Category: 4410-99-5

Zheng, Sheng published the artcileProdrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer, HPLC of Formula: 4410-99-5, the publication is Journal of Nanobiotechnology (2021), 19(1), 381, database is CAplus and MEDLINE.

The prognosis of patients with advanced gastric cancer (GC) remains unsatisfactory owing to distant metastasis and resistance to concurrent systemic therapy. Cancer-associated fibroblasts (CAFs), as essential participators in the tumor microenvironment (TME), play a vital role in tumor progression. Thus, CAFs-targeting therapy is appealing for remodeling TME and sensitizing GC to conventional systemic therapy. Amphiphilic SN38 prodrug polymeric micelles (PSN38) and encapsulated the hydrophobic esterase-responsive prodrug of Triptolide (TPL), triptolide-naphthalene sulfonamide (TPL-nsa), were synthesized to form PSN38@TPL-nsa nanoparticles. Then, CAFs were isolated from fresh GC tissues and immortalized. TPL at low dose concentration was used to investigate its effect on CAFs and CAFs-induced GC cells proliferation and migration. The synergistic mechanism and antitumor efficiency of SN38 and TPL co-delivery nanoparticle were investigated both in vitro and in vivo. Fibroblast activation protein (FAP), a marker of CAFs, was highly expressed in GC tissues and indicated poorer prognosis. TPL significantly reduced CAFs activity and inhibited CAFs-induced proliferation, migration and chemotherapy resistance of GC cells. In addition, TPL sensitized GC cells to SN38 treatment through attenuated NF-κB activation in both CAFs and GC cells. PSN38@TPL-nsa treatment reduced the expression of collagen, FAP, and α-smooth muscle actin (α-SMA) in tumors. Potent inhibition of primary tumor growth and vigorous anti-metastasis effect were observed after systemic administration of PSN38@TPL-nsa to CAFs-rich peritoneal disseminated tumor and patient-derived xenograft (PDX) model of GC. TPL suppressed CAFs activity and CAFs-induced cell proliferation, migration and chemotherapy resistance to SN38 of GC. CAFs-targeted TPL and SN38 co-delivery nanoparticles exhibited potent efficacy of antitumor and reshaping TME, which was a promising strategy to treat advanced GC.

Journal of Nanobiotechnology published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C9H4F6O, HPLC of Formula: 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Jun Jie published the artcileSynthesis of vinyl iodide chain-end polymers via organocatalyzed chain-end transformation, Recommanded Product: 2-Phenylethanethiol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(9), 1105-1108, database is CAplus and MEDLINE.

In the presence of alkynes (CH=C-R²), iodide chain-end polymers (Polymer-I) were successfully transformed to vinyl iodide chain-end polymers (polymer-CH=CR²-I) in a single step via organocatalysis. This reaction is completely metal-free and easy to carry out without using special reagents or special conditions. The polymers encompassing polyacrylates and polymethacrylate, and addnl. functionalities (e.g., OH and CF₃) were also incorporated into the R² moiety. The obtained Polymer-CH=CR²-I further served as a useful precursor for copper-catalyzed cross-coupling reactions with various thiols (R³-SH) to yield vinyl sulfide chain-end polymers (polymer-CH=CR²-SR³) with various R³ moieties. Interestingly, under selected conditions, this organocatalysis also offered block-like copolymers containing a conjugated oligo-alkyne segment and a non-conjugated polyacrylate segment. Exploiting the unique structure, the block-like copolymer was used as an efficient dispersant of carbon nanotubes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Du, Bingnan published the artcileThioether-Directed NiH-Catalyzed Remote γ-C(sp³)-H Hydroamidation of Alkenes by 1,4,2-Dioxazol-5-ones, SDS of cas: 4410-99-5, the publication is Journal of the American Chemical Society (2021), 143(37), 14962-14968, database is CAplus and MEDLINE.

A NiH-catalyzed thioether-directed cyclometalation strategy was developed to enable remote methylene C-H bond amidation of unactivated alkenes. Due to the preference for five-membered nickelacycle formation, the chain-walking isomerization initiated by the NiH insertion to an alkene could be terminated at the γ-methylene site remote from the alkene moiety. By employing 2,9-dibutyl-1,10-phenanthroline as the ligand and dioxazolones as the reagent, the amidation occurs at the γ-C(sp³)-H bonds to afford the amide products in up to 90% yield (<40 examples) with remarkable regioselectivity (up to 24:1 rr).

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, SDS of cas: 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Eitzinger, Andreas published the artcileEnantioselective Bifunctional Ammonium Salt-Catalyzed Syntheses of 3-CF₃S-, 3-RS-, and 3-F-Substituted Isoindolinones, COA of Formula: C8H10S, the publication is Advanced Synthesis & Catalysis (2021), 363(7), 1955-1962, database is CAplus and MEDLINE.

Herein, ammonium salt-catalyzed synthesis of chiral 3,3-disubstituted isoindolinones, e.g., I bearing a heteroatom functionality in the 3-position was reported. A broad variety of differently substituted CF₃S- and RS-derivatives were obtained with often high enantioselectivities when using Maruoka’s bifunctional chiral ammonium salt catalyst. In addition, a first proof-of-concept for the racemic synthesis of the analogous F-containing products was obtained as well, giving access to one of the rare examples of a fairly stable α-F-α-amino acid derivative

Advanced Synthesis & Catalysis published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, COA of Formula: C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sorrentino, Jacob P. published the artcileAcid-Catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers, Recommanded Product: 2-Phenylethanethiol, the publication is Journal of Organic Chemistry (2021), 86(3), 2297-2311, database is CAplus and MEDLINE.

The substitution of hydrogen atoms with fluorine in bioactive mols. can greatly impact physicochem., pharmacokinetic, and pharmacodynamic properties. However, current synthetic methods cannot readily access many fluorinated motifs, which impedes utilization of these groups. Thus, the development of new methods to introduce fluorinated functional groups was critical for developing the next generation of biol. probes and therapeutic agents. The synthesis of one such substructure, the α,α-difluoroalkylthioether, typically requires specialized conditions that necessitate early-stage installation. A late-stage and convergent approach to access α,α-difluoroalkylthioethers could involve nucleophilic addition of thiols across gem-difluorostyrenes. Unfortunately, under basic conditions, nucleophilic addition to gem-difluorostyrenes generates an anionic intermediate that can undergo facile elimination of fluoride to generate α-fluorovinylthioethers. To overcome this decomposition,acid-based catalyst system to facilitate simultaneous nucleophilic addition and protonation of the unstable intermediate. Ultimately, the optimized mild conditions afford the desired α,α-difluoroalkylthioethers in high selectivity and moderate to excellent yields. These α,α-difluoroalkylthioethers were less nucleophilic and more oxidatively stable relative to nonfluorinated thioethers, suggesting the potential application of this unexplored functional group in biol. probes and therapeutic agents.

Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C3H5F3O, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hanaya, Kengo published the artcileNickel(II)-Mediated C-S Cross-Coupling Between Thiols and ortho-Substituted Arylboronic Acid, Quality Control of 4410-99-5, the publication is Asian Journal of Organic Chemistry (2021), 10(3), 582-587, database is CAplus.

Herein, a C-S cross-coupling reaction between alkyl thiols or aryl thiols and ortho-substituted arylboronic acids that proceeded in the presence of an inexpensive and ligand-free NiCl₂.6H₂O salt and N-methylmorpholine, a weak base, at 25°C in air were reported. The presence of coordinating and electron-withdrawing groups at the ortho-position of the arylboronic acids played a crucial role in determining the efficiency of the reaction. X-ray crystallog. anal. revealed that the [NiCl₂(DMF)₂(H₂O)₂] complex was formed in-situ. The complex was an excellent precursor of the active nickel species. The reaction offered an extremely mild and operationally convenient method to access a wide variety of alkyl aryl sulfides and diaryl sulfides without using expensive transition metals such as palladium, gold, and rhodium and specialized and expensive ligands.

Asian Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maman, Manju P. published the artcileReversible polymorphic structural transition of crown-like nickel nanoclusters and its effect on conductivity, Name: 2-Phenylethanethiol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(23), 2935-2938, database is CAplus and MEDLINE.

The reversible polymorphic phase transition of [Ni₆(PET)₁₂] (PET = phenylethanethiol) and its effect on the conductivity are reported. This cluster′s self-assembly leads to 2 polymorphic structures with distinct conductivity, caused by variation of the noncovalent S···S interactions. These results enlighten the effect of noncovalent interactions on conductivity

Chemical Communications (Cambridge, United Kingdom) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rival, Jose V. published the artcileLight-Emitting Atomically Precise Nanocluster-Based Flexible QR Codes for Anticounterfeiting, Application In Synthesis of 4410-99-5, the publication is ACS Applied Materials & Interfaces (2021), 13(8), 10583-10593, database is CAplus and MEDLINE.

Despite tremendous progress in the field of fluorescence-based anticounterfeiting, the advanced anticounterfeiting techniques are still posing challenges all over the world due to their cost and reliability. Recently, light-emitting atomically precise nanoclusters have emerged as attractive building blocks because of their well-defined structure, function, and stable photoluminescence. Herein, we report the room temperature fabrication of a stable, flexible, nontoxic, and low-cost precision nanocluster-based luminescent ink for the stencil printing of an optically unclonable security label. Nanocluster-based printing ink shows brilliant photoluminescence owing to its extended C-H···π/π···π interactions. Spectroscopic and microscopic investigations show that intercalated nanoclusters in the printed security labels are highly stable as their optical features and mol. compositions are unaffected. The exceptional mech., thermal, photo, and aqueous stabilities of the printed security labels endorse to demonstrate the printing and smartphone-based electronic reading of the quick response code on a currency. Finally, confidential information protection and decryption under a precise window of light have been achieved by adopting the optical contrast illusion. The overall cost of the security label is found to be approx. 0.013 USD per stamp.

ACS Applied Materials & Interfaces published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application In Synthesis of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tao, Wenjie published the artcileRedox-Neutral S-nitrosation Mediated by a Dicopper Center, Name: 2-Phenylethanethiol, the publication is Angewandte Chemie, International Edition (2021), 60(29), 15980-15987, database is CAplus and MEDLINE.

A redox-neutral S-nitrosation of thiol has been achieved at a dicopper(I,I) center. Treatment of dicopper (I,I) complex with excess NO^. and thiol generates a dicopper (I,I) di-S-nitrosothiol complex [Cu^ICu^I(RSNO)₂]²⁺ or dicopper (I,I) mono-S-nitrosothiol complex [Cu^ICu^I(RSNO)]²⁺, which readily release RSNO in 88-94% yield. The S-nitrosation proceeds by a mixed-valence [Cu^IICu^III(μ-O)(μ-NO)]²⁺ species, which deprotonates RS-H at the basic μ-O site and nitrosates RS^– at the μ-NO site. The [Cu^IICu^III(μ-O)(μ-NO)]²⁺ complex is also competent for O-nitrosation of MeOH. A rare [Cu^IICu^II(μ-NO)(OMe)]²⁺ intermediate was isolated and fully characterized, suggesting the S-nitrosation may proceed through the intermediary of analogous [Cu^IICu^II(μ-NO)(SR)]²⁺ species. This redox- and proton-neutral S-nitrosation process is the first functional model of ceruloplasmin in mediating S-nitrosation of external thiols, with implications for biol. copper sites in the interconversion of NO^./RSNO.

Angewandte Chemie, International Edition published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H7ClO3, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Teng, Shuang published the artcileTogni-II Reagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes, COA of Formula: C8H10S, the publication is Chinese Journal of Chemistry (2021), 39(12), 3429-3434, database is CAplus.

Based on the redox reactions of Togni-II reagent and thiols (such as propane-2-thiol, cyclohexanethiol, dodecan-1-thiol, p-toluenethiol, etc.), a thiol-tuned selective functionalization of unactivated olefins was disclosed. In combination with aryl thiol (p-toluenethiol), stoichiometric amount of Togni-II reagent prompted a hydrotrifluoromethylation of alkenes (such as N-allyl-benzamide, 1-phenyl-but-3-en-1-ol, 4-chloro-benzoic acid pent-4-enyl ester, etc.), in which, aryl thiol played as reductant and hydrogen source; while by utilization of alkyl thiols (such as propane-2-thiol, cyclohexanethiol, dodecan-1-thiol, etc.), catalytic amount of Togni-II reagent initiated thiol-ene and thiol-yne reactions. The reported applications are characterized by their operational simplicity and wide functional group tolerance.

Chinese Journal of Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C14H19NO8, COA of Formula: C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts