Category: 4396-13-8

Jung, Jong-Woon; Damodar, Kongara; Kim, Jin-Kyung; Jun, Jong-Gab published the artcile< First synthesis and in vitro biological assessment of isosideroxylin, 6,8-dimethylgenistein and their analogues as nitric oxide production inhibition agents>, Related Products of 4396-13-8, the main research area is isosideroxylin preparation nitric oxide inhibitory antiinflammatory activity; dimethylgenistein preparation nitric oxide inhibitory antiinflammatory activity; Vilsmeier Haack Friedel Crafts acylation Gammill protocol Suzuki.

A modular and efficient synthesis of the biol. significant C-methylisoflavones isosideroxylin (I), 6,8-dimethylgenistein (II) and their analogs is established for the first time. The synthesis is realized in 7-8 steps in overall yields of 16%-24% from com. inexpensive phloroglucinol and features a high yielding Vilsmeier-Haack reaction, Friedel-Crafts acylation, Gammill’s protocol and Suzuki coupling as the pivotal transformations. Next, these compounds evaluated for their inhibitory potency on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW-264.7 cells as an indicator of anti-inflammatory activity. The results showed that all the compounds decreased NO production in a dose-dependent manner without marked cytotoxicity and IC50 values are found in the range of 10.17-33.88 μmol/L. Of note, some compounds show comparable inhibitory activity with pos. control (N-monomethyl-L-arginine, L-NMMA).

Chinese Chemical Letters published new progress about Anti-inflammatory agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chaudhuri, Susri Ray; Modak, Arindam; Bhaumik, Asim; Swarnakar, Snehasikta published the artcile< Phloroglucinol derivatives as potential anti-ulcer compound that inhibits matrix metalloproteinase-9>, Related Products of 4396-13-8, the main research area is antiulcer phloroglucinol derivative matrix metalloproteinase 9 gastric ulceration.

Three phloroglucinol based polyphenolic compounds have been synthesized and their potential efficacy against gastric ulceration in mice was investigated. Polyphenol (I, II, III) were synthesized through Vilsmeier-Haack formylation, Schiff-base condensation of diformyl- phloroglucinol with 4-amino salicylic acid and Duff formylation reactions resp. We administered indomethacin, a non-steroidal anti inflammatory drug (NSAID), to induce gastric ulceration in Balb/c mice and tested antiulcer efficacy of synthesized phloroglucinol derivatives The pathogenesis of NSAID-induced ulceration is known to be associated to upregulation of matrix metalloproteinase (MMP)-9. All derivatives of phloroglucinol were found to prevent gastric ulceration in mice through depletion of oxidative stress in gastric tissue. Phloroglucinol derivatives also possessed antioxidant activity and they suppressed antioxidant enzymes in gastric tissues to almost normalcy during gastroprotection. Compound III was found to be most efficient anti-ulcer agent among others that inhibited the MMP-9 activity near to control value during prevention of NSAID-induced gastric ulceration. Thus, new polyphenolic compounds derived from phloroglucinol have antioxidant as well as anti-ulcer activity. We conclude that phloroglucinol derivatives as potent anti-ulcer compound in prevention of indomethacin induced gastric ulceration via attenuation of MMP-9 activity.

International Journal of Pharmaceutical Applications published new progress about Antioxidants. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhanja, Piyali; Das, Sabuj K.; Bhunia, Kousik; Pradhan, Debabrata; Hayashi, Taku; Hijikata, Yuh; Irle, Stephan; Bhaumik, Asim published the artcile< A New Porous Polymer for Highly Efficient Capacitive Energy Storage>, Application In Synthesis of 4396-13-8, the main research area is porous polymer supercapacitor electrode capacitance triazine isophthalaldehyde.

The new porous polymer TPDA-1 has been synthesized via solvothermal Schiff base condensation reaction between two organic monomers, i.e., 2,4,6-trihydroxyisophthalaldehyde and 1,3,5-tris(4-aminophenyl)triazine. The TPDA-1 material showed a very high specific capacitance of 469.4 F g-1, at 2 mV s-1 scan rate, together with a high sp. surface area of 545 m2 g-1. It also exhibited excellent cyclic stability with 95% retention of its initial specific capacitance after 1000 cycles at 5 A g-1, suggesting its potential as a high performance supercapacitor. Extended π-conjugation and ion conduction inside the micropores throughout the whole polymeric matrix and high BET surface area could be responsible for this high supercapacitor performance in energy storage device. TPDA-1 has been characterized thoroughly by various electrochem. techniques such as cyclic voltammetry, galvanic charge-discharge, and electrochem. impedance spectroscopy. Our exptl. results suggested a high potential of this porous polymer in energy storage devices for future generation.

