Category: 454-91-1

Electric Literature of 454-91-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol, molecular formula is C9H9F3O, molecular weight is 190.16, as common compound, the synthetic route is as follows.

Example 90 1-[3-(Trifluoromethyl)phenyl]ethyl N-{4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}carbamate 4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline (89 mg) was added to toluene/triethylamine = 10/1 (9 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (120 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethyl-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (80 mg, yield 48%). 1H-NMR (CDCl3, 400 MHz): 8.75 (1H, s), 8.07 (1H, s), 7.14 – 7.63 (8H, m), 6.95 (1H, s), 6.79 (1H, d, J = 8.8 Hz), 5.93 (1H, q, J = 6.6 Hz), 4.15 (3H, s), 4.09 (3H, s), 1.61 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 514 (M++1)

Statistics shows that 454-91-1 is playing an increasingly important role. we look forward to future research findings about 1-[3-(Trifluoromethyl)phenyl]ethanol.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-[3-(Trifluoromethyl)phenyl]ethanol, blongs to alcohols-buliding-blocks compound. Safety of 1-[3-(Trifluoromethyl)phenyl]ethanol

At room temperature, in a 50 ml round-bottom flask is sequentially added in 3 – trifluoromethyl -1 – phenethyl alcohol (0.19 g, 1 mmol), benzoic acid (0.183g, 1.5 mmol), NBS (0.356g, 2 mmol) and 1, 4 – dioxane (2 ml). In the 60 C stirring 1 hour, then adding DBU (0.304 g, 2 mmol), continue to reaction 4 hours (TLC detection reaction). Then, stopping the reaction, concentrated under reduced pressure, to obtain crude product. Finally petroleum ether and ethyl acetate mixed eluent flushing, rapid column chromatography (silica gel column) to obtain the corresponding product alpha – acyloxy ketone compound (white solid 0.170, yield 55%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Qufu Normal University; Wang, Hua; Wei, Wei; Zhu, Minghui; Cui, Huanhuan; (19 pag.)CN106518663; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 454-91-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol, molecular formula is C9H9F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 13 Separation of rac.-3-(trifluoromethyl)phenylethanol using a chiral selector generated from (4R,5R)-bis(hydroxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane and Al(O-isopropyl)3 (selector:alcohol ratio 1:1) 13.0 mmol (6.0 g) of (4R,5R)-bis(hydroxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane and 13.0 mmol (2.62 g) of aluminum triisopropoxide are put into 40 ml of diphenyl ether in a glove box. The resulting suspension is stirred under protective gas at 90 C. for 60 min. This is followed by addition of 13 mmol (2.50 g) of racemic 1-(3-trifluoromethylphenyl)ethanol and stirring for a further 10 min. Subsequently, the resulting isopropanol is distilled out under about 20 mbar. Then, at 1 mbar and 90 C., 1.25 g of a mixture of the enantiomers of 1-(3-trifluoromethylphenyl)ethanol as distillate are obtained. Investigation of the distillate by chiral gas chromatography (BGB-Analytikvertrieb BGB-174S) revealed an enantiomeric excess of 27.8%.

According to the analysis of related databases, 454-91-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF SE; US2009/30235; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 454-91-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol, molecular formula is C9H9F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

0.200 g (0.6 mmol) of (3R)-4-(4-toluenesulfonyl)thiomorpholine-3-carboxylic acid, 0.190 g (1.0 mmol) of 1-methyl-1-(3-trifluoromethylphenyl)-methanol, 0.088 g (0.33 mmol) of CAS, 0.227 g (1.2 mmol) of DCC and 0.04 g (0.33 mmol) of DMAP were dissolved in 15 mL of CH2Cl2. The mixture was stirred for 24 h at room temperature. The solid was filtrated and the solvent was evaporated. The residual was dissolved in a suitable amount of ethyl acetate (20 ml) and then the mixture was filtered to remove insoluble substance. The ethyl acetate was added to 60 ml and then the liquid was washed with 10% NaHCO3 solution, saturated NaCl solution and dried over Na2SO4. After the drying agent was removed and part of ethyl acetate was evaporated, the crude product was purified by flash column chromatography (eluent: ethyl acetate_cyclohexane=1:9) to obtain the product as a oil (0.13 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol.

Reference:
Patent; Li, Song; Nie, Aihua; Shen, Beifen; Wang, Lili; Pei, Wuhong; Xiao, Junhai; Yang, Songcheng; Yun, Liuhong; Liu, Hongying; Shu, Cuiling; Wang, Hongxia; Rao, Zihe; US2005/130958; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 454-91-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 87 1-[3-(Trifluoromethyl)phenyl]ethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (74 mg) was added to toluene/triethylamine = 10/1 (7 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (115 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min.Subsequently, 3-trifluoromethyl-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (81 mg, yield 59%). 1H-NMR (CDCl3, 400 MHz): 8.41 – 8.48 (1H, m), 8.11 (1H, s), 7.45 – 7.68 (7H, m), 7.13 – 7.18 (2H, m), 6.93 (1H, s), 6.65 (1H, d, J = 6.6 Hz), 5.94 (1H, q, J = 6.6 Hz), 4.14 (3H, s), 4.08 (3H, s), 1.63 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 513 (M++1)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 454-91-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 3-1 Synthesis of O-{1-(3-trifluoromethylphenyl)ethyl}-acetohydroxamate A 20 mg portion of DMF was added to 5 ml of toluene solution containing 3 g (15.8 mmol) of 1-(3-trifluoromethylphenyl)ethylalcohol. Then, 2.25 g (18.9 mmol) of thionyl chloride was added under ice-cooling. After 2 hours of stirring at 10C or less, this was concentrated under a reduced pressure on a water bath at temperature of 50 to 60C. After cooling to room temperature, 8 ml of DMF, 3.3 g (23.9 mmol) of anhydrous potassium carbonate and 2.15 g (20.5 mmol) of acetohydroxamic acid were added, and the mixture was stirred for 6 hours while heating at 120 to 130C. After cooling, ethyl acetate was added to the reaction mixture, and the mixture was washed with water and saturated brine in that order and then dried over anhydrous sodium sulfate. This was concentrated under a reduced pressure, and the resulting residue was purified by a silica gel column chromatography (n-Hex:AcOEt = 1:1 ? 1:2) to give 2.32 g of the title compound (yield = 59.5%). Melting point; 75.3 – 76.5C 1H-NMR delta (CDCl3); 1.57 (3H, d), 1.8 – 2.2 (3H, br), 4.8 – 5.15 (1H, br), 7.45 – 7.55 (4H, m), 7.8 – 8.0 (1H, br)

According to the analysis of related databases, 454-91-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MITSUBISHI CHEMICAL CORPORATION; EP949243; (1999); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 454-91-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol. This compound has unique chemical properties. The synthetic route is as follows.

4-(2-Fluorophenyl)-2-methyl-2H-pyrazol-3-amine (150 mg, 0.78 mmol) and triphosgene (303 mg, 1.02 mmol) were dissolved in dichloromethane (3 mL). Toluene (8 mL) was added and the mixture was sealed. The mixture was stirred in an ice bath and TEA (0.9 mL, 8.0 eq) was added. The mixture was stirred at 85 C for 20 minutes and l-(3-(trifluoromethyl)-phenyl)ethanol (194 mg, 1.02 mmol) in toluene (2 mL) was added. The mixture was stirred at 90 C for 2 fir. Solvents were evaporated and the residue was extracted with ethyl acetate and water. The organic layer was washed with brine and dried. Solvents were evaporated and the residue was purified by ISCO flash column chromatography (0% to 60% ethyl acetate in hexanes) to give [4-(2-fluoro- phenyl)-2-methyl-2H-pyrazol-3-yl]-carbamic acid l-(3-trifluoromethyl-phenyl)-ethyl ester as a pale yellow waxy material (226 mg, 70.7% yield). 1H-NMR (400 MHz, DMSO-de) delta ppm 1.11- 1.29 (m, 0.6H), 1.55 (br d, J=5.81 Hz, 2.4H), 3.65 (s, 3H), 5.73-5.85 (m, 1H), 7.06-7.24 (m, 2H), 7.25-7.52 (m, 3H), 7.56-7.82 (m, 4H), 9.29 (br s, 0.2H), 9.66 (s, 0.8H); LC/MS calcd for C2oHi7F4N302 (m/e) 407.0, obsd 408.0 (M+H, ES+)..

According to the analysis of related databases, 454-91-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GABRIEL, Stephen Deems; HAMILTON, Matthew Michael; QIAN, Yimin; SIDDURI, Achyutharao; WO2013/189862; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol, molecular formula is C9H9F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C9H9F3O

Example 89 1-[3-(Trifluoromethyl)phenyl]ethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline (76 mg) was added to toluene/triethylamine = 10/1 (8 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (110 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethyl-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (78 mg, yield 58%). 1H-NMR (CDCl3, 400 MHz): 8.40 – 8.47 (1H, m), 8.12 (1H, s), 7.84 (1H, s), 7.45 – 7.68 (5H, m), 6.93 (1H, s), 6.47 – 6.57 (2H, m), 5.93 (1H, q, J = 6.8 Hz), 4.14 (3H, s), 4.08 (3H, s), 2.27 (3H, s), 2.09 (3H, s), 1.63 (3H, d, J = 6.8 Hz) Mass spectrometry value (ESI-MS, m/z): 542 (M++1)

With the rapid development of chemical substances, we look forward to future research findings about 454-91-1.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 454-91-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol. A new synthetic method of this compound is introduced below.

Example 88 1-[3-(Trifluoromethyl)phenyl]ethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylaniline (72 mg) was added to toluene/triethylamine = 10/1 (7 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (110 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethyl-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue waspurified on a column using chloroform/methanol to give the title compound (90 mg, yield 68%). 1H-NMR (CDCl3, 400 MHz): 8.39 – 8.45 (1H, m), 8.13 (1H, s), 7.40 – 7.72 (6H, m), 6.99 (1H, d, J = 9.0 Hz), 6.48 – 6.55 (2H, m), 5.93 (1H, 1, J = 6.6 Hz), 4.15 (3H, s), 4.09 (3H, s), 2.24 (3H, s), 2.07 (3H, s), 1.63 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 542 (M++1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,454-91-1, its application will become more common.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts