Category: 4654-39-1

Adding a certain compound to certain chemical reactions, such as: 4654-39-1, 2-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4654-39-1, blongs to alcohols-buliding-blocks compound. 4654-39-1

Bis(pinacolato)diboron (7.58 g, 29.85 mmol), potassium acetate (7.32 g, 74.58 mmol), Pd(dppf)Cl2 (50 mg) and 4-Bromophenethyl alcohol (5 g, 24.8 mmol) were dissolved in dry dioxane under nitrogen. After stirring at 100 C for 24 h, the mixture was transferred to a separatory funnel, extracted with dichloromethane (DCM) and then washed with brine and dried with anhydrous magnesium sulfate. The crude product was purified by silica gel column chromatography with a mixture of petroleum ether (PE): ethyl acetate (EA) = 4:1 as eluent to obtain the pure product 4.63 g (yield, 75%). 1H NMR (600 MHz, CDCl3): 2.84(1.9H, t, J=6.78 Hz), 3.79 (1.9H, t, J=6.78 Hz), 7.21 (1.9H, d, J=7.76 Hz), 7.75 (1.8H, d, J=7.76 Hz).

With the rapid development of chemical substances, we look forward to future research findings about 4654-39-1.

Reference:
Article; Liu, Jikang; Jiang, Pengfei; Wang, Yao; Tu, Guoli; Chinese Chemical Letters; (2019);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

4654-39-1, Adding some certain compound to certain chemical reactions, such as: 4654-39-1, name is 2-(4-Bromophenyl)ethanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4654-39-1.

EXAMPLE 10 This example demonstrates the preparation of 2-AMINO-2- [2- (2 , 3′, 4′- trimethoxybiphenyl-4-yl) ETHYL]-1, 3-propanediol hydrochloride. (10-1) PREPARATION OF 2- (4-BROMOPHENYL) ETHYL IODIDE Methanesulfonylchloride (11.5 ml) was added to a solution of 2- (4- BROMOPHENYL) ethylalcohol (25.0 G) and triethylamine (22.6 ml) in dichloromethane (250 ml) at 0 C. The resulting suspension was stirred at room temperature for 2 hours. The reaction mixture was washed with brine and dried over sodium sulfate and concentrated in vacuo to yield a red oil (39. 1 g). Sodium iodide (18.6 g) was added to a solution of methanesulfonate in 2-butanone (400 ml), and the resulting suspension was heated under reflux for 4.5 hours. The reaction mixture was diluted with ethyl acetate and washed with water, 10% aqueous sodium thiosulfate, and brine. The organic layer was dried over sodium sulfate and concentrated in vacuo. Purification by silica-gel column chromatography using hexane/ethyl acetate 30: 1 gave the title compound (34.2 g) as a colorless oil.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4654-39-1.

Reference:
Patent; Mitsubishi Pharma Corporation; WO2005/14525; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts