Category: 445-26-1

Related Products of 445-26-1 ,Some common heterocyclic compound, 445-26-1, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 122 1-(2-Fluorophenyl)ethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (77 mg) was added to toluene/triethylamine = 10/1 (8 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (117 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 2-fluoro-alpha-methylbenzyl alcohol (55 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (101 mg, yield 78%). Mass spectrometry value (ESI-MS, m/z): 524 (M++1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,445-26-1, its application will become more common.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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Reference of 445-26-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 445-26-1, name is 1-(2-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

h. 1-(2-Fluorophenyl)ethyl chloride was prepared as follows: Thionyl chloride (100 ml.) was added to a solution of 1-(2-fluorophenyl)ethanol [described by McCall, J.A.C.S. 74, 4809 (1952)] (105 g.) in dry chloroform (200 ml.). After the vigorous initial reaction had subsided, the solution was heated at reflux on a steam bath for 30 minutes. The excess of thionyl chloride was removed by repeated co-distillation with dry toluene and the residue was diluted with diethyl ether, washed with water (2 * 100 ml.), dried over sodium sulphate, filtered and evaporated to a yellow liquid, which was distilled to give 1-(2-fluorophenyl)ethyl chloride (73.2 g.), b.p. 70-75 C./20 mm.Hg, as a pale yellow oil. By proceeding in a similar manner but replacing 1-(2-fluorophenyl)ethanol by the appropriate phenyl ethanols there were prepared:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,445-26-1, its application will become more common.

Reference:
Patent; May & Baker Limited; US4067723; (1978); A;,
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Adding a certain compound to certain chemical reactions, such as: 445-26-1, 1-(2-Fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1-(2-Fluorophenyl)ethanol, blongs to alcohols-buliding-blocks compound. Quality Control of 1-(2-Fluorophenyl)ethanol

General procedure: In a vacuum dried 100 mL Schlenk flask, secondary or primary benzyl alcohol I (10.0 mmol),4-dimethylaminopyridine (2 mmol), and triethylamine (2.78 mL, 20.0 mmol) were dissolved inTHF (50 mL) under Ar atmosphere. Then, HClSiiPr2 or HClSiMetBu (12 mmol) was added atroom temperature and the reaction mixture was stirred overnight at room temperature or 50 oC.After the reaction was complete (monitored by TLC or GC-MS), the reaction mixture was filteredto remove the white precipitate and the solvent was removed via rotary evaporation. Water (20 mL)and MTBE (20 mL) were added, and the mixture was extracted with MTBE (20 mL×3). Thecombined organic layer was washed with saturated sodium chloride (20 mL), and dried overNa2SO4. Evaporation of organic solvent afforded a colorless liquid, which was further purified byflash silica column chromatography with petroleum ether as the eluent to give the corresponding(hydrido)silyl ether product as a colorless liquid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,445-26-1, 1-(2-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Fang, Huaquan; He, Qiaoxing; Liu, Guixia; Huang, Zheng; Synlett; vol. 28; 18; (2017); p. 2468 – 2472;,
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Electric Literature of 445-26-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 445-26-1, name is 1-(2-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 126 1-(2-Fluorophenyl)ethyl N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}carbamate 2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]aniline (83 mg) was added to toluene/triethylamine = 10/1 (8 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (134 mg)in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 2-fluoro-alpha-methylbenzyl alcohol (55 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (60 mg, yield 45%). 1H-NMR (CDCl3, 400 MHz): 8.80 (1H, s), 8.37 (1H, d, J = 9.2 Hz), 8.15 (1H, s), 7.58 (1H, s), 7.43 – 7.52 (1H, m), 7.32 (1H, d, J = 2.7 Hz), 7.28 – 7.35 (1H, m), 7.15 – 7.20 (2H, m), 7.06 – 7.11 (1H, m), 6.19 (1H, q, J = 6.6 Hz), 4.19 (3H, s), 4.12 (3H, s), 1.66 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 499 (M++1)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 445-26-1, 1-(2-Fluorophenyl)ethanol.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 445-26-1, name is 1-(2-Fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. name: 1-(2-Fluorophenyl)ethanol

Step 1: 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid (4 g, 14.2 mmol) was dissolved in toluene (150 mL). Triethylamine (2.187 mL, 15.6 mmol) was added, followed by diphenylphosphoryl azide (3.372 mL, 15.6 mmol), and the mixture was stirred for 10 minutes. 2-Fluoro-alpha-methylbenzyl alcohol (2 g, 15.6 mmol) was added, and the reaction was stirred at 80 C. overnight. The mixture was cooled to room temperature and concentrated, and the residue was partitioned between with EtOAc and water. The organic layer was washed 4 times with water and once with brine, and then dried, filtered, and concentrated, and the residue was purified by silica gel chromatography (dry load; 0-100% EtOAc in hexanes) to give [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid 1-(2-fluoro-phenyl)-ethyl ester.

The synthetic route of 445-26-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; US2010/152257; (2010); A1;,
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Application of 445-26-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.445-26-1, name is 1-(2-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.

Example 125 1-(2-Fluorophenyl)ethyl N-{4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}carbamate 4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline (90 mg) was added to toluene/triethylamine = 10/1 (9 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (136 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 2-fluoro-alpha-methylbenzyl alcohol (55 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (79 mg, yield 52%). 1H-NMR (CDCl3, 400 MHz): 8.74 (1H, s), 8.06 (1H, s), 7.58 (1H, s), 7.54 (2H, d, J = 9.0 Hz), 7.39 – 7.43 (1H, m), 7.23 – 7.32 (1H, m), 7.12 – 7.17 (3H, m), 7.03 – 7.08 (1H, m), 6.86 (1H, s), 6.14 (1H, q, J = 6.6.Hz), 4.15 (3H, s), 4.09 (3H, s), 1.62 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 464 (M++1)

Statistics shows that 445-26-1 is playing an increasingly important role. we look forward to future research findings about 1-(2-Fluorophenyl)ethanol.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 445-26-1 ,Some common heterocyclic compound, 445-26-1, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add 0.5 mmol of 1-phenylethanol to the test tube.Add 1.5 mmol of dipropylene glycol dimethyl ether to the oxygen balloon.Reaction at 120 C for 12 hours,By gas chromatography, the reaction was complete,To the reaction system, sodium formate 2.5 mmol was added.Add 0.0025 mmol of Catalyst B and add 4 mL of methanol:water (3:1).Nitrogen replacement 3 times, 50 C reaction 12h, after the end of the reaction, washed with water,The aqueous phase was extracted three times with ethyl acetate.Column chromatography separation (petroleum ether: ethyl acetate = 10:1),(S)-1-ethanol (57.3 mg) was obtained in a yield of 93%.The ee value is 95%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,445-26-1, its application will become more common.

Reference:
Patent; China Three Gorges University; Zhou Haifeng; Cui Peng; Chen Yongsheng; Liu Qixing; (12 pag.)CN110002961; (2019); A;,
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Alcohols – Chemistry LibreTexts

Related Products of 445-26-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 445-26-1, name is 1-(2-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

To a solution of ethyl 2-fluoro-4-iodonicotinate (0.70 g) obtained by a known method (Organic Letters, 7(10), 1943-1946; 2005) and 1-(2-fluorophenyl)ethanol (0.50 g) in THF (7 mL) was added 60% sodium hydride (0.14 g) at 0C, and the mixture was stirred at the same temperature for 1 hr. To the reaction solution was added water at 0C, and the mixture was diluted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate) to give the title compound (0.77 g). 1H NMR (300 MHz, CDCl3) delta 1.42 (3H, t, J = 7.1 Hz), 1.61 (3H, d, J = 6.6 Hz), 4.47 (2H, q, J = 7.2 Hz), 6.48 (1H, q, J = 6.5 Hz), 6.94-7.14 (2H, m), 7.17-7.24 (1H, m), 7.25-7.30 (1H, m), 7.41 (1H, td, J = 7.5, 1.6 Hz), 7.73 (1H, d, J = 5.5 Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,445-26-1, 1-(2-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; SUZUKI, Shinkichi; YAMADA, Masami; KAMATA, Makoto; KOJIMA, Takuto; FUJIMORI, Ikuo; SHIMOKAWA, Kenichiro; EP2921480; (2015); A1;,
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445-26-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 445-26-1, name is 1-(2-Fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below.

Intermediate 1-17-1 Preparation of 1 -(1 -bromoethyl)-2-fluorobenzene 500 mg 1 -(2-Fluorophenyl)ethanol (3.6 mmol, 1 .0 eq.) was dissolved in 1 .6 mL hydrobromicacid (33% solution in acetic acid, 9.8 mmol, 2.8 eq.) and stirred at room temperature over night. The reaction mixture was poured into diethylether and stirred for 5 min. The solution was added portionwise into 30 mL of saturated sodium hydrogen carbonate solution and stirred for 15 min. The layers were separated and the aqueous layer was extracted with diethylether twice. The collected organic layers were rinsed with brine, dried over a silicon filter and concentrated in vacuo. The crude product was used without further purification: 554 mg, 2.73 mmol, 77%. 1 H NMR (300 MHz, DMSO-d6) delta [ppm] = 1 .98 (d, 3H), 5.57 (q, 1 H), 7.13 – 7.24 (m, 2H), 7.31 – 7.41 (m, 1 H), 7.56 – 7.65 (m, 1 H).

Statistics shows that 445-26-1 is playing an increasingly important role. we look forward to future research findings about 1-(2-Fluorophenyl)ethanol.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HITCHCOCK, Marion; MENGEL, Anne; MUeLLER, Thomas; BAeRFACKER, Lars; CLEVE, Arwed; BRIEM, Hans; SIEMEISTER, Gerhard; BONE, Wilhelm; FERNANDEZ-MONTALVAN, Amaury, Ernesto; SCHROeDER, Jens; MOeNNING, Ursula; HOLTON, Simon; PREUSSE, Cornelia; (165 pag.)WO2017/157991; (2017); A1;,
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