Category: 4720-29-0

Application of 4720-29-0 , The common heterocyclic compound, 4720-29-0, name is 3-(Benzylamino)-1-propanol, molecular formula is C10H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1,1-bis(methylthio)-2-nitroethylene 9 (1.00 g, 6.06 mmol) was added to asolution of N-benzylamino-3-propan-1-ol 8a (1.00 g, 6.06 mmol) and DMAP (0.74 g, 6.06mmol) in t-butanol (20 mL). The resulting solution was heated to reflux for 24 h under nitrogenatmosphere. The reaction was monitored by TLC (CH2Cl2/MeOH, 97/3). After cooling to roomtemperature, the solvent was removed in vacuo to afford an oily residue which was purified byflash chromatography on silica gel (CH2Cl2/MeOH, 98/2) to give nitroacetamide 11a (oil, 0.42 g,28%), a mixture of (Z)- and (E)-isomers in a ratio close to 1/1.

The synthetic route of 4720-29-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fante, Bamba; Soro, Yaya; Siaka, Sorho; Marrot, Jerome; Coustard, Jean-Marie; Synlett; vol. 25; 7; (2014); p. 969 – 974;,
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Reference of 4720-29-0, Adding some certain compound to certain chemical reactions, such as: 4720-29-0, name is 3-(Benzylamino)-1-propanol,molecular formula is C10H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4720-29-0.

A solution of N-benzylpropanolamine (3.3 g) and benzyl(S)-(+)-glycidyl ether (3.6 g) in ethanol (40 mL) was heated at 40 C. for 18 h. The solvent was evaporated under reduced pressure to give the subtitled compound as a colourless oil (6.8 g, 100%), which was used without further purification. 1H NMR (400 MHz, DMSO-d6): delta 7.29 (m, 10H), 4.54 (m, 1H), 4.45 (s, 2H), 4.36 (t, 2H), 3.76 (m, 1H), 3.44 (m, 5H), 2.47 (m, 4H), 1.57 (m, 2H).

According to the analysis of related databases, 4720-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AstraZeneca AB; Lonn, Hans Roland; Connolly, Stephen; Swallow, Steven; Karlsson, Staffan PO; Aurell, Carl-Johan; Ponten, John Fritiof; Doyle, Kevin James; Van de Poel, Amanda Jane; Jones, Graham Peter; Watson, David Wyn; MacRitchie, Jaqueline Anne; Palmer, Nicholas John; (50 pag.)US9522894; (2016); B2;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 4720-29-0, 3-(Benzylamino)-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4720-29-0, blongs to alcohols-buliding-blocks compound. name: 3-(Benzylamino)-1-propanol

Step 1: Preparation of Intermediate 33A. Compound 1C (5.4 g) was stirred with 3-benzylaminopropanol (1.0 equiv) and anhydrous Na2SO4 (10 g) in THF for 30 min. Sodium triacetoxyborohydride (2.0 equiv) was added and the mixture was stirred at room temperature over night. The reaction was quenched with brine and extracted with ethyl acetate. The organic phase was dried over anhydrous Na2SO4 and evaporated to give crude Intermediate 33A (12.05 g) which was used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4720-29-0, its application will become more common.

Reference:
Patent; CARA THERAPEUTICS, INC.; US2008/318935; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 4720-29-0 ,Some common heterocyclic compound, 4720-29-0, molecular formula is C10H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of N-benzylpropanolamine (3.3 g) and benzyl(S)-(+)-glycidyl ether (3.6 g) in ethanol (40 mL) was heated at 40 C. for 18 h. The solvent was evaporated under reduced pressure to give the subtitled compound as a colourless oil (6.8 g, 100%), which was used without further purification. 1H NMR (400 MHz, DMSO-d6): delta 7.29 (m, 10H), 4.54 (m, 1H), 4.45 (s, 2H), 4.36 (t, 2H), 3.76 (m, 1H), 3.44 (m, 5H), 2.47 (m, 4H), 1.57 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4720-29-0, 3-(Benzylamino)-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; LONN, Hans Roland; CONNOLLY, Stephen; SWALLOW, Steven; KARLSSON, Staffan PO; AURELL, Carl-Johan; PONTEN, John Fritiof; DOYLE, Kevin James; VAN DE POEL, Amanda Jane; JONES, Graham Peter; WATSON, David Wyn; MACRITCHIE, Jaqueline Anne; PALMER, Nicholas John; US2015/210655; (2015); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4720-29-0, name is 3-(Benzylamino)-1-propanol, the common compound, a new synthetic route is introduced below. Computed Properties of C10H15NO

EXAMPLE 20 5-[N-Benzyl-N-(3-hydroxypropyl)amino]-4-chloro-2-methyl-3(2H)-pyridazinone A solution of 11.48 g (64,1 mmol) of 4,5-dichloro-2-methyl-3(2H)-pyridazinone and 31.84 g (193.0 mmol) of 3-(N-benzylamino)propanol in 250 ml of water is boiled for 25 hours while stirring. The mixture is cooled, its pH is set with concentrated hydrochloric acid to 3 and it is extracted with 2*400 ml of ethyl acetate. The organic phase is dried and evaporated, 10 ml of ethyl acetate are added to the evaporation residue, then it is left to stand overnight at -10 C. The precipitated crystals are filtered and washed with ethyl acetate and then with diethyl ether. In this way 10.60 g (54%) of the title compound are obtained with a melting point of 94-95 C.

The synthetic route of 4720-29-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IVAX Drug Research Institute, Ltd.; US6602865; (2003); B1;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4720-29-0, name is 3-(Benzylamino)-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3-(Benzylamino)-1-propanol

3-(N-tert-Butoxycarbonyl-N-phenylmethylamino)-propan-1-ol (4f) (R3=H, q=1, x=2, R1=BOC) from 3f (method B). 1H-NMR (CDCl3): 7.37-7.15 (m, 5H, Ar); 4.38 (s, 2H, CH2 -Ar); 3.58-3.50 (m, 2H, CH2OH); 3.40-3.30 (m, 2H, N-CH2); 3.10 (bs, 1H, OH); 1.70-1.55 (m, 2H, CH2-CH2-CH2); 1.40 (s, 9H, t.Bu).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4720-29-0, 3-(Benzylamino)-1-propanol.

Reference:
Patent; Zambon Group S.p.A.; US6214833; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 4720-29-0, Adding some certain compound to certain chemical reactions, such as: 4720-29-0, name is 3-(Benzylamino)-1-propanol,molecular formula is C10H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4720-29-0.

Step-1: N-Benzyl-2-chloro-N-(3-hydroxy-propyl)-acetamideTo a solution of 3-benzylamino-propan-1-ol (28 g, 0.17 mol) solution in DCM was added triethylamine (25.9 ml, 0.19 mol) and chloroacetyl chloride (13.4 ml, 0.17 mol) at 0 C. The mixture was stirred for 2 h at room temperature, then concentrated and extracted with ethyl acetate. Concentration of organic layer afforded 41 g (93%) of N-benzyl-2-chloro-N-(3-hydroxy-propyl)-acetamide. LC/MS [M+H]+: 242.3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4720-29-0, 3-(Benzylamino)-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KHAMRAI, Uttam; Ronsheim, Matthew; Karak, Sumit Kumar; US2010/152160; (2010); A1;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4720-29-0, name is 3-(Benzylamino)-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C10H15NO

(a) A solution of 7 g of 3-N-benzylamino-propanol in 40 ml of dimethylformamide is reacted analogously to the process described in Example (1a) with 1.9 g of a sodium hydride suspension (55% strength in paraffin oil), and then with 5.5 g of 6-chloro-nicotinic acid amide. The crude 6-(3-N-benzylamino-propyloxy)-nicotinic acid amide thus obtainable is reacted with 4.9 g of 1,2-epoxy-3-(2-methyl-phenoxy)propane; this gives 1-{N-benzyl-N-[3-(5-carbamoyl-2-pyridyloxy)-propyl]-amino}-3-(2-methyl-phenyloxy)-2-propanol, which is processed further without purification.

With the rapid development of chemical substances, we look forward to future research findings about 4720-29-0.

Reference:
Patent; Ciba-Geigy Corporation; US4027027; (1977); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts