Category: 438565-33-4

Zhang, Da-Wei published the artcileEfficient synthesis of bis-isoxazole ethers via 1,3-dipolar cycloaddition catalysed by Zn/Zn²⁺ and their antifungal activities, Computed Properties of 438565-33-4, the publication is Chemical Papers (2015), 69(11), 1500-1511, database is CAplus.

A series of novel bis-isoxazole ether compounds I [R = 3-pyridyl, 3-O₂NC₆H₄, 4-O₂NC₆H₄, 4-(H₃C)₃CC₆H₄; R¹ = 4-C(CH₃)₃, 3-NO₂, (Z)-CH=CHC₆H₅, etc.] were synthesized starting from different substituted aldehydes RCHO and R¹CHO via 1,3-dipolar cycloaddition using Zn/Zn²⁺ as a catalyst. In addition, the antimicrobial properties of synthesized products were investigated. The synthesized compounds I exhibited significant antifungal activities in comparison with the standard drugs, fluconazole and itraconazole. It was found that Candida albicans was sensitive to 2-substituted Ph bis-isoxazole ethers bearing pyridyl I [R¹ = 2-OCH₃, 2-Cl].

Chemical Papers published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C12H17NS2, Computed Properties of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Fan published the artcileDesign, Ultrasonic-assisted Synthesis and Evaluation In vitro Antimicrobial Activity of Bis-isoxazole Derivatives Bearing Chloro-pyridinyl Group, Computed Properties of 438565-33-4, the publication is Chemical Research in Chinese Universities (2021), 37(3), 668-673, database is CAplus.

An ultrasonic-assisted synthesis of bis-isoxazole derivatives was developed. Eight 3-(6-chloropyridin-3-yl)-5-{[(3-arylisoxazol-5-yl)methoxy]methyl}isoxazoles I [R¹ = H, 4-Me, 2-Cl, etc.] were synthesized by 1,3-dipolar cycloaddition reaction between substituted isoxazolyl alkyne compounds and 6-chloro-N-hydroxynicotinimidoyl chloride. The structures of the synthesized compounds were confirmed by HRMS, FTIR, ¹H and ¹³C NMR spectroscopy. Wherein, the antifungal and antibacterial activities of target compounds were tested. The synthesized compounds I [R¹ = 2-methoxy, 2-Cl] exhibited better antifungal activity in comparison with the standard drug itraconazole. The min. inhibitory concentrations(MICs) of compound I [R¹ = 2-methoxy, 2-Cl] were both 4μg/mL against Candida albicans ATCC 10231.

Chemical Research in Chinese Universities published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C10H8ClNO2, Computed Properties of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Datong published the artcileSynthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings, Category: alcohols-buliding-blocks, the publication is Archives of Pharmacal Research (2010), 33(6), 831-842, database is CAplus and MEDLINE.

Two series of novel 2-Bu succinate-based Hydroxamate derivatives containing isoxazole rings, e.g. I [R = H, i-Bu], were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcusaureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.

Archives of Pharmacal Research published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C8H14O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xi-Zhao published the artcileConcise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins, Computed Properties of 438565-33-4, the publication is Journal of the Chinese Chemical Society (Taipei, Taiwan) (2007), 54(3), 643-652, database is CAplus.

The synthesis of a series of penicillin aryl-isoxazole derivatives, such as I [R = Ph, C₆H₄-4-F, -2-Cl, -4-Cl, -2-Br, -2-OMe, -4-OMe, -3-NO₂, -4-NO₂, -3-CF₃, -4-CF₃, C₆H₃-2,4-Cl₂, -3,4-Cl₂, C₆H₂-2,4,5-Cl₃, -3,4,5-Cl₃, pyridin-2-yl, pyridin-4-yl], were prepared via amidation reactions of the corresponding aryl-substituted isoxazolecarbonyl chlorides with 6-aminopenicillanic acid. Concise large-scale synthesis of the 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition reactions of the intermediate aryloximes RCH:NOH with HCCCH₂OH using CuSO₄.5H₂O as catalyst was also investigated. Some of the synthesized compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-neg. bacteria.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H7BrO2, Computed Properties of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, L. published the artcileDesign, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2011), 50B(5), 695-703, database is CAplus.

N-formylhydroxylamines RC(NH₂):COCH₂NHCOCHBuCH₂N(OH)CHO (R = substituted Ph) were synthesized through a multi-step protocol starting from H₂C(CO₂Et)₂. The newly synthesized compounds were screened for antibacterial activity. All the compounds exhibited potent in-vitro inhibitory activity against S. aureus and weak activity against K. pneumoniae.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Ran published the artcileMicrowave-assisted efficient synthesis of 3-substituted bis-isoxazole ether bearing 2-chloro-3-pyridyl via 1,3-dipolar cycloaddition, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Molecular Diversity (2020), 24(2), 423-435, database is CAplus and MEDLINE.

An efficient strategy for synthesizing of 3-substituted bis-isoxazole ether bearing 2-chloro-3-pyridyl under microwave radiation was reported. The reactive regioselectivity was improved by changing mainly the solvent and acid-binding agent. 3-(2-Chloropyridin-3-yl)-5-(((3-substituted Ph isoxazol-5-yl)methoxy)methyl)isoxazoles were synthesized in 31-92% yields and were characterized by FT-IR, HRMS, ¹H and ¹³C NMR spectroscopy. The single crystal of 3-(2-chloropyridin-3-yl)-5-(((3-(p-tolyl)isoxazol-5-yl)methoxy)methyl)isoxazole was obtained and the structure of compound was also determined by X-ray diffraction technique. Weak intra- and intermol. C-H···O interactions and a C-H···π interaction link mols. into a three-dimensional network. The results showed that the synthesized compounds belonged to triclinic system, and their regioselectivity depended on the solvent and acid-binding agent. The merits of this method include the environmentally friendly, efficient, simple operation, and higher regional selectivity. An efficient synthesis of 3-substituted bis-isoxazole ethers was developed via 1,3-dipolar cycloaddition reaction starting from 3-substituted phenyl-5-((prop-2-yn-1-yloxy)methyl)isoxazoles and (Z)-2-chloro-N-hydroxynicotinimidoyl chloride using NaHCO₃ as an acid-binding agent in THF solvent-dissolved trace water under catalyst-free microwave-assisted conditions.

Molecular Diversity published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C9H4F6O, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Dawei published the artcileAn efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO₂ under microwave irradiation, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Monatshefte fuer Chemie (2016), 147(9), 1605-1614, database is CAplus.

An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, Et acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86-96 %), and were characterized by HRMS, FTIR, ¹H NMR, and ¹³C NMR spectroscopy. Solid support SiO₂ possesses favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO₂. Moreover, the crystal structure of compound di-Et 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented.

Monatshefte fuer Chemie published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C6H6N2O, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts