Category: 4541-14-4

Electric Literature of 4541-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General Procedure P. A solution of the alcohol (1 equiv) in anhydrous CH2Cl2 (0.2 M) at 0 0C was treated with PCC (1.5 equiv) and the mixture was stirred for 45 min. The reaction mixture was allowed to warm at 25 C and stirred for 3 h. The suspension was filtered through Celite and concentrated. Column chromatography (SiO2) afforded the aldehyde.; 4-(Benzyloxy)butan-l-ol was oxidized to 4-(benzyloxy)butanal (7.35 g, 79%) following general procedure P

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Patent; BOGER, Dale, L.; WO2008/150492; (2008); A1;,
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Reference of 4541-14-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. A new synthetic method of this compound is introduced below.

4-Benzyloxy-butan-1-ol (5.0 g), potassium bromide (0.66 g), and 2,2,6,6-tetramethylpiperidine 1-oxyl free radical (43.1 mg) were mixed in toluene (15 mL), ethyl acetate (15 mL), and water (3 mL). To the reaction solution were added dropwise a mixed solution of potassium hydrogen carbonate (5.55 g) in water (15 mL) and then 15 w/w/o aqueous sodium hypochlorite solution (16.5 mL) under ice cooling. The reaction solution was stirred under ice cooling for 1.5 hours. To the reaction solution was added 15 w/w % aqueous sodium hypochlorite solution (4 mL), and the reaction solution was stirred for additional 2 hours. The reaction solution was extracted with toluene. The organic layer was washed sequentially with water, a mixed solution of potassium iodide (73 mg) in 1M hydrochloric acid (5 mL), a mixed solution of sodium thiosulfate (2.3 g) and potassium carbonate (4.02 g) in water (8.3 mL), and aqueous saturated sodium chloride solution, and dried over magnesium sulfate. After removing magnesium sulfate on a filter, the filtrate was concentrated under reduced pressure to give the titled compound (4.08 g) as a crude product. (0850) 1H-NMR (400 MHz, CDCl3) 1.91-1.99 (m, 2H), 2.55 (td, J=7.05, 1.62 Hz, 2H), 3.51 (t, J=6.13 Hz, 2H), 4.49 (s, 2H), 7.15-7.37 (m, 5H), 9.79 (t, J=1.62 Hz, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4541-14-4, its application will become more common.

Reference:
Patent; JAPAN TOBACCO INC.; YOKOTA, Masahiro; IKENOGAMI, Taku; WATANABE, Eiichi; SEKI, Noriyoshi; SAKAI, Takayuki; FUJIOKA, Shingo; SHIOZAKI, Makoto; SUWA, Katsunori; OGOSHI, Yosuke; NOGUCHI, Masato; MAEDA, Katsuya; (228 pag.)US2016/194290; (2016); A1;,
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Application of 4541-14-4 , The common heterocyclic compound, 4541-14-4, name is 4-(Benzyloxy)butan-1-ol, molecular formula is C11H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

DMSO (9.8 mL, 138.8 mmol) was added at -78 C to a solution of oxalyl chloride (9.7 mL, 111.0 mmol) in CH2Cl2 (100 mL), and the resulting solution was stirred for 15 min. A solution of the mono benzylated alcohol 18 (10 g, 55.5 mmol) in CH2Cl2(50 mL), was added drop wise at -78 C over 30 min. After the solution had been stirred for an additional 30 min, Et3N (38.2 mL, 275.0 mmol) was added and the reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into ice cooled water and extracted with CH2Cl2. The organic layer was washed with brine, dried with Na2SO4 and concentrated under reduced pressure to give crude aldehyde (8.9 g) which was directly used for next step without further purification.

The synthetic route of 4541-14-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Avuluri, Srilatha; Bujaranipalli, Sheshurao; Das, Saibal; Yadav; Tetrahedron Letters; vol. 59; 39; (2018); p. 3547 – 3549;,
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Alcohols – Chemistry LibreTexts

Related Products of 4541-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

DMSO (7.88 mL, 0.11 mol) was added at -78 oC to a solution of oxalyl chloride (7.24 mL, 0.08 mol) in CH2Cl2 (100 mL), and the resulting solution was stirred for 15 min. A solution of the monobenzylated alcohol 19 (10 g, 55.55 mmol) in CH2Cl2 (50 mL), was added drop wise at -78 oC over 30 min. After the solution had been stirred for an additional 30 min, Et3N (46.37 mL, 0.33 mol) was added and the reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into ice cooled water and extracted with CH2Cl2. The organic layer was washed with brine, dried with Na2SO4, and concentrated under reduced pressure to give crude aldehyde (8.9 g) which was directly used for next step without further purification. To a stirred solution of aldehyde (8.9 g, 50.0 mmol) in C6H6 (100 mL), was added (ethoxycarbonylmethylene)triphenylphosphorane (19.2 g, 55.0 mmol) and the mixture was heated at reflux for 4 h. After completion of the reaction, solvent was removed in vacuo then purified by column chromatography to afford 20 (11.78 g, 85% over two steps) as a light yellow oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Article; Bujaranipalli, Sheshurao; Das, Saibal; Tetrahedron Letters; vol. 57; 25; (2016); p. 2800 – 2802;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 4541-14-4 ,Some common heterocyclic compound, 4541-14-4, molecular formula is C11H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A flame-dried round-bottom flask was charged with a solution of oxalylchloride (3.8 mL, 43.1 mmol) in CH2Cl2 (45 mL) at -78 C. The mixture was added to dimethylsulfoxide (6.1 mL, 87.1 mmol) at -78 C. This mixture was stirred for 20 min,and then a solution of the alcohol (5.0 g, 27.7 mmol), prepared as described inthe preceding procedure, in CH2Cl2 (14 mL) was added.After 20 min, triethylamine (19.3 mL, 138.5 mmol) was added to the reactionmixture and stirred for 10 min. The resulting mixture was warmed to roomtemperature and stirred for 1 h. The reaction mixture was diluted with ether(30 mL), and water (30 mL) was added. The organic layer was separated, and theaqueous layer was extracted with ether (2 × 30 mL), and washed with saturatedaqueous NaHCO3 (15 mL) and saturated aqueous NaCl (15 mL). Theorganic solutions were combined, dried (Na2SO4), and concentratedto afford the desired crude aldehyde (4.90 g, 27.5 mmol, 99%) as a colorlessoil which was used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4541-14-4, its application will become more common.

Reference:
Article; Lee, Jungmee; Oh, Hong-Se; Kang, Han-Young; Tetrahedron Letters; vol. 56; 9; (2015); p. 1099 – 1102;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C11H16O2

To stirred solution of alcohol 21 (10 g, 55.5 mmol) in dichloromethane (150 mL) at 0 C were added pyridinium chlorochromate (17.96 g, 83.33 mmol) and Celite (17.96 g) and stirred at room temperature for 5 h. Diethyl ether (100 mL) was added and the reaction mixture was filtered through a small pad of Celite and silica gel. The filtered cake was washed thoroughly with ether (2 ¡Á 150 mL) and the filtrate was concentrated under reduced pressure. After flash column chromatography on silica gel (100-200 mesh, eluent: 8% EtOAc in hexane) aldehyde 22 (9.09 g, 92%) was obtained as a colorless liquid. 1H NMR (400 MHz, CDCl3): delta 9.76 (t, J = 1.5 Hz, 1H), 7.36-7.17 (m, 5H), 4.46 (s, 2H), 3.47 (q, J = 5.1 Hz, 2H), 2.53 (td, J = 7.0, 1.5 Hz, 2H), 1.92 (ddd, J = 13.0, 7.0, 6.0 Hz, 2H); 13C NMR (75 MHz, CDCl3): delta 201.3, 138.2, 128.4, 127.6, 73.0, 69.0, 41.0, 22.6; MASS (EIMS): m/z 178 (M)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Article; Venkatesham, Akkaladevi; Nagaiah, Kommu; Tetrahedron Asymmetry; vol. 23; 15-16; (2012); p. 1186 – 1197,12;,
Alcohol – Wikipedia,
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