Reference of 4640-44-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4640-44-2, name is 3-Aminocyclobutanol, molecular formula is C4H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 2: 3-Bromo-N-(3-hydroxycyclobutyl)-4-methylbenzenesulfonamide (2875) To a stirring solution of 3-aminocyclobutanol (480 mg, 3.88 mmol) in DMF (24.300 ml), under N2, was added 3-bromo-4-methylbenzene-1-sulfonyl chloride (1047 mg, 3.88 mmol) and DIPEA (1.492 ml, 8.55 mmol). The reaction mixture was stirred for 24 hours at room temperature. The mixture was concentrated under reduced pressure and added to 0.1 M HCI (150ml) and product extracted into EtOAc (200ml). The organic extract was washed with sat. Na2C03 (150ml), brine, dried over MgS04 and concentrated under reduced pressure to afford the title compound as a mixture of stereoisomers; (2876) LCMS: Rt 0.93, 0.95 mins; MS m/z 320.2 [M+H]+; Method 2minLowpHv01 (2877)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4640-44-2, 3-Aminocyclobutanol.
Reference:
Patent; NOVARTIS AG; BELLENIE, Benjamin Richard; BLOOMFIELD, Graham Charles; BRUCE, Ian; CULSHAW, Andrew James; HALL, Edward Charles; HOLLINGWORTH, Gregory; NEEF, James; SPENDIFF, Matthew; WATSON, Simon James; WO2015/162456; (2015); A1;,
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