Category: 4719-04-4

On November 30, 2011, Latorre, Nuria; Borrego, Leopoldo; Fernandez-Redondo, Virginia; Garcia-Bravo, Begona; Gimenez-Arnau, Ana Maria; Sanchez, Javier; Silvestre, Juan Francisco published an article.COA of Formula: C9H21N3O3 The title of the article was Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009). And the article contained the following:

Background. Formaldehyde and formaldehyde-releasers are common causes of allergic contact dermatitis. Objectives. To determine the frequency of sensitization to formaldehyde and seven formaldehyde-releasers. To establish and characterize groups of patients according to the results of patch testing. Materials and methods. We performed a 5-yr retrospective study, in six Spanish hospitals, of patients with pos. patch test reactions to formaldehyde or any of seven formaldehyde-releasers. Results. The most frequent allergens were formaldehyde (1.72%), imidazolidinyl urea (1.05%), quaternium-15 (0.88%), and diazolidinyl urea (0.79%). Patients with sensitization to only formaldehyde had a higher frequency of occupational dermatitis (25%) than patients with sensitization to only formaldehyde-releasers (9.5%). The most common sites of dermatitis were the hands (31.7%) in patients with sensitization to only formaldehyde and the face and legs (31.3% and 24.6%) in patients with sensitization to only formaldehyde-releasers. We found a subgroup of 25 patients who were sensitized to both imidazolidinyl urea and diazolidinyl urea, and only 6 of these (24%) were also sensitized to formaldehyde. Conclusions. The inclusion of imidazolidinyl urea and diazolidinyl urea in the baseline series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) should enable better classification of patients allergic to formaldehyde, and could aid in their management. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).COA of Formula: C9H21N3O3

The Article related to formaldehyde releaser allergy allergen, Toxicology: Chemicals (Household, Industrial, General) and other aspects.COA of Formula: C9H21N3O3

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On March 31, 2008, Geier, Johannes; Lessmann, Holger; Hellriegel, Simin; Fuchs, Thomas published an article.Recommanded Product: 4719-04-4 The title of the article was Positive patch test reactions to formaldehyde releasers indicating contact allergy to formaldehyde. And the article contained the following:

A case of formaldehyde allergy detected by pos. patch tests to several formaldehyde releasers is presented. In cases suspected formaldehyde allergy but the patch test with formaldehyde 1% aqueous remains neg., repeating the formaldehyde patch test may help to clarify the diagnosis especially when unexplained reactions to formaldehyde releasers are observed The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Recommanded Product: 4719-04-4

The Article related to formaldehyde releaser allergy skin, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Recommanded Product: 4719-04-4

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On November 30, 2008, Henriks-Eckerman, Maj-Len; Suuronen, Katri; Jolanki, Riitta published an article.Synthetic Route of 4719-04-4 The title of the article was Analysis of allergens in metalworking fluids. And the article contained the following:

Background: Metalworking fluids (MWFs) are well-known causes of occupational contact dermatitis in machinists. Objective: To gain information about skin sensitizers in MWFs and to compare it with the information in safety data sheets (SDSs). Methods: A total of 17 samples of MWF concentrates were analyzed for skin sensitizers known or suspected to be used in MWF. Alkanolamines, formaldehyde, isothiazolinones, methyldibromo glutaronitrile (MDBGN), and iodopropynyl butylcarbamate (IPBC) were separated by liquid chromatog. Resin acids of colophonium (colophony) were separated by gas chromatog. The substances were identified with mass spectrometric detection and UV detection. Results: Of the MWFs, 15 contained 6-39% of alkanolamines, mostly monoethanolamine and triethanolamine. Formaldehyde was detected in all MWFs: the concentrations of total formaldehyde ranged between 0.002% and 1.3%. Benzisothiazolinone and octylisothiazolinone were detected in one fluid each. IPBC was detected in nine MWFs, and the highest concentration was 0.09%. Methylisothiazolinone and MDBGN were not detected in any of the fluids. Resin acids of colophonium were detected in seven MWFs in concentrations ranging from 0.41% to 3.8%. On the whole, the allergens analyzed were poorly declared in the SDSs. Conclusions: The content of total formaldehyde was not declared in any SDS. IPBC, a relatively new allergen, seems to be common in MWFs. Isothiazolinones may be relevant allergens of machinists, and they should be analyzed in MWFs in case other sources are not identified. The occupational relevance of pos. patch test results to MWF ingredients in machinists is difficult to determine if information in the SDSs is relied upon. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Synthetic Route of 4719-04-4

The Article related to metalworking fluid allergen, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Synthetic Route of 4719-04-4

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On February 29, 2008, Steinhauer, K.; Goroncy-Bermes, P. published an article.Application of 4719-04-4 The title of the article was Treatment of water-based metalworking fluids to prevent hypersensitivity pneumonitis associated with Mycobacterium spp.. And the article contained the following:

To prevent further outbreaks of hypersensitivity pneumonitis (HP), biocides are required which are capable of protecting water-based coolants from proliferating mycobacteria. The aim of this study was therefore, to test different biocide preparations on their mycobactericidal activity. Minimal inhibitory concentration values were determined for Mycobacterium chelonae and Mycobacterium immunogenum for triazine-based, methyloxazolidine-based, N/O-formal-based biocidal formulations. All biocides were effective already at a low dosage (<0.05%) irresp. of the presence or absence of organic soiling, except for one N/O-formal-based formulation containing Kathon 886 (CMI). Quenching of CMI in the presence of organic soiling was found to account for loss in efficacy as determined by high-performance liquid chromatog. measurement. Preservation tests were carried out to investigate the efficacy of the biocidal preparations under practical conditions. Results indicate that methyloxazolidine-based biocidal preparations were most effective to prevent coolants from microbial contamination including rapidly growing mycobacteria. Furthermore, it could be demonstrated that common dipslides can be used to easily monitor coolants for contamination by mycobacteria. Our data does not support the hypothesis that mycobacterial proliferation is enhanced by the reduction of competitive microbial population by biocides such as triazines as described earlier but rather suggests a protective effect of biocides regarding mycobacteria in the presence of competitive microbial flora, thereby preventing further outbreaks of HP. The experimental process involved the reaction of 2,2',2''-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Application of 4719-04-4

The Article related to mycobacterium methyloxazolidine antimicrobial hypersensitivity pneumonitis, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Application of 4719-04-4

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Owens, Thomas R.; Clark, Peter D. published an article in 2011, the title of the article was Triazine chemistry: removing H2S and mercaptans.COA of Formula: C9H21N3O3 And the article contains the following content:

Arguably, one of the most common methods for removing low levels of hydrogen sulfide from natural gas (i.e., < 1 ton of sulfur per day) is triazine based chem. scavengers. Triazines are produced from the reaction of primary amines such as monoethanolamine or methylamine with aldehydes, specifically, formaldehyde. Despite their wide spread usage throughout the industry only a few studies have been published regarding the reaction of triazines with hydrogen sulfide. In studies conducted by Bakke and coworkers, the kinetics and reaction products (i.e., dithiazines) for the reaction of different triazines with hydrogen sulfide were investigated under various pH conditions. Another type of sulfur compounds that intermittently needs to be removed from hydrocarbon streams is mercaptans. Although some in the industry have indicated triazines can be used remove mercaptans, there is no specific information in the open literature regarding the reaction of triazines with mercaptans in regards to reaction products or kinetics. In this paper, we present a thorough background into the chem. of triazines, in particular, their reaction with hydrogen sulfide and potential problems produced from the formation of dithiazine. In addition, the current results of a systematic study for the reaction of two triazines, 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine (1) and 1,3,5-trimethylhexahydro-s-triazine (2) with different mercaptans: methanethiol (MeSH), ethanethiol (EtSH) and n-propanethiol (n-PrSH) will be presented. The experimental process involved the reaction of 2,2',2''-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).COA of Formula: C9H21N3O3

The Article related to hydrogen sulfide mercaptan triazine chem, Fossil Fuels, Derivatives, and Related Products: Natural Gas and other aspects.COA of Formula: C9H21N3O3

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Lozano, Hugo; Trauffer, Edward A. published an article in 2000, the title of the article was Re-generable H2S scavenger.Synthetic Route of 4719-04-4 And the article contains the following content:

A novel way has been developed to utilize a proprietary catalyst incorporated into the liquid scavenging chem., called ENVIRO-TEK, to regenerate the spent chem. The regeneration is accomplished with air. This technol. innovation has dramatically reduced the cost of removing sulfur from several gas streams. The chem. of the process may be summarized as: REACTION 1 (contactor): triazine (1,3,5-tri(2-hydroxyethyl)hexahydro-s-triazine) + H2S ———-> dithiazine (5,6-dihydro-5-(2-hydroxyethyl)-4H-1,3,5-dithiazine) REACTION 2 (regeneration tank): dithiazine + O2 + catalyst —-> triazine + S0 + H2O. Single use triazine based liquid scavengers have been widely and successfully used in the natural gas industry for a long time to remove small amounts of H2S. The global natural gas industry is projected to spend more than $60 million/yr on chem. scavenging operating costs. However operators have been reporting difficulties in obtaining acceptable H2S removal costs and performance. The process utilizes a scrubbing tower or in line injection to contact the ENVIRO-TEK with the sulfur bearing gas. H2S and mercaptans are removed from the gas in the contactor and the sulfur is chem. bound in the spent chem. The chem. is then regenerated with the use of air in a sep. regeneration tank. Finally, the elemental sulfur formed in the regeneration tank is removed with the use of a solids separation step such as a settling tank, a centrifuge, or a filter press. The regenerated Enviro-tek is then ready for re-use in the scrubbing tower or direct injection pipeline. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Synthetic Route of 4719-04-4

The Article related to natural gas hydrogen sulfide scavenger regeneration, Fossil Fuels, Derivatives, and Related Products: Natural Gas and other aspects.Synthetic Route of 4719-04-4

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On January 31, 2018, Subramaniam, Ramalingam; Yasa, Santosh; Bertrand, Tre; Fontenot, Brittany; Dupuis, Thomas F.; Hernandez, Rafael published an article.Name: 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol The title of the article was Advanced simulation of H2S scavenging process with triazine at different depths of gas well. And the article contained the following:

Over the 10 years the world has experienced significant growth in global natural gas consumption, rendering natural gas as one of the most important energy sources of the future. However, more than 40% of the natural gas reservoirs are sub quality because of the presence of acid gases like hydrogen sulfide (H2S) and carbon dioxide (CO2). Removal of these impurities from natural gas is of prime importance because of the health, environment, and corrosion issues in pipelines and other processing equipment. Absorption of H2S by 1,3,5-tri-(2-hydroxyethyl)-hexahydro-s-triazine has many advantages in terms of economics and efficiency over alkanolamines. The main objective of this work is to develop a Visual Basic simulation for hydrogen sulfide removal from natural gas at different depths of gas well using triazine. The thermodn. properties of the components, triazine, thiadiazine, and diathiazine estimated from the Aspen Plus have closer agreement with Spartan simulation results. H2S concentration in the clean gas and the triazine requirement per lb of H2S removal at different depths along the well obtained from the Visual Basic simulation were validated with the Coastal Chem. Inc., field data. With the increase in mass flowrate of triazine solution, the H2S concentration in the clean gas decreased, and the amount of triazine required per lb of H2S removal decreased. The developed simulation calculates the quantity of triazine required per lb of H2S removal at different depths of the gas well, which allows the user to determine the optimum depth for maximum H2S removal with min. triazine requirement. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Name: 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to hydrogen sulfide triazine scavenging process gas well, Fossil Fuels, Derivatives, and Related Products: Natural Gas and other aspects.Name: 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

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On January 31, 2022, Kireeva, D. R.; Sadretdinov, S. S.; Musina, A. I.; Ishmetova, D. V.; Vakhitov, V. A.; Murinov, Yu. I.; Dokichev, V. A. published an article.Related Products of 4719-04-4 The title of the article was Synthesis and Cytotoxic Activity of 1,3,5-Triazinane Derivatives Based on Primary Amines and Amino Acids Esters. And the article contained the following:

A series of 1,3,5-triazinane derivatives I (R = n-Pr, Bn, 1-methoxy-4-methyl-1-oxopentan-2-yl, etc.) was synthesized and their cytotoxic activity was studied in vitro on normal cell line (HEK293) and tumor cell lines (SH-SY5Y, MCF-7, A549). It was shown that the studied compounds have moderate cytotoxic activity against normal and tumor cell lines. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Related Products of 4719-04-4

The Article related to triazinane primary amine amino acid ester preparation antitumor cytotoxicity, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Related Products of 4719-04-4

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On September 25, 2007, Jasinski, Marcin; Mloston, Grzegorz; Mucha, Paulina; Linden, Anthony; Heimgartner, Heinz published an article.Electric Literature of 4719-04-4 The title of the article was Synthesis of new bis-imidazole derivatives. And the article contained the following:

The reaction of aldimines with α-(hydroxyimino) ketones (1,2-diketone monooximes) was used to prepare 2-unsubstituted imidazole 3-oxides bearing an alkanol chain at N(1). These products were transformed into 2H-imidazol-2-ones and 2H-imidazole-2-thiones by treatment with Ac2O and 2,2,4,4-tetramethylcyclobutane-1,3-dithione, resp. The three-component reaction of the α-(hydroxyimino) ketones, formaldehyde, and an alkane-1,ω-diamine gave bis[1H-imidazole 3-oxides]. The latter reacted with Ac2O, 2,2,4,4-tetramethylcyclobutane-1,3-dithione or Raney-Ni to give bis[2H-imidazol-2-ones], bis[2H-imidazol-2-thione], and bis[imidazole] derivatives Two structures were established by X-ray crystallog. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Electric Literature of 4719-04-4

The Article related to bisimidazole preparation aldimine dione monoxime, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 4719-04-4

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On December 2, 2004, Laufer, Stefan A.; Zimmermann, Werner; Ruff, Kathrin J. published an article.Category: alcohols-buliding-blocks The title of the article was Tetrasubstituted Imidazole Inhibitors of Cytokine Release: Probing Substituents in the N-1 Position. And the article contained the following:

Novel 1,2,4,5-tetrasubstituted imidazole derivatives with high anti-inflammatory activity were prepared by a previously described regiospecific synthesis. Systematic optimization of the imidazole N-1 substituent resulted in compound I that potently inhibited the p38 mitogen-activated protein kinase (p38 IC50 = 0.218 μM) as well as the release of the proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα) from human whole blood after stimulation with LPS. Furthermore, I exhibited reduced cytochrome P 450 interaction in comparison with SB203580. This result is particularly important, since cytochrome P 450 interaction is observed for some p38 inhibitors and in turn can potentially cause drug-drug interaction or lead to other hepatic changes such as P 450 enzyme induction. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Category: alcohols-buliding-blocks

The Article related to imidazole tetrasubstituted preparation cytokine inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: alcohols-buliding-blocks

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