Category: 4464-18-0

Electric Literature of 4464-18-0 ,Some common heterocyclic compound, 4464-18-0, molecular formula is C9H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 2 1,3,5-Tris(bromomethyl)benzene A solution of thionyl bromide (3.1 mL, 8.3 g, 0.04 M) in chloroform (25 mL) is added dropwise over a period of 10 minutes to a stirred slurry of 1,3,5-tris(hydroxymethyl)-benzene (Preparation 1, 1.9 g, 0.012 M) in chloroform (100 mL). The mixture is stirred at room temperature for four hours during which the solids dissolve into solution. The solution is heated at reflux temperature for 45 minutes, cooled to room temperature, and examined by TLC which shows the reaction is complete. The chloroform and excess thionyl bromide are removed under reduced pressure, leaving a reddish-yellow solid residue. The crude product is chromatographed on a filtration column of gravity silica gel (63-200 mmu, 60 g) in methylene chloride. The column is eluted with methylene chloride and three fractions of 250 mL each are collected. The desired product is eluted in fraction 2 (4.13 g) and is recrystallized from hexane, giving the title compound (3.20 g) as colorless crystals, mp 95.5-97.5 C. W. Reppe and W. J. Schweckendiek, Justus Liebigs Ann. Chem., 560:1041 (1948) report amp of 94 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4464-18-0, Benzene-1,3,5-triyltrimethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Upjohn Company; US5500417; (1996); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4464-18-0, name is Benzene-1,3,5-triyltrimethanol. A new synthetic method of this compound is introduced below., name: Benzene-1,3,5-triyltrimethanol

1 ,3,5-Tris(hydroxymethyl)benzene 15 (927 mg, 5.12 mmol) was suspended in CH2CI2 (25 mL) and solid PCC (5.94g, 27.6 mmol) was added. After 30 minutes of stirring, the reaction was diluted with acetone (10 mL) and was allowed to stir for 3 hr at RT. TLC (10% MeOH, 90% CH2CI2 Rf=0.50) was used to determine if the reaction was complete. After the reaction was complete, the precipitated chromium salts were filtered off and washed with CH2CI2. The aqueous layer was extracted 3 times in CH2CI2 and saturated Na2CO3. The organic layers were combined and dried over anhydrous Na2SO4, filtered, and concentrated. Flash column chromatography (100% CH2CI2 Rf=0.4) gave 16 (272 mg, 1.68 mmol, 33%). 1H NMR (CDCI3): delta 10.21 (s, 3H), 8.63 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4464-18-0, Benzene-1,3,5-triyltrimethanol.

Reference:
Patent; UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.; PHANSTIEL, Otto; ARCHER, Jennifer, J.; WO2010/148390; (2010); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 4464-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4464-18-0, name is Benzene-1,3,5-triyltrimethanol. This compound has unique chemical properties. The synthetic route is as follows.

As asolution A, 16.8 g (0.1 mol) of 1,3,5-tris (hydroxymethyl) benzene and 0.32 g (0.5 mmol) of dibutyltin EGI-1 (2-methacryloyloxyethyloxy) ethyl isocyanate was changed to a solution in which dilaurate was dissolved and the addition amount of 2- (2-methacryloyloxyethyloxy) ethyl isocyanate was changed to 61.8 g (0.31 mol) EGI-6 (76.2 g, yield 99%) was obtained by synthesizing in the same manner as in the synthesis procedure of EGI-6.The dataof1H NMR spectrum ofthe obtained EGI-6were as follows.

According to the analysis of related databases, 4464-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOKUYAMA DENTAL CORPORATION; SUZUKI, TAKESHI; SAKATA, EIBU; YAMAGAWA, JUN-ICHIRO; (25 pag.)JP6225054; (2017); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 4464-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4464-18-0, name is Benzene-1,3,5-triyltrimethanol. This compound has unique chemical properties. The synthetic route is as follows.

Benzene-1,3,5-triyltrimethanol (400 mg, 2.38 mmol) was suspended in 8 ml of tBuOH, and IBX (4.00 g, 14.27 mmol, 6 equiv) was added. The mixture was heated to reux and stirred for 5h. The suspension was cooled to rt and the solids were filtered off, and subsequently washed with CH2Cl2. The clear liquid was evaporated to dryness, yielding the tri-aldehyde as white powder (385 mg, 2.38 mmol, quant). 1H NMR (500 MHz, Chloroform-d) 8 10.21 (s, 3H), 8.64 (s, 3H). 130 NMR (126 MHZ, CDCl3) 6 189.78, 137.80, 134.76.

According to the analysis of related databases, 4464-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN; UNIVERSITEIT VAN AMSTERDAM; RICHELLE, Gaston Julia Johannes; STREEFKERK, Dieuwertje Emma; VAN MAARSEVEEN, Jan Herman; TIMMERMAN, Peter; (162 pag.)WO2018/106112; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts