Category: 4442-79-9

Electric Literature of 4442-79-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4442-79-9, name is 2-Cyclohexylethanol. A new synthetic method of this compound is introduced below.

A flame-dried 50 mL flask was charged with 2-cyclohexylethanol (696 mg, 5.00mmol) in dry THF (10 mL). The mixture was cooled at 0 C and sodium hydride (60wt% on mineral oil, 300 mg, 7.50 mmol) was added in one portion. After stirring for10 min, allyl bromide (0.65 mL, 7.50 mmol) was added dropwise at the sametemperature. The cooling bath was removed and the suspension was stirred at roomtemperature for 30 min. The reaction mixture was then heated to reflux for 16 h. Afterfull conversion, the suspension was cooled to room temperature and quenched by theaddition of a saturated aqueous solution of NH4Cl (10 mL). The biphasic mixture wasthen extracted with Et2O (3 x 10 mL). The combined organic layers were dried overNaSO4 and concentrated in vacuo. The crude material was purified by columnchromatography on silica gel (Pet. Ether/EtOAc 100:1); Colorless oil; 87% yield;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4442-79-9, 2-Cyclohexylethanol, and friends who are interested can also refer to it.

Reference:
Article; Voutyritsa, Errika; Triandafillidi, Ierasia; Tzouras, Nikolaos V.; Nikitas, Nikolaos F.; Pefkianakis, Eleftherios K.; Vougioukalakis, Georgios C.; Kokotos, Christoforos G.; Molecules; vol. 24; 9; (2019);,
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Reference of 4442-79-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4442-79-9 as follows.

General procedure: To a solution of Ph3P(OAc)2, was added 3-phenylpropanol (1 mmol, 0.137 mL). The progress of the reaction was monitored by TLC (Table 3, entry 2). After completion of the reaction (0.3 h) the reaction mixture was filtered to remove the precipitated NH4Br followed by evaporation of the solvent. Column chromatography of the crude mixture on silica gel using n-hexane/EtOAc (3:1) as the eluent gave 3-phenylpropyl acetate in 90% yield (0.159 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4442-79-9, its application will become more common.

Reference:
Article; Iranpoor, Nasser; Firouzabadi, Habib; Elham, Etemadi Davan; Tetrahedron Letters; vol. 54; 14; (2013); p. 1813 – 1816;,
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Electric Literature of 4442-79-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4442-79-9, name is 2-Cyclohexylethanol. A new synthetic method of this compound is introduced below.

General procedure: To a solution of oleoside 11-methylester tetraacetate 3 or oleoside tetraacetate 5 (1 equiv.) in dichloromethane were added at 0C 1.2 equiv of trichlorobenzoyl chloride and 1.4 equiv triethylamine. After 2h stirring at room temperature, the mixture was cooled to 0C and a solution of alcohol/thiol/amine (1.5 equiv.) in dichloromethane and DMAP (1.4 equiv.) were added. After stirring for 2hat room temperature, the mixture was quenched with a saturated aqueous solution of NH4Cl and extracted with dichloromethane and ethyl acetate. The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. Purification by flash chromatography (cyclohexane/ethylacetate 1:1) led to the acetylated derivatives.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4442-79-9, 2-Cyclohexylethanol, and friends who are interested can also refer to it.

Reference:
Article; Samara, Pinelopi; Christoforidou, Nikoleta; Lemus, Christelle; Argyropoulou, Aikaterini; Ioannou, Kyriaki; Vougogiannopoulou, Konstantina; Aligiannis, Nektarios; Paronis, Efthimios; Gaboriaud-Kolar, Nicolas; Tsitsilonis, Ourania; Skaltsounis, Alexios-Leandros; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 11 – 29;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4442-79-9, name is 2-Cyclohexylethanol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

150 mg (1.17 mmol, 1 eq) of 2-cyclohexylethanol were diluted in 4 mL of DCM, 214 muL (1.52 mmol, 1.3 eq) of triethylamine were added. The mixture was cooled to 0C and 100 muL (1.29 mmol, 1.1 eq) of mesyl chloride were added. The mixture was stirred for 15 min at 00C then water was added. The aqueous phase was extracted with dichloromethane. The organic phase was washed with water, brine, dried over MgSO4, filtered and concentrated in vacuo. The crude product (241 mg) was used directly for synthesis of 2. TLC : Rf : 0.48 (eluant : Heptane/EtOAc : 1/1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4442-79-9, 2-Cyclohexylethanol.

Reference:
Patent; AMGEN INC.; WO2009/9122; (2009); A2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4442-79-9, name is 2-Cyclohexylethanol, the common compound, a new synthetic route is introduced below. Safety of 2-Cyclohexylethanol

General procedure: The N-substituted phthalimides were prepared according to literature.30 A mixture of phthalimide (2.21 g, 15 mmol), triphenylphosphine (3.93 g, 15 mmol), and appropriate alcohol (15 mmol) in 20 mL of dry THF was cooled to 0 C. Diethyl azodicarboxylate (DEAD) (2.61 g, 15 mmol) in 15 mL of dry THF was slowly added dropwise (1 h). The reaction mixture was then allowed to warm to room temperature and stirred overnight. Solvent was evaporated under reduced pressure and the residue suspended in Et2O. After the precipitate was filtered, the solvent was evaporated and the residue purified by column chromatography [eluent CH2Cl2] to afford appropriate N-substituted phthalimide.

The synthetic route of 4442-79-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wicek, Ma?gorzata; Kottke, Tim; Ligneau, Xavier; Schunack, Walter; Seifert, Roland; Stark, Holger; Handzlik, Jadwiga; Kie?-Kononowicz, Katarzyna; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 2850 – 2858;,
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Synthetic Route of 4442-79-9 ,Some common heterocyclic compound, 4442-79-9, molecular formula is C8H16O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 81Preparation of Derivative 81 According to the Present InventionDerivative 81 having the following formula was prepared as follows. Sodium hydride (343.2 mg, 8.58 mmol, 60% dispersed oil) was slowly added to cyclohexaneethanol (1 g, 7.8 mmol) dissolved in 30 ml of dried dimethylformamide under nitrogen at room temperature while stirring. The mixture was further stirred at room temperature for 30 minutes. Then, 4-fluoro-2-(trifluoromethyl)benzaldehyde (1.2 g, 7.8 mmol) dissolved in dried dimethylformamide was added thereto over 10 minutes and stirred at room temperature for 18 hours until the initial product disappeared. Subsequently, ice water was added thereto, and the resulting mixture was extracted with ethyl acetate and water. The organic layer was washed with water several times, dried with anhydrous magnesium sulfate, filtered and solvent-evaporated. The residual oil was chromatographed on the silica gel column (hexane:ethyl acetate-20:1) to afford the intermediate, 4-(2-cyclohexylethoxy)-2-(trifluoromethyl)benzaldehyde (1.77 g, yield: 75.6%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4442-79-9, its application will become more common.

Reference:
Patent; Cho, Hoon; Wu, Ying; Choi, Cheol-Hee; US2011/269954; (2011); A1;,
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Application of 4442-79-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4442-79-9, name is 2-Cyclohexylethanol. A new synthetic method of this compound is introduced below.

General procedure: The PBr3 (1.5 equiv) was added to a solution of alkyl alcohol (1.0equiv) in anhydrous tetrahydrofuran (5.0 mL) at 0 C and then theice bath was removed and the reaction mixture was further stirredat room temperature for 5 h. Water (30.0 mL) was added and thenextracted with EtOAc, the combined organic extracts were driedwith Na2SO4, and the solvent was evaporated in vacuo to get titlecompound, suitable for the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4442-79-9, 2-Cyclohexylethanol, and friends who are interested can also refer to it.

Reference:
Article; Chen, Ying; Wu, Bolin; Hao, Yameng; Liu, Yunqi; Zhang, Zhili; Tian, Chao; Ning, Xianling; Guo, Ying; Liu, Junyi; Wang, Xiaowei; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 420 – 433;,
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Application of 4442-79-9, Adding some certain compound to certain chemical reactions, such as: 4442-79-9, name is 2-Cyclohexylethanol,molecular formula is C8H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4442-79-9.

A flame-dried 50 mL flask was charged with 2-cyclohexylethanol (1.00 equiv., 696 mg, 5.00 mmol) in dry THF (10 mL). The mixture was cooled at 0 C and sodium hydride (60 wt% on mineral oil, 1.50 equiv., 300 mg, 7.50 mmol) was added in one portion. After stirring for 10 min, allyl bromide (1.50 equiv., 0.65 mL, 7.50 mmol) was added dropwise at the same temperature. The cooling bath was removed and the suspension was stirred at r.t. for 30 min. The reaction mixture was then heated to reflux for 16 h. After full conversion, the suspension was cooled to r.t. and quenched by the addition of a saturated aqueous solution of NH4Cl (10 mL). The biphasic mixture was then extracted with Et2O (3 x 10 mL). The combined organic layers were dried over Na2SO4, and concentrated in vacuo. The crude material was purified by column chromatography on silica gel (Pet.Ether/EtOAc 100:1); Colorless oil; 87% yield; 1H NMR (200 MHz, CDCl3) delta: 5.98-5.73 (1H, m, =CH), 5.21 (1H, d, J = 17.2 Hz, =CHH), 5.10 (1H, d, J = 10.4 Hz, =CHH), 3.90 (2H, d, J = 4.0 Hz, OCH2), 3.40 (2H, t, J = 6.6 Hz, OCH2), 1.76-1.49 (5H, m, 2 x CH2 and CH), 1.49-1.33 (3H, m, 3 x CHH), 1.22-1.05 (3H, m, 3 x CHH), 0.73-0.69 (2H, m, 2x CHH); 13C NMR (50 MHz, CDCl3) delta: 135.0, 116.4, 71.7, 68.2, 37.1, 34.4, 33.3, 26.5, 26.2; MS 169 [M+H]+.

According to the analysis of related databases, 4442-79-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Voutyritsa, Errika; Nikitas, Nikolaos F.; Apostolopoulou, Mary K.; Gerogiannopoulou, Anna Dimitra D.; Kokotos, Christoforos G.; Synthesis; vol. 50; 17; (2018); p. 3395 – 3401;,
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Adding a certain compound to certain chemical reactions, such as: 4442-79-9, 2-Cyclohexylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4442-79-9, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H16O

General procedure: The alcohol (1.0 eq) was added to a suspension of Dess-Martin periodinane (1.2 eq) in CH2Cl2(100 mM) under an argon atmosphere at room temperature. The mixture was allowed to stir for0.5 – 20 hours, while consumption of starting material was monitored by TLC. After the reactionwas complete, 1M Na2S2O3 (equal volume to CH2Cl2) was added. After stirring for 15 minutes,the phases were separated and the aqueous phase was extracted with CH2Cl2 twice. Thecombined organic layers were washed with 5% NaHCO3 and brine, and dried over Na2SO4. Thesolvent was evaporated under reduced pressure and the residue was purified by columnchromatography to afford analytically pure aldehydes.b) alcohol precursors for aldehydes 13, 14, 20 (solid alcohols)The alcohol (1.0 eq) was dissolved in CH2Cl2 (200 mM) and the solution was added to asuspension of Dess-Martin periodinane (1.2 eq) in CH2Cl2 (200 mM) under an argon atmosphereat room temperature. The mixture was allowed to stir for 0.5 – 20 hours (TLC monitoring). Then,Et2O (equal volume to CH2Cl2), 1M Na2S2O3 and saturated NaHCO3 (both equal volume toCH2Cl2) were added. After stirring for 15 minutes, the phases were separated and the aqueousphase was extracted with Et2O twice. The combined organic layers were washed with sat.NaHCO3 and brine, and dried over Na2SO4. The solvent was evaporated under reduced pressureand the residue was purified by column chromatography to afford analytically pure aldehydes.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4442-79-9, its application will become more common.

Reference:
Article; Ruff, Bettina M.; Braese; O’Connor, Sarah E.; Tetrahedron Letters; vol. 53; 9; (2012); p. 1071 – 1074;,
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Synthetic Route of 4442-79-9 ,Some common heterocyclic compound, 4442-79-9, molecular formula is C8H16O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 10 l-(2-Cyclohexyl-l-hydroxyethyl)-2-phenyl-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-onePart A To a mixture of cyclohexylmethanol (5,0 mL, 36 mmol) and dichloromethane (27 mL) at 0 0C was added triethyl amine (27 mL), dimethyl sulfoxide (27 mL), and sulfur trioxide pyridine (8.5 g, 54 mmol). The reaction was stirred 2 hours before diluting with ethyl acetate and saturated aqueous ammonium chloride. The layers were separated and the aqueous layer was extracted with additional ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated to 12 g of cyclohexylacetaldehyde as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4442-79-9, its application will become more common.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2006/107771; (2006); A2;,
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