ACS Sustainable Chemistry & Engineering published new progress about Aminoplasts Role: PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PREP (Preparation), USES (Uses). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Application In Synthesis of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Das, Sabuj Kanti; Bhanja, Piyali; Kundu, Sudipta K.; Mondal, Saptarsi; Bhaumik, Asim published the artcile< Role of Surface Phenolic-OH Groups in N-Rich Porous Organic Polymers for Enhancing the CO2 Uptake and CO2/N2 Selectivity: Experimental and Computational Studies>, Electric Literature of 4396-13-8, the main research area is surface phenolic porous carbon dioxide polyamine aminoplast; CO2 uptake; N-rich porous surface; phenolic-OH groups; porous organic polymers; selective CO2/N2 adsorption.

Design and successful synthesis of phenolic-OH and amine-functionalized porous organic polymers as adsorbent for postcombustion CO2 uptake from flue gas mixtures along with high CO2/N2 selectivity is a very demanding research area in the context of developing a suitable adsorbent to mitigate greenhouse gases. Herein, we report three triazine-based porous organic polymers TrzPOP-1, -2, and -3 through the polycondensation of two triazine rings containing tetraamine and three dialdehydes. These porous organic polymers possess high Brunauer-Emmett-Teller (BET) surface areas of 995, 868, and 772 m2 g-1, resp. Out of the three materials, TrzPOP-2 and TrzPOP-3 contain addnl. phenolic-OH groups along with triazine moiety and secondary amine linkages. At 273 K, TrzPOP-1, -2, and -3 displayed CO2 uptake capacities of 6.19, 7.51, and 8.54 mmol g-1, resp., up to 1 bar pressure, which are considerably high among all porous polymers reported till date. Despite the lower BET surface area, TrzPOP-2 and TrzPOP-3 containing phenolic-OH groups showed higher CO2 uptakes. To understand the CO2 adsorption mechanism, we have further performed the quantum chem. studies to analyze noncovalent interactions between CO2 mols. and different polar functionalities present in these porous polymers. TrzPOP-1, -2, and -3 have the capability of selective CO2 uptake over that of N2 at 273 K with the selectivity of 61:1, 117:1, and 142:1 by using the initial slope comparing method, along with 108.4, 140.6, and 167.4 by using ideal adsorbed solution theory (IAST) method, resp. On the other hand, at 298 K, the calculated CO2/N2 selectivities in the initial slope comparing method for TrzPOP-1, -2, and -3 are 27:1, 72:1, and 96:1, whereas those using IAST method are 42.1, 75.7, and 94.5, resp. Cost effective and scalable synthesis of these porous polymeric materials reported herein for selective CO2 capture has a very promising future for environmental clean-up.

ACS Applied Materials & Interfaces published new progress about Activation energy. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Electric Literature of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mudududdla, Ramesh; Jain, Shreyans K.; Bharate, Jaideep B.; Gupta, Ajai P.; Singh, Baldev; Vishwakarma, Ram A.; Bharate, Sandip B. published the artcile< ortho-Amidoalkylation of phenols via tandem one-pot approach involving oxazine intermediate>, Quality Control of 4396-13-8, the main research area is hydroxybenzyl lactam regioselective preparation; phenol lactam tandem Knoevenagel condensation Diels Alder cycloaddition; perchloric acid amidoalkylation catalyst.

An efficient method for ortho-amidoalkylation of phenols via Mannich-type condensation with formaldehyde and lactams using recyclable solid acid catalyst is described. This is the first report for ortho-amidoalkylation of phenols by lactams via Mannich-type condensation. LC-ESI-MS/MS based mechanistic study revealed that reaction proceeds through o-quinone methide (o-QM) and an oxazine intermediate via tandem Knoevenagel condensation, formal [4 + 2]-Diels-Alder cycloaddition and acid catalyzed oxazine ring-opening.

Journal of Organic Chemistry published new progress about Amidoalkylation. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Quality Control of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chenavas, Sophie; Fiorini-Puybaret, Christel; Joulia, Philippe; Larrouquet, Camille; Waton, Hugues; Martinez, Agathe; Casabianca, Herve; Fabre, Bernard published the artcile< New formylated phloroglucinol compounds from Eucalyptus globulus foliage>, Related Products of 4396-13-8, the main research area is Eucalyptus formylated phloroglucinol compound acylphloroglucinol.

Two new acylphloroglucinols were isolated from the leaves of Eucalyptus globulus Labill and identified as macrocarpals P (1) and Q (2). Structural elucidations were carried out using conventional 1D and 2D NMR and mass spectrometry together with complementary techniques (UV and IR). Macrocarpal Q was a diastereoisomer of macrocarpal E (3), configuration of which was not precised. Simultaneous isolation of macrocarpals E and Q allowed to determine the configurations of both compounds The diformylphloroglucinol (4) was also isolated as well as already known compounds grandinol, macrocarpals D, I, L, N, O and am-1.

Phytochemistry Letters published new progress about Eucalyptus globulus. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bharate, Sandip B.; Khan, Shabana I.; Tekwani, Babu L.; Jacob, Melissa; Khan, Ikhlas A.; Singh, Inder Pal published the artcile< S-Euglobals: Biomimetic synthesis, antileishmanial, antimalarial, and antimicrobial activities>, SDS of cas: 4396-13-8, the main research area is euglobal analog preparation antileishmanial antimalarial antimicrobial structure.

Several new euglobal analogs (named as S-euglobals) were synthesized from phloroglucinol using a biomimetic three-component reaction involving Knoevenagel condensation and Diels-Alder cycloaddition with a monoterpene. Newly synthesized euglobal analogs involve monoterpenes that have not yet been encountered in natural euglobals. S-Euglobals along with previously synthesized robustadial A and B were evaluated for in vitro antileishmanial, antimalarial, antimicrobial, and cytotoxic activities. Out of sixteen analogs prepared, nine analogs were found to exhibit antileishmanial activity against Leishmania donovani promastigotes. A 2-carene-derived S-euglobal was the most potent antileishmanial with IC50 of 2.4 μg/mL and IC90 of 8 μg/mL, followed by a second 2-carene-derived S-euglobal and a nopol-derived S-euglobal (IC50 5.5 and 9.5 μg/mL). Antileishmanial activity of robustadial A (5) and B (6) was moderate with IC50 of 20 and 16 μg/mL, resp. Robustadial A and B and a 2-carene-derived S-euglobal exhibited weak antimalarial activity against Plasmodium falciparum (IC50 of 2.7-4.76 μg/mL). Few of the euglobal analogs showed antibacterial activity against methicillin-resistant Staphylococcus aureus. Amongst these, a nopol-derived S-euglobal was the most potent with IC50 of 1.0 μg/mL and MIC of 5.0 μg/mL. Most of the compounds were not cytotoxic up to 25 μg/mL in a panel of cell lines consisting of both cancer (SK-MEL, KB, BT-549, and SK-OV-3) as well as non-cancer kidney (Vero and LLC-PK11) cells.

Bioorganic & Medicinal Chemistry published new progress about Antimalarials. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, SDS of cas: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jung, Jong-Woon; Damodar, Kongara; Kim, Jin-Kyung; Jun, Jong-Gab published the artcile< First synthesis and in vitro biological assessment of isosideroxylin, 6,8-dimethylgenistein and their analogues as nitric oxide production inhibition agents>, Related Products of 4396-13-8, the main research area is isosideroxylin preparation nitric oxide inhibitory antiinflammatory activity; dimethylgenistein preparation nitric oxide inhibitory antiinflammatory activity; Vilsmeier Haack Friedel Crafts acylation Gammill protocol Suzuki.

A modular and efficient synthesis of the biol. significant C-methylisoflavones isosideroxylin (I), 6,8-dimethylgenistein (II) and their analogs is established for the first time. The synthesis is realized in 7-8 steps in overall yields of 16%-24% from com. inexpensive phloroglucinol and features a high yielding Vilsmeier-Haack reaction, Friedel-Crafts acylation, Gammill’s protocol and Suzuki coupling as the pivotal transformations. Next, these compounds evaluated for their inhibitory potency on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW-264.7 cells as an indicator of anti-inflammatory activity. The results showed that all the compounds decreased NO production in a dose-dependent manner without marked cytotoxicity and IC50 values are found in the range of 10.17-33.88 μmol/L. Of note, some compounds show comparable inhibitory activity with pos. control (N-monomethyl-L-arginine, L-NMMA).

Chinese Chemical Letters published new progress about Anti-inflammatory agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chaudhuri, Susri Ray; Modak, Arindam; Bhaumik, Asim; Swarnakar, Snehasikta published the artcile< Phloroglucinol derivatives as potential anti-ulcer compound that inhibits matrix metalloproteinase-9>, Related Products of 4396-13-8, the main research area is antiulcer phloroglucinol derivative matrix metalloproteinase 9 gastric ulceration.

Three phloroglucinol based polyphenolic compounds have been synthesized and their potential efficacy against gastric ulceration in mice was investigated. Polyphenol (I, II, III) were synthesized through Vilsmeier-Haack formylation, Schiff-base condensation of diformyl- phloroglucinol with 4-amino salicylic acid and Duff formylation reactions resp. We administered indomethacin, a non-steroidal anti inflammatory drug (NSAID), to induce gastric ulceration in Balb/c mice and tested antiulcer efficacy of synthesized phloroglucinol derivatives The pathogenesis of NSAID-induced ulceration is known to be associated to upregulation of matrix metalloproteinase (MMP)-9. All derivatives of phloroglucinol were found to prevent gastric ulceration in mice through depletion of oxidative stress in gastric tissue. Phloroglucinol derivatives also possessed antioxidant activity and they suppressed antioxidant enzymes in gastric tissues to almost normalcy during gastroprotection. Compound III was found to be most efficient anti-ulcer agent among others that inhibited the MMP-9 activity near to control value during prevention of NSAID-induced gastric ulceration. Thus, new polyphenolic compounds derived from phloroglucinol have antioxidant as well as anti-ulcer activity. We conclude that phloroglucinol derivatives as potent anti-ulcer compound in prevention of indomethacin induced gastric ulceration via attenuation of MMP-9 activity.

International Journal of Pharmaceutical Applications published new progress about Antioxidants. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts