Category: 4719-04-4

On July 17, 2018, Di, Anke; Xiong, Shiqin; Ye, Zhiming; Malireddi, R. K. Subbarao; Kometani, Satoshi; Zhong, Ming; Mittal, Manish; Hong, Zhigang; Kanneganti, Thirumala-Devi; Rehman, Jalees; Malik, Asrar B. published an article.Synthetic Route of 4719-04-4 The title of the article was The TWIK2 potassium efflux channel in macrophages mediates NLRP3 inflammasome-induced inflammation. And the article contained the following:

Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Here we identified the two-pore domain K+ channel (K2P) TWIK2 as the K+ efflux channel triggering NLRP3 inflammasome activation. Deletion of Kcnk6 (encoding TWIK2) prevented NLRP3 activation in macrophages and suppressed sepsis-induced lung inflammation. Adoptive transfer of Kcnk6-/- macrophages into mouse airways after macrophage depletion also prevented inflammatory lung injury. The K+ efflux channel TWIK2 in macrophages has a fundamental role in activating the NLRP3 inflammasome and consequently mediates inflammation, pointing to TWIK2 as a potential target for anti-inflammatory therapies. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Synthetic Route of 4719-04-4

The Article related to twik2 nlrp3 macrophage adoptive cell transfer lung inflammation, kcnk6, nlrp3 inflammasome, p2x7 receptor, twik2, inflammation, potassium channel, Immunochemistry: Immunopathology and other aspects.Synthetic Route of 4719-04-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vorberg, Susann; Tetko, Igor V. published an article in 2014, the title of the article was Modeling the Biodegradability of Chemical Compounds Using the Online CHEmical Modeling Environment (OCHEM).Formula: C9H21N3O3 And the article contains the following content:

Biodegradability describes the capacity of substances to be mineralized by free-living bacteria. It is a crucial property in estimating a compound’s long-term impact on the environment. The ability to reliably predict biodegradability would reduce the need for laborious exptl. testing. However, this endpoint is difficult to model due to unavailability or inconsistency of exptl. data. Our approach makes use of the Online Chem. Modeling Environment (OCHEM) and its rich supply of machine learning methods and descriptor sets to build classification models for ready biodegradability. These models were analyzed to determine the relationship between characteristic structural properties and biodegradation activity. The distinguishing feature of the developed models is their ability to estimate the accuracy of prediction for each individual compound The models developed using seven individual descriptor sets were combined in a consensus model, which provided the highest accuracy. The identified overrepresented structural fragments can be used by chemists to improve the biodegradability of new chem. compounds The consensus model, the datasets used, and the calculated structural fragments are publicly available at http://ochem.eu/article/31660. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Formula: C9H21N3O3

The Article related to computational modeling biodegradability carboxylic acid ester primary alc, outlier detection, ready biodegradability, structural and functional interpretation, Pharmacology: Structure-Activity and other aspects.Formula: C9H21N3O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2020, Brown, Brenna Arlyce published an article.Related Products of 4719-04-4 The title of the article was The application of benchtop NMR for investigating the performance of H2S scavengers. And the article contained the following:

Hydrogen sulfide is a common product in natural gas in many of the gas fields in Alberta, Canada. This gas is extremely toxic to human health and highly corrosive to pipelines and gas plant infrastructure. A common method for removal of H2S is the use of liquid hydrogen sulfide scavengers, most commonly, 1,3,5,-tris(2-hydroxyethyl)hexahydro-s-triazine (triazine, 1). Triazine reacts with 2 mol of H2S to produce 5-(2-hydroxyethyl)hexahydro-1,3,5-dithiazine (dithiazine, 3) and two moles of monoethanolamine (MEA, 4). The reaction proceeds through 3,5-bis(2-hydroxyethyl)hexahydro-1,3,5-thiadiazine (thiadiazine, 2) as an intermediate. “Overspent” scavenger, triazine that has been heavily consumed by H2S can lead to formation of solid dithiazine or amorphous dithiazine, leading to downstream plant problems. Qual. characterization of the reaction products would allow for plant operators to determine “how spent” their scavenger is and evaluate its potential scavenging capacity. NMR characterization remains uncommon industrially, despite triazine and its reaction products extensive characterization in the literature. Presented herein is the application low-field benchtop NMR for characterization of spent triazine, from both field and laboratory samples, using 1H and 13C NMR. By using low-field NMR, the authors were able to determine that even under aggressive field conditions, the starting triazine will not be fully used and that the scavenger stops effective removal of HS before both 1 or 2 are completely consumed. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Related Products of 4719-04-4

The Article related to benchtop low field nmr hydrogen sulfide removal scavenger reaction, Unit Operations and Processes: Other and other aspects.Related Products of 4719-04-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2001, Sondossi, M.; Rossmoore, H. W.; Williams, R. published an article.Formula: C9H21N3O3 The title of the article was Relative formaldehyde resistance among bacterial survivors of biocide-treated metalworking fluid. And the article contained the following:

Surviving Gram-neg. bacterial populations of a metalworking fluid, soluble-oil emulsion, exposed to a formaldehyde (FA)-based industrial biocide were isolated and identified. Resistance of isolates to FA and FA-based biocides was determined and significant differences were noted. The most resistant strain survived 25 mM FA when tested in tryptic soy broth. Attempts to induce greater resistance in less resistant isolates yielded mixed results. The FA-resistant isolates were shown to be cross-resistant to a number of FA-based biocides. Detoxification (removal) of FA by mixtures of FA-resistant and PA-sensitive organisms was a function of the level of resistant organism present. This may explain the varied resistance levels among isolates from a single system to FA. The results suggest that protection of susceptible strains by resistant organisms may occur under field conditions. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Formula: C9H21N3O3

The Article related to formaldehyde resistance bacteria survivor biocide metalworking fluid, oil water metalworking emulsion formaldehyde biocide bacterial fungal resistance, Agrochemical Bioregulators: Microbial and other aspects.Formula: C9H21N3O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 31, 2008, Davis, Mark D. P.; Scalf, Leigh Ann; Yiannias, James A.; Cheng, Janet F.; El-Azhary, Rokea A.; Rohlinger, Audrey L.; Farmer, Sara A.; Fett, Debra D.; Johnson, Janis S.; Linehan, Diane L. Nordberg; Richardson, Donna M.; Schroeter, Arnold L.; Connolly, Suzanne M. published an article.Formula: C9H21N3O3 The title of the article was Changing trends and allergens in the patch test standard series: a Mayo Clinic 5-year retrospective review, January 1, 2001, through December 31, 2005. And the article contained the following:

Objective: To present and interpret results of patch testing with the Mayo Clinic standard series over 5 years. Design: Retrospective study. A standardized patch testing technique was used. Data were recorded on a standardized computer program from Jan. 1, 2001, to Dec. 31, 2005, and analyzed. Setting: Tertiary referral center. Patients: Patients who were referred for patch testing. Intervention: Patch testing with the “standard series,” ie, a standard series of allergens used by most clinicians to identify the most common offending allergens in patients with allergic contact dermatitis. Main Outcome Measures: Number of patients patch tested, allergens used over this period, and rates of allergic patch test reactions to allergens. Results: A total of 3854 patients (mean age, 55.1 years; age range, 6.2-99.4 years; 2576 female [66.8%]) were tested. All dermatologists in the department performed patch testing. The mean number of allergens included was 69.3 (range, 6-87). There were 2664 patients with at least 1 pos. reaction (69.1%) and 1933 with 2 or more pos. reactions (50.2%). Metals, fragrances, topical antibiotics, preservatives, and individual allergens used in hair-care products, topical corticosteroids, glues, plastics, and rubber were still the most common allergen groups associated with allergic patch test reactions. Conclusions: We describe the structure of the patch testing service at our referral center. Ongoing anal. of our patch test reaction rates allows us to recommend broad, clin. relevant, and up-to-date allergens for testing. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Formula: C9H21N3O3

The Article related to patch test diagnosis allergen contact dermatitis, Toxicology: Methods (Including Analysis) and other aspects.Formula: C9H21N3O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 31, 2007, Toropov, Andrey A.; Benfenati, Emilio published an article.Safety of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol The title of the article was Optimization of correlation weights of SMILES invariants for modeling oral quail toxicity. And the article contained the following:

The SMILES (simplified mol. input line entry system) nomenclature was used to elucidate the mol. structure in constructing the quant. structure-property/activity relationships (QSPR/QSAR) for predicting quail toxicity after oral exposure. The presence of chem. elements in different electronic states (e.g., C, c, O, o, Cl, Br, etc.) and of different covalent bonds (i.e., -,=, and #) was used as local invariants. Combinations of different presence/absence codes for local features of the SMILES were used as global invariants. The statistical characteristics of this model are n = 97, r2 = 0.755, s = 0.445, F = 293 (training set); n = 18, r2 = 0.731, s = 0.587, F = 43 (test set). The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Safety of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to qsar optimization smiles invariant model quail toxicity, Toxicology: Methods (Including Analysis) and other aspects.Safety of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 31, 2012, Lee, Sang S.; Hong, Dong K.; Jeong, Nam J.; Lee, Jeung H.; Choi, Yun-Seok; Lee, Ai-Young; Lee, Cheol-Heon; Kim, Kea J.; Park, Hae Y.; Yang, Jun-Mo; Lee, Ga-Young; Lee, Joon; Eun, Hee C.; Moon, Kee-Chan; Seo, Seong J.; Hong, Chang K.; Lee, Sang W.; Choi, Hae Y.; Lee, Jun Y. published an article.Product Details of 4719-04-4 The title of the article was Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea. And the article contained the following:

As many new cosmetic products are introduced into the market, attention must be given to contact dermatitis, which is commonly caused by cosmetics. We investigate the prevalence of preservative allergy in 584 patients with suspected cosmetic contact dermatitis at 11 different hospitals. From Jan. 2010 to March 2011, 584 patients at 11 hospital dermatol. departments presented with cosmetic contact dermatitis symptoms. These patients were patch-tested for preservative allergens. An irritancy patch test performed on 30 control subjects using allergens of various concentrations showed high irritancy rates. Preservative hypersensitivity was detected in 41.1% of patients. Allergens with the highest pos. test rates were benzalkonium chloride (12.1%), thimerosal (9.9%) and methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) (5.5%). Benzalkonium chloride and chlorphenesin had the highest irritancy rate based on an irritancy patch test performed using various concentrations Seven of 30 normal subjects had a pos. irritant patch reading with 0.1 % benzalkonium chloride and eight of 30 normal subjects had a pos. irritant patch reading at 4 days with 0.5% chlorphenesin in petrolatum. Although benzalkonium chloride was highly pos. for skin reactions in our study, most reactions were probably irritation. MCI/MI and thimerosal showed highly pos. allergy reactions in our study. The optimum concentration of chlorphenesin to avoid skin reactions is less than 0.5%. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Product Details of 4719-04-4

The Article related to cosmetic benzalkonium chloride merthiolate contact dermatitis preservative, Immunochemistry: Allergy and Anaphylaxis and other aspects.Product Details of 4719-04-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 28, 2018, Kamata, Ryo; Nakajima, Daisuke; Shiraishi, Fujio published an article.SDS of cas: 4719-04-4 The title of the article was Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. And the article contained the following:

The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. The authors used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects. Eighty-four percent of CAR-activating compounds were aromatic compounds, and >65% of these active compounds were aromatic hydrocarbons, bisphenols, monoalkyl phenols, phthalates, styrene dimers, di-Ph ethers, organochlorines, and organophosphates. The ten most potent compounds were 4-tert-octylphenol (4tOP; reference substance), 4-nonylphenol, diethylstilbestrol, benzyl Bu phthalate, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, o,p’-DDT, methoxychlor, di-Pr phthalate, hexestrol, and octachlorostyrene. The activities of these nine non-reference compounds exceeded 10% of the 4tOP activity. Anal. of para-monoalkyl phenols suggests that branching of the alkyl group and chlorination at the ortho position raises potency. This study provides critical information for identifying the potential of CAR-mediated toxic hazards and for understanding the relevant mechanism. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).SDS of cas: 4719-04-4

The Article related to xenobiotic constitutive androstane receptor, alkyl phenol, bisphenol, constitutive androstane receptor, organochlorine, recombinant yeast, styrene dimer, Toxicology: Methods (Including Analysis) and other aspects.SDS of cas: 4719-04-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 21, 2010, Taylor, Grahame N.; Matherly, Ron published an article.HPLC of Formula: 4719-04-4 The title of the article was Gas chromatographic-mass spectrometric analysis of chemically derivatized hexahydrotriazine-based hydrogen sulfide scavengers: Part II. And the article contained the following:

A gas chromatog.-mass spectrometry method of assaying various thiadiazines and dithiazines in laboratory and field fluids is described. This method also involves the tris-trifluoroacetylation of anhydrous 5-(hydroxyethyl)dithiazine, which unexpectedly yields a novel derivative The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).HPLC of Formula: 4719-04-4

The Article related to hexahydrotriazine derivative hydrogen sulfide scavenger reaction product gc ms, hydrogen sulfide hexahydrotriazine derivative reaction product analysis gc ms, Organic Analytical Chemistry: Detections and other aspects.HPLC of Formula: 4719-04-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tong, Dingyi; Li, Wenying; Zhao, Yunxing; Zhang, Li; Zheng, Jian; Cai, Tao; Liu, Shenggao published an article in 2016, the title of the article was Non-conjugated polyurethane polymer dots based on crosslink enhanced emission (CEE) and application in Fe3+ sensing.Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol And the article contains the following content:

Non-conjugated polymer dots (NCPDs) based on crosslink enhanced emission were synthesized via polyurethane polymerization of triazine derivatives These non-conjugated polymer dots can be applied in recognizing Fe3+. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to polyurethane polymer dot iron crosslink enhanced emission, Inorganic Analytical Chemistry: Separations and other aspects.Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts