Category: 4704-94-3

Adding a certain compound to certain chemical reactions, such as: 4704-94-3, 2-(Hydroxymethyl)propane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H10O3, blongs to alcohols-buliding-blocks compound. Formula: C4H10O3

A mixture of 2-(hydroxymethyl)-1,3-propanediol (4.09 g, 38.5 mmol), acetone (130 ml, 1.768 mmol) and 70percent perchloric acid (1.37 g, 9.55 mmol) was stirred for 21 hours at room temperature. The reaction mixture was concentrated after adjusting to pH 9 with concentrated ammonia. The residue was purified by silica gel column chromatography (silica gel: 100 g, elution solvent: heptane, heptane/ethyl acetate = 1/3) to obtain the target compound (4.83 g, yield: 85.8percent) as a colorless oily substance. 1H-NMR (400 MHz, DMSO-d6) deltappm: 1.29 (3H,s), 1.30 (3H,s), 1.64-1.74 (1H,m), 3.35-3.41 (2H,m), 3.61 (2H,dd,J=7,12 Hz), 3.82 (2H,dd,J=4,12 Hz), 4.54 (1H,t,J=5 Hz)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4704-94-3, 2-(Hydroxymethyl)propane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2065379; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4704-94-3 , The common heterocyclic compound, 4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1 a) 5,9-dioxaspiro[3.51non-7-ylmethanolCyclobutanone (3.3 g, 47.1 mmol), 2-(hydroxymethyl)-1 ,3-propanediol (5 g, 47.1 mmol), p-toluenesulfonic acid monohydrate (450 mg, 2.37 mmol), and benzene (50 ml) were mixed together in a round-bottom flask equipped with a Dean-Stark and a cooling tube, and the mixture was stirred for 6 hours under reflux, and then allowed to stand at room temperature overnight. Triethylamine (2 ml) was added to the reaction mixture, and then the reaction liquid was concentrated. The resulting residue was purified by silica gel column chromatography (silica gel, eluent: heptane / ethyl acetate = 1 / 1 -1 / 3 gradient), whereby the title compound (5.56 g, yield 67.1 %) was obtained as a colorless oil.1H-NMR (400 MHz, DMSO-d6) delta ppm: 1.56-1.66 (2H, m), 1.66-1.76 (1 H, m), 2.05-2.15 (4H, m), 3.33 (2H, dd, J = 5, 6 Hz), 3.50 (2H1 dd, J = 8, 12 Hz), 3.76 (2H, dd, J = 4, 12 Hz), 4.54 (1 H, t, J = 5 Hz).

The synthetic route of 4704-94-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai R & D Management Co., Ltd.; WO2008/47849; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 4704-94-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol, molecular formula is C4H10O3, molecular weight is 106.12, as common compound, the synthetic route is as follows.

4b. 2-((Nitrooxy)methyl)propane-1,3-diol This compound was isolated from the mixture obtained in Example 4a. 1H NMR (300 MHz, CDCl3) delta 4.61 (d, J=6.5 Hz, 2H), 3.91-3.78 (m, 4H), 2.66 (br, 2H), 2.19-2.14 (m, 1H). 13C NMR (75 MHz, CDCl3) delta 71.1, 61.8, 40.5.

Statistics shows that 4704-94-3 is playing an increasingly important role. we look forward to future research findings about 2-(Hydroxymethyl)propane-1,3-diol.

Reference:
Patent; NitroMed, Inc.; US2004/24014; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows. 4704-94-3

Step a. 3-Methoxy-2-methoxymethyl-propane-1-ol Sodium hydride (60% dispersion in oil) (2.93 g, 73.2 mmol) was added to an ice-cooled solution of 2-hydroxymethyl-propane-1,3-diol (M. R. Harnden et al. J. Med. Chem. 1990, 33, 187) (3.53 g, 33.3 mmol) in DMF (100 ml) and the mixture was stirred at room temperature for 40 min. The reaction mixture was cooled with ice and iodomethane (4.56 ml, 73.2 mmol) was added, the stirring was continued allowing the mixture to reach room temperature over 24 h. The mixture was poured into ethyl acetate (300 ml) and washed with brine (150 ml). The organic phase was dried (MgSO4), and the solvent was evaporated. The crude product was purified by flash column chromatography (silica, ethyl acetate) to afford colourless oil. 1H NMR (300 MHz, CDCl3) 3.72 (2H, d), 3.47 (2H, d), 3.45 (2H, d), 3.32 (6H, s), 2.07(1H, m).

Statistics shows that 4704-94-3 is playing an increasingly important role. we look forward to future research findings about 2-(Hydroxymethyl)propane-1,3-diol.

Reference:
Patent; James Black Foundation Limited; US6479531; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts