Category: 44565-27-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 44565-27-7, name is 4-Amino-2-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 44565-27-7

Reference Example 17 (+/-)-N-[3,5-Bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(4-hydroxy-3-methylbutyl)-5-(4-methylphenyl)-8-oxo-6-pyrido[3,4-b]pyridinecarboxamide The compound as obtained in Reference Example 3 was reacted with 4-amino-2-methyl-1-butanol and treated in the same manner as in Reference Example 13, to obtain the entitled compound as colorless crystals. m.p. 129-130 C. (after once melted, this again solidified), 188-190 C. (re-melted) (recrystallized from ethyl acetate-isopropyl ether) NMR(200 MHz, CDCl3) ppm: 0.79(3H,d,J=6.6 Hz), 1.4-1.8(3H,m), 2.28(3H,s), 3.03(1H,t,J=6.6 Hz,-OH), 3.2-3.7(4H,m), 4.49(2H,d,J=5.8 Hz), 7.0-7.3(4H,m), 7.30(1H,dd,J=8.4,4.4 Hz), 7.53(1H,dd,J=8.4,1.4 Hz), 7.68(2H,s), 7.78(1H,s), 8.48(1H,t,J=6.0 Hz), 8.61(1H,dd,J=4.4,1.4 Hz).

With the rapid development of chemical substances, we look forward to future research findings about 44565-27-7.

Reference:
Patent; Natsugari, Hideaki; Doi, Takayuki; Ikeura, Yoshinori; US2002/132817; (2002); A1;,
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Electric Literature of 44565-27-7 ,Some common heterocyclic compound, 44565-27-7, molecular formula is C5H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Nitrobenzaldehyde (7.33 g, 48.5 mmol) and 4-amino-2-methylbutanol (5.00 g, 48.5 mmol) where dissolved in toluene (50 ml) and heated to reflux for two hours with Dean Stark dehydration apparatus. After allowed to cool, the solvent was evaporated under reduced pressure. The obtained concentrate was dissolved in methanol (100 ml), added with sodium borohydride (2.75 g, 72.8 mmol) under ice cooled condition and stirred at the same temperature for two hours. The reaction mixture was further stirred at room temperature for two hours, adjusted to pH 4 by adding 1N hydrochloric acid, and the solvent was evaporated under reduced pressure. Water (30 ml) was added to dissolve the concentrate alter extracted with ethyl acetate, pH was adjusted to 8 by added a saturated sodium hydrogen carbonate aqueous solution and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to obtain 2-methyl-4-(2-nitrobenzylamino)butanol (11.12 g). Yield: 96% Physical properties: nD 1.5372 (24C)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 44565-27-7, 4-Amino-2-methylbutan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nihon Nohyaku CO., LTD.; EP2085392; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.44565-27-7, name is 4-Amino-2-methylbutan-1-ol, molecular formula is C5H13NO, molecular weight is 103.1628, as common compound, the synthetic route is as follows.name: 4-Amino-2-methylbutan-1-ol

Reference Example 39 tert-Butyl (4-{[tert-butyl(dimethyl)silyl]oxy}-3-methylbutyl)carbamate A solution of di-tert-butyl dicarbonate (11.1 g) in methylene chloride (30 mL) was added to a solution of 4-amino-2-methylbutan-1-ol (5.00 g) in methylene chloride (50 mL) with stirring at room temperature. After stirring overnight at room temperature, the reaction solution was washed with a saturated aqueous solution of ammonium chloride, a saturated aqueous solution of sodium bicarbonate, and saturated sodium chloride solution in this order. The organic layer was dried over anhydrous sodium sulfate, then filtered, and concentrated under reduced pressure. The obtained residue was dissolved in methylene chloride (150 mL). To the solution, tert-butyldimethylchlorosilane (8.77 g) and imidazole (8.25 g) were added with stirring at 0 C. The mixture was heated to room temperature and stirred overnight, and the reaction solution was then washed with water, a 1 M aqueous citric acid solution, and saturated sodium chloride solution in this order. The organic layer was dried over anhydrous sodium sulfate, then filtered, and concentrated under reduced pressure to obtain the title compound (16.2 g). 1H-NMR (CDCl3) delta: 0.04 (6H, s), 0.89 (3H, d, J=6.6 Hz), 0.89 (9H, s), 1.27-1.38 (1H, m), 1.44 (9H, s), 1.53-1.70 (2H, m), 3.07-3.15 (1H, m), 3.17-3.25 (1H, m), 3.39-3.47 (2H, m), 4.70 (1H, br s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,44565-27-7, 4-Amino-2-methylbutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; Nagata, Tsutomu; Kobayashi, Jun; Onishi, Yoshiyuki; Kishida, Masamichi; Noguchi, Kengo; US2013/12532; (2013); A1;,
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Synthetic Route of 44565-27-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 44565-27-7, name is 4-Amino-2-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Compound 7b (90 mg, 0.26 mmol) and 4-amino-2-methyl-butan-1-ol (40 mg, 0.26 mmol) were refluxed overnight in BuOH (2 mL). The resulting solution was poured into saturated NH4Cl solution, and extractedwith EtOAc. The organic layer was washed with saturated NaCl, and then dried over Na2SO4, evaporated under reduce pressure. The residue was purified by a silica gel column chromatography (CHCl3:MeOH=95:5) to give 3b as white powder (73 mg, 68 % yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 44565-27-7, 4-Amino-2-methylbutan-1-ol.

Reference:
Article; Hayashi, Ken-Ichiro; Kusaka, Naoyuki; Ando, Kazuki; Mitsui, Taichi; Aoyama, Takashi; Nozaki, Hiroshi; Bioorganic and Medicinal Chemistry Letters; vol. 22; 17; (2012); p. 5663 – 5667;,
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