Category: 4410-99-5

Nematulloev, Saidkhodzha published the artcile[Cu₁₅(PPh₃)₆(PET)₁₃]²⁺: a Copper Nanocluster with Crystallization Enhanced Photoluminescence, Name: 2-Phenylethanethiol, the publication is Small (2021), 17(27), 2006839, database is CAplus and MEDLINE.

Due to their atomically precise structure, photoluminescent copper nanoclusters (Cu NCs) have emerged as promising materials in both fundamental studies and technol. applications, such as bio-imaging, cell labeling, phototherapy, and photo-activated catalysis. In this work, a facile strategy is reported for the synthesis of a novel Cu NCs coprotected by thiolate and phosphine ligands, formulated as [Cu₁₅(PPh₃)₆(PET)₁₃]²⁺, which exhibits bright emission in the near-IR (NIR) region (≈720 nm) and crystallization-induced emission enhancement (CIEE) phenomenon. Single crystal x-ray crystallog. shows that the NC possesses an extraordinary distorted trigonal antiprismatic Cu₆ core and a, unique among metal clusters, “tri-blade fan”-like structure. An in-depth structural investigation of the ligand shell combined with d. functional theory calculations reveal that the extended C-H···π and π-π intermol. ligand interactions significantly restrict the intramol. rotations and vibrations and, thus, are a major reason for the CIEE phenomena. This study provides a strategy for the controllable synthesis of structurally defined Cu NCs with NIR luminescence, which enables essential insights into the origins of their optical properties.

Small published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dong, Chunwei published the artcile[Cu₃₆H₁₀(PET)₂₄(PPh₃)₆Cl₂] Reveals Surface Vacancy Defects in Ligand-Stabilized Metal Nanoclusters, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2021), 143(29), 11026-11035, database is CAplus and MEDLINE.

Precise identification and in-depth understanding of defects in nanomaterials can aid in rationally modulating defect-induced functionalities. However, few studies have explored vacancy defects in ligand-stabilized metal nanoclusters with well-defined structures, owing to the substantial challenge of synthesizing and isolating such defective metal nanoclusters. Herein, a novel defective copper hydride nanocluster, [Cu₃₆H₁₀(PET)₂₄(PPh₃)₆Cl₂] (Cu36; PET: phenylethanethiolate; PPh₃: triphenylphosphine), is successfully synthesized at the gram scale via a simple one-pot reduction method. Structural anal. reveals that Cu36 is a distorted half cubic nanocluster, evolved from the perfect Nichol’s half cube. The two surface copper vacancies in Cu36 are found to be the principal imperfections, which result in some structural adjustments, including copper atom reconstruction near the vacancies as well as ligand modifications (e.g., substitution, migration, and exfoliation). D. functional theory calculations imply that the above-mentioned defects have a considerable influence on the electronic structure and properties. The modeling suggests that the formation of defective Cu36 rather than the perfect half cube is driven by the enlargement of the energy gap between the HOMO and the LUMO of the nanocluster. The structural evolution induced by the surface copper atom vacancies provides atomically precise insights into the defect-induced readjustment of the local structure and introduces new avenues for understanding the chem. of defects in nanomaterials.

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Haag, Franziska published the artcileKey Food Furanones Furaneol and Sotolone Specifically Activate Distinct Odorant Receptors, Application of 2-Phenylethanethiol, the publication is Journal of Agricultural and Food Chemistry (2021), 69(37), 10999-11005, database is CAplus and MEDLINE.

Furanones formed during the Maillard reaction often are natural aroma-determining compounds found in numerous foods. Prominent economically relevant representatives are the structural homologues Furaneol and sotolone, which are important natural flavoring compounds because of their distinct caramel- and seasoning-like odor qualities. These, however, cannot be predicted by the odorants’ mol. shape, rather their receptors’ activation parameters help to decipher the encoding of odor quality. Here, the distinct odor qualities of Furaneol and sotolone suggested an activation of at least two out of our ca. 400 different odorant receptor types, which are the mol. biosensors of our chem. sense of olfaction. While an odorant receptor has been identified for sotolone, a receptor specific for Furaneol has been elusive. Using a bidirectional screening approach employing 616 receptor variants and 187 key food odorants in a HEK-293 cell-based luminescence assay, we newly identified OR5M3 as a receptor specifically activated by Furaneol and homofuraneol.

Journal of Agricultural and Food Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yuming published the artcileTwo-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of alcs., Computed Properties of 4410-99-5, the publication is European Journal of Organic Chemistry (2021), 2021(7), 1179-1183, database is CAplus.

We have developed a two-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of primary and secondary alcs. to afford products containing a C-N, C-S, or C-O bond. In the first step the alc. undergoes iodination with iodotrimethylsilane, and in the second, the iodine atom is replaced by a N, S, or O nucleophile. Compared with traditional Mitsunobu reaction, non-acidic pre-nucleophiles can be used, and the reaction proceeds with retention of configuration. This operationally simple, highly efficient protocol can be used for some natural products and small-mol. drugs containing hydroxy-group.

European Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Wangzhi published the artcilePalladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters, Name: 2-Phenylethanethiol, the publication is Organic Letters, database is CAplus and MEDLINE.

A Pd-catalyzed hydrothiocarbonylation of unactivated terminal alkenes is presented. According to this protocol, aliphatic thioesters were synthesized with exclusive linear selectivity under mild reaction conditions. Good to excellent yields (up to 91% yield), broad substrate scope, broad functional group tolerance, and utility of the method demonstrated the advantages of this protocol.

Organic Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C29H24FN7O, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Peng published the artcileSolvent-free, B(C₆F₅)₃-Catalyzed S-H Insertion of Thiophenols and Thiols with α-Diazoesters, Quality Control of 4410-99-5, the publication is Chemistry – An Asian Journal (2022), 17(16), e202200465, database is CAplus and MEDLINE.

A B(C₆F₅)₃-catalyzed S-H insertion reaction of thiophenols and thiols with α-diazoesters to access valuable α-thioesters was described. With the established protocol, an array of α-thioester products were generated in moderate to good yields with broad scope and functional group tolerance. In addition, this reaction maintained its high efficiency on gram scale and the product can be easily transformed into other useful motifs. This reaction proceeded under solvent-free conditions at room temperature, and generally finished in twenty minutes upon magnet stirring, which offers an expedient way for synthesis of thioether-containing compounds

Chemistry – An Asian Journal published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H11NO, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavaca, Lidia A. S. published the artcilePreparation of Thioaminals in Water, Product Details of C8H10S, the publication is Molecules (2022), 27(5), 1673, database is CAplus and MEDLINE.

In this work, the formation of thioaminals RSCH(R¹)N(R²)(R³) [R = Ph, benzyl, Pr, etc.; R¹ = furan-2-yl, Ph, 4-bromophenyl, etc. ; R² = benzyl; R³ = benzyl ; R²R³ = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-, -(CH₂)₂N(CH₃)(CH₂)₂-] in water promoted by copper(II) triflate was described.

Molecules published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Product Details of C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeminejs, Andris published the artcileApplication of Azide-Tetrazole Tautomerism and Arylsulfanyl Group Dance in the Synthesis of Thiosubstituted Tetrazoloquinazolines, Synthetic Route of 4410-99-5, the publication is Synthesis (2021), 53(8), 1443-1456, database is CAplus.

Nucleophilic aromatic substitution reaction between 4-arylthio-2-chloroquinazolines I (Ar = C₆H₅, 4-BrC₆H₄, 4-FC₆H₄, 4-ClC₆H₄, 4-CH₃C₆H₄) and NaN₃ takes place with an unusual sulfanyl group dance and leads to the formation of 5-(arylthio)tetrazolo[1,5-c]-quinazolines II, which do not form the azide tautomer and do not undergo CuAAC reactions with alkynes. On the other hand, 5-azidotetrazolo[1,5-a]quinazoline (formally described as 2,4-diazidoquinazoline) undergoes regioselective nucleophilic aromatic substitution with thiols at C5 and forms 5-(alkyl/arylthio)tetrazolo[1,5-a]quinazolines III (R¹ = cyclopentyl, C₆H₅, CH₂C₆H₅, etc.), the structure of which has been proved by X-ray crystallog. The latter exist in tautomeric equilibrium with their 2-azidoquinazoline form, which provides possibility for copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction, leading to the 4-alkyl/arylthio-2-(1H-1,2,3-triazol-1-yl)quinazolines IV (R² = C₆H₅, cyclopropyl, Bu, etc.).

Synthesis published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Synthetic Route of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Tongfei published the artcileCopper-catalyzed thioketalization of enones featuring trifluoromethyl groups, Computed Properties of 4410-99-5, the publication is RSC Advances (2021), 11(32), 19832-19835, database is CAplus and MEDLINE.

Here, a copper-catalyzed thioketalization of enones bearing CF₃ groups and various mercaptans was developed, thioketal mols. I [R = Et, i-Pr, allyl, etc.; RR = (CH₂)₂; R² = Me, Ph] had been obtained with moderate to excellent yield. Meanwhile, a preparative scale experiment had been performed giving over 95% yield. This work allowed the straightforward formation of thioketals I containing CF₃ groups and unsaturated double bonds.

RSC Advances published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C7H15NO, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Xiao-Ling published the artcileNetwork pharmacology study on mechanism of Zhen-Wu decoction for chronic heart failure treatment, Recommanded Product: 2-Phenylethanethiol, the publication is Drug Combination Therapy (2021), 3(1), 1, database is CAplus.

To explore and predict the mechanism of classic ancient prescription of Chinese medicine Zhen-Wu decoction for chronic heart failure treatment based on network pharmacol. Traditional Chinese medicine systems pharmacol. database was used to search the effective components and targets of herbs in classic ancient prescription of Chinese medicine Zhen-Wu decoction. Relevant target genes of chronic heart failure were obtained from GeneCards and Online Mendelian Inheritance in Man databases. Then we obtained the intersection target genes of classic ancient prescription of Chinese medicine Zhen-Wu decoction in treating chronic heart failure, constructing the classic ancient prescription of Chinese medicine Zhen-Wu decoction-active ingredient-chronic heart failure-targets network using Cytoscape, and performing network anal. using a network ananlyzer plug-in to acquire hub compounds and key targets. Proton pump inhibitor network was constructed through STRING database. Gene ontol. function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment anal. were carried out in Database for Annotation, Visualization and Integrated Discovery. There are 61 active ingredients and 134 action targets in classic ancient prescription of Chinese medicine Zhen-Wu decoction, among which 49 target genes and 11 important compounds related to the chronic heart failure treatment. After network anal., we obtained 12 key targets, 77 gene ontol. entries and 22 signal pathways, including tumor necrosis factor signaling pathway, NF-kappaB signal pathway, PI3K-Akt signal pathway, et al. Classic ancient prescription of Chinese medicine Zhen-Wu decoction was used for chronic heart failure treatment for the multi-component, multi-target and multi-channel interaction. The components such as kaempferol and β-sitosterol were combined with target proteins such as CHRM1 and AChE, involving biol. processes such as DNA transcription regulation, cholinergic synaptic transmission and apoptosis regulation, as well as signal pathways such as tumor necrosis factor signaling pathway, NF-kappa B signal pathway, PI3K-Akt signal pathway, et al.

Drug Combination Therapy published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts