in different incubation stages and the 7th day to the 15th day of incubation was the critical period for the formation of VOCs. The content of non-VOCs, especially sugars, increased steeply in the first four days of incubation. The network anal. between microbes and metabolites showed that Thermoactinomyces and Staphylococcus had opposite correlations with most non-VOCs. Alternaria and Mycosphaerella had strong pos. correlations with fructose. As key functional fungal genera in wheat-origin microbiota, Mycosphaerella, Aspergillus, and Alternaria participated in multiple metabolic pathways (gluconeogenesis I, sucrose degradation III, pentose phosphate pathway, 5-aminoimidazole ribonucleotide biosynthesis I, Me ketone biosynthesis, and GDP-mannose biosynthesis) at the early stage of incubation, which played an important role in the formation of flavors and succession of microbiota. This work highlighted the shifts and functionality of wheat-origin microbiota in Daqu incubation, which can be a guideline to stabilize Daqu quality by wheat-origin microbiota control. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4

The Article related to multidimensional profiling wheat microbiota high temperature daqu incubation, daqu, incubation, microbiota, non-vocs, vocs, wheat, Food and Feed Chemistry: Analysis and other aspects.Related Products of 473-81-4

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On October 30, 2022, Yin, Zhibin; Dong, Tao; Huang, Wenjie; Du, Mingyi; Chen, Dong; Fernie, Alisdair R.; Yi, Ganjun; Yan, Shijuan published an article.Synthetic Route of 473-81-4 The title of the article was Spatially resolved metabolomics reveals variety-specific metabolic changes in banana pulp during postharvest senescence. And the article contained the following:

Banana is one of most popular fruits globally due to health-promoting and disease-preventing effects, yet little is known about in situ metabolic changes across banana varieties. Here, we integrated gold nanoparticle (AuNP)-assisted laser desorption/ionization mass spectrometry imaging (LDI-MSI) and metabolomics to investigate the spatiotemporal distribution and levels of metabolites within Brazil and Dongguan banana pulps during postharvest senescence. Metabolomics results indicated that both postripening stages and banana varieties contribute to metabolite levels. Benefiting from improved ionization efficiency of small-mol. metabolites and less peak interference, we visualized the spatiotemporal distribution of sugars, amino acids (AAs) and monoamines within pulps using AuNP-assisted LDI-MSI for the first time, revealing that AAs and monoamines exclusively accumulated in the middle region near the seed zone. Monosaccharides and di/trisaccharides were generally distributed across entire pulps but exhibited different accumulation patterns. These findings provide a guide for breeding new varieties and improving extraction efficiency of bioactive compounds The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4

The Article related to banana pulp tryptophan glyceric acid postharvest senescence metabolomics, amino acid, banana, mass spectrometry imaging, metabolomics, monoamine, soluble sugars, Food and Feed Chemistry: Analysis and other aspects.Synthetic Route of 473-81-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts