Category: 438565-33-4

Zhang, Da-Wei published the artcileEfficient solvent-free synthesis of bis(indolyl)methanes on SiO₂ solid support under microwave irradiation, HPLC of Formula: 438565-33-4, the publication is Chemical Papers (2015), 69(3), 470-478, database is CAplus.

An efficient synthesis of bis(indolyl)methanes I (R¹ = C₆H₅, 3-pyridinyl, 4-CH₃C₆H₄, etc.) was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98%). Solid support SiO₂ was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring II (R² = H, t-Bu, 4-Cl, etc.) were synthesized via this method in excellent yields (> 94%) using 3-substituted isoxazole-5-carbaldehydes and indole.

Chemical Papers published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C9H11NO4, HPLC of Formula: 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Da-wei published the artcileUltrasonic-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via various terminal acetylenes and azide and their quorum sensing inhibition, Product Details of C10H8ClNO2, the publication is Ultrasonics Sonochemistry (2017), 343-353, database is CAplus and MEDLINE.

An efficient synthesis of 1,4-disubstituted 1,2,3-triazole derivatives I (R = C₆H₅, 2-ClC₆H₄, 3-O₂NC₆H₄, etc.) and II was studied. 1,4-Disubstituted 1,2,3-triazoles containing isoxazole and thymidine structures were synthesized in 84-96% yields starting from various terminal isoxazole ether alkynes and β-thymidine azide derivatives via a 1,3-dipolar cycloaddition using copper acetate, sodium ascorbate as the catalyst under ultrasonic assisted condition. Furthermore, the quorum sensing inhibitory activities of synthesized compounds were evaluated with Chromobacterium violaceum (C. Violaceum CV026) based on their inhibition of violacein production, with compound C₁₀-HSL as a pos. control. The compounds II (R = C₆H₅, 4-ClC₆H₄,and 4-C(CH₃)₃C₆H₄) exhibited considerable levels of inhibitory activity against violacein production, and IC₅₀ values were 217 +/- 19, 223 +/- 20 and 42.8 +/- 4.5 μM, resp., which highlighted the potential of these compounds as lead structures for further research towards the development of novel QS inhibitors.

Ultrasonics Sonochemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C12H17NS2, Product Details of C10H8ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Chuansheng published the artcileOne-pot synthesis of (3-phenylisoxazol-5-yl)methanol derivatives under ultrasound, Quality Control of 438565-33-4, the publication is Letters in Organic Chemistry (2011), 8(4), 278-281, database is CAplus.

An ultrasonic-assisted, one-pot, efficient, convenient procedure for the synthesis of (3-phenylisoxazol-5-yl)methanol derivatives was developed. (3-Phenylisoxazol-5-yl)methanol derivatives with biol. and pharmaceutical property were synthesized in moderate to excellent yields. The synthetic methods possess the advantages of high yield, facile operation process and shorter reaction time, and so on.

Letters in Organic Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C24H29N5O3, Quality Control of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shang, Yong-Jia published the artcileSoluble polymer-supported synthesis of isoxazoles, Product Details of C10H8ClNO2, the publication is Tetrahedron Letters (2002), 43(12), 2247-2249, database is CAplus.

The first soluble polymer-supported synthesis of isoxazoles through a 1,3-dipolar cycloaddition is described. A soluble polymer-supported alkyne reacts with nitrile oxides generated in situ to give isoxazoles in good yield.

Tetrahedron Letters published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C10H10O2, Product Details of C10H8ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shang, Yong-Jia published the artcileSynthesis of isoxazolines and isoxazoles using poly(ethylene glycol) as support, Product Details of C10H8ClNO2, the publication is Synthesis (2002), 1663-1668, database is CAplus.

A general method for the liquid-phase syntheses of isoxazoles and isoxazolines through a 1,3-dipolar cycloaddition is described. The poly(ethylene glycol) (PEG)-supported alkyne or alkene reacted with nitrile oxides generated in situ from aldoximes, followed by cleavage from the PEG, to give isoxazoles or isoxazolines in good yield and purity.

Synthesis published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H3Cl2N3, Product Details of C10H8ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II), Name: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(9), 1148-1155, database is CAplus and MEDLINE.

