Category: 4396-13-8

Newton, Christopher G.; Tran, Duc N.; Wodrich, Matthew D.; Cramer, Nicolai published the artcile< One-Step Multigram-Scale Biomimetic Synthesis of Psiguadial B>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is caryophyllene benzaldehyde diformylphloroglucinol biomimetic three component coupling cascade; psiguadial B biomimetic synthesis; biomimetic synthesis; cyclization; natural products; terpenoids; total synthesis.

A gram-scale synthesis of psiguadial B (I), a purported inhibitor of human hepatoma cell growth, has been achieved in one step by a biomimetic three-component coupling of caryophyllene, benzaldehyde, and diformylphloroglucinol. This cascade reaction is catalyzed by N,N’-dimethylethylenediamine, and proceeds at ambient temperature to generate four stereocenters, two rings, one C-O bond, and three C-C bonds. Combined computational and exptl. investigations suggest the biosynthesis of the natural product is non-enzyme mediated, and is the result of a Michael addition between caryophyllene and a reactive ortho-quinone methide, followed by two sequential intramol. cationic cyclization events.

Angewandte Chemie, International Edition published new progress about Biomimetic synthesis. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saraf, Isha; Marsh, Karen J.; Kumar, Vineet; Foley, William J.; Singh, Inder Pal published the artcile< Comparative qualitative analysis of different classes of compounds in selected Australian and Indian Eucalyptus and Corymbia species: a convenient de-replication method for the eucalypts>, Category: alcohols-buliding-blocks, the main research area is Australian Indian eucalyptus corymbia flavonoid glycoside triterpenoid phloroglucinol; high performance thin layer chromatog dereplication qual analysis.

Eucalypts are a large group of woody trees with about 900 taxa in 3 genera: Eucalyptus, Corymbia and Angophora. The secondary metabolites of eucalypts have shown a plethora of biol. activities. The chem. behind the activities of eucalypts is being unearthed with advancements in modern medicine and drugstore. This has demanded the phytochem. profiling of eucalypts with respect to their bioactive constituents. A large number of secondary metabolites (flavonoids, glycosides, triterpenoids, phloroglucinols) from several species of eucalypts have been earlier isolated by our group. In order to develop quick identification of secondary metabolites from eucalypts for de-replication purposes, we thought it worthwhile to develop qual. HPTLC methods for these compounds in 15 eucalypts (13 Eucalyptus and 2 Corymbia) collected from Australia and India. High-performance thin-layer chromatog. fingerprints using 87 compounds of the above chem. classes of natural products were developed for the quality assessment of eucalypts.

Journal of Planar Chromatography–Modern TLC published new progress about Angophora. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Boruah, Tribani; Das, Sabuj Kanti; Kumar, Greesh; Mondal, Saptarsi; Dey, Ramendra Sundar published the artcile< Dual active sites in a triazine-based covalent organic polymeric framework promoting oxygen reduction reaction>, COA of Formula: C8H6O5, the main research area is triazine covalent organic polymeric framework oxygen reduction reaction.

A new significant feature of a triazine-based covalent organic polymer electrocatalyst is demonstrated. The metal-free electrocatalyst has dual-active sites, which enable it to entangle oxygen via a push-pull interaction that plays a crucial role in promoting the oxygen reduction reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystallinity. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, COA of Formula: C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bharate, Sandip B.; Mudududdla, Ramesh; Bharate, Jaideep B.; Battini, Narsaiah; Battula, Satyanarayana; Yadav, Rammohan R.; Singh, Baldev; Vishwakarma, Ram A. published the artcile< Tandem one-pot synthesis of flavans by recyclable silica-HClO4 catalyzed Knoevenagel condensation and [4 + 2]-Diels-Alder cycloaddition>, Product Details of C8H6O5, the main research area is flavan preparation Knoevenagel condensation Diels Alder silica perchloric acid.

An efficient one-pot multi-component synthesis of flavans, e.g., I, using perchloric acid supported on silica as a recyclable heterogeneous catalyst has been described. This is the first report of direct one-step construction of a flavan skeleton from a phenolic precursor, e.g., II. The method involves a Knoevenagel-type condensation leading to in situ formation of transient O-quinone methide which further undergoes [4 + 2]-Diels-Alder cycloaddition with styrene, e.g., 4-H2C:CHC6H4CMe3, to yield a flavan skeleton. The method provides easy access to a wide range of bio-active natural products viz. flavonoids, anthocyanins and catechins.

Organic & Biomolecular Chemistry published new progress about Diels-Alder reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Product Details of C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Caijuan; Li, Guoxun; Mu, Yu; Wu, Wenxi; Cao, Bixuan; Wang, Zixuan; Yu, Hainan; Guan, Peipei; Han, Li; Li, Liya; Huang, Xueshi published the artcile< Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, In Vitro and In Vivo Investigations of Jamunones>, Name: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is jamunone analog preparation antitumor triple neg breast cancer.

Twenty-three natural jamunone analogs along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the Me group on chromanone affected the selectivity of mols. against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (I; JM) was screened as the most effective anti-triple-neg. breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Name: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sharma, Rohit; Abbat, Sheenu; Mudududdla, Ramesh; Vishwakarma, Ram A.; Bharatam, Prasad V.; Bharate, Sandip B. published the artcile< ortho-Quinone methides: TFA-mediated generation in water and trapping with lactams and styrenes>, Formula: C8H6O5, the main research area is quinone methide TFA generation water trapping lactam styrene.

A simple and efficient trifluoroacetic acid mediated protocol for ortho-amidomethylation of phenols in aqueous medium was described. Developed protocol has a good substrate scope, involves mild reaction conditions, and products are obtained in good yields. The quantum chem. calculations were performed in implicit solvent (water) conditions, which helped in tracing the reaction mechanism and getting insights on the possible reaction pathway, which involves the N-C bond formation and simultaneous hydrogen transfer to give final product. The applicability of this protocol for 1-pot synthesis of flavans from phenols, formaldehyde and styrene also was demonstrated.

Tetrahedron Letters published new progress about Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Formula: C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhunia, Subhajit; Molla, Rostam Ali; Kumari, Vandana; Islam, Sk. Manirul; Bhaumik, Asim published the artcile< Zn(II) assisted synthesis of porous salen as an efficient heterogeneous scaffold for capture and conversion of CO2>, Safety of 2,4,6-Trihydroxyisophthalaldehyde, the main research area is zinc salphen functionalized porous polymer preparation heterogeneous catalyst; carbon dioxide cyclization epoxide zinc salphen polymer heterogeneous catalyst; dioxolanone derivative preparation.

The authors have designed a unique strategy to obtain a Zn-salphen functionalized porous polymer (Zn@SBMMP) with high Zn content (15.3%) by an easy one-step, cost effective and scalable process, from the solvothermal reaction of 3,3′-diaminobenzidine, phloroglucinoldialdehyde, and zinc acetate in DMF under N2, which shows unprecedented catalytic efficiency in the CO2 fixation reaction via cycloaddition of CO2 with epoxides. The authors hypothesize that a high d. of Zn-Schiff base/salphen units present in the porous polymer network is responsible for the exceptionally high catalytic performance of Zn@SBMMP.

Chemical Communications (Cambridge, United Kingdom) published new progress about Carbon sequestration. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Safety of 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bharate, Sandip B.; Singh, Inder Pal published the artcile< A two-step biomimetic synthesis of antimalarial robustadials A and B>, HPLC of Formula: 4396-13-8, the main research area is phloroglucinol Vilsmeier Haak formylation; diformylphloroglucinol preparation isobutanal pinene Knoevenagel condensation Diels Alder cycloaddition; robustadial A B asym synthesis.

The antimalarial robustadials A and B have been synthesized in two steps starting from com. available phloroglucinol comprising a key biomimetic three-component reaction that involves in situ generation of an o-quinone methide via Knoevenagel condensation and subsequent Diels-Alder cycloaddition with (-)-β-pinene.

Tetrahedron Letters published new progress about Biomimetic synthesis. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, HPLC of Formula: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bharate, Sandip B.; Singh, Inder Pal published the artcile< A two-step biomimetic synthesis of antimalarial robustadials A and B>, HPLC of Formula: 4396-13-8, the main research area is phloroglucinol Vilsmeier Haak formylation; diformylphloroglucinol preparation isobutanal pinene Knoevenagel condensation Diels Alder cycloaddition; robustadial A B asym synthesis.

The antimalarial robustadials A and B have been synthesized in two steps starting from com. available phloroglucinol comprising a key biomimetic three-component reaction that involves in situ generation of an o-quinone methide via Knoevenagel condensation and subsequent Diels-Alder cycloaddition with (-)-β-pinene.

Tetrahedron Letters published new progress about Biomimetic synthesis. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, HPLC of Formula: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhong, Lin-Fang; Shang, Zhi-Chun; Sun, Fu-Juan; Zhu, Pan-Hu; Yin, Yong; Kong, Ling-Yi; Yang, Ming-Hua published the artcile< Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is formyl phloroglucinol meroterpenoid preparation anticandidal antibiofilm; Antibiofilm activity; Anticandidal activity; Essential oil; Formyl phloroglucinol meroterpenoids.

Inspired by the diversity-oriented synthesis, some novel formyl phloroglucinol meroterpenoids were synthesized via biomimetic synthesis using essential oils. Eight of them were demonstrated with good in vitro fungicidal activity against Candida albicans and C. glabrata. Cedartriol B (I) showed the best anticandidal ability that was powerfully comparable to fluconazole when testing against several strains in vitro. The antibiofilm activity was also found for the I treating group which was evidenced to block the hyphal elongation and filamentation of C. albicans. Therefore, compound I is a promising candidate for further antifungal-based structure modification.

Bioorganic Chemistry published new progress about [4+2] Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts