Category: 456-47-3

Adding a certain compound to certain chemical reactions, such as: 456-47-3, 3-Fluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 456-47-3, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: To the stirred mixture of 4-tert-butyl benzyl alcohol (1 mmol, 0.164 g) and ethyl formate (2 mL), tribromo melamine (0.1 mmol) was added without additional solvents. The resulting mixture was stirred at room temperature for 30 min. The reaction was monitored by TLC. On completion of reaction, the product was extracted with CH2Cl2 (5 mL × 4). The organic layer was separated, dried over anhydrous Na2SO4 (1.5 g), and concentrated under reduced pressure. Finally, the organic solvents were evaporated, and 4-tert-butylbenzyl formate was obtained in 92% yield. The identity of the product was confirmedby comparing the physical and spectral data with those of the known compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,456-47-3, its application will become more common.

Reference:
Article; Hajjami, Maryam; Ghorbani-Choghamarani, Arash; Karamshahi, Zahra; Norouzi, Masoomeh; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 35; 2; (2014); p. 260 – 263;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 456-47-3, name is 3-Fluorobenzyl alcohol, the common compound, a new synthetic route is introduced below. name: 3-Fluorobenzyl alcohol

General procedure: A solution of benzyl alcohol (1 mmol), SCC (1 mol %), 70% TBHP (1 mmol or 3 mmol),and 4-methylpyridine (1.0 mmol) in H2O (2 mL) was stirred at 60 C (or 80 C) for 10 h (or 15 h).The reaction mixture was quenched with a saturated solution of sodium thiosulfate (5 mL) andextracted using dichloromethane (3 10 mL). The combined organic layers were dried over anhydrous Na2SO4, filtrated, and then the solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate as the eluent to obtain the desired product.

The synthetic route of 456-47-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Shi-juan; Zhang, Miao; Lu, Rong; Li, Xiu-ying; Che, Guang-bo; Molecules; vol. 23; 8; (2018);,
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Adding a certain compound to certain chemical reactions, such as: 456-47-3, 3-Fluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H7FO, blongs to alcohols-buliding-blocks compound. Formula: C7H7FO

General procedure: A round-bottom flask was charged with alcohol (2 mmol), CuOTf (0.1 mmol, 0.05 equiv) (S)-5-(pyrrolidin-2-yl)-1H-tetrazole (0.1 mmol, 0.05 equiv), TEMPO (0.1 mmol, 0.05 equiv), DMAP (0.15 mmol, 0.075 equiv) and CH3CN (5 ml). The reaction mixture was stirred at 25 C open to air until the completion of the reaction, as monitored by TLC. After completion, CH3CN was evaporated under vacuum. The residue was then diluted with CH2Cl2 (5 ml) and filtered through a plug of silica gel to afford the desired product.

The synthetic route of 456-47-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Yangyang; Xie, Aming; Li, Junjian; Xu, Xiao; Dong, Wei; Wang, Boliang; Tetrahedron; vol. 70; 52; (2014); p. 9791 – 9796;,
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Related Products of 456-47-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 456-47-3, name is 3-Fluorobenzyl alcohol. A new synthetic method of this compound is introduced below.

General procedure: Sodium hydride (60% in mineral oil, 0.04g, 1mmol) was added to a stirred solution of benzyl alcohol derivative (1mmol) in anhydrous N,N-dimethylformamide (3mL of DMF) at room temperature and stirring was continued for 1h. 2-Amino-3-chloropyrazine (10b, 0.13g, 1mmol) was added to the reaction mixture and the reaction mixture was stirred at 100C for 15h. After cooling, the solvent was evaporated and the residue was partitioned between water and dichloromethane. The organic layer was dried over sodium sulfate anhydrous, filtered, and concentrated. The residue was purified by column chromatography (SiO2, EA/n-Hex=1/5). 4.1.2.1 3-(3-Fluorobenzyloxy)pyrazin-2-amine (11e) (0027) Light orange solid, yield: 75.6%, 1H NMR (400MHz, DMSO-d6) delta=5.39 (2H, s, OCH2Ph), 6.36 (2H, br, NH2), 7.14 (1H, td, J=2.6Hz, 9.0Hz, ArH), 7.25 (1H, d, J=3.1Hz, ArH), 7.32 (1H, d, J=7.6Hz, ArH), 7.37-7.44 (2H, m, ArH), 7.49 (1H, d, J=3.1Hz, ArH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,456-47-3, its application will become more common.

Reference:
Article; Park, Jung-eun; Elkamhawy, Ahmed; Hassan, Ahmed H.E.; Pae, Ae Nim; Lee, Jiyoun; Paik, Sora; Park, Beoung-Geon; Roh, Eun Joo; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 322 – 334;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 456-47-3, name is 3-Fluorobenzyl alcohol, molecular formula is C7H7FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 456-47-3

General procedure: The product analysis was carried out under kinetic conditions. In a typical experiment, benzyl alcohol(0.1 mol), TsOH (1.0 mol) and BIDC (0.02 mol) were made up to 50 ml in DMSO and kept in the dark for ca. 12 h to ensure completion of the reaction. The solution was then treated with excess (200 ml) of a saturated solution of 2,4-dinitrophenylhydrazine in 2 mol dm3 HCl and kept overnight in a refrigerator. The precipitated 2,4-dinitrophenylhydrazone(DNP) was filtered off, dried, weighed, recrystallized from ethanol, and weighed again. The yields of DNP before and after recrystallization were 7.89 g (92%) and 6.86 g (80%)respectively, indicating the amount of benzaldehyde formed is about 3.0-3.1 g. The DNP was found identical (m.p. andmixed m.p.) with the DNP of benzaldehyde. The identity of the DNP was confirmed by the elemental analysis also. The observed values were C, 54.79%; H, 3.40% and N, 19.39%,the calculated values for C13H10N4O4 are C, 54.55%; H,3.50% and N, 19.58%. In similar experiments, with the other substituted benzyl alcohols the yields of DNP, after recrystallization, were in the range of 75 88%. CrVI is reduced to CrIII.

With the rapid development of chemical substances, we look forward to future research findings about 456-47-3.

Reference:
Article; Kothari, Seema; Kumar, Pravesh; Panday, Dinesh; Journal of the Indian Chemical Society; vol. 95; 10; (2018); p. 1207 – 1215;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 456-47-3, name is 3-Fluorobenzyl alcohol, molecular formula is C7H7FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 456-47-3

General procedure: GeneralProcedure for the preparation of 2-Phenyl-1H-benzoimidazole (3aa): A 25mL over-dried Schlenk tube was charged with 2-nitroaniline (41.4 mg, 0.3 mmol),benzyl alcohol (97.2 mg, 0.90 mmol) and Pd(dppf)Cl2 (12.2 mg, 0.015mmol). The tube was purged with nitrogen three times. Toluene (1 mL) was addedto the sealed reaction vessel by syringe. The reaction mixture was stirred in apreheated oil bath at 160 oC for 24 h. After cooling to roomtemperature, the reaction mixture was then concentrated in vacuo, and theresidue was purified by column chromatography (silica gel, petroleumether/ ethyl acetate = 4:1) to give 3aa as a pale yellow solid (56.5 mg, 97%).

With the rapid development of chemical substances, we look forward to future research findings about 456-47-3.

Reference:
Article; Li, Xiaotong; Hu, Renhe; Tong, Yao; Pan, Qiang; Miao, Dazhuang; Han, Shiqing; Tetrahedron Letters; vol. 57; 41; (2016); p. 4645 – 4649;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 456-47-3, name is 3-Fluorobenzyl alcohol. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H7FO

2-Bromo-4-nitrophenol (4.86 g, 0.0223 mol), triphenylphosphine (7.6 g, 0.0290 mol), 3-fluorobenzylalcohol (3.65 g, 0.0290 mol) were combined and dissolved in THF (89 mL). The reaction temperature was cooled to 0 C. and DIAD (4.50 g, 0.0290 mol) was added. The reaction was allowed to warm slowly to room temperature and stirred for 3 hours before it was diluted with water (100 mL) and EtOAc (100 mL). The layers were separated and the aqueous layer was extracted with EtOAc (200 mL*2). The organic extracts were combined and washed with brine, followed by drying over sodium sulfate. The volatiles were removed in vacuo and the residual semi-solid was treated with diethyl ether. The solids were removed by filtration. The volatiles from the resulting filtrate were removed in vacuo and the material was purified using EtOAc:Hexanes (90/10) in a biotage LC system to afford the title compound as a yellow solid (3.73 g, 68% yield). 1H NMR (DMSO-d6) delta 8.43 (d, 1H); 8.26 (m, 1H); 7.45 (m, 1H); 7.38 (d, 1H); 7.30 (m, 2H); 7.17 (m, 1H); 5.39 (s, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 456-47-3, 3-Fluorobenzyl alcohol.

Reference:
Patent; NOVARTIS AG; Lackey, Karen Elizabeth; Mullin, Robert J.; Spector, Neil; Wood, III, Edgar Raymond; Xia, Wenle; (22 pag.)US2015/366868; (2015); A1;,
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Electric Literature of 456-47-3 ,Some common heterocyclic compound, 456-47-3, molecular formula is C7H7FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of H2O (5 mL) and CH2Cl2 (5 mL) wasadded to the chlorinated polymeric beads (2 g). (The unchlorinated beads were obtained from HaloSource, Inc. The unchlorinated beads were chlorinated by soaking the beads in bleach solution, with pH adjusted to 7 by additionof AcOH, for an hour. Then, the chlorinated beads were filtered and dried in air.) After addition of TEMPO (10 mg,0.064 mmol) and benzyl alcohol (0.2 g, 1.8 mmol), NaHCO3(0.5 g) was added to the mixture. The mixture was stirred at r.t. for 3 h and filtered. The residue on the filter paper was washed with H2O (20 mL) and CH2Cl2 (10 mL), and the organic phase of the filtrate was separated, dried over MgSO4, and filtered. The solvent was removed under vacuum to obtain benzaldehyde.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 456-47-3, 3-Fluorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Akdag, Akin; Oeztuerk, Perihan; Synlett; vol. 24; 18; (2013); p. 2451 – 2453;,
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Electric Literature of 456-47-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 456-47-3, name is 3-Fluorobenzyl alcohol, molecular formula is C7H7FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The oxidation of alcohols was carried out under O2 in a 50-mL two-necked, round-bottom flask equipped with a magnetic stirrer. Typically, Fe2(SO4)3 (0.25 mmol) and TMHPO (0.25 mmol) were added to the flask, followed by 15 mL of a CH3CN/H2O (1:2) solvent mixture. After stirring for 5 min, the alcohol (5 mmol) was added, followed by NaNO2 (0.25 mmol). The resulting mixture was stirred at room temperature and 1 atm pressure of oxygen. When the reactions were completed, the reaction mixture was transferred to a separating funnel and extracted with dichloromethane. The organic layer was dried over anhydrous Na2SO4 and concentrated and further purified by flash chromatography to give the desired product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 456-47-3, 3-Fluorobenzyl alcohol.

Reference:
Article; Shi, Xiang-Jun; Qian, Jie; Tan, Fan-Fan; Yu, Chuan-Ming; Journal of Chemical Research; vol. 37; 7; (2013); p. 398 – 401;,
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Adding a certain compound to certain chemical reactions, such as: 456-47-3, 3-Fluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H7FO, blongs to alcohols-buliding-blocks compound. COA of Formula: C7H7FO

Aniline (46.5 mg, 0.5 mmol),Cat.[Ir] (5.4 mg, 0.005 mmol, 1 mol%), cesium carbonate (49 mg, 0.15 mmol, 0.3 equiv.),3-Fluorobenzyl alcohol (75.6 mg, 0.6 mmol) and t-amyl alcohol (1 ml) were sequentially added to a 5 mL round-bottomed flask.The reaction mixture was refluxed in air for 12 hours and then cooled to room temperature.The solvent is removed by rotary evaporation and then passed through column chromatography (developer:Petroleum ether/ethyl acetate gives the pure target compound, yield: 95%.

The synthetic route of 456-47-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing University of Science and Technology; Fan Hongjun; Li Shun; Liu Pengcheng; Li Feng; (9 pag.)CN107778182; (2018); A;,
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