Category: 4410-99-5

Spinaci, Andrea published the artcileA3 Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity, Category: alcohols-buliding-blocks, the publication is Pharmaceuticals (2022), 15(2), 164, database is CAplus and MEDLINE.

The overexpression of the A3 adenosine receptor (AR) in a number of cancer cell types makes it an attractive target for tumor diagnosis and therapy. Hence, in the search for new A3AR ligands, a series of novel 2,N⁶-disubstituted adenosines (Ados) I (R¹ = (CH₂)₂C₆H₅, (CH₂)₂CH(C₆H₅)₂; R² = (CH₂)₃CH₃, C₆H₅) was synthesized and tested in radioligand binding and functional assays at ARs. Derivatives bearing a 2-phenethylamino group in the N⁶-position were found to exert higher A3AR affinity and selectivity than the corresponding N⁶-(2,2-diphenylethyl) analogs. 2-Chloro-N⁶-phenylethylAdo was found to be a potent full A3AR agonist with a Ki of 0.024 nM and an EC₅₀ of 14 nM, in a cAMP accumulation assay. Unlike 2-chloro-N⁶-phenylethylAdo, the other ligands behaved as A3AR antagonists, which concentration-dependently reduced cell growth and exerted cytostatic activity on the prostate cancer cell line PC3, showing comparable and even more pronounced effects with respect to the ones elicited by the reference full agonist Cl-IB-MECA. In particular, the N⁶-(2,2-diphenylethyl)-2-phenylethynylAdo (GI₅₀ = 14μM, TGI = 29μM, and LC₅₀ = 59μM) showed the highest activity proving to be a potential antitumor agent. The cytostatic effect of both A3AR agonist (Cl-IB-MECA) and antagonists (other newly synthesized compounds) confirm previous observations according to which, in addition to the involvement of A3ARs, other cellular mechanisms are responsible for the anticancer effects of these ligands.

Pharmaceuticals published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H15ClN2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Samanta, Partha Kumar published the artcileCopper(0) nanoparticles immobilized on SBA-15: a versatile recyclable heterogeneous catalyst for solvent and ligand free C-S coupling reaction from diverse substrates, Recommanded Product: 2-Phenylethanethiol, the publication is Microporous and Mesoporous Materials (2021), 111198, database is CAplus.

A SBA-15 supported copper(0) nanoparticles based catalyst (Cu(0)MS) has been prepared using wet impregnation method. The catalyst was thoroughly characterized by several techniques including powder X-ray diffraction, nitrogen adsorption-desorption, field emission SEM-energy dispersive X-ray, transmission electron microscopy, high angle annular dark field scanning transmission electron microscopy and inductively coupled plasma-optical emission spectrometry. This mesoporous silica supported copper(0) nanoparticles had been exploited as a catalyst for ligand-free and solvent-free C-S cross-coupling reactions. Sym./unsym. aryl/alkyl sulfides R¹SR² (R¹ = Ph, 2-MeOC₆H₄, PhCH₂, PhCH:CH, 2-thienyl, etc.; R² = Ph, n-octyl, PhCH₂CH₂, 2-pyridyl, etc.) had been synthesized by the S-arylation of aromatic, heteroaromatic and aliphatic thiols R²SH with aryl, heteroaryl or vinyl halides R¹X (X = I, Br). Aryl chlorides also responded the reaction very well to produce aryl sulfides. The applicability of the current protocol had also been explored for the synthesis of the starting materials of different C-S bond containing pharmaceuticals. In addition, the present catalytic system was also suitable for the synthesis of a variety of sym. diaryl sulfides from aryl halides using thiourea as a sulfur source. Furthermore, it was also found that the Cu(0)MS catalyst could be reused five times without substantial loss in activity.

Microporous and Mesoporous Materials published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brahmachari, Goutam published the artcileVisible Light-Driven and Singlet Oxygen-Mediated Photochemical Cross-Dehydrogenative C₃-H Sulfenylation of 4-Hydroxycoumarins with Thiols Using Rose Bengal as a Photosensitizer, Synthetic Route of 4410-99-5, the publication is Journal of Organic Chemistry (2021), 86(14), 9658-9669, database is CAplus and MEDLINE.

A visible light (white light-emitting diode/direct sunlight)-driven photochem. synthesis of a new series of biol. interesting 3-(alkyl/benzylthio)-4-hydroxy-2H-chromen-2-ones has been achieved through a cross-dehydrogenative C₃-H sulfenylation of 4-hydroxycoumarins with thiols at ambient temperature in the presence of rose bengal in acetonitrile under an oxygen atm. The notable features of this newly developed method are mild reaction conditions, energy efficiency, metal-free synthesis, good to excellent yields, use of low-cost materials, and eco-friendliness.

Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Synthetic Route of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ben Khemis, Ismahene published the artcileAdsorption of 2-phenylethanethiol on two broadly tuned human olfactory receptors OR1A1 and OR2W1: Interpretation of the effect of copper ions via statistical physics monolayer adsorption model, Safety of 2-Phenylethanethiol, the publication is Journal of Molecular Liquids (2021), 116926, database is CAplus.

This paper aims to investigate the effect of metal especially copper ions on the adsorption of a key food odorant (2-phenylethanethiol) on two human olfactory receptors OR1A1 and OR2W1 that was interpreted via a statistical physics monolayer model. To this purpose, four exptl. dose-olfactory response curves were used without and with the presence of Cu2+ for each human receptor. In order to reach a theor. interpretation of the exptl. data and understand the effect of the used metal on adsorption process introduced on the olfaction mechanism, a statistical physics monolayer adsorption model with identical and independent sites was applied. The used model showed that the presence of copper ions decreased the efficacy (olfactory response at saturation) of 2-phenylethanethiol key food odorant activating OR1A1, suggesting a neg. allosteric action. However, the presence of Cu2+ reduced the potency (concentration at half saturation) of the studied thiol key food odorant in activating OR2W1, suggesting an orthosteric competitive action. Furthermore, the molar adsorption energies retrieved from data anal. varied from 5.568 to 9.886 kJ/mol in studied systems, whose values showed that the process based on a phys. adsorption. Lastly, the dose-olfactory response curves of 2-phenylethanethiol on two broadly tuned human olfactory receptors OR1A1 and OR2W1 provided access to the olfactory receptor site size distribution (RSD) and also the adsorption energy distribution (AED).

Journal of Molecular Liquids published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Safety of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Neumaier, Marco published the artcileKinetics of Intercluster Reactions between Atomically Precise Noble Metal Clusters [Ag₂₅(DMBT)₁₈]^– and [Au₂₅(PET)₁₈]^– in Room Temperature Solutions, Name: 2-Phenylethanethiol, the publication is Journal of the American Chemical Society (2021), 143(18), 6969-6980, database is CAplus and MEDLINE.

The kinetics of intercluster metal atom exchange reactions between solvated [Ag₂₅(DMBT)₁₈]^– and [Au₂₅(PET)₁₈]^– (DMBT and PET are 2,4-dimethylbenzenethiol and 2-phenylethanethiol, resp., both C₈H₁₀S) were probed by electrospray ionization mass spectrometry and computer-based modeling. Anion mass spectra and collision induced dissociation (CID) measurements show that both cluster monomers and dimers are involved in the reactions. We have modeled the corresponding kinetics assuming a reaction mechanism in which metal atom exchange occurs through transient dimers. Our kinetic model contains three types of generic reactions: dimerization of monomers, metal atom exchange in the transient dimers, and dissociation of the dimers to monomers. There are correspondingly 377 discrete species connected by in total 1302 reactions (i.e., dimerization, dissociation and atom exchange reactions) leading to the entire series of monomeric and dimeric products [Ag_mAu_25-m]^– (m = 1-24) and [Ag_mAu_50-m]^2- (m = 0-50), resp. The rate constants of the corresponding reactions were fitted to the exptl. data, and good agreement was obtained with exchange rate constants which scale with the probability of finding a silver or gold atom in the resp. monomeric subunit of the dimer, i.e., reflecting an entropic driving force for alloying. Allowing the dimerization rate constant to scale with increasing gold composition of the resp. reactants improves the agreement further. The rate constants obtained are phys. plausible, thus strongly supporting dimer-mediated metal atom exchange in this intercluster reaction system.

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mitsui, Masaaki published the artcileOn the Origin of Photoluminescence Enhancement in Biicosahedral Ag_xAu_25-x Nanoclusters (x = 0-13) and Their Application to Triplet-Triplet Annihilation Photon Upconversion, SDS of cas: 4410-99-5, the publication is Advanced Optical Materials, database is CAplus.

Numerous reports hitherto show that the photoluminescence (PL) properties of metal nanoclusters (NCs) can be enhanced by alloying the metal cores. In particular, biicosahedral [Ag_xAu_25-x(PPh₃)10(SR)5Cl₂]²⁺ (abbreviated as Ag_xAu_25-x hereafter; with PPh₃ = triphenylphosphine; SR = thiolate ligand) NCs attract significant attention because their PL quantum yield is improved by 200 times when 13 Au atoms are replaced with Ag atoms (x = 13). In this contribution, the origin of the PL in the Ag_xAu_25-x system and its remarkable enhancement are investigated on the basis of spectroscopic investigations of the PL behavior and its quenching by an organic fluorophore, finding that (i) the observed PL of Ag_xAu_25-x is phosphorescent; (ii) not only Ag₁₃Au₁₂ but also Ag₁₂Au₁₃ NCs contribute to the PL; and (iii) replacing the central vertex atom of the biicosahedron with an Ag atom causes a blue shift of the triplet states, which suppresses the T1-S0 intersystem crossing and enhances the phosphorescence emission. Addnl., the results of single-particle PL spectroscopy and defocused imaging with rotation of linearly polarized excitation light reveal that the phosphorescence transition dipole moment of Ag₁₃Au₁₂ exists in the long axis direction of the biicosahedron. Furthermore, the Ag_xAu_25-x NCs can sensitize mol. triplets and efficiently induce red-to-blue photon upconversion via triplet-triplet annihilation.

Advanced Optical Materials published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, SDS of cas: 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kesavan, Arunachalam published the artcileCatalytic enantioselective oxysulfenylation of o-vinylanilides, Safety of 2-Phenylethanethiol, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(2), 282-285, database is CAplus and MEDLINE.

Tf₂NH-Assisted BINAM-derived thiophosphoramide catalysis was accomplished for the enantioselective oxysulfenylation of o-vinylanilides with N-(aryl/alkylthio)imides. The developed reaction offered access to diverse substituted aryl/alkylthio tethered 3,1-benzoxazines I [R = 6-MeO, 6-Cl, 7-Cl, 8-MeO, 8-BzO; R¹ = Ph, 4-EtC₆H₄, 4-FC₆H₄, etc.; Ar = Ph, Bn, 2-MeC₆H₄, etc.; Ar¹ = Ph, 4-MeC₆H₄, 3-IC₆H₄, etc.] in excellent yields and enantiomeric ratios. Furthermore, synthetic applications of benzoxazines and aryl/alkylthio moieties and a transition state model for the observed enantioselectivity were also discussed.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Safety of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gershonov, Eytan published the artcileRegio- and chemoselectivity in S- and O- difluoromethylation reactions using diethyl (bromodifluoromethyl)phosphonate, Related Products of alcohols-buliding-blocks, the publication is Journal of Fluorine Chemistry (2021), 109867, database is CAplus.

The effective difluoromethylations of various S- and O- based- nucleophiles, presenting a wide range of pKa values, using diethyl(bromodifluoromethyl)phosphonate under basic conditions was described. These reactions, which rely on the quant. generation of difluorocarbene formed through the hydrolysis of phosphonate, were found to be effective only once the starting materials had pKa values of less than ca. 11. Importantly, in cases in which the substrates held two or three nucleophilic centers this feature was successfully implemented to achieve a high chemo- or regioselective difluoromethylation of the center exhibiting the lowest pKa value and the highest polarizability.

Journal of Fluorine Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bansal, Kuldeep Kumar published the artcileEvaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers, Category: alcohols-buliding-blocks, the publication is International Journal of Polymeric Materials and Polymeric Biomaterials, database is CAplus.

Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus and poly(lactide) copolymer. The presence of “ene” groups on PJL′s backbone offers a unique opportunity to insert functional groups. We introduced -COOH and Ph groups onto the PJL copolymer and observed a ∼334-fold increment in aqueous solubility of clotrimazole with -COOH-terminated PJL copolymer compared to Soluplus. We thus successfully demonstrated that the presence of appropriate free functional groups on the polymer chain can facilitate the solubilization potential of PM.

International Journal of Polymeric Materials and Polymeric Biomaterials published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts