Category: 4410-99-5

Marcinkowska, Monika published the artcileKey Odorants of Raw and Cooked Green Kohlrabi (Brassica oleracea var. gongylodes L.), Computed Properties of 4410-99-5, the publication is Journal of Agricultural and Food Chemistry (2021), 69(41), 12270-12277, database is CAplus and MEDLINE.

Volatile compounds of raw and cooked green kohlrabi were investigated using a sensomics approach. A total of 55 odor-active compounds were detected and identified in raw and cooked green kohlrabi using GC-O. Twenty-eight odor-active compounds with high flavor dilution (FD) factors ranging from 64 to 1024 were quantitated, and odor activity values (OAVs) were determined Eight compounds showed high OAVs in raw and cooked kohlrabi: five sulfur compounds (di-Me trisulfide, Me 2-methyl-3-furyl disulfide, and three isothiocyanates (1-isothiocyanato-3-(methylsulfanyl)propane, benzyl isothiocyanate, and 1-isothiocyanato-4-(methylsulfanyl)butane)), two lipid oxidation products (1-octen-3-one and trans-4,5-epoxy-(2E)-dec-2-enal), and 2-isopropyl-3-methoxypyrazine. Among these, the sulfur compounds contributed most to the overall smell of the raw and cooked vegetables. The quantitation anal. indicates that the eight odorants are the backbone compounds for raw and cooked kohlrabi. The OAVs for the backbone compounds and also for minor odorants are clearly higher in raw kohlrabi than in the cooked one. Differences can be explained by the influence of the cooking process.

Journal of Agricultural and Food Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rozsar, Daniel published the artcileBifunctional Iminophosphorane Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α,β-Unsaturated Amides, Application of 2-Phenylethanethiol, the publication is Journal of the American Chemical Society (2022), 144(2), 1006-1015, database is CAplus and MEDLINE.

The first metal-free catalytic intermol. enantioselective Michael addition to unactivated α,β-unsaturated amides was described. Consistently high enantiomeric excesses and yields were obtained over a wide range of alkyl thiol pronucleophiles and electrophiles under mild reaction conditions, enabled by a novel squaramide-based bifunctional iminophosphorane (BIMP) catalyst. Low catalyst loadings (2.0 mol %) were achieved on a decagram scale, demonstrating the scalability of the reaction. Computational anal. revealed the origin of the high enantiofacial selectivity via anal. of relevant transition structures and provided substantial support for specific noncovalent activation of the carbonyl group of the α,β-unsaturated amide by the catalyst.

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Shuting published the artcileDNA-compatible diversification of indole π-activated alcohols via a direct dehydrative coupling strategy, Quality Control of 4410-99-5, the publication is Organic Letters (2022), 24(4), 1022-1026, database is CAplus and MEDLINE.

Indole-based diversification is highly desired in the DNA-encoded chem. library construction. Herein, we present a general strategy for on-DNA synthesis of diverse C3-functionalized indole derivatives via indole π-activated alc. formation followed by direct dehydrative coupling. Highly efficient bond linkages of C-C, C-N, and C-S were achieved to fuse building blocks that are widely com. available. DNA-encoding compatibility of the method has been further demonstrated to pave an avenue for application in constructing indole-focused three-dimensional libraries.

Organic Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C3H3Br2ClO, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaoman published the artcileCatalyst- and Metal-Free Photo-Oxidative Coupling of Thiols with BrCCl₃, Recommanded Product: 2-Phenylethanethiol, the publication is European Journal of Organic Chemistry (2022), 2022(23), e202200340, database is CAplus.

This paper reported a catalyst- and metal-free method to construct disulfide bond with BrCCl₃ under light irradiation This clean and mild reaction promoted the oxidative coupling of thiols with wide substrate scope, and was applicable to benzylic, aryl and aliphatic thiols, especially cysteine derivative The disulfides were obtained in high yields up to 98%, avoiding the use of heating, strong oxidant, metal reagent or catalyst. This facile strategy facilitated the synthesis of disulfide compounds

European Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Han, Yunfei published the artcileAn Efficiency of 16.46% and a T₈₀ Lifetime of Over 4000 h for the PM6:Y6 Inverted Organic Solar Cells Enabled by Surface Acid Treatment of the Zinc Oxide Electron Transporting Layer, Application of 2-Phenylethanethiol, the publication is ACS Applied Materials & Interfaces (2021), 13(15), 17869-17881, database is CAplus and MEDLINE.

For the inverted organic solar cells (OSCs), the interface contacts between the ZnO electron transporting layer and the organic active layer play an important role in the device performance and stability. Since the solution-processed ZnO surface always contains some base or zinc salt contaminants, we explored how the surface pH conditions influence the performance and stability of the nonfullerene acceptor (NFA) cells. A tight relationship between the surface pH condition and the device performance and stability was established. Specifically, device performance and stability were improved by treating the ZnO films with acid solutions but worsened after base treatment. The large number of hydroxyl groups on the surface of the solution-processed ZnO films was proved to be the main reason for the surface pH condition-related performance, which caused oxygen-deficient defects and unfavorable vertical phase separation in the blend films, hindered the photogenerated charge transfer and collection, and consequently resulted in low short-circuit c.d. and power conversion efficiency (PCE). The surface -OH groups also boosted the photocatalytic activity and led to fast degradation of the nonfullerene acceptor. Removal of the surface -OH groups can alleviate such problems. Different acid solutions, ZrAcac, 2-phenylethylmercaptan (PET), and glutamic acid (GC), were used to treat the ZnO films, and PET treatment was the most effective treatment for performance improvement. An efficiency of 16.46% was achieved for the PM6:Y6 cells and the long-term stability under continuous illumination conditions was significantly improved with a T₈₀ lifetime of over 4000 h (4410 h), showing the excellent long-term stability of this heterojunction solar cell. Our understanding of the surface pH condition-related device performance and stability would guide the development of a feasible method for solving the interface problems in OSCs. We also provide a practical strategy to modify ZnO with acid solutions for high-performance and stable NFA OSCs.

ACS Applied Materials & Interfaces published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beattie, Deborah L. published the artcileRAFT aqueous dispersion polymerization of 4-hydroxybutyl acrylate: effect of end-group ionization on the formation and colloidal stability of sterically-stabilized diblock copolymer nanoparticles, Recommanded Product: 2-Phenylethanethiol, the publication is Polymer Chemistry (2022), 13(5), 655-667, database is CAplus.

A series of all-acrylic poly(2-hydroxyethyl acrylate)_x-poly(4-hydroxybutyl acrylate)_y (PHEA_x-PHBA_y) diblock copolymer nanoparticles were prepared via an efficient one-pot RAFT aqueous dispersion polymerization protocol using either a carboxylic acid-functionalized RAFT agent (HOOC-PHEA_x-PHBA_y) or a morpholine-functionalized RAFT agent (Mo-PHEA_x-PHBA_y). The pH-dependent colloidal stability of the resulting sterically-stabilized nanoparticles was assessed by dynamic light scattering and aqueous electrophoresis. The HOOC-PHEA₇₃-PHBA₂₁₇ nanoparticles exhibited reversible flocculation below pH 5.1, whereas the Mo-PHEA₇₆-PHBA₁₆₀ nanoparticles flocculated above pH 5. Moreover, the HOOC-PHEA₇₃-PHBA₂₁₇ nanoparticles proved to be sensitive to added salt, with incipient flocculation occurring in the presence of 20-60 mM KCl owing to charge screening. Thus, such nanoparticles require end-group ionization to confer colloidal stability via electrosteric stabilization. However, reducing the PHBA/PHEA molar ratio and/or increasing the PHEA_x stabilizer DP, leads to more efficient steric stabilization and hence enhanced colloidal stability. A series of HOOC-PHEA₇₃-PHBA_104-421 nano-objects prepared at pH 7 were characterized by visual inspection, DLS studies and shear-induced polarized light imaging. Discrepancies between these characterization techniques indicated that the worms and vesicles were unstable with respect to dilution TEM studies were conducted after covalent stabilization of the nano-objects using glutaraldehyde (GA). More specifically, TEM studies of GA-crosslinked HOOC-PHEA₇₃-PHBA₂₄₃ and HOOC-PHEA₇₃-PHBA₄₂₁ nano-objects indicated the presence of spheres in both cases when crosslinked at 0.1% weight/weight and either worms or vesicles resp., when crosslinked at 10-20% weight/weight Finally, HOOC-PHEA₇₃-PHBA₂₆₅ nano-objects were examined by variable temperature oscillatory rheol.; thermoreversible sphere/worm and worm/vesicle transitions were observed between 2 and 50°.

Polymer Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Eswaramoorthy, Senthil Kumar published the artcileAtomically Precise Palladium Nanoclusters with 21 and 38 Pd Atoms Protected by Phenylethanethiol, Application In Synthesis of 4410-99-5, the publication is Journal of Physical Chemistry C (2022), 126(1), 444-450, database is CAplus.

Monolayer thiolate-protected nanoclusters (MPCs) are extensively studied due to their distinctive properties. The at. precision in MPCs, especially in gold MPCs, is determined through mass spectrometry, which leads to the accurate identification of metal-ligand composition The total structure determination of gold and silver MPCs using ScXRD revolutionized the field by providing insights into the structural arrangement at an at. level. The synthesis of atomically precise MPCs using other metals like palladium (Pd) to study and compare properties is tedious and complex. In one end, larger size monodisperse Pd nanoparticles (NPs) were synthesized and studied for various catalytic properties. Meanwhile, on the other end, a small-mol. tiara-like Pd-thiolate complex was reported. However, at. precise Pd MPCs in the middle and its detailed studies are not yet explored. Here, we report the synthesis and identification of atomically precise phenylethanethiol-protected Pd₂₁(SCH₂CH₂Ph)₁₈ and Pd₃₈(SCH₂CH₂Ph)₂₁S₂ Pd nanoclusters. The size distribution is confirmed using matrix-assisted laser desorption ionization mass spectra (MALDI-MS), and electrospray ionization mass spectrometry (ESI-MS) confirms the composition through the isotopically resolved peak. The XPS spectra elucidate the cluster formation in smaller size.

Journal of Physical Chemistry C published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application In Synthesis of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Pengxin published the artcileDearomatization-rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions, Computed Properties of 4410-99-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(96), 12968-12971, database is CAplus and MEDLINE.

We have developed a dearomatization-rearomatization strategy for the modification of peptides/proteins through a thiol-Michael addition to the electrophilic cyclohexadienone intermediate that is generated in situ via the oxidation of tyrosine. This strategy enriches the conjugation toolbox and has great potential for applications in medicinal chem. and chem. biol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C9H8O4, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hamala, Vojtech published the artcileThe effect of deoxyfluorination and O-acylation on the cytotoxicity of N-acetyl-D-gluco- and D-galactosamine hemiacetals, Application of 2-Phenylethanethiol, the publication is Organic & Biomolecular Chemistry (2021), 19(20), 4497-4506, database is CAplus and MEDLINE.

Fully acetylated deoxyfluorinated hexosamine analogs and non-fluorinated 3,4,6-tri-O-acylated N-acetyl-hexosamine hemiacetals have previously been shown to display moderate anti-proliferative activity. We prepared a set of deoxyfluorinated GlcNAc and GalNAc hemiacetals that comprised both features: O-acylation at the non-anomeric positions with an acetyl, propionyl and butanoyl group, and deoxyfluorination at selected positions. Determination of the in vitro cytotoxicity towards the MDA-MB-231 breast cancer and HEK-293 cell lines showed that deoxyfluorination enhanced cytotoxicity in most analogs. Increasing the ester alkyl chain length had a variable effect on the cytotoxicity of fluoro analogs, which contrasted with non-fluorinated hemiacetals where butanoyl derivatives had always higher cytotoxicity than acetates. Reaction with 2-phenylethanethiol indicated that the recently described S-glyco-modification is an unlikely cause of cytotoxicity.

Organic & Biomolecular Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zaksauskas, Audrius published the artcileMethyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX, Quality Control of 4410-99-5, the publication is International Journal of Molecular Sciences (2022), 23(1), 130, database is CAplus and MEDLINE.

Among the twelve catalytically active carbonic anhydrase isoenzymes present in the human body, the CAIX is highly overexpressed in various solid tumors. Many attempts have been made to design chem. compounds that would exhibit high affinity and selective binding to CAIX over the remaining eleven catalytically active CA isoenzymes to limit undesired side effects. Herein, a series of compounds, Me 5-sulfamoyl-benzoates, which bear a primary sulfonamide group, a well-known marker of CA inhibitors is designed and their affinities for all twelve CA isoenzymes has been determined. Variations of substituents on the benzenesulfonamide ring led to compound Me 2-bromo-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate, which exhibited an extremely high observed binding affinity to CAIX; the K_d was 0.12 nM. The intrinsic dissociation constant, where the binding-linked protonation reactions have been subtracted, reached 0.08 pM. The compound also exhibited more than 100-fold selectivity over the remaining CA isoenzymes. The X-ray crystallog. structure of compound Me 2-chloro-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate bound to CAIX showed the structural position, while several structures of compounds bound to other CA isoenzymes showed structural reasons for compound selectivity towards CAIX. Since this series of compounds possess physicochem. properties suitable for drugs, they may be developed for anticancer therapeutic purposes.

International Journal of Molecular Sciences published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H6BF3O3, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts