9/18 News Extracurricular laboratory: Synthetic route of 4358-87-6

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4358-87-6, Methyl 2-hydroxy-2-phenylacetate.

Related Products of 4358-87-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4358-87-6, name is Methyl 2-hydroxy-2-phenylacetate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Entry 5: According to general procedure II (chapter 2.1.2) racemic methyl mandelate (rac-132, 336 mg, 2.00 mmol, 1.0 equiv), DMF (30.9 ilL, 29.2 mg, 0.40 mmol, 20 molpercent), dioxane (1 mL, 2 M)and 2-fluoro benzoyl chloride (372 ilL, 490 mg, 3.00 mmol, 1.5 equiv) were combined and allowed to react for 36 h at 80 C. Chromatographic purification of the crude material (540 mg, 232/332 86:14) on silica gel (mass of crude material/Si02 1:9) with Et20/nPen 5:95 gave rise of the chloride rac-232 ascolorless oil (227 mg, 1.23 mmol, 62percent).M (C9H9C102) = 184.62 g/mol; rf (Si02, Et20/nPen 5:95) = 0.37; [aID2° = +134.1 (c = 1.48 g/100 mL,CHCI3).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4358-87-6, Methyl 2-hydroxy-2-phenylacetate.

Reference:
Patent; UNIVERSITAET DES SAARLANDES; HUY, Peter Helmut; (208 pag.)WO2016/202894; (2016); A1;,
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