New structures of isoxazole-moiety-containing thieno[2,3-d]pyrimidine derivatives I (R¹ = Me, Ph; R² = H, Me; R³ = H, Ph; R⁴ = H, 4-Me, 4-MeO, etc.) were synthesized for the first time and their in vitro anticancer activity against lung cancer A549, colorectal HCT116 and breast cancer MCF-7 cell lines was preliminarily evaluated using the MTT method. Most of the compounds exhibited good to excellent anticancer activity. In particular, I (R¹ = Me; R², R³ = H; R⁴ = Br), I (R¹, R³ = Ph; R² = H; R⁴ = 4-MeO) and I (R¹, R³ = Ph; R² = H; R⁴ = 4-Br) exhibited a broad spectrum and more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising anticancer drug-candidates.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Name: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jian-Ping published the artcilePotential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(1), 131-136, database is CAplus and MEDLINE.

14 New structures of isoxazole-moiety-containing quinazoline derivatives(3a∼3n) were synthesized for the first time and characterized by IR, 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, most compounds showed good to excellent anticancer activity, especially 3d, 3i, 3k and 3m exhibited the more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising drug candidates for development of anticancer drugs.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis and Biological Evaluation of Quinazoline Derivatives as Potential Anticancer Agents (II), Quality Control of 438565-33-4, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(10), 1326-1332, database is CAplus and MEDLINE.

Under the guidance of our previous work, we synthesized 21 new structures of quinazolines (3a∼3u) and evaluated their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines using the MTT method. Most compounds showed good to excellent anticancer activity. In particular, 3o (regarded as erlotinib analogs) has marked anticancer activity against A549, HCT116 and MCF-7 cell lines (IC50s: 4.26, 3.92 and 0.14 M, resp.) as compared with the standard anticancer drug gefitinib (IC50s: 17.9, 21.55 and 20.68 M, resp.), and which can be regarded as the best candidate for development of anticancer drugs.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Quality Control of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis of isoxazole moiety containing ferrocene derivatives and preliminarily in vitro anticancer activity, Related Products of alcohols-buliding-blocks, the publication is MedChemComm (2014), 5(7), 968-972, database is CAplus.

Seven isoxazole-ring-containing ferrocene derivatives were synthesized and characterized by ¹H NMR, ¹³C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116, and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, ferrocenecarboxylic acid 3-(2-chlorophenyl)isoxazol-5-ylmethyl ester (3d) exhibited wide spectrum anticancer activity and is the most potent among the isoxazole-ring-containing ferrocene derivatives Compound 3d is more active against A549 and HCT116 cell lines (IC₅₀s: 0.747 and 3.65 nM, resp.) than the reference drug gefitinib (IC₅₀s: 17.90 and 21.55 μM, resp.). 3D can be seen as the best candidate for development of anticancer drugs.

MedChemComm published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Dejin published the artcileSynthesis and herbicidal activities of N^ε-[(anilino)carbonyl]-N^α-[(3-phenyl-5-isoxazolyl)carbonyl]lysine, HPLC of Formula: 438565-33-4, the publication is Youji Huaxue (2010), 30(9), 1366-1371, database is CAplus.

Recently the D1 protease located in the thylakoid membranes of higher plants was found to be a potential herbicide target and based on a lead compound [N^α-[(5-isoxazolyl)carbonyl]lysine, D1 protease inhibitor] a series of novel N⁵-[(phenylamino)carbonyl]-N₂-[(3-phenyl-5-isoxazolyl)carbonyl]lysine derivatives were designed. The synthesis of the target compounds was achieved using as reactants 3-phenyl-5-isoxazolecarbonyl chlorides and N⁵-[(phenylamino)carbonyl]lysine and the products thus obtained were confirmed by IR, ¹H-NMR and elemental anal. The biol. activity was examined in vivo and it was discovered that most compounds possessed moderate herbicidal activity. Meanwhile, the e activity of one compound was evaluated against spinach D1 protease (i.e., thylakoid protein precursor processing peptidase, chloroplast protein precursor-processing proteinase, photosystem D1 protein precursor carboxyl-terminal processing proteinase, proteinase CtpA) and the result showed its inhibiting effect against this enzyme.

Youji Huaxue published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C10H8ClNO2, HPLC of Formula: 